Q04952

PR
Gene name
FKS3 (YMR306W, YM9952.08)
Protein name
1,3-beta-glucan synthase component FKS3
Names
1,3-beta-D-glucan-UDP glucosyltransferase, FK506 sensitivity protein 3
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YMR306W
EC number
2.4.1.34: Hexosyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

89-170 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q04952

Entry ID Method Resolution Chain Position Source
AF-Q04952-F1 Predicted AlphaFoldDB

15 variants for Q04952

Variant ID(s) Position Change Description Diseaes Association Provenance
s13-881268 37 E>D No SGRP
s13-881282 42 F>Y No SGRP
s13-882455 433 G>E No SGRP
s13-882631 492 A>T No SGRP
s13-882808 551 P>S No SGRP
s13-882823 556 W>R No SGRP
s13-883460 768 T>R No SGRP
s13-884015 953 E>G No SGRP
s13-884045 963 S>L No SGRP
s13-884245 1030 I>V No SGRP
s13-884675 1173 T>N No SGRP
s13-884872 1239 I>V No SGRP
s13-885056 1300 A>V No SGRP
s13-885384 1409 F>L No SGRP
s13-885847 1564 V>I No SGRP

No associated diseases with Q04952

1 regional properties for Q04952

Type Name Position InterPro Accession
domain 1,3-beta-glucan synthase component FKS1-like, domain-1 180 - 293 IPR026899

Functions

Description
EC Number 2.4.1.34 Hexosyltransferases
Subcellular Localization
  • Mitochondrion
  • Membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
1,3-beta-D-glucan synthase complex A protein complex that catalyzes the transfer of a glucose group from UDP-glucose to a (1->3)-beta-D-glucan chain.
endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

2 GO annotations of molecular function

Name Definition
1,3-beta-D-glucan synthase activity Catalysis of the reaction: UDP-glucose + [(1->3)-beta-D-glucosyl](n) = UDP + [(1->3)-beta-D-glucosyl](n+1).
glucosyltransferase activity Catalysis of the transfer of a glucosyl group to an acceptor molecule, typically another carbohydrate or a lipid.

4 GO annotations of biological process

Name Definition
(1->3)-beta-D-glucan biosynthetic process The chemical reactions and pathways resulting in the formation of (1->3)-beta-D-glucans, compounds composed of glucose residues linked by (1->3)-beta-D-glucosidic bonds.
ascospore wall assembly The aggregation, arrangement and bonding together of a set of components to form an ascospore wall. During sporulation in Ascomycota, each ascospore nucleus becomes surrounded by a specialized spore wall, formed by deposition of spore wall components in the lumenal space between the outer and inner leaflets of the prospore membrane. An example of this process is found in Saccharomyces cerevisiae.
fungal-type cell wall polysaccharide biosynthetic process The chemical reactions and pathways resulting in the formation of the polysaccharides which make up the fungal-type cell wall.
regulation of cell shape Any process that modulates the surface configuration of a cell.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P38631 FKS1 1,3-beta-glucan synthase component FKS1 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
P40989 GSC2 1,3-beta-glucan synthase component GSC2 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q9ZT82 CALS12 Callose synthase 12 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MDFMSPKFSL TDVEYPAWCQ DDEVPITMQE IREIFVELMD KFGFQKSSME NMYQHLMGQL
70 80 90 100 110 120
DSRASRTGAQ NALVSLHVSY IGGEHANYRK WYFAAQLDLD EEIGFQNMRL HGKARQRNVK
130 140 150 160 170 180
MAKKRGVSIK EQIKQWNEKE QEFINNHPKI TLTQEQLEDQ TNLKSADYKW KLKMKKLTPE
190 200 210 220 230 240
NMIRQLALYL LCWGEANQVR FAPECLCFIF KCALDYDIST SSSEKTVKSP EYSYLNDVIT
250 260 270 280 290 300
PLYEFLRGQV YKKDAKGNWK RREKDHKNII GYDDINQLFW YPEGFERIIL NNGERLVDKP
310 320 330 340 350 360
LEERYLYFKD VAWSKVFYKT YRETRSWKHC FTNFNRFWII HFAPFWFFTT FNSPTLYTKN
370 380 390 400 410 420
YIQLLNNQPT PQVRLSVIAF GGTIACLVQI LATVFEWGFV PREWPGAQHL SSRMIGLLFC
430 440 450 460 470 480
LAINLGPSVY VLGFFEWDVH SKSAYIVSIV QLIIAFLTTF FFAVRPLGGL FRPYLNKDKK
490 500 510 520 530 540
HRRYISSQTF TASFPKLTGR SKWFSYGLWV FVYLAKYIES YFFLTLSLRD PIRVLSIMDL
550 560 570 580 590 600
SRCQGEYLLG PILCKWQAKI TLVLMLLSDL GLFFLDTYLW YIICNCIFSI VLSFSLGTSI
610 620 630 640 650 660
LTPWKNVYSR LPKRIYSKIL ATSEMDVKFK AKILISQVWN AIVISMYREH LLSIEHLQRL
670 680 690 700 710 720
LFQQVDSLMG DTRTLKSPTF FVAQDDSTFK SMEFFPSNSE AKRRISFFAQ SLATPISEPV
730 740 750 760 770 780
PVDCMPTFTV LVPHYSEKIL LGLKEIIREE SPKSKITVLE YLKHLHPTEW ECFVKDTKLL
790 800 810 820 830 840
SMEKSFLKEA ESSHDEDRLE IPDALYDPRS SPLSDHTESR KLPTEDDLIK EKINDLPFSY
850 860 870 880 890 900
FGFNSSEPSY TLRTRIWASL RTQTLYRTLS GFMNYSKAIK LLYRIENPSL VSLYRGNNEA
910 920 930 940 950 960
LENDLENMAS RKFRMVVAMQ RYAKFNKDEV EATELLLRAY PNMFISYLLE ELEQNESEKT
970 980 990 1000 1010 1020
YYSCLTNGYA EFDEESGLRK PIFKIRLSGN PILGDGKSDN QNHSIIFYRG EYIQVIDANQ
1030 1040 1050 1060 1070 1080
DNYLEECLKI RSVLSEFEEL ELNPTIPYIP GIEYEEEPPP IAIVGSREYI FSENIGVLGD
1090 1100 1110 1120 1130 1140
IAAGKEQTFG TLFARTLAEI GGKLHYGHPD FLNGIFMTTR GGLSKAQRGL HLNEDIYAGM
1150 1160 1170 1180 1190 1200
NAICRGGKIK HSDYYQCGKG RDLGFGSILN FTTKIGAGMG EQLLSREYYY LGTQLPMDRF
1210 1220 1230 1240 1250 1260
LSFFYAHPGF HLNNLFISFS VQLFFVLLLN LGALNHEIIA CFYDKDAPIT NLETPVGCYN
1270 1280 1290 1300 1310 1320
IQPALHWVSI FVLSIFIVFF IAFAPLLIQE VLEKGIWRAA SRFLHHLLSM APLFEVFVCQ
1330 1340 1350 1360 1370 1380
VYSNSLLMDL TFGGAKYIST GRGFAITRLD FFTLYSRFVN ISIYSGFQVF FMLLFAIISM
1390 1400 1410 1420 1430 1440
WQPALLWFWI TVISMCFAPF IFNPHQFAFM DFFIDYKTFI HWLFSGNTKY QKESWANFVK
1450 1460 1470 1480 1490 1500
SSRSRFTGYK SKTVDDISED SGHDSKKARF WNVFFAELFL PFCVFLFNFT AFSFINAQTG
1510 1520 1530 1540 1550 1560
VSDSTPTSAV FRLLLVTFLP IFLNSIVLFL LFWVSLFVVP GLSYCCKDAG AVIAFIAHTF
1570 1580 1590 1600 1610 1620
SVLVYLLDFE LMWFLQGWNF TRTLILLITC INMHLILFKV FTTIFLTREY KNNKAHLAWW
1630 1640 1650 1660 1670 1680
NGKWYNTGMG WSIILQPIRE YFVKIMESSY FAADFFLGHF LLFIQTPIIL LPFIDYWHTM
1690 1700 1710 1720 1730 1740
VLFWMNPRSI IAHKRILTRK QRALRSRIVS KYFSLYFVML GVLLFMLIAP FFAGDFVSSP
1750 1760 1770 1780
QELLEGTLFE GIFQPNNQNN NDTGPNAPST ILTTTPTLPT FRTVA