AiPD: Autoinhibited Protein Database

Gene name	P4HA1
Protein name	Prolyl 4-hydroxylase subunit alpha-1
Names	4-PH alpha-1, Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-1
Species	Bos taurus (Bovine)
KEGG Pathway	bta:518288
EC number	1.14.11.2: With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

79-150 (Predicted disordered autoinhibitory region) PR

79-150 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q1RMU3-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs435633383	21	F>V	No	EVA
rs443129649	23	T>P	No	EVA
rs478310888	107	S>L	No	EVA
rs478687100	124	D>E	No	EVA
rs451391994	205	V>I	No	EVA
rs437835480	206	S>A	No	EVA
rs475947776	228	T>I	No	EVA
rs457935106	293	C>*	No	EVA
rs444311863	294	R>G	No	EVA
rs449982538	305	Q>E	No	EVA
rs436386326	309	F>C	No	EVA
rs468285287	316	N>S	No	EVA
rs459552468	324	A>D	No	EVA
rs479616006	324	A>S	No	EVA
rs445842113	329	E>D	No	EVA
rs477131672	331	E>Q	No	EVA
rs457612594	332	W>*	No	EVA
rs457612594	332	W>L	No	EVA
rs463486415	332	W>R	No	EVA
rs474623461	336	R>G	No	EVA
rs441510535	341	H>P	No	EVA
rs472728461	347	A>V	No	EVA
rs479876675	361	R>G	No	EVA
rs460366489	362	R>G	No	EVA

Type	Name	Position	InterPro Accession
domain	Oxoglutarate/iron-dependent dioxygenase	411 - 519	IPR005123
domain	Prolyl 4-hydroxylase, alpha subunit	335 - 518	IPR006620
domain	Prolyl 4-hydroxylase alpha-subunit, N-terminal	24 - 154	IPR013547
repeat	Tetratricopeptide repeat	205 - 238	IPR019734
domain	Prolyl 4-hydroxylase alpha subunit, Fe(2+) 2OG dioxygenase domain	415 - 518	IPR044862

		Description
EC Number	1.14.11.2	With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
Subcellular Localization	Endoplasmic reticulum lumen
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
endoplasmic reticulum	The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
endoplasmic reticulum lumen	The volume enclosed by the membranes of the endoplasmic reticulum.

Name	Definition
iron ion binding	Binding to an iron (Fe) ion.
L-ascorbic acid binding	Binding to L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species.
procollagen-proline 4-dioxygenase activity	Catalysis of the reaction: procollagen L-proline + 2-oxoglutarate + O2 = procollagen trans-4-hydroxy-L-proline + succinate + CO2.

Name	Definition
peptidyl-proline hydroxylation to 4-hydroxy-L-proline	The modification of peptidyl-proline to form 4-hydroxy-L-proline; catalyzed by procollagen-proline,2-oxoglutarate-4-dioxygenase.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P16924	P4HA1	Prolyl 4-hydroxylase subunit alpha-1	Gallus gallus (Chicken)	PR
O15460	P4HA2	Prolyl 4-hydroxylase subunit alpha-2	Homo sapiens (Human)	PR
P13674	P4HA1	Prolyl 4-hydroxylase subunit alpha-1	Homo sapiens (Human)	PR
Q60715	P4ha1	Prolyl 4-hydroxylase subunit alpha-1	Mus musculus (Mouse)	PR
P54001	P4ha1	Prolyl 4-hydroxylase subunit alpha-1	Rattus norvegicus (Rat)	PR
Q20065	phy-2	Prolyl 4-hydroxylase subunit alpha-2	Caenorhabditis elegans	PR
Q9SZT0	P4H11	Probable prolyl 4-hydroxylase 11	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9ZW86	P4H1	Prolyl 4-hydroxylase 1	Arabidopsis thaliana (Mouse-ear cress)	PR