Q5CAZ6

PR
Gene name
B3GAT2
Protein name
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 2
Names
Beta-1,3-glucuronyltransferase 2, GlcAT-D, UDP-glucuronosyltransferase S, GlcAT-S, Glucuronosyltransferase S
Species
Canis lupus familiaris (Dog) (Canis familiaris)
KEGG Pathway
cfa:481875
EC number
2.4.1.135: Hexosyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

6-114 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5CAZ6

Entry ID Method Resolution Chain Position Source
AF-Q5CAZ6-F1 Predicted AlphaFoldDB

No variants for Q5CAZ6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5CAZ6

No associated diseases with Q5CAZ6

No regional properties for Q5CAZ6

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q5CAZ6

Functions

Description
EC Number 2.4.1.135 Hexosyltransferases
Subcellular Localization
  • Golgi apparatus membrane ; Single-pass type II membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
Golgi membrane The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

2 GO annotations of molecular function

Name Definition
galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity Catalysis of the reaction: UDP-glucuronate + 3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein = UDP + 3-beta-D-glucuronosyl-3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein.
metal ion binding Binding to a metal ion.

3 GO annotations of biological process

Name Definition
carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.
chondroitin sulfate proteoglycan biosynthetic process The chemical reactions and pathways resulting in the formation of chondroitin sulfate proteoglycan, any glycoprotein whose glycosaminoglycan units are chondroitin sulfate. Chondroitin sulfates are a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues; the repeat units consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate.
protein glycosylation A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9NPZ5 B3GAT2 Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 2 Homo sapiens (Human) PR
Q653F4 IRX14 Probable beta-1,4-xylosyltransferase IRX14 Oryza sativa subsp japonica (Rice) PR
Q9ZQC6 IRX9 Beta-1,4-xylosyltransferase IRX9 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MKSALFSRFF ILLPWILIVI IMLDVDTRRP APPLTPRPYF SPYAVGRGGA RLPPRRGGPD
70 80 90 100 110 120
SGPGRGWEKR NESRPHARPR PEPPLPTIYA ITPTYSRPVQ KAELTRLANT FRQVAQLHWI
130 140 150 160 170 180
LVEDAAARSE LVSRFLARAG LPSTHLHVPT PRRYKRPGLP RATEQRNAGL AWLRQRHQHQ
190 200 210 220 230 240
RAQPGVLFFA DDDNTYSLEL FQEMRTTRKV SVWPVGLVGG RRYERPLVEN GKVVGWYTGW
250 260 270 280 290 300
RADRPFAIDM AGFAVSLQVI LSNPKAVFKR RGSQPGMQES DFLKQITTVE ELEPKANNCT
310 320
KVLVWHTRTE KVNLANEPKY RLDTVKIEV