A5PJN5

PR
Gene name
TCAF1
Protein name
TRPM8 channel-associated factor 1
Names
TRP channel-associated factor 1
Species
Bos taurus (Bovine)
KEGG Pathway
bta:533126
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

169-249 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A5PJN5

Entry ID Method Resolution Chain Position Source
AF-A5PJN5-F1 Predicted AlphaFoldDB

No variants for A5PJN5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A5PJN5

No associated diseases with A5PJN5

No regional properties for A5PJN5

Type Name Position InterPro Accession
No domain, repeats, and functional sites for A5PJN5

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane
  • Colocalizes with TRPM8 on the plasma membrane
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

1 GO annotations of molecular function

Name Definition
transmembrane transporter binding Binding to a transmembrane transporter, a protein or protein complex that enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.

3 GO annotations of biological process

Name Definition
positive regulation of anion channel activity Any process that activates or increases the frequency, rate or extent of anion channel activity.
positive regulation of protein targeting to membrane Any process that increases the frequency, rate or extent of the process of directing proteins towards a membrane, usually using signals contained within the protein.
regulation of anion channel activity Any process that modulates the frequency, rate or extent of anion channel activity.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9Y4C2 TCAF1 TRPM8 channel-associated factor 1 Homo sapiens (Human) PR
A4IG42 tcaf TRPM8 channel-associated factor homolog Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MATPSAAFEA LMNGVTSWNV PEDAVPCELL LIGEASFPVM VNDMGQVLIA ASSYGRGRLV
70 80 90 100 110 120
VVSHEDYLVE AQLTPFLLNA VGWLCSSPGA PVGVHPSLAP LAKILEGSGV EAKVEPEVKD
130 140 150 160 170 180
SLGVYCIDAY NETMTEKLVK FMKRGGGLLI GGQAWDWANQ GDDERVLFTF PGNLVTSVAG
190 200 210 220 230 240
VYFTDNKGDT SFFKVSKKMP KIPVLVSCED DLSEDRDELL HGISELDITN SDCFPSQLLV
250 260 270 280 290 300
HGALAFPLGL DSYHGCVIAA ARYGRGRVVV TGHKVLFTVG KLGPFLLNAV RWLDAGRRGK
310 320 330 340 350 360
IVVQTELRTL SGLLAVGGID TSIEPNLTSD ASVYCFEPVS DVGVKELQEF VAEGGGLFVG
370 380 390 400 410 420
AQAWWWAFKN PGVSPLARFP GNLLLNPFGI SITSQSLNPG PFRTPKAGIR TYHFRSTLAE
430 440 450 460 470 480
FQVIMGRKRG NVEKGWLAKL GPDGAAFLQI PAEEIPAYMS VHRLLRKLLS RYRLPVATRE
490 500 510 520 530 540
NPVINDCCRG AMLSLATGLA HSGSDLSLLV PEIEDMYSSP YLRPSESPIT VEVNCNNPGT
550 560 570 580 590 600
RYCWMSTGLY IPGRQIIEVS LPEAAASADL KIQIGCHTDD LTRASKLFRG PLVINRCCLD
610 620 630 640 650 660
KPTKSITCLW GGLLYIIVPQ SSKLGTVPVT IKGAVRAPYY KLGETTQEEW KRQIQENPGP
670 680 690 700 710 720
WGELATDNII LTVPTANLRT LENPEPLLRL WDEVMQAVAR LGAEPFPLRL PQRIVADVQI
730 740 750 760 770 780
SVGWMHAGYP IMCHLESVQE LINEKLIRTK GLWGPVHELG RNQQRQEWEF PPHTTEATCN
790 800 810 820 830 840
LWCVYVHETV LGIPRGRANI ALWPPVREKR VRIYLGKGPN VKNWNAWTAL ETYLQLQEAF
850 860 870 880 890 900
GWEPFIRLFT EYRNQTNLPT DNVDKMNLWV KMFSHQVQKN LAPFFEAWAW PIQKEVATSL
910 920
AYLPEWEENI MKLYLLTQMP H