A6QLG5

PR
Gene name
RPS9
Protein name
40S ribosomal protein S9
Names
Species
Bos taurus (Bovine)
KEGG Pathway
bta:533892
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-57 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A6QLG5

Entry ID Method Resolution Chain Position Source
AF-A6QLG5-F1 Predicted AlphaFoldDB

93 variants for A6QLG5

Variant ID(s) Position Change Description Diseaes Association Provenance
rs459615115 4 A>P No EVA
rs468439335 5 R>P No EVA
rs442616057 6 S>G No EVA
rs457462177 11 K>R No EVA
rs437282037 12 T>P No EVA
rs471836679 13 Y>F No EVA
rs451726757 15 T>A No EVA
rs451726757 15 T>P No EVA
rs451726757 15 T>S No EVA
rs434736295 17 R>G No EVA
rs449544886 18 R>S No EVA
rs435819873 20 F>S No EVA
rs479486838 43 V>F No EVA
rs465766152 46 V>F No EVA
rs480514255 51 A>T No EVA
rs443460872 67 D>A No EVA
rs477969750 68 P>R No EVA
rs453379146 77 L>M No EVA
rs474250864 81 L>P No EVA
rs457333813 82 V>L No EVA
rs465644046 83 R>P No EVA
rs435010867 86 V>G No EVA
rs466373469 87 L>P No EVA
rs466373469 87 L>R No EVA
rs446551765 88 D>E No EVA
rs480925088 89 E>G No EVA
rs450419512 112 T>A No EVA
rs481603594 112 T>S No EVA
rs458817974 116 K>N No EVA
rs438677663 117 L>R No EVA
rs473233555 118 G>R No EVA
rs442605324 122 S>P No EVA
rs474308146 123 I>T No EVA
rs443671332 124 H>P No EVA
rs457397172 124 H>Y No EVA
rs471794254 125 H>P No EVA
rs451950153 126 A>P No EVA
rs435071356 131 R>P No EVA
rs466376531 134 H>P No EVA
rs463301261 140 Q>H No EVA
rs482806223 140 Q>P No EVA
rs439885080 141 V>A No EVA
rs477688792 143 N>Y No EVA
rs440600160 150 R>C No EVA
rs451702294 153 S>L No EVA
rs472301509 154 Q>K No EVA
rs455399250 155 K>R No EVA
rs441674915 160 S>T No EVA
rs476194489 163 S>A No EVA
rs456463594 164 P>A No EVA
rs433078700 164 P>L No EVA
rs433078700 164 P>R No EVA
rs456463594 164 P>T No EVA
rs433722341 165 Y>* No EVA
rs453856133 165 Y>N No EVA
rs469355567 169 R>G No EVA
rs445982053 169 R>H No EVA
rs460817895 170 P>S No EVA
rs481594263 171 G>R No EVA
rs441736074 172 R>P No EVA
rs456075300 173 V>A No EVA
rs456075300 173 V>G No EVA
rs476300029 173 V>L No EVA
rs439151742 174 K>E No EVA
rs470892851 175 R>G No EVA
rs453974330 176 K>* No EVA
rs453974330 176 K>E No EVA
rs433789938 176 K>R No EVA
rs438062018 177 N>K No EVA
rs454926078 177 N>T No EVA
rs446014272 178 A>G No EVA
rs469462911 178 A>P No EVA
rs432328487 179 K>E No EVA
rs467269066 179 K>N No EVA
rs432328487 179 K>Q No EVA
rs481662062 181 G>R No EVA
rs451076198 182 Q>K No EVA
rs482801338 182 Q>P No EVA
rs462620845 183 G>R No EVA
rs470588069 185 A>D No EVA
rs470588069 185 A>G No EVA
rs470588069 185 A>V No EVA
rs440262840 186 G>V No EVA
rs454588709 187 A>D No EVA
rs454588709 187 A>G No EVA
rs452557970 189 D>E No EVA
rs475929862 189 D>G No EVA
rs432409550 190 D>A No EVA
rs466986041 190 D>E No EVA
rs446816364 191 E>G No EVA
rs436696760 192 E>G No EVA
rs451137374 194 D>G No EVA
rs468034293 194 D>Y No EVA

No associated diseases with A6QLG5

3 regional properties for A6QLG5

Type Name Position InterPro Accession
domain Ribosomal protein S4/S9, N-terminal 3 - 107 IPR001912
domain RNA-binding S4 domain 108 - 179 IPR002942
conserved_site Ribosomal protein S4, conserved site 106 - 130 IPR018079

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Nucleus, nucleolus
  • Localized in cytoplasmic mRNP granules containing untranslated mRNAs
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
cytosolic small ribosomal subunit The small subunit of a ribosome located in the cytosol.
nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
ribonucleoprotein complex A macromolecular complex that contains both RNA and protein molecules.
small ribosomal subunit The smaller of the two subunits of a ribosome.
synapse The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.

3 GO annotations of molecular function

Name Definition
rRNA binding Binding to a ribosomal RNA.
structural constituent of ribosome The action of a molecule that contributes to the structural integrity of the ribosome.
translation regulator activity Any molecular function involved in the initiation, activation, perpetuation, repression or termination of polypeptide synthesis at the ribosome.

3 GO annotations of biological process

Name Definition
positive regulation of cell population proliferation Any process that activates or increases the rate or extent of cell proliferation.
positive regulation of translational fidelity Any process that increases the ability of the translational apparatus to interpret the genetic code.
translation The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome.

7 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P0A7V8 rpsD 30S ribosomal protein S4 Escherichia coli (strain K12) PR
P55935 RpS9 40S ribosomal protein S9 Drosophila melanogaster (Fruit fly) PR
P46781 RPS9 40S ribosomal protein S9 Homo sapiens (Human) PR
Q6ZWN5 Rps9 40S ribosomal protein S9 Mus musculus (Mouse) PR
P29314 Rps9 40S ribosomal protein S9 Rattus norvegicus (Rat) PR
Q20228 rps-9 40S ribosomal protein S9 Caenorhabditis elegans PR
Q9FLF0 RPS9C 40S ribosomal protein S9-2 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MPVARSWVCR KTYVTPRRPF EKSRLDQELK LIGEYGLRNK REVWRVKFTL AKIRKAAREL
70 80 90 100 110 120
LTLDEKDPRR LFEGNALLRR LVRIGVLDEG KMKLDYILGL KIEDFLERRL QTQVFKLGLA
130 140 150 160 170 180
KSIHHARVLI RQRHIRVRKQ VVNIPSFIVR LDSQKHIDFS LRSPYGGGRP GRVKRKNAKK
190
GQGGAGAGDD EEED