Q9ZW86

PR
Gene name
P4H1
Protein name
Prolyl 4-hydroxylase 1
Names
AtP4H-1, AtP4H1
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT2G43080
EC number
1.14.11.2: With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

11-154 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9ZW86

Entry ID Method Resolution Chain Position Source
AF-Q9ZW86-F1 Predicted AlphaFoldDB

12 variants for Q9ZW86

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH00272338 7 I>V No 1000Genomes
tmp_2_17915796_T_G 14 F>L No 1000Genomes
ENSVATH05708183 21 I>V No 1000Genomes
ENSVATH00272341 42 P>S No 1000Genomes
ENSVATH00272342 50 Q>R No 1000Genomes
tmp_2_17916353_G_A 53 R>H No 1000Genomes
tmp_2_17916542_T_C 59 S>P No 1000Genomes
tmp_2_17916585_G_A 73 G>D No 1000Genomes
tmp_2_17917689_T_C 154 V>A No 1000Genomes
ENSVATH05708217 200 M>V No 1000Genomes
ENSVATH05708218 209 E>K No 1000Genomes
tmp_2_17918337_G_A 227 G>D No 1000Genomes

No associated diseases with Q9ZW86

3 regional properties for Q9ZW86

Type Name Position InterPro Accession
domain Oxoglutarate/iron-dependent dioxygenase 162 - 279 IPR005123
domain Prolyl 4-hydroxylase, alpha subunit 84 - 278 IPR006620
domain Prolyl 4-hydroxylase alpha subunit, Fe(2+) 2OG dioxygenase domain 166 - 278 IPR044862

Functions

Description
EC Number 1.14.11.2 With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
Subcellular Localization
  • Endoplasmic reticulum membrane ; Single-pass type II membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
Golgi apparatus A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
Golgi cis cisterna The Golgi cisterna closest to the endoplasmic reticulum; the first processing compartment through which proteins pass after export from the ER.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

3 GO annotations of molecular function

Name Definition
iron ion binding Binding to an iron (Fe) ion.
L-ascorbic acid binding Binding to L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species.
procollagen-proline 4-dioxygenase activity Catalysis of the reaction: procollagen L-proline + 2-oxoglutarate + O2 = procollagen trans-4-hydroxy-L-proline + succinate + CO2.

1 GO annotations of biological process

Name Definition
peptidyl-proline hydroxylation to 4-hydroxy-L-proline The modification of peptidyl-proline to form 4-hydroxy-L-proline; catalyzed by procollagen-proline,2-oxoglutarate-4-dioxygenase.

8 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q1RMU3 P4HA1 Prolyl 4-hydroxylase subunit alpha-1 Bos taurus (Bovine) PR
P16924 P4HA1 Prolyl 4-hydroxylase subunit alpha-1 Gallus gallus (Chicken) PR
O15460 P4HA2 Prolyl 4-hydroxylase subunit alpha-2 Homo sapiens (Human) PR
P13674 P4HA1 Prolyl 4-hydroxylase subunit alpha-1 Homo sapiens (Human) PR
Q60715 P4ha1 Prolyl 4-hydroxylase subunit alpha-1 Mus musculus (Mouse) PR
P54001 P4ha1 Prolyl 4-hydroxylase subunit alpha-1 Rattus norvegicus (Rat) PR
Q20065 phy-2 Prolyl 4-hydroxylase subunit alpha-2 Caenorhabditis elegans PR
Q9SZT0 P4H11 Probable prolyl 4-hydroxylase 11 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MAPAMKIVFG LLTFVTVGMV IGSLLQLAFI NRLEDSYGTG FPSLRGLRGQ NTRYLRDVSR
70 80 90 100 110 120
WANDKDAELL RIGNVKPEVV SWSPRIIVLH DFLSPEECEY LKAIARPRLQ VSTVVDVKTG
130 140 150 160 170 180
KGVKSDVRTS SGMFLTHVER SYPIIQAIEK RIAVFSQVPA ENGELIQVLR YEPQQFYKPH
190 200 210 220 230 240
HDYFADTFNL KRGGQRVATM LMYLTDDVEG GETYFPLAGD GDCTCGGKIM KGISVKPTKG
250 260 270 280
DAVLFWSMGL DGQSDPRSIH GGCEVLSGEK WSATKWMRQK ATS