AiPD: Autoinhibited Protein Database

Gene name	Cavin4 (Murc)
Protein name	Caveolae-associated protein 4
Names	Muscle-related coiled-coil protein, Muscle-restricted coiled-coil protein
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:68016
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-362 (Predicted disordered autoinhibitory region) PR

1-362 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-A2AMM0-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3388686000	19	S>T	No	EVA
rs27843433	20	S>G	No	EVA
rs3388684964	24	D>H	No	EVA
rs3410377037	71	D>E	No	EVA
rs3388682741	73	L>V	No	EVA
rs3388681375	117	V>I	No	EVA
rs3388685978	126	K>R	No	EVA
rs3394274497	129	K>N	No	EVA
rs256971285	133	V>E	No	EVA
rs3388688784	145	L>M	No	EVA
rs3388682373	155	E>G	No	EVA
rs3388684147	159	E>*	No	EVA
rs3388670384	183	S>T	No	EVA
rs27843359	212	T>N	No	EVA
rs3388677266	218	S>I	No	EVA
rs3388688734	246	R>K	No	EVA
rs3388663706	258	I>N	No	EVA
rs3388681406	268	F>L	No	EVA
rs246259679	282	E>K	No	EVA
rs3388670370	288	R>S	No	EVA
rs3388679324	300	A>P	No	EVA
rs3388682298	301	L>M	No	EVA
rs3388678951	335	P>L	No	EVA
rs3388681370	344	P>H	No	EVA
rs3388682369	344	P>T	No	EVA
rs3388682696	351	D>N	No	EVA
rs3388688745	352	E>V	No	EVA

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for A2AMM0

		Description
EC Number
Subcellular Localization	Cytoplasm, myofibril, sarcomere Cytoplasm Cytoplasm, cytosol Membrane, caveola Cell membrane, sarcolemma Cell membrane	In cardiomyocytes, accumulates in the Z-line of the sarcomere In vascular smooth muscle cells, detected diffusely throughout the cytoplasm (PubMed:18332105) Localizes in the caveolae in a caveolin-dependent manner (PubMed:19546242)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
caveola	A membrane raft that forms small pit, depression, or invagination that communicates with the outside of a cell and extends inward, indenting the cytoplasm and the cell membrane. Examples include flask-shaped invaginations of the plasma membrane in adipocytes associated with caveolin proteins, and minute pits or incuppings of the cell membrane formed during pinocytosis. Caveolae may be pinched off to form free vesicles within the cytoplasm.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
sarcolemma	The outer membrane of a muscle cell, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers.
sarcoplasm	The cytoplasm of a muscle cell; includes the sarcoplasmic reticulum.
Z disc	Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached.

Name	Definition
GTPase activator activity	Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.

Name	Definition
cardiac myofibril assembly	The process whose specific outcome is the progression of the cardiac myofibril over time, from its formation to the mature structure. A cardiac myofibril is a myofibril specific to cardiac muscle cells.
muscle organ development	The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work.
positive regulation of transcription by RNA polymerase II	Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
regulation of gene expression	Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
regulation of Rho protein signal transduction	Any process that modulates the frequency, rate or extent of Rho protein signal transduction.
Rho protein signal transduction	The series of molecular signals within the cell that are mediated by a member of the Rho family of proteins switching to a GTP-bound active state.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
A5PJI6	CAVIN4	Caveolae-associated protein 4	Bos taurus (Bovine)	PR
Q6NZI2	CAVIN1	Caveolae-associated protein 1	Homo sapiens (Human)	PR
Q5BKX8	CAVIN4	Caveolae-associated protein 4	Homo sapiens (Human)	PR
O54724	Cavin1	Caveolae-associated protein 1	Mus musculus (Mouse)	PR
B1PRL5	Cavin4	Caveolae-associated protein 4	Rattus norvegicus (Rat)	PR