Q9TW45

PR
Gene name
par-1 (H39E23.1)
Protein name
Serine/threonine-protein kinase par-1
Names
EC 2.7.11.1
Species
Danio rerio (Zebrafish) (Brachydanio rerio)
KEGG Pathway
cel:CELE_H39E23.1
EC number
7.6.2.1: Linked to the hydrolysis of a nucleoside triphosphate
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1092-1192 (KA1 domain) SS

Target domain

170-421 (Protein kinase domain)

Relief mechanism

Others

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

0 structures for Q9TW45

Entry ID Method Resolution Chain Position Source
No available structures

No variants for Q9TW45

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9TW45

No associated diseases with Q9TW45

6 regional properties for Q9TW45

Type Name Position InterPro Accession
conserved_site ATP-dependent RNA helicase DEAD-box, conserved site 169 - 177 IPR000629
domain Helicase, C-terminal 241 - 405 IPR001650
domain DEAD/DEAH box helicase domain 33 - 212 IPR011545
domain Helicase superfamily 1/2, ATP-binding domain 28 - 237 IPR014001
domain RNA helicase, DEAD-box type, Q motif 9 - 37 IPR014014
domain Domain of unknown function DUF4217 402 - 465 IPR025313

Functions

Description
EC Number 7.6.2.1 Linked to the hydrolysis of a nucleoside triphosphate
Subcellular Localization
  • Golgi apparatus, trans-Golgi network membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cell cortex The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.
cell periphery The broad region around and including the plasma membrane of a cell, encompassing the cell cortex (inside the cell), the plasma membrane, and any external encapsulating structures.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
P granule A small cytoplasmic, non-membranous RNA/protein complex aggregate in the primordial germ cells of many higher eukaryotes.

7 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
metal ion binding Binding to a metal ion.
myosin II tail binding Binding to the tail region of a myosin II heavy chain.
protein serine kinase activity Catalysis of the reactions
protein serine/threonine kinase activity Catalysis of the reactions
tau-protein kinase activity Catalysis of the reaction
ubiquitin protein ligase binding Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins.

10 GO annotations of biological process

Name Definition
asymmetric neuroblast division The process resulting in the physical partitioning and separation of a neuroblast into two daughter cells with different developmental potentials.
asymmetric protein localization involved in cell fate determination Any process in which a protein is transported to, or maintained in, a specific asymmetric distribution, resulting in the formation of daughter cells of different types.
embryonic pattern specification The process that results in the patterns of cell differentiation that will arise in an embryo.
establishment of cell polarity The specification and formation of anisotropic intracellular organization or cell growth patterns.
establishment or maintenance of cell polarity Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns.
intracellular signal transduction The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
microtubule cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins.
phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.
polarity specification of anterior/posterior axis Any process resulting in the establishment of polarity along the anterior/posterior axis.
vulval development The process whose specific outcome is the progression of the egg-laying organ of female and hermaphrodite nematodes over time, from its formation to the mature structure. In nematodes, the vulva is formed from ventral epidermal cells during larval stages to give rise to a fully formed vulva in the adult.

15 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P57059 SIK1 Serine/threonine-protein kinase SIK1 Homo sapiens (Human) PR
P27448 MARK3 MAP/microtubule affinity-regulating kinase 3 Homo sapiens (Human) SS
Q96L34 MARK4 MAP/microtubule affinity-regulating kinase 4 Homo sapiens (Human) SS
Q9P0L2 MARK1 Serine/threonine-protein kinase MARK1 Homo sapiens (Human) EV
Q7KZI7 MARK2 Serine/threonine-protein kinase MARK2 Homo sapiens (Human) SS
Q8C0N0 Gm4922 Sperm motility kinase Z Mus musculus (Mouse) PR
Q8C0X8 Sperm motility kinase X Mus musculus (Mouse) PR
A0AUV4 Gm7168 Sperm motility kinase Y Mus musculus (Mouse) PR
Q03141 Mark3 MAP/microtubule affinity-regulating kinase 3 Mus musculus (Mouse) SS
Q8CIP4 Mark4 MAP/microtubule affinity-regulating kinase 4 Mus musculus (Mouse) SS
Q8VHJ5 Mark1 Serine/threonine-protein kinase MARK1 Mus musculus (Mouse) SS
Q05512 Mark2 Serine/threonine-protein kinase MARK2 Mus musculus (Mouse) SS
Q8VHF0 Mark3 MAP/microtubule affinity-regulating kinase 3 Rattus norvegicus (Rat) SS
O08678 Mark1 Serine/threonine-protein kinase MARK1 Rattus norvegicus (Rat) SS
O08679 Mark2 Serine/threonine-protein kinase MARK2 Rattus norvegicus (Rat) SS
10 20 30 40 50 60
MADGIPLNPV RKNLRKTAYY DASRPARYQI EDESSNLDEM PLMMSEEAFE NDESDYQTLP
70 80 90 100 110 120
RARVSQRRRG LGWFLCGGWK VLCSSCCECL VHTCRRKKEL KARTVWLGHP EKCEEKYPKN
130 140 150 160 170 180
AIKNQKYNIV TFVPGVLYQQ FKFFLNLYFL VVACSQFVPS LKIGYLYTYW APLGFVLAVT
190 200 210 220 230 240
MVREAVDEVR RCRRDKEMNS QLYSKLTVRG KVQVKSSDIQ VGDLIIVEKN QRIPADMIFL
250 260 270 280 290 300
RTSEKTGSCF IRTDQLDGET DWKLRIGVAC TQRLPALGDL FSISAYVYVQ KPQLDIHSFE
310 320 330 340 350 360
GNFTREDCDP PIHESLSIEN TLWASTVVAS GTVIGVVIYT GKEMRSVMNT SQSKNKVGLL
370 380 390 400 410 420
DLELNRLTKA LFLAQVVLSV VMVALQGFLG PWFRNLFRFV VLFSYIIPIS LRVNLDMGKS
430 440 450 460 470 480
AYGWMIMKDE NIPGTVVRTS TIPEELGRLV YLLTDKTGTL TQNEMVFKRL HLGTVSYGTD
490 500 510 520 530 540
TMDEIQSHII QSYAQVSSAQ SNGSSASSTP SRKPQPPAPK VRKSVSSRIH EAVKAIALCH
550 560 570 580 590 600
NVTPVYESRV NGANAEPEST EADQDFSDDN RTYQASSPDE VALVRWTESV GLTLVNRDLT
610 620 630 640 650 660
SLQLKTPAGQ ILTYYILQIF PFTSESKRMG IIVREEATGD ITFYMKGADV AMASIVQYND
670 680 690 700 710 720
WLEEECGNMA REGLRTLVVA KKSLTEEQYQ DFENRYNQAK LSIHDRNLKV AAVVESLERE
730 740 750 760 770 780
MELLCLTGVE DQLQADVRPT LELLRNAGIK IWMLTGDKLE TATCIAKSSH LVSRNQDIHV
790 800 810 820 830 840
FKPVSNRGEA HLELNAFRRK HDCALVISGD SLEVCLRYYE HEFVELACQC PAVVCCRCSP
850 860 870 880 890 900
TQKAQIVRLL QQHTANRTCA IGDGGNDVSM IQAADCGIGI EGKEGKQASL AADFSITQFK
910 920 930 940 950 960
HIGRLLMVHG RNSYKRSAAL GQFVMHRGMI ISTMQAVFSS IFYFASVPLY QGFLMVGYAT
970 980 990 1000 1010 1020
IYTMFPVFSL VLDQDVKPEM ALLYPELYKD LTKGRSLSFK TFLIWVLISI YQGGILMYGA
1030 1040 1050 1060 1070 1080
LVLFDQEFVH VVAISFTALI LTELLMVALT IRTWHWLMVV AQLISLACYL ASLAFLNEYF
1090 1100 1110 1120
DLSFITTRVF LWKVCVITLV SCLPLYIIKY LKRKFSPPSY SKLSS