Q9SZT0
Gene name |
P4H11 |
Protein name |
Probable prolyl 4-hydroxylase 11 |
Names |
AtP4H11 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT4G35820 |
EC number |
1.14.11.2: With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9SZT0
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9SZT0-F1 | Predicted | AlphaFoldDB |
34 variants for Q9SZT0
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH00554143 | 3 | K>* | No | 1000Genomes | |
| ENSVATH06831007 | 9 | T>I | No | 1000Genomes | |
| tmp_4_16971267_G_T | 16 | R>M | No | 1000Genomes | |
| ENSVATH00554144 | 41 | E>K | No | 1000Genomes | |
| tmp_4_16971344_C_T | 42 | Q>* | No | 1000Genomes | |
| ENSVATH12417522 | 42 | Q>L | No | 1000Genomes | |
| tmp_4_16971368_G_A | 50 | E>K | No | 1000Genomes | |
| ENSVATH06831008 | 52 | K>I | No | 1000Genomes | |
| ENSVATH06831011 | 78 | A>P | No | 1000Genomes | |
| ENSVATH06831013 | 91 | I>M | No | 1000Genomes | |
| ENSVATH06831017 | 110 | I>M | No | 1000Genomes | |
| tmp_4_16971704_C_T | 129 | A>V | No | 1000Genomes | |
| tmp_4_16971719_G_A | 134 | R>H | No | 1000Genomes | |
| ENSVATH06831022 | 137 | L>I | No | 1000Genomes | |
| tmp_4_16971843_C_T | 146 | S>L | No | 1000Genomes | |
| tmp_4_16971855_C_G | 150 | S>* | No | 1000Genomes | |
| tmp_4_16971874_T_G | 156 | S>R | No | 1000Genomes | |
| tmp_4_16971884_A_T | 160 | K>* | No | 1000Genomes | |
| ENSVATH06831027 | 163 | K>E | No | 1000Genomes | |
| tmp_4_16971908_A_T | 168 | R>W | No | 1000Genomes | |
| tmp_4_16971930_T_C | 175 | I>T | No | 1000Genomes | |
| ENSVATH06831032 | 182 | T>K | No | 1000Genomes | |
| tmp_4_16972060_A_G | 184 | Q>R | No | 1000Genomes | |
| tmp_4_16972096_C_T | 196 | P>L | No | 1000Genomes | |
| ENSVATH12417615 | 196 | P>S | No | 1000Genomes | |
| tmp_4_16972107_G_T | 200 | G>* | No | 1000Genomes | |
| tmp_4_16972108_G_T | 200 | G>V | No | 1000Genomes | |
| tmp_4_16972110_T_G | 201 | F>V | No | 1000Genomes | |
| ENSVATH06831034 | 211 | L>H | No | 1000Genomes | |
| ENSVATH06831040 | 215 | D>E | No | 1000Genomes | |
| tmp_4_16972259_G_A | 217 | G>S | No | 1000Genomes | |
| ENSVATH00554148 | 257 | P>H | No | 1000Genomes | |
| tmp_4_16972395_G_C,A | 262 | G>A | No | 1000Genomes | |
| tmp_4_16972395_G_C,A | 262 | G>D | No | 1000Genomes |
No associated diseases with Q9SZT0
Functions
| Description | ||
|---|---|---|
| EC Number | 1.14.11.2 | With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| endoplasmic reticulum | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). |
| endoplasmic reticulum membrane | The lipid bilayer surrounding the endoplasmic reticulum. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| iron ion binding | Binding to an iron (Fe) ion. |
| L-ascorbic acid binding | Binding to L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species. |
| procollagen-proline 4-dioxygenase activity | Catalysis of the reaction: procollagen L-proline + 2-oxoglutarate + O2 = procollagen trans-4-hydroxy-L-proline + succinate + CO2. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| peptidyl-proline hydroxylation to 4-hydroxy-L-proline | The modification of peptidyl-proline to form 4-hydroxy-L-proline; catalyzed by procollagen-proline,2-oxoglutarate-4-dioxygenase. |
8 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q1RMU3 | P4HA1 | Prolyl 4-hydroxylase subunit alpha-1 | Bos taurus (Bovine) | PR |
| P16924 | P4HA1 | Prolyl 4-hydroxylase subunit alpha-1 | Gallus gallus (Chicken) | PR |
| O15460 | P4HA2 | Prolyl 4-hydroxylase subunit alpha-2 | Homo sapiens (Human) | PR |
| P13674 | P4HA1 | Prolyl 4-hydroxylase subunit alpha-1 | Homo sapiens (Human) | PR |
| Q60715 | P4ha1 | Prolyl 4-hydroxylase subunit alpha-1 | Mus musculus (Mouse) | PR |
| P54001 | P4ha1 | Prolyl 4-hydroxylase subunit alpha-1 | Rattus norvegicus (Rat) | PR |
| Q20065 | phy-2 | Prolyl 4-hydroxylase subunit alpha-2 | Caenorhabditis elegans | PR |
| Q9ZW86 | P4H1 | Prolyl 4-hydroxylase 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSKSTSVSTI | LYLRQRLQGL | KIYETSDLIQ | HINTFDELVG | EQVSVDVKIE | EKTKDMILLC |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SLSPLLTTLT | CSMVKVAASL | RFPNERWLEV | ITKEPRAFVY | HNFLALFFKI | CKTNEECDHL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ISLAKPSMAR | SKVRNALTGL | GEESSSRTSS | GTFIRSGHDK | IVKEIEKRIS | EFTFIPQENG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| ETLQVINYEV | GQKFEPHFDG | FQRIATVLMY | LSDVDKGGET | VFPEAKGIKS | KKGVSVRPKK |
| 250 | 260 | 270 | |||
| GDALLFWSMR | PDGSRDPSSK | HGKRHCLSLN | LF |