A0AUV4
Gene name |
Gm7168 |
Protein name |
Sperm motility kinase Y |
Names |
|
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:635895 |
EC number |
2.7.11.1: Protein-serine/threonine kinases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
164-186 (Activation loop from InterPro)
Target domain |
28-276 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
Autoinhibited structure
Activated structure
1 structures for A0AUV4
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-A0AUV4-F1 | Predicted | AlphaFoldDB |
No variants for A0AUV4
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for A0AUV4 | |||||
No associated diseases with A0AUV4
14 regional properties for A0AUV4
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Leucine-rich repeat N-terminal domain | 31 - 63 | IPR000372 |
| domain | Cysteine-rich flanking region, C-terminal | 160 - 208 | IPR000483 |
| domain | Protein kinase domain | 538 - 814 | IPR000719 |
| domain | Serine-threonine/tyrosine-protein kinase, catalytic domain | 539 - 809 | IPR001245 |
| repeat | Leucine-rich repeat | 104 - 160 | IPR001611 |
| conserved_site | Tyrosine-protein kinase, receptor class II, conserved site | 703 - 711 | IPR002011 |
| domain | Immunoglobulin subtype | 216 - 302 | IPR003599 |
| domain | Immunoglobulin-like domain | 210 - 300 | IPR007110 |
| active_site | Tyrosine-protein kinase, active site | 675 - 687 | IPR008266 |
| domain | Immunoglobulin I-set | 323 - 391 | IPR013098 |
| domain | Immunoglobulin-like beta-sandwich domain | 218 - 296 | IPR013151 |
| binding_site | Protein kinase, ATP binding site | 544 - 572 | IPR017441 |
| domain | Tyrosine-protein kinase, catalytic domain | 538 - 810 | IPR020635 |
| domain | Growth factor receptor NTRK, leucine rich repeat C-terminal | 163 - 208 | IPR031635 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.1 | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| protein serine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. |
| protein serine/threonine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| intracellular signal transduction | The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. |
| protein phosphorylation | The process of introducing a phosphate group on to a protein. |
39 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P06782 | SNF1 | Carbon catabolite-derepressing protein kinase | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | EV |
| Q96L34 | MARK4 | MAP/microtubule affinity-regulating kinase 4 | Homo sapiens (Human) | SS |
| P57059 | SIK1 | Serine/threonine-protein kinase SIK1 | Homo sapiens (Human) | PR |
| Q7KZI7 | MARK2 | Serine/threonine-protein kinase MARK2 | Homo sapiens (Human) | SS |
| P27448 | MARK3 | MAP/microtubule affinity-regulating kinase 3 | Homo sapiens (Human) | SS |
| Q9P0L2 | MARK1 | Serine/threonine-protein kinase MARK1 | Homo sapiens (Human) | EV |
| O60285 | NUAK1 | NUAK family SNF1-like kinase 1 | Homo sapiens (Human) | PR |
| Q8VHJ5 | Mark1 | Serine/threonine-protein kinase MARK1 | Mus musculus (Mouse) | SS |
| Q03141 | Mark3 | MAP/microtubule affinity-regulating kinase 3 | Mus musculus (Mouse) | SS |
| Q8CIP4 | Mark4 | MAP/microtubule affinity-regulating kinase 4 | Mus musculus (Mouse) | SS |
| Q05512 | Mark2 | Serine/threonine-protein kinase MARK2 | Mus musculus (Mouse) | SS |
| O35280 | Chek1 | Serine/threonine-protein kinase Chk1 | Mus musculus (Mouse) | PR |
| Q69Z98 | Brsk2 | Serine/threonine-protein kinase BRSK2 | Mus musculus (Mouse) | EV |
| Q5RJI5 | Brsk1 | Serine/threonine-protein kinase BRSK1 | Mus musculus (Mouse) | EV |
| Q61846 | Melk | Maternal embryonic leucine zipper kinase | Mus musculus (Mouse) | PR |
| O54863 | Tssk2 | Testis-specific serine/threonine-protein kinase 2 | Mus musculus (Mouse) | PR |
| Q61241 | Tssk1b | Testis-specific serine/threonine-protein kinase 1 | Mus musculus (Mouse) | PR |
| Q8C0X8 | Sperm motility kinase X | Mus musculus (Mouse) | PR | |
| Q8C0N0 | Gm4922 | Sperm motility kinase Z | Mus musculus (Mouse) | PR |
| Q641K5 | Nuak1 | NUAK family SNF1-like kinase 1 | Mus musculus (Mouse) | PR |
| Q5EG47 | Prkaa1 | 5'-AMP-activated protein kinase catalytic subunit alpha-1 | Mus musculus (Mouse) | SS |
| Q8BRK8 | Prkaa2 | 5'-AMP-activated protein kinase catalytic subunit alpha-2 | Mus musculus (Mouse) | SS |
| A2KF29 | Smoktcr | Sperm motility kinase Tcr mutant form | Mus musculus (Mouse) | PR |
| O08678 | Mark1 | Serine/threonine-protein kinase MARK1 | Rattus norvegicus (Rat) | SS |
| Q8VHF0 | Mark3 | MAP/microtubule affinity-regulating kinase 3 | Rattus norvegicus (Rat) | SS |
| O08679 | Mark2 | Serine/threonine-protein kinase MARK2 | Rattus norvegicus (Rat) | SS |
| Q8LIG4 | CIPK3 | CBL-interacting protein kinase 3 | Oryza sativa subsp japonica (Rice) | PR |
| Q852Q1 | OSK4 | Serine/threonine protein kinase OSK4 | Oryza sativa subsp. japonica (Rice) | SS |
| Q852Q2 | OSK1 | Serine/threonine protein kinase OSK1 | Oryza sativa subsp. japonica (Rice) | SS |
| Q6ZLP5 | CIPK23 | CBL-interacting protein kinase 23 | Oryza sativa subsp japonica (Rice) | PR |
| Q2RAX3 | CIPK33 | CBL-interacting protein kinase 33 | Oryza sativa subsp japonica (Rice) | PR |
| Q2QY53 | CIPK32 | CBL-interacting protein kinase 32 | Oryza sativa subsp japonica (Rice) | PR |
| Q9TW45 | par-1 | Serine/threonine-protein kinase par-1 | Caenorhabditis elegans | SS |
| Q94CG0 | CIPK21 | CBL-interacting serine/threonine-protein kinase 21 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q93VD3 | CIPK23 | CBL-interacting serine/threonine-protein kinase 23 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LDI3 | CIPK24 | CBL-interacting serine/threonine-protein kinase 24 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FLZ3 | KIN12 | SNF1-related protein kinase catalytic subunit alpha KIN12 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| P92958 | KIN11 | SNF1-related protein kinase catalytic subunit alpha KIN11 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q38997 | KIN10 | SNF1-related protein kinase catalytic subunit alpha KIN10 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MPAHIEEELP | PPSPQPSNPE | DGELYSQYKV | VRTLGHGTYA | KVLLAKHWLT | GTPVAVKVLL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KNKPCFQPAM | KEANIMKKIK | HPNIVSLLQV | FETKTRGYLI | MELVEGQELY | EYIKSSGHIE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| EDEARQIFLQ | ILSAVSYCHG | LGIVHRDLKP | DNIMIDDKGS | IKIIDFGLST | QVKPGDLLDE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| HCGAYAFGAP | ELFLWKSYDG | TKSDLWALGV | ILYYMVVGKV | PFDSYIIPEL | QRQILAGVYP |
| 250 | 260 | 270 | 280 | 290 | 300 |
| APCGVSNELK | DLLSLLMTVN | PKYRPTVTEV | MKHPWLRGHC | KGLTNIHEEP | VPVRPDPDIV |
| 310 | 320 | 330 | 340 | 350 | 360 |
| DAMQYIGFQA | KDIRESLTKE | KFNEMSAAYY | LLEEQALQRE | VRSTQAPTVS | QVKAPFPSMD |
| 370 | 380 | 390 | 400 | 410 | 420 |
| AGEASCLKIK | RSGSASILGR | SVWPPSIDQE | PAYVQKVRQR | AGRRSSGHGL | LFEANQMTPT |
| 430 | 440 | 450 | 460 | 470 | 480 |
| QDQHHIRAMS | VPCMLSTSSI | SEESVSEKRE | ENLSHIALAE | DKPIRSRGWC | RGIMRWTRRV |
| 490 | 500 | ||||
| GNAIRTLCCC | IPSRKTPQLG | QSRVSPQK |