P40989

PR
Gene name
GSC2 (FKS2, GLS2, YGR032W)
Protein name
1,3-beta-glucan synthase component GSC2
Names
1,3-beta-D-glucan-UDP glucosyltransferase, FK506 sensitivity protein 2, Glucan synthase of cerevisiae protein 2
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YGR032W
EC number
2.4.1.34: Hexosyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-202 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P40989

Entry ID Method Resolution Chain Position Source
AF-P40989-F1 Predicted AlphaFoldDB

17 variants for P40989

Variant ID(s) Position Change Description Diseaes Association Provenance
s07-548807 180 I>M No SGRP
s07-549399 378 T>S No SGRP
s07-549411 382 R>C No SGRP
s07-550224 653 A>S No SGRP
s07-550638 791 V>I No SGRP
s07-550758 831 D>N No SGRP
s07-551443 1059 N>S strain: SK1 [UniProt] No SGRP
s07-552012 1249 V>I No SGRP
s07-552309 1348 V>I No SGRP
s07-552661 1465 A>V No SGRP
s07-553250 1661 M>I No SGRP
s07-553800 1845 P>S No SGRP
s07-553825 1853 T>K No SGRP
1853 T>KD strain: SK1 [UniProt] No
s07-553828 1854 G>D No SGRP
s07-553882 1872 S>F No SGRP
s07-553881 1872 S>P No SGRP

No associated diseases with P40989

1 regional properties for P40989

Type Name Position InterPro Accession
domain 1,3-beta-glucan synthase component FKS1-like, domain-1 318 - 430 IPR026899

Functions

Description
EC Number 2.4.1.34 Hexosyltransferases
Subcellular Localization
  • Membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

6 GO annotations of cellular component

Name Definition
1,3-beta-D-glucan synthase complex A protein complex that catalyzes the transfer of a glucose group from UDP-glucose to a (1->3)-beta-D-glucan chain.
cell periphery The part of a cell encompassing the cell cortex, the plasma membrane, and any external encapsulating structures.
cellular bud neck The constriction between the mother cell and daughter cell (bud) in an organism that reproduces by budding.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
prospore membrane The prospore membrane is a double-membraned structure that extends from the cytoplasmic face of the spindle pole bodies to encompass the spindle pole bodies and the four nuclear lobes that are formed during meiosis. It helps isolate the meiotic nuclei from the cytoplasm during spore formation and serves as a foundation for the formation of the spore walls. An example of this component is found in Schizosaccharomyces pombe.

2 GO annotations of molecular function

Name Definition
1,3-beta-D-glucan synthase activity Catalysis of the reaction: UDP-glucose + [(1->3)-beta-D-glucosyl](n) = UDP + [(1->3)-beta-D-glucosyl](n+1).
glucosyltransferase activity Catalysis of the transfer of a glucosyl group to an acceptor molecule, typically another carbohydrate or a lipid.

4 GO annotations of biological process

Name Definition
(1->3)-beta-D-glucan biosynthetic process The chemical reactions and pathways resulting in the formation of (1->3)-beta-D-glucans, compounds composed of glucose residues linked by (1->3)-beta-D-glucosidic bonds.
ascospore wall assembly The aggregation, arrangement and bonding together of a set of components to form an ascospore wall. During sporulation in Ascomycota, each ascospore nucleus becomes surrounded by a specialized spore wall, formed by deposition of spore wall components in the lumenal space between the outer and inner leaflets of the prospore membrane. An example of this process is found in Saccharomyces cerevisiae.
fungal-type cell wall polysaccharide biosynthetic process The chemical reactions and pathways resulting in the formation of the polysaccharides which make up the fungal-type cell wall.
regulation of cell shape Any process that modulates the surface configuration of a cell.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q04952 FKS3 1,3-beta-glucan synthase component FKS3 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
P38631 FKS1 1,3-beta-glucan synthase component FKS1 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q9ZT82 CALS12 Callose synthase 12 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MSYNDPNLNG QYYSNGDGTG DGNYPTYQVT QDQSAYDEYG QPIYTQNQLD DGYYDPNEQY
70 80 90 100 110 120
VDGTQFPQGQ DPSQDQGPYN NDASYYNQPP NMMNPSSQDG ENFSDFSSYG PPSGTYPNDQ
130 140 150 160 170 180
YTPSQMSYPD QDGSSGASTP YGNGVVNGNG QYYDPNAIEM ALPNDPYPAW TADPQSPLPI
190 200 210 220 230 240
EQIEDIFIDL TNKFGFQRDS MRNMFDHFMT LLDSRSSRMS PEQALLSLHA DYIGGDTANY
250 260 270 280 290 300
KKWYFAAQLD MDDEIGFRNM KLGKLSRKAR KAKKKNKKAM QEASPEDTEE TLNQIEGDNS
310 320 330 340 350 360
LEAADFRWKS KMNQLSPFEM VRQIALFLLC WGEANQVRFT PECLCFIYKC ASDYLDSAQC
370 380 390 400 410 420
QQRPDPLPEG DFLNRVITPL YRFIRSQVYE IVDGRYVKSE KDHNKVIGYD DVNQLFWYPE
430 440 450 460 470 480
GIAKIVMEDG TRLIDLPAEE RYLKLGEIPW DDVFFKTYKE TRSWLHLVTN FNRIWIMHIS
490 500 510 520 530 540
VYWMYCAYNA PTFYTHNYQQ LVDNQPLAAY KWATAALGGT VASLIQVAAT LCEWSFVPRK
550 560 570 580 590 600
WAGAQHLSRR FWFLCVIMGI NLGPVIFVFA YDKDTVYSTA AHVVGAVMFF VAVATLVFFS
610 620 630 640 650 660
VMPLGGLFTS YMKKSTRSYV ASQTFTASFA PLHGLDRWMS YLVWVTVFAA KYAESYFFLI
670 680 690 700 710 720
LSLRDPIRIL STTSMRCTGE YWWGNKICKV QPKIVLGLMI ATDFILFFLD TYLWYIVVNT
730 740 750 760 770 780
VFSVGKSFYL GISILTPWRN IFTRLPKRIY SKILATTDME IKYKPKVLIS QIWNAIIISM
790 800 810 820 830 840
YREHLLAIDH VQKLLYHQVP SEIEGKRTLR APTFFVSQDD NNFETEFFPR DSEAERRISF
850 860 870 880 890 900
FAQSLSTPIP EPLPVDNMPT FTVLTPHYAE RILLSLREII REDDQFSRVT LLEYLKQLHP
910 920 930 940 950 960
VEWDCFVKDT KILAEETAAY ENNEDEPEKE DALKSQIDDL PFYCIGFKSA APEYTLRTRI
970 980 990 1000 1010 1020
WASLRSQTLY RTISGFMNYS RAIKLLYRVE NPEIVQMFGG NADGLERELE KMARRKFKFL
1030 1040 1050 1060 1070 1080
VSMQRLAKFK PHELENAEFL LRAYPDLQIA YLDEEPPLNE GEEPRIYSAL IDGHCEILEN
1090 1100 1110 1120 1130 1140
GRRRPKFRVQ LSGNPILGDG KSDNQNHALI FYRGEYIQLI DANQDNYLEE CLKIRSVLAE
1150 1160 1170 1180 1190 1200
FEELGIEQIH PYTPGLKYED QSTNHPVAIV GAREYIFSEN SGVLGDVAAG KEQTFGTLFA
1210 1220 1230 1240 1250 1260
RTLAQIGGKL HYGHPDFINA TFMTTRGGVS KAQKGLHLNE DIYAGMNAVL RGGRIKHCEY
1270 1280 1290 1300 1310 1320
YQCGKGRDLG FGTILNFTTK IGAGMGEQML SREYYYLGTQ LPIDRFLTFY YAHPGFHLNN
1330 1340 1350 1360 1370 1380
LFIQLSLQMF MLTLVNLHAL AHESILCVYD RDKPITDVLY PIGCYNFHPA IDWVRRYTLS
1390 1400 1410 1420 1430 1440
IFIVFWIAFV PIVVQELIER GLWKATQRFF RHILSLSPMF EVFAGQIYSS ALLSDIAVGG
1450 1460 1470 1480 1490 1500
ARYISTGRGF ATSRIPFSIL YSRFAGSAIY MGSRSMLMLL FGTVAHWQAP LLWFWASLSA
1510 1520 1530 1540 1550 1560
LIFAPFIFNP HQFAWEDFFL DYRDYIRWLS RGNNKYHRNS WIGYVRMSRS RVTGFKRKLV
1570 1580 1590 1600 1610 1620
GDESEKSAGD ASRAHRTNLI MAEIIPCAIY AAGCFIAFTF INAQTGVKTT DEDRVNSTLR
1630 1640 1650 1660 1670 1680
IIICTLAPIV IDIGVLFFCM GLSCCSGPLL GMCCKKTGSV MAGIAHGIAV VVHIVFFIVM
1690 1700 1710 1720 1730 1740
WVLEGFSFVR MLIGVVTCIQ CQRLIFHCMT VLLLTREFKN DHANTAFWTG KWYSTGLGYM
1750 1760 1770 1780 1790 1800
AWTQPTRELT AKVIELSEFA ADFVLGHVIL IFQLPVICIP KIDKFHSIML FWLKPSRQIR
1810 1820 1830 1840 1850 1860
PPIYSLKQAR LRKRMVRRYC SLYFLVLIIF AGCIVGPAVA SAHVPKDLGS GLTGTFHNLV
1870 1880 1890
QPRNVSNNDT GSQMSTYKSH YYTHTPSLKT WSTIK