Q6P6V7

PR
Gene name
Tcaf3
Protein name
TRPM8 channel-associated factor 3
Names
Experimental autoimmune prostatitis antigen 2 homolog
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:494321
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-60 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6P6V7

Entry ID Method Resolution Chain Position Source
AF-Q6P6V7-F1 Predicted AlphaFoldDB

No variants for Q6P6V7

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6P6V7

No associated diseases with Q6P6V7

2 regional properties for Q6P6V7

Type Name Position InterPro Accession
domain Peptidase family M60 domain 533 - 880 IPR031161
domain M60-like domain, N-terminal 517 - 623 IPR035423

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

1 GO annotations of molecular function

Name Definition
transmembrane transporter binding Binding to a transmembrane transporter, a protein or protein complex that enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.

3 GO annotations of biological process

Name Definition
negative regulation of anion channel activity Any process that stops, prevents, or reduces the frequency, rate, or extent of the anion channel activity.
positive regulation of protein targeting to membrane Any process that increases the frequency, rate or extent of the process of directing proteins towards a membrane, usually using signals contained within the protein.
regulation of anion channel activity Any process that modulates the frequency, rate or extent of anion channel activity.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q6QR59 Tcaf3 TRPM8 channel-associated factor 3 Mus musculus (Mouse) PR
A4IG42 tcaf TRPM8 channel-associated factor homolog Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MATTPDAAFE ALMNGVTSWN LPKEPTPSEL LLTGEAAFPV MVNDKDQVLI AASFYGHGRL
70 80 90 100 110 120
VVLSHESYLL HAGLAPFLLN AVSWLCPSPE APIAVHSSLA SLVKILGDSG VNAVVQPEPR
130 140 150 160 170 180
EALGVYCIDA YSETLTETLI RFMKNGGGLL IGGQALTWAV HHGHEKVLSS FPGNQVTSVA
190 200 210 220 230 240
GVYFTDISGN RDWFKVSKEI PNLTLYVQCE DELKYDQQQL LKGMSEMDIE TGPVPSQLLV
250 260 270 280 290 300
HGQRAFPLGV DNSFNCFLAA ARFGRGRVVL AGHESLILNQ TMLPFVLNAL RWLMGNQTGR
310 320 330 340 350 360
IGLASEMKAL KSVLPNSSFE WSETELLTND LSVFCSCSLG KTDPKKVEEF VAEGGGLLIG
370 380 390 400 410 420
AEAWMWGRRN PDSNCMTQYP NNIILKRFGV GIISQVVQRG RFPVPNPEVI NYHIRRALSQ
430 440 450 460 470 480
YESVIHSQGS SLQEGWLNKL SQDCFYMFQM THQRISIYDS VKEHALKMIQ SQGFPSVTEQ
490 500 510 520 530 540
HPITKGSSQA FLLSLAYELF KSGVDRSQLL PPPTLLSPTE SPMTIKISTG NDNSWVSTGL
550 560 570 580 590 600
YLPEGQVAQV TLPTEATHAK LKVLIGCHID NISQAKTYIR PPVMTYVYHL TSSQTSISWL
610 620 630 640 650 660
YGGLLYIMVP DKYNQDNVSV TISGAVSAPY FRLGKTTQEE WKNLIEHSKA PWGELATDNI
670 680 690 700 710 720
ILTIPTVNLK VLQDPYPLLQ LWDKIVKAVA KLAARPFPFQ RPERIVLDKQ ISFGFLHSGY
730 740 750 760 770 780
PIMGLIIIVE GIINEFKIRS HGVWGVTHEL GHNHQKPGWT FRPHTTEALC NLWSIYVHET
790 800 810 820 830 840
VLNIPRDQAH PSLNPELRKQ RIKDHLNKGA PLSNWIVWTA LETYLQLQEG FGWEPFIQLF
850 860 870 880 890 900
ANYQTLTGLP QNNEDKMNLW VKKFSEVVQK NLAPFFKAWG WPVQHAVAKS LASLPEWQEN
910
PMKMYTAEST EHTE