B1PRL5
Gene name |
Cavin4 |
Protein name |
Caveolae-associated protein 4 |
Names |
Muscle-related coiled-coil protein, Muscle-restricted coiled-coil protein |
Species |
Rattus norvegicus (Rat) |
KEGG Pathway |
rno:313225 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for B1PRL5
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-B1PRL5-F1 | Predicted | AlphaFoldDB |
No variants for B1PRL5
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for B1PRL5 | |||||
No associated diseases with B1PRL5
No regional properties for B1PRL5
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for B1PRL5 | |||
Functions
7 GO annotations of cellular component
| Name | Definition |
|---|---|
| caveola | A membrane raft that forms small pit, depression, or invagination that communicates with the outside of a cell and extends inward, indenting the cytoplasm and the cell membrane. Examples include flask-shaped invaginations of the plasma membrane in adipocytes associated with caveolin proteins, and minute pits or incuppings of the cell membrane formed during pinocytosis. Caveolae may be pinched off to form free vesicles within the cytoplasm. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| sarcolemma | The outer membrane of a muscle cell, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers. |
| sarcoplasm | The cytoplasm of a muscle cell; includes the sarcoplasmic reticulum. |
| Z disc | Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| cell differentiation | The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. |
| muscle organ development | The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work. |
| positive regulation of transcription by RNA polymerase II | Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. |
| regulation of gene expression | Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). |
| regulation of Rho protein signal transduction | Any process that modulates the frequency, rate or extent of Rho protein signal transduction. |
5 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| A5PJI6 | CAVIN4 | Caveolae-associated protein 4 | Bos taurus (Bovine) | PR |
| Q6NZI2 | CAVIN1 | Caveolae-associated protein 1 | Homo sapiens (Human) | PR |
| Q5BKX8 | CAVIN4 | Caveolae-associated protein 4 | Homo sapiens (Human) | PR |
| A2AMM0 | Cavin4 | Caveolae-associated protein 4 | Mus musculus (Mouse) | PR |
| O54724 | Cavin1 | Caveolae-associated protein 1 | Mus musculus (Mouse) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEHNGSASNA | GKIHQNRLSS | VTEDEDQDAA | LTIVTVLDRV | ATVVDSVQAS | QKRIEERHRE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| MGNAIKSVQI | DLLKLSQSHS | NTGYVVNKLF | EKTRKVSAHI | KDVKARVEKQ | QVRVTKVETK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| QEEIMKKNKF | RVVIFQEDVP | CPASLSVVKD | RSLPENEEEA | EEVFDPPIDL | SSDEEYYVEE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SRSARLRKSG | KEHIDHIKKA | FSKENMQKTR | QNFDKKVSGI | RTRIVTPERR | ERLRQSGERL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| RQSGERLRQS | GERFKKSISN | ATPSKEAFKI | RSLRKPKDPK | AEGQEVDRGM | GVDIISGSLA |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LGPIHEFHSD | GFSETEKEVT | KVGYIPQEGG | DPPTPEPLKV | TFKPQVRVED | DESLLLELKQ |
| SS |