Q9ZT82

PR
Gene name
CALS12 (GSL5, PMR4, At4g03550, F9H3.18, T5L23.4)
Protein name
Callose synthase 12
Names
1,3-beta-glucan synthase, Protein GLUCAN SYNTHASE-LIKE 5, Protein POWDERY MILDEW RESISTANT 4
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT4G03550
EC number
2.4.1.34: Hexosyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-47 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9ZT82

Entry ID Method Resolution Chain Position Source
AF-Q9ZT82-F1 Predicted AlphaFoldDB

57 variants for Q9ZT82

Variant ID(s) Position Change Description Diseaes Association Provenance
tmp_4_1573564_G_A 18 A>T No 1000Genomes
tmp_4_1573570_G_T 20 A>S No 1000Genomes
ENSVATH02633720 21 V>A No 1000Genomes
ENSVATH02633720 21 V>G No 1000Genomes
tmp_4_1573577_G_A 22 G>E No 1000Genomes
tmp_4_1573592_C_T 27 P>L No 1000Genomes
tmp_4_1573690_G_A 60 D>N No 1000Genomes
tmp_4_1573699_C_T 63 R>C No 1000Genomes
ENSVATH00458381 97 M>V No 1000Genomes
tmp_4_1573900_C_A 130 L>I No 1000Genomes
ENSVATH00458382 132 A>S No 1000Genomes
ENSVATH06435387 136 S>N No 1000Genomes
tmp_4_1574213_C_G 234 A>G No 1000Genomes
tmp_4_1574363_A_G 284 K>R No 1000Genomes
ENSVATH06435392 350 L>F No 1000Genomes
tmp_4_1574593_C_T 361 L>F No 1000Genomes
ENSVATH02633723 369 A>T No 1000Genomes
ENSVATH00458386 413 Q>R No 1000Genomes
tmp_4_1574777_C_G 422 T>R No 1000Genomes
ENSVATH06435394 432 V>M No 1000Genomes
ENSVATH10575449 436 L>V No 1000Genomes
ENSVATH10575451 439 E>K No 1000Genomes
ENSVATH00458387 527 D>E No 1000Genomes
tmp_4_1575091_G_A 527 D>N No 1000Genomes
tmp_4_1575221_C_T 570 A>V No 1000Genomes
ENSVATH10575452 621 G>S No 1000Genomes
ENSVATH13895111 633 R>K No 1000Genomes
ENSVATH10575477 719 C>R No 1000Genomes
ENSVATH00458391 745 V>I No 1000Genomes
ENSVATH06435402 748 E>D No 1000Genomes
tmp_4_1575960_C_G 763 S>C No 1000Genomes
ENSVATH02633733 765 Q>H No 1000Genomes
ENSVATH06435403 776 D>E No 1000Genomes
tmp_4_1576068_G_T 799 S>I No 1000Genomes
tmp_4_1576176_G_A 835 R>Q No 1000Genomes
ENSVATH06435405 869 T>I No 1000Genomes
tmp_4_1576395_T_C 908 M>T No 1000Genomes
tmp_4_1576422_A_G 917 Y>C No 1000Genomes
tmp_4_1576436_G_T 922 V>L No 1000Genomes
ENSVATH13895125 1005 A>T No 1000Genomes
ENSVATH13895126 1045 R>Q No 1000Genomes
tmp_4_1576842_C_T 1057 T>M No 1000Genomes
ENSVATH00458394 1099 K>R No 1000Genomes
ENSVATH02633736 1103 A>G No 1000Genomes
ENSVATH13895127 1106 I>S No 1000Genomes
tmp_4_1577166_G_A 1165 R>H No 1000Genomes
ENSVATH00458396 1169 V>I No 1000Genomes
ENSVATH13895128 1170 Q>K No 1000Genomes
tmp_4_1577748_T_C 1299 V>A No 1000Genomes
tmp_4_1577945_G_A 1365 A>T No 1000Genomes
ENSVATH10575528 1384 A>T No 1000Genomes
ENSVATH06435416 1387 T>M No 1000Genomes
tmp_4_1578051_A_T 1400 Q>L No 1000Genomes
tmp_4_1578595_C_A 1581 D>E No 1000Genomes
ENSVATH06435420 1596 I>L No 1000Genomes
tmp_4_1578888_A_G 1679 H>R No 1000Genomes
tmp_4_1579190_G_A 1780 V>I No 1000Genomes

No associated diseases with Q9ZT82

3 regional properties for Q9ZT82

Type Name Position InterPro Accession
conserved_site Cathelicidin, conserved site 35 - 48 IPR018216-1
conserved_site Cathelicidin, conserved site 79 - 101 IPR018216-2
domain Cathelicidin, antimicrobial peptide, C-terminal 136 - 163 IPR022746

Functions

Description
EC Number 2.4.1.34 Hexosyltransferases
Subcellular Localization
  • Cell membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
1,3-beta-D-glucan synthase complex A protein complex that catalyzes the transfer of a glucose group from UDP-glucose to a (1->3)-beta-D-glucan chain.
Golgi apparatus A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
plasmodesma A fine cytoplasmic channel, found in all higher plants, that connects the cytoplasm of one cell to that of an adjacent cell.

2 GO annotations of molecular function

Name Definition
1,3-beta-D-glucan synthase activity Catalysis of the reaction: UDP-glucose + [(1->3)-beta-D-glucosyl](n) = UDP + [(1->3)-beta-D-glucosyl](n+1).
glucosyltransferase activity Catalysis of the transfer of a glucosyl group to an acceptor molecule, typically another carbohydrate or a lipid.

14 GO annotations of biological process

Name Definition
(1->3)-beta-D-glucan biosynthetic process The chemical reactions and pathways resulting in the formation of (1->3)-beta-D-glucans, compounds composed of glucose residues linked by (1->3)-beta-D-glucosidic bonds.
defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack.
defense response by callose deposition Any process in which callose is transported to, and/or maintained in, a specific location during the defense response. Callose is a linear 1,3-beta-d-glucan formed from UDP-glucose and is found in certain plant cell walls.
defense response by callose deposition in cell wall Any process in which callose is transported to, and/or maintained in, the cell wall during the defense response. Callose is a linear 1,3-beta-d-glucan formed from UDP-glucose and is found in certain plant cell walls.
defense response to bacterium Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism.
defense response to fungus Reactions triggered in response to the presence of a fungus that act to protect the cell or organism.
innate immune response-activating signal transduction The series of molecular signals generated as a consequence of a pathogen or microbial effector binding to a plant 'resistance-gene' receptor to activate a plant immune response, usually plant-type hypersensitive response.
leaf morphogenesis The process in which the anatomical structures of the leaf are generated and organized.
leaf senescence The last stage of leaf development during which programmed degradation of macromolecules and nutrient recycling take place.
pollen development The process whose specific outcome is the progression of the pollen grain over time, from its formation to the mature structure. The process begins with the meiosis of the microsporocyte to form four haploid microspores. The nucleus of each microspore then divides by mitosis to form a two-celled organism, the pollen grain, that contains a tube cell as well as a smaller generative cell. The pollen grain is surrounded by an elaborate cell wall. In some species, the generative cell immediately divides again to give a pair of sperm cells. In most flowering plants, however this division takes place later, in the tube that develops when a pollen grain germinates.
regulation of cell shape Any process that modulates the surface configuration of a cell.
reproduction The production of new individuals that contain some portion of genetic material inherited from one or more parent organisms.
response to fungus Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a fungus.
salicylic acid mediated signaling pathway The series of molecular signals mediated by salicylic acid.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q04952 FKS3 1,3-beta-glucan synthase component FKS3 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
P38631 FKS1 1,3-beta-glucan synthase component FKS1 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
P40989 GSC2 1,3-beta-glucan synthase component GSC2 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
10 20 30 40 50 60
MSLRHRTVPP QTGRPLAAEA VGIEEEPYNI IPVNNLLADH PSLRFPEVRA AAAALKTVGD
70 80 90 100 110 120
LRRPPYVQWR SHYDLLDWLA LFFGFQKDNV RNQREHMVLH LANAQMRLSP PPDNIDSLDS
130 140 150 160 170 180
AVVRRFRRKL LANYSSWCSY LGKKSNIWIS DRNPDSRREL LYVGLYLLIW GEAANLRFMP
190 200 210 220 230 240
ECICYIFHNM ASELNKILED CLDENTGQPY LPSLSGENAF LTGVVKPIYD TIQAEIDESK
250 260 270 280 290 300
NGTVAHCKWR NYDDINEYFW TDRCFSKLKW PLDLGSNFFK SRGKSVGKTG FVERRTFFYL
310 320 330 340 350 360
YRSFDRLWVM LALFLQAAII VAWEEKPDTS SVTRQLWNAL KARDVQVRLL TVFLTWSGMR
370 380 390 400 410 420
LLQAVLDAAS QYPLVSRETK RHFFRMLMKV IAAAVWIVAF TVLYTNIWKQ KRQDRQWSNA
430 440 450 460 470 480
ATTKIYQFLY AVGAFLVPEI LALALFIIPW MRNFLEETNW KIFFALTWWF QGKSFVGRGL
490 500 510 520 530 540
REGLVDNIKY STFWIFVLAT KFTFSYFLQV KPMIKPSKLL WNLKDVDYEW HQFYGDSNRF
550 560 570 580 590 600
SVALLWLPVV LIYLMDIQIW YAIYSSIVGA VVGLFDHLGE IRDMGQLRLR FQFFASAIQF
610 620 630 640 650 660
NLMPEEQLLN ARGFGNKFKD GIHRLKLRYG FGRPFKKLES NQVEANKFAL IWNEIILAFR
670 680 690 700 710 720
EEDIVSDREV ELLELPKNSW DVTVIRWPCF LLCNELLLAL SQARELIDAP DKWLWHKICK
730 740 750 760 770 780
NEYRRCAVVE AYDSIKHLLL SIIKVDTEEH SIITVFFQII NQSIQSEQFT KTFRVDLLPK
790 800 810 820 830 840
IYETLQKLVG LVNDEETDSG RVVNVLQSLY EIATRQFFIE KKTTEQLSNE GLTPRDPASK
850 860 870 880 890 900
LLFQNAIRLP DASNEDFYRQ VRRLHTILTS RDSMHSVPVN LEARRRIAFF SNSLFMNMPH
910 920 930 940 950 960
APQVEKMMAF SVLTPYYSEE VVYSKEQLRN ETEDGISTLY YLQTIYADEW KNFKERMHRE
970 980 990 1000 1010 1020
GIKTDSELWT TKLRDLRLWA SYRGQTLART VRGMMYYYRA LKMLAFLDSA SEMDIREGAQ
1030 1040 1050 1060 1070 1080
ELGSVRNLQG ELGGQSDGFV SENDRSSLSR ASSSVSTLYK GHEYGTALMK FTYVVACQIY
1090 1100 1110 1120 1130 1140
GSQKAKKEPQ AEEILYLMKQ NEALRIAYVD EVPAGRGETD YYSVLVKYDH QLEKEVEIFR
1150 1160 1170 1180 1190 1200
VKLPGPVKLG EGKPENQNHA MIFTRGDAVQ TIDMNQDSYF EEALKMRNLL QEYNHYHGIR
1210 1220 1230 1240 1250 1260
KPTILGVREH IFTGSVSSLA WFMSAQETSF VTLGQRVLAN PLKVRMHYGH PDVFDRFWFL
1270 1280 1290 1300 1310 1320
SRGGISKASR VINISEDIFA GFNCTLRGGN VTHHEYIQVG KGRDVGLNQI SMFEAKVASG
1330 1340 1350 1360 1370 1380
NGEQVLSRDV YRLGHRLDFF RMLSFFYTTV GFFFNTMMVI LTVYAFLWGR VYLALSGVEK
1390 1400 1410 1420 1430 1440
SALADSTDTN AALGVILNQQ FIIQLGLFTA LPMIVEWSLE EGFLLAIWNF IRMQIQLSAV
1450 1460 1470 1480 1490 1500
FYTFSMGTRA HYFGRTILHG GAKYRATGRG FVVEHKGFTE NYRLYARSHF VKAIELGLIL
1510 1520 1530 1540 1550 1560
IVYASHSPIA KDSLIYIAMT ITSWFLVISW IMAPFVFNPS GFDWLKTVYD FEDFMNWIWY
1570 1580 1590 1600 1610 1620
QGRISTKSEQ SWEKWWYEEQ DHLRNTGKAG LFVEIILVLR FFFFQYGIVY QLKIANGSTS
1630 1640 1650 1660 1670 1680
LFVYLFSWIY IFAIFVLFLV IQYARDKYSA KAHIRYRLVQ FLLIVLAILV IVALLEFTHF
1690 1700 1710 1720 1730 1740
SFIDIFTSLL AFIPTGWGIL LIAQTQRKWL KNYTIFWNAV VSVARMYDIL FGILIMVPVA
1750 1760 1770
FLSWMPGFQS MQTRILFNEA FSRGLRIMQI VTGKKSKGDV