A4IG42

PR
Gene name
tcaf (zgc:162193)
Protein name
TRPM8 channel-associated factor homolog
Names
Species
Danio rerio (Zebrafish) (Brachydanio rerio)
KEGG Pathway
dre:323315
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

394-463 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A4IG42

Entry ID Method Resolution Chain Position Source
AF-A4IG42-F1 Predicted AlphaFoldDB

No variants for A4IG42

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A4IG42

No associated diseases with A4IG42

2 regional properties for A4IG42

Type Name Position InterPro Accession
domain Peptidase family M60 domain 539 - 886 IPR031161
domain M60-like domain, N-terminal 525 - 628 IPR035423

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

1 GO annotations of molecular function

Name Definition
transmembrane transporter binding Binding to a transmembrane transporter, a protein or protein complex that enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.

2 GO annotations of biological process

Name Definition
positive regulation of protein targeting to membrane Any process that increases the frequency, rate or extent of the process of directing proteins towards a membrane, usually using signals contained within the protein.
regulation of anion channel activity Any process that modulates the frequency, rate or extent of anion channel activity.

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
A5PJN5 TCAF1 TRPM8 channel-associated factor 1 Bos taurus (Bovine) PR
Q9Y4C2 TCAF1 TRPM8 channel-associated factor 1 Homo sapiens (Human) PR
Q6QR59 Tcaf3 TRPM8 channel-associated factor 3 Mus musculus (Mouse) PR
Q6P6V7 Tcaf3 TRPM8 channel-associated factor 3 Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MAREQDYYTL MSGMQQLDLQ GKAVPSDLVL IGEHAFPLAM NPRGQVLMAA SHYGRGRIVV
70 80 90 100 110 120
LGHEEYLTRF PGLIENAIMW LMPCTGDAGV VGIQKSLRTV AENLNYSPFK TELGDFQDRF
130 140 150 160 170 180
AIYITDAYSV ESSAKDLIAF LKAGGGLIIA GQAWSWSYEH PQENTIRNFP GNKVCSVAGI
190 200 210 220 230 240
YFSELEGEVG TFPVPRNIPS SWLAVAIGKD FKEDLEFLLE GVSEFDTQGG AIASEVMVHG
250 260 270 280 290 300
PLAFPIAVTP NGKTFIAGAY YGQGRVIVVS HEGYMGRDSL SSFMINAIKW LDEGRKGVVG
310 320 330 340 350 360
IVPNLTAAHT VLSKSGLDCQ LTGFREDLSV YVCTSYSDAQ CAEIQEFVAE GGGLLIGGHA
370 380 390 400 410 420
WYWAQTHCGS NVMTEYPGNH ILNKMGLCLL GNTLGGGLYK APEIEHSCKH GYHFRSMLQR
430 440 450 460 470 480
FAQHVSQGQE LTDREQGCLK QLGTDCASYL QMRCHDSAAY TSVVALLSDI VKEVGVPQVC
490 500 510 520 530 540
SNCPVESPKD HLMLHIGTEV YKVTPDPDAL LPYIIKDRPN LPTLSNARVR ITANTGGCEE
550 560 570 580 590 600
WISTGLYLSP GMKTYIAVPP EIVGKNWQVQ LGCQTDNIGG SNTLKRAPVV HARFPLDSEM
610 620 630 640 650 660
VQVWNLWGGL IYLIAPSQTK VDGVEIVVQN AVQAPYFKSG ETSVADWVSH IRQAPAPWAE
670 680 690 700 710 720
LEFENLIMTF DSAFIRNLDR PDEVAKLWDT IMRTITDLAA RPPKLPRKER FVADVQISYG
730 740 750 760 770 780
FMHAGYPIMM HSGSAPGLVN VEEAYKCGLW GAIHELGHNQ QRGVWEFPPH TTECTCNLWS
790 800 810 820 830 840
LYVHEQVFGI KSANAHPAIT PADRQARTKM YFDGGKDLNS WCMWMALETY MQLQEKFGWD
850 860 870 880 890 900
AFKKVFSLYH DMTGVPNDNA GKMNLYAQTF SKVVNLNLSP FFKAWGWPIQ PNTEQNLSHL
910
PAWSDHPVSQ YA