A2KF29
Gene name |
Smoktcr |
Protein name |
Sperm motility kinase Tcr mutant form |
Names |
SmokTcr, Tcr, Dominant negative form of Smok, Responder protein Smok-Tcr |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
|
EC number |
2.7.11.1: Protein-serine/threonine kinases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
144-166 (Activation loop from InterPro)
Target domain |
8-256 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
Autoinhibited structure
Activated structure
1 structures for A2KF29
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-A2KF29-F1 | Predicted | AlphaFoldDB |
No variants for A2KF29
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for A2KF29 | |||||
No associated diseases with A2KF29
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.1 | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| protein serine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. |
| protein serine/threonine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
| protein tyrosine kinase activity | Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| intracellular signal transduction | The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. |
| protein phosphorylation | The process of introducing a phosphate group on to a protein. |
26 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P06782 | SNF1 | Carbon catabolite-derepressing protein kinase | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | EV |
| O60285 | NUAK1 | NUAK family SNF1-like kinase 1 | Homo sapiens (Human) | PR |
| O35280 | Chek1 | Serine/threonine-protein kinase Chk1 | Mus musculus (Mouse) | PR |
| Q69Z98 | Brsk2 | Serine/threonine-protein kinase BRSK2 | Mus musculus (Mouse) | EV |
| Q5RJI5 | Brsk1 | Serine/threonine-protein kinase BRSK1 | Mus musculus (Mouse) | EV |
| Q61846 | Melk | Maternal embryonic leucine zipper kinase | Mus musculus (Mouse) | PR |
| O54863 | Tssk2 | Testis-specific serine/threonine-protein kinase 2 | Mus musculus (Mouse) | PR |
| Q61241 | Tssk1b | Testis-specific serine/threonine-protein kinase 1 | Mus musculus (Mouse) | PR |
| Q8C0X8 | Sperm motility kinase X | Mus musculus (Mouse) | PR | |
| A0AUV4 | Gm7168 | Sperm motility kinase Y | Mus musculus (Mouse) | PR |
| Q8C0N0 | Gm4922 | Sperm motility kinase Z | Mus musculus (Mouse) | PR |
| Q641K5 | Nuak1 | NUAK family SNF1-like kinase 1 | Mus musculus (Mouse) | PR |
| Q5EG47 | Prkaa1 | 5'-AMP-activated protein kinase catalytic subunit alpha-1 | Mus musculus (Mouse) | SS |
| Q8BRK8 | Prkaa2 | 5'-AMP-activated protein kinase catalytic subunit alpha-2 | Mus musculus (Mouse) | SS |
| Q8LIG4 | CIPK3 | CBL-interacting protein kinase 3 | Oryza sativa subsp japonica (Rice) | PR |
| Q2RAX3 | CIPK33 | CBL-interacting protein kinase 33 | Oryza sativa subsp japonica (Rice) | PR |
| Q2QY53 | CIPK32 | CBL-interacting protein kinase 32 | Oryza sativa subsp japonica (Rice) | PR |
| Q6ZLP5 | CIPK23 | CBL-interacting protein kinase 23 | Oryza sativa subsp japonica (Rice) | PR |
| Q852Q1 | OSK4 | Serine/threonine protein kinase OSK4 | Oryza sativa subsp. japonica (Rice) | SS |
| Q852Q2 | OSK1 | Serine/threonine protein kinase OSK1 | Oryza sativa subsp. japonica (Rice) | SS |
| Q94CG0 | CIPK21 | CBL-interacting serine/threonine-protein kinase 21 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q93VD3 | CIPK23 | CBL-interacting serine/threonine-protein kinase 23 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LDI3 | CIPK24 | CBL-interacting serine/threonine-protein kinase 24 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FLZ3 | KIN12 | SNF1-related protein kinase catalytic subunit alpha KIN12 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| P92958 | KIN11 | SNF1-related protein kinase catalytic subunit alpha KIN11 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q38997 | KIN10 | SNF1-related protein kinase catalytic subunit alpha KIN10 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEKFHAQYEM | LETIGQGGCA | QVKLARHRLT | GTHVAVKVIV | KRECWFNPVM | SEAELLMMTD |
| 70 | 80 | 90 | 100 | 110 | 120 |
| HPNIISLLQV | IETKKKVYLI | MELCEGKSLY | QHIQNAGYLQ | EDEARPLFKQ | LLSAMNYCHN |
| 130 | 140 | 150 | 160 | 170 | 180 |
| QGIVHRDLTP | DNIMVEKDGK | VKIIDFGLGT | QEKPGQNHNL | FCEIYPFSTP | EVLFNRPYDM |
| 190 | 200 | 210 | 220 | 230 | 240 |
| RKIDVWGLGV | VLYFMVTGKI | LFDTASVEKL | RKQIVAEKCS | VPCRLSVELQ | DLIRLLMTDI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| PELRPTVAEV | MVHPWVTEGS | GVLPDPCEEH | IPLKPDPAIA | KAMGFIGFQA | QDIEDSLCQR |
| 310 | 320 | 330 | 340 | 350 | 360 |
| KFNETMASYC | LLKKQILKEC | DRPIRAQPMN | PSVTPLSSLV | DAPTFHLGLR | RTETEPTGLR |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LSDNKEVPVC | GNSTSKKRER | SFSGPGVLSR | PINTTPTMDQ | THTRTWSGPC | IYSNVCTIHP |
| 430 | 440 | 450 | 460 | 470 | 480 |
| NSINESTEGH | ISTSAEDKPV | HSRGWPRGIK | GWTRKIGNAM | RKLCCCIPSK | ETSHLGQRRV |
| CPKI |