Q9ZPY7

PR
Gene name
CAS (At2g46520, F11C10, F13A10.5)
Protein name
Exportin-2
Names
Exp2, Cellular apoptosis susceptibility protein homolog, Importin-alpha re-exporter
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT2G46520
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-128 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9ZPY7

Entry ID Method Resolution Chain Position Source
AF-Q9ZPY7-F1 Predicted AlphaFoldDB

32 variants for Q9ZPY7

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH05728947 17 N>S No 1000Genomes
tmp_2_19096975_G_T 37 A>S No 1000Genomes
tmp_2_19096999_G_A 45 A>T No 1000Genomes
ENSVATH05728950 78 A>S No 1000Genomes
tmp_2_19097314_G_T 150 V>L No 1000Genomes
tmp_2_19097365_A_G 167 S>G No 1000Genomes
ENSVATH14621283 193 I>M No 1000Genomes
tmp_2_19097450_T_G 195 L>R No 1000Genomes
ENSVATH05728951 205 A>V No 1000Genomes
ENSVATH05728953 311 D>N No 1000Genomes
ENSVATH13656494 313 S>L No 1000Genomes
ENSVATH05728954 344 D>E No 1000Genomes
ENSVATH05728955 368 I>V No 1000Genomes
ENSVATH14621285 425 A>T No 1000Genomes
ENSVATH14621286 427 P>R No 1000Genomes
tmp_2_19098241_A_G 459 I>V No 1000Genomes
ENSVATH01994561 476 R>H No 1000Genomes
ENSVATH01994562 505 M>I No 1000Genomes
ENSVATH05728957 527 A>T No 1000Genomes
tmp_2_19098536_A_C 557 Q>P No 1000Genomes
tmp_2_19098639_T_G 591 S>R No 1000Genomes
tmp_2_19098650_C_G 595 A>G No 1000Genomes
ENSVATH00277288 681 T>P No 1000Genomes
tmp_2_19099000_C_T 712 L>F No 1000Genomes
ENSVATH14621288 761 D>E No 1000Genomes
ENSVATH01994563 785 T>S No 1000Genomes
ENSVATH05728962 803 H>Y No 1000Genomes
ENSVATH05728966 875 V>L No 1000Genomes
ENSVATH14621290 887 L>V No 1000Genomes
ENSVATH01994564 893 P>L No 1000Genomes
ENSVATH13656517 946 Q>P No 1000Genomes
ENSVATH13656518 968 N>S No 1000Genomes

No associated diseases with Q9ZPY7

3 regional properties for Q9ZPY7

Type Name Position InterPro Accession
domain Importin-beta, N-terminal domain 29 - 104 IPR001494
domain Exportin-2, C-terminal 531 - 962 IPR005043
domain Exportin-2, central domain 162 - 530 IPR013713

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nuclear envelope The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).
plasmodesma A fine cytoplasmic channel, found in all higher plants, that connects the cytoplasm of one cell to that of an adjacent cell.

2 GO annotations of molecular function

Name Definition
nuclear export signal receptor activity Combining with a nuclear export signal (NES) on a cargo to be transported, to mediate transport of a the cargo through the nuclear pore, from the nuclear lumen to the cytoplasm. The cargo can be either a RNA or a protein.
small GTPase binding Binding to a small monomeric GTPase.

2 GO annotations of biological process

Name Definition
protein export from nucleus The directed movement of a protein from the nucleus into the cytoplasm.
protein import into nucleus The directed movement of a protein from the cytoplasm to the nucleus.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9XZU1 Cse1 Exportin-2 Drosophila melanogaster (Fruit fly) PR
P55060 CSE1L Exportin-2 Homo sapiens (Human) PR
F4J738 At3g59020 Importin beta-like SAD2 homolog Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MEWNRETLVF LSQCFLNTLS PIPEPRRTAE RALSDAADQA NYGLAVLRLV AEPAIDEQTR
70 80 90 100 110 120
HAAAVNFKNH LRSRWHPAGD SGISPIVDSE KEQIKTLIVS LMLSASPRIQ SQLSEALTVI
130 140 150 160 170 180
GKHDFPKAWP ALLPELIANL QNAALAGDYV SVNGILGTAS SIFKKFSYEY RTDALFVDLK
190 200 210 220 230 240
YCLDNFAAPL TEIFLKTSSL IDSAASSGGS PPILKPLFES QRLCCTIFYS LNFQDLPEFF
250 260 270 280 290 300
EDHMKEWMGE FKKYLSSNYP ALESTEEGLT LVDDLRAAIC ENINHYIEKN EEEFQGFLNE
310 320 330 340 350 360
FASVVWTLLR DVSKSPSRDQ LATTAIKFLT SVSTSVHHAL FAGDNVIKEI CQSIVIPNVS
370 380 390 400 410 420
LRVEDEEIFE MNYIEFIRRD MEGSDVDTRR RIACELLKGL ATNYKTQVTE VVSLEIQRLL
430 440 450 460 470 480
SSFSANPSAN WKDKDCAIYL VVSLSTKKAG GASVSTDLID VQNFFANIIL PELQSRDVNS
490 500 510 520 530 540
FPMLKAGSLK FLTMFRSHIP KPFAMQLFPE LVRFLKAESN VVHSYAASCI EKLLLVKEEG
550 560 570 580 590 600
ARGNRYAAGD LSPFLLQLMT NLFDALKFPE SEENQYLMKC IMRVLGVADI SAEVAGPCIG
610 620 630 640 650 660
GLTSILSEVC KNPKNPIFNH YLFESVAVLV RRACERDISL ISAFETSLFP SLQMILANDI
670 680 690 700 710 720
TEFLPYGFQL LAQLVELNRP TLSPNYMQIF LLLLSPESWK RSGNVPALVR LLQAFLQKAP
730 740 750 760 770 780
HEVTQENRLS QVLGIFEKLV ASPSTDEQGF YILNTIIENL DYSVIAPYMK GVWSALFTRV
790 800 810 820 830 840
QNKKTVKFQK SLVIFMSLFL VKHGQAYLVE TMNTVQPNII TAIVEHFWIP NLKLIMGSME
850 860 870 880 890 900
VKLTAVAATR LICETPALLD PSAAKLWGKM LDSIVTLVSR PEQERVLDEP EMPEISENVG
910 920 930 940 950 960
YTAAFVKLHN AGKKEEDPLK DIKDPKQFLV ASVSRLSSAS PGRYPQIIGE NLEQANQTAL
970
IQLCNAYNCG IA