AiPD: Autoinhibited Protein Database

Gene name	CAVIN4 (MURC)
Protein name	Caveolae-associated protein 4
Names	Muscle-related coiled-coil protein, Muscle-restricted coiled-coil protein
Species	Bos taurus (Bovine)
KEGG Pathway	bta:528386
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-361 (Predicted disordered autoinhibitory region) PR

1-361 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-A5PJI6-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs458202750	13	I>M	No	EVA
rs718020247	68	V>I	No	EVA
rs457217170	71	D>G	No	EVA
rs435526720	71	D>N	No	EVA
rs475657186	90	F>Y	No	EVA
rs458919704	96	V>F	No	EVA
rs459826970	108	E>A	No	EVA
rs481415452	110	Q>E	No	EVA
rs448554595	112	T>P	No	EVA
rs463896285	117	V>F	No	EVA
rs482546244	117	V>G	No	EVA
rs464147384	122	E>D	No	EVA
rs434507273	123	E>D	No	EVA
rs468410771	126	K>N	No	EVA
rs446556015	126	K>R	No	EVA
rs435387341	127	K>Q	No	EVA
rs457080336	129	K>N	No	EVA
rs469292151	130	F>L	No	EVA
rs433034899	130	F>Y	No	EVA
rs452452114	134	I>L	No	EVA
rs442866948	140	Q>H	No	EVA
rs136523899	140	Q>R	No	EVA
rs476767762	143	T>P	No	EVA
rs443695603	148	V>E	No	EVA
rs477396919	155	E>D	No	EVA
rs441324832	156	S>R	No	EVA
rs459878091	160	V>E	No	EVA
rs459878091	160	V>G	No	EVA
rs481493051	171	S>A	No	EVA
rs378825487	193	R>H	No	EVA
rs448023414	235	Q>H	No	EVA
rs469779226	236	S>A	No	EVA
rs482026074	254	F>V	No	EVA
rs448430813	279	R>*	No	EVA
rs434569231	283	E>*	No	EVA
rs453100741	283	E>A	No	EVA
rs468488078	283	E>D	No	EVA
rs435463384	284	G>D	No	EVA
rs476639011	288	V>A	No	EVA
rs443734125	291	M>L	No	EVA
rs452586395	293	V>G	No	EVA
rs470856618	299	G>S	No	EVA
rs459767395	309	Y>C	No	EVA
rs459767395	309	Y>S	No	EVA
rs481552746	310	P>L	No	EVA
rs463359058	320	E>A	No	EVA
rs481878885	321	A>P	No	EVA
rs464279218	323	A>T	No	EVA
rs479473151	324	T>P	No	EVA
rs435526800	328	Q>K	No	EVA
rs207769902	330	G>S	No	EVA
rs208569913	331	G>R	No	EVA
rs452390452	334	S>T	No	EVA
rs470921951	335	T>P	No	EVA
rs714549169	345	P>S	No	EVA
rs442153821	347	V>G	No	EVA
rs475001996	347	V>M	No	EVA
rs464067364	348	K>Q	No	EVA
rs717233783	348	K>R	No	EVA
rs476077350	349	V>E	No	EVA
rs479534424	350	E>D	No	EVA
rs457715997	350	E>K	No	EVA
rs446554175	352	D>Y	No	EVA
rs450548836	355	L>R	No	EVA
rs480458002	355	L>V	No	EVA

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for A5PJI6

		Description
EC Number
Subcellular Localization	Cytoplasm, myofibril, sarcomere Cytoplasm Cytoplasm, cytosol Cell membrane, sarcolemma Membrane, caveola	In cardiomyocytes, accumulates in the Z-line of the sarcomere In vascular smooth muscle cells, detected diffusely throughout the cytoplasm Localizes in the caveolae in a caveolin-dependent manner
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
caveola	A membrane raft that forms small pit, depression, or invagination that communicates with the outside of a cell and extends inward, indenting the cytoplasm and the cell membrane. Examples include flask-shaped invaginations of the plasma membrane in adipocytes associated with caveolin proteins, and minute pits or incuppings of the cell membrane formed during pinocytosis. Caveolae may be pinched off to form free vesicles within the cytoplasm.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
sarcolemma	The outer membrane of a muscle cell, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers.
sarcoplasm	The cytoplasm of a muscle cell; includes the sarcoplasmic reticulum.
Z disc	Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached.

Name	Definition
No GO annotations for molecular function

Name	Definition
cell differentiation	The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
muscle organ development	The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work.
positive regulation of transcription by RNA polymerase II	Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
regulation of gene expression	Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
regulation of Rho protein signal transduction	Any process that modulates the frequency, rate or extent of Rho protein signal transduction.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q6NZI2	CAVIN1	Caveolae-associated protein 1	Homo sapiens (Human)	PR
Q5BKX8	CAVIN4	Caveolae-associated protein 4	Homo sapiens (Human)	PR
O54724	Cavin1	Caveolae-associated protein 1	Mus musculus (Mouse)	PR
A2AMM0	Cavin4	Caveolae-associated protein 4	Mus musculus (Mouse)	PR
B1PRL5	Cavin4	Caveolae-associated protein 4	Rattus norvegicus (Rat)	PR