AiPD: Autoinhibited Protein Database

Gene name	IRX9
Protein name	Beta-1,4-xylosyltransferase IRX9
Names	Protein IRREGULAR XYLEM 9, Xylan xylosyltransferase IRX9
Species	Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway	ath:AT2G37090
EC number	2.4.2.24: Pentosyltransferases
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

35-136 (Predicted disordered autoinhibitory region) PR

35-136 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q9ZQC6-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
ENSVATH13558273	33	F>C	No	1000Genomes
tmp_2_15589060_G_A	55	S>F	No	1000Genomes
tmp_2_15589015_T_A	70	H>L	No	1000Genomes
ENSVATH01959073	72	L>F	No	1000Genomes
tmp_2_15588999_T_G	75	R>S	No	1000Genomes
ENSVATH05669880	94	E>D	No	1000Genomes
tmp_2_15588929_A_C	99	S>A	No	1000Genomes
tmp_2_15588906_C_A	106	E>D	No	1000Genomes
ENSVATH05669878	137	M>I	No	1000Genomes
tmp_2_15588770_C_G	152	V>L	No	1000Genomes
ENSVATH01959069	166	T>S	No	1000Genomes
ENSVATH13558272	170	K>T	No	1000Genomes
tmp_2_15588709_C_T	172	G>D	No	1000Genomes
tmp_2_15588681_C_G	181	K>N	No	1000Genomes
ENSVATH01959067	204	H>Q	No	1000Genomes
ENSVATH01959066	209	G>A	No	1000Genomes
ENSVATH01959063	223	D>G	No	1000Genomes
tmp_2_15588547_A_T	226	V>D	No	1000Genomes
tmp_2_15588536_C_T	230	D>N	No	1000Genomes
tmp_2_15588397_C_T,G	250	V>I	No	1000Genomes
tmp_2_15588397_C_T,G	250	V>L	No	1000Genomes

Type	Name	Position	InterPro Accession
domain	Beclin-1, BH3 domain	103 - 127	IPR029318
domain	Atg6, BARA domain	262 - 443	IPR040455
domain	Atg6/beclin, coiled-coil domain	133 - 259	IPR041691

		Description
EC Number	2.4.2.24	Pentosyltransferases
Subcellular Localization	Golgi apparatus membrane ; Single-pass type II membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
Golgi apparatus	A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
Golgi membrane	The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

Name	Definition
1,4-beta-D-xylan synthase activity	Catalysis of the reaction: UDP-D-xylose + [(1->4)-beta-D-xylan](n) = UDP + [(1->4)-beta-D-xylan](n+1).
galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity	Catalysis of the reaction: UDP-glucuronate + 3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein = UDP + 3-beta-D-glucuronosyl-3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein.
xylosyltransferase activity	Catalysis of the transfer of a xylosyl group to an acceptor molecule, typically another carbohydrate or a lipid.

Name	Definition
carbohydrate metabolic process	The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.
cell wall organization	A process that results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis.
glucuronoxylan biosynthetic process	The chemical reactions and pathways resulting in the formation of glucuronoxylan, a polymer containing a beta-1,4-linked D-xylose backbone substituted with glucuronic acid residues.
glucuronoxylan metabolic process	The chemical reactions and pathways involving xylan, a polymer containing a beta-(1->4)-linked D-xylose backbone decorated with glucuronic acid side units.
plant-type secondary cell wall biogenesis	A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of inextensible cellulose- and pectin-containing cell walls that are formed between the plasma membrane and primary cell wall after cell expansion is complete. An example of this is found in Arabidopsis thaliana.
xylan biosynthetic process	The chemical reactions and pathways resulting in the formation of xylan, a polymer containing a beta-1,4-linked D-xylose backbone.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q5CAZ6	B3GAT2	Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 2	Canis lupus familiaris (Dog) (Canis familiaris)	PR
Q9NPZ5	B3GAT2	Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 2	Homo sapiens (Human)	PR
Q653F4	IRX14	Probable beta-1,4-xylosyltransferase IRX14	Oryza sativa subsp japonica (Rice)	PR