Q6QR59

PR
Gene name
Tcaf3
Protein name
TRPM8 channel-associated factor 3
Names
Experimental autoimmune prostatitis antigen 2
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:403088
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

478-559 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6QR59

Entry ID Method Resolution Chain Position Source
AF-Q6QR59-F1 Predicted AlphaFoldDB

86 variants for Q6QR59

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3388824808 20 D>V No EVA
rs3388817105 31 L>I No EVA
rs3396683618 32 L>H No EVA
rs3396272159 35 E>K No EVA
rs1132257338 44 D>G No EVA
rs37212519 63 V>I No EVA
rs3388826026 93 I>M No EVA
rs233546988 94 A>V No EVA
rs238402066 120 G>R No EVA
rs3388805197 131 Y>C No EVA
rs215222242 135 L>F No EVA
rs3388810134 136 T>S No EVA
rs3388824795 145 N>D No EVA
rs3396739370 175 Q>G No EVA
rs3388810072 181 G>V No EVA
rs3388810092 186 D>V No EVA
rs224495739 199 E>K No EVA
rs3388822278 207 V>I No EVA
rs244182707 215 D>Y No EVA
rs3388822290 216 D>E No EVA
rs3388827308 217 Q>K No EVA
rs3388833408 227 I>T No EVA
rs3388827627 232 G>D No EVA
rs3388826076 243 Q>* No EVA
rs3388817045 266 G>E No EVA
rs3388827300 267 R>W No EVA
rs3388827565 269 V>E No EVA
rs3388805159 270 L>M No EVA
rs3388821776 271 G>A No EVA
rs3388814024 282 M>L No EVA
rs3388814089 291 H>P No EVA
rs3388827609 298 T>I No EVA
rs246410142 316 N>S No EVA
rs3388821772 320 Q>L No EVA
rs3388814078 323 E>D No EVA
rs3388829834 335 C>F No EVA
rs264974380 379 Y>H No EVA
rs243720966 381 D>N No EVA
rs219873924 395 H>R No EVA
rs254416926 410 T>I No EVA
rs222159323 463 K>R No EVA
rs3388817013 466 L>Q No EVA
rs3388794532 468 M>L No EVA
rs3388794489 471 S>C No EVA
rs3388826042 502 S>F No EVA
rs581498875 529 T>P No EVA
rs36321963 530 D>G No EVA
rs3388822256 546 Q>L No EVA
rs235444380 550 V>I No EVA
rs217251969 551 L>S No EVA
rs3396272105 554 S>K* No EVA
rs257430461 576 R>K No EVA
rs3388810043 576 R>S No EVA
rs246976521 588 Y>F No EVA
rs218193305 593 S>C No EVA
rs3388822327 599 W>R No EVA
rs250615961 611 N>D No EVA
rs3388805164 625 A>S No EVA
rs3388833449 629 P>L No EVA
rs3388822285 648 S>I No EVA
rs212513213 671 E>V No EVA
rs3388814015 672 L>P No EVA
rs1135369144 676 Y>D No EVA
rs3388827559 706 V>L No EVA
rs3388805148 747 I>R No EVA
rs3388817067 748 H>D No EVA
rs3388805146 749 E>G No EVA
rs3388824814 778 H>Y No EVA
rs3396860697 792 S>P No EVA
rs3388829837 794 N>S No EVA
rs3396434908 796 E>K No EVA
rs3388833467 814 N>D No EVA
rs3388829792 816 I>F No EVA
rs3388829817 829 E>* No EVA
rs3388805145 830 G>* No EVA
rs3388829875 831 F>L No EVA
rs3388794449 831 F>S No EVA
rs37152294 839 V>L No EVA
rs224210688 842 D>E No EVA
rs263327017 844 R>Q No EVA
rs37882504 867 A>V No EVA
rs249382320 877 E>A No EVA
rs37028360 885 Y>H No EVA
rs3388817078 896 E>D No EVA
rs216466354 904 R>M No EVA
rs3388833426 910 T>I No EVA

No associated diseases with Q6QR59

2 regional properties for Q6QR59

Type Name Position InterPro Accession
domain Peptidase family M60 domain 533 - 880 IPR031161
domain M60-like domain, N-terminal 518 - 623 IPR035423

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cell junction A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

1 GO annotations of molecular function

Name Definition
transmembrane transporter binding Binding to a transmembrane transporter, a protein or protein complex that enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.

3 GO annotations of biological process

Name Definition
negative regulation of anion channel activity Any process that stops, prevents, or reduces the frequency, rate, or extent of the anion channel activity.
positive regulation of protein targeting to membrane Any process that increases the frequency, rate or extent of the process of directing proteins towards a membrane, usually using signals contained within the protein.
regulation of anion channel activity Any process that modulates the frequency, rate or extent of anion channel activity.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9Y4C2 TCAF1 TRPM8 channel-associated factor 1 Homo sapiens (Human) PR
Q6P6V7 Tcaf3 TRPM8 channel-associated factor 3 Rattus norvegicus (Rat) PR
A4IG42 tcaf TRPM8 channel-associated factor homolog Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MATTPDAAFE TLMNGVTSWD LPKEPIPSEL LLTGESAFPV MVNDKGQVLI AASSYGQGRL
70 80 90 100 110 120
VVVSHESYLL HDGLVPFLLN VVKWLCPCPG APIAVHSSLA SLVNILGDSG INALVQPEPG
130 140 150 160 170 180
EALGVYCIDA YNDALTEKLI QFLKNGGGLL IGGQALNWAA HHGHDKVLSI FPGNQVTSVA
190 200 210 220 230 240
GVYFTDISAN RDWFKVSKEI PNLRLYVQCE DELEDDQQQL LKGMSEIYIE AGVIPSQLLV
250 260 270 280 290 300
HGQRAFPLGV DNSLNCFLAA ARYGRGRVVL GGNESLILNQ TMLPFVLNAL HWLMGNQTGR
310 320 330 340 350 360
IGLASDMKVL KSMLPNSSFQ WSESELLTSD LSVFCCCSLA NIDSEEVEEF VAEGGGLLIG
370 380 390 400 410 420
AEAWSWGRRN PYSSCMTQYP DNIVLKRFGL GITSHVAQRG SFPFPNPEGT NYHFRRALSQ
430 440 450 460 470 480
FESVIYSRGS SLHESWLNKL SQDCFYMFQM THQRISIYDS VKKHALKMIQ SKDFPSVTEQ
490 500 510 520 530 540
YPIARGSSQA FLLSLAYELF KSGVDRSQLL PPPALLPPTE SPITIKISTD NDNSWVSTGL
550 560 570 580 590 600
YLPEGQVAQV LLPSEATHAK LKVLIGCHRD NISQARTYFR PPVMTYVYHL TSSQTSISWL
610 620 630 640 650 660
YGGLLYIMVP NKYNQDNVSV TIRGAVSAPY FRLGKTTQEE WKNLITHSKA PWGELATDNI
670 680 690 700 710 720
ILTIPTVNLK ELQDPYPLLQ LWDKMVRAVA KLAARPFPFQ RAERVVLDKQ ISFGFLHSGY
730 740 750 760 770 780
PIMGLISIVE GIISEFKIRS HGIWGVIHEL GHNHQKSGWT FPPHTTEALC NLWTIYVHET
790 800 810 820 830 840
VLNIPREQAH PSLNPELRRQ RIKYHLNKGA PLSNWIMWTA LETYLQLQEG FGWEPFIQVF
850 860 870 880 890 900
ADYRTLSGLP QNNEDKMNLW VKKFSEAVHK NLAPFFEAWG WPVKYAVAKS LASLPEWQEN
910
PMKRYTAEGT EGRE