Q9XZU1

PR
Gene name
Cse1
Protein name
Exportin-2
Names
Exp2, Cellular apoptosis susceptibility protein homolog, Chromosome segregation protein 1, Importin-alpha re-exporter
Species
Drosophila melanogaster (Fruit fly)
KEGG Pathway
dme:Dmel_CG13281
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-60 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9XZU1

Entry ID Method Resolution Chain Position Source
AF-Q9XZU1-F1 Predicted AlphaFoldDB

No variants for Q9XZU1

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9XZU1

No associated diseases with Q9XZU1

3 regional properties for Q9XZU1

Type Name Position InterPro Accession
domain Importin-beta, N-terminal domain 29 - 105 IPR001494
domain Exportin-2, C-terminal 530 - 966 IPR005043
domain Exportin-2, central domain 159 - 529 IPR013713

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nuclear envelope The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.

2 GO annotations of molecular function

Name Definition
nuclear export signal receptor activity Combining with a nuclear export signal (NES) on a cargo to be transported, to mediate transport of a the cargo through the nuclear pore, from the nuclear lumen to the cytoplasm. The cargo can be either a RNA or a protein.
small GTPase binding Binding to a small monomeric GTPase.

2 GO annotations of biological process

Name Definition
protein export from nucleus The directed movement of a protein from the nucleus into the cytoplasm.
protein import into nucleus The directed movement of a protein from the cytoplasm to the nucleus.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P55060 CSE1L Exportin-2 Homo sapiens (Human) PR
Q9ZPY7 CAS Exportin-2 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MEVTEANLQL LAGYLQQTLS ADPNVRRPAE KLLESTELQQ NYPILLLNLI DKAQMDMTTR
70 80 90 100 110 120
VAGAIAFKNY IKRNWAAHLD SDGPDRIHES DRNTIKTLIV TLMLHSPVAL QKQLSDAVSI
130 140 150 160 170 180
IGKYDFPKKW PQLIDEMVER FASGDFNVIN GVLQTAHSLF KRYRYEFKSQ ALWEEIKFVL
190 200 210 220 230 240
DRMAKPLTDL LQAKMQLTKV HENNAGALKV IYGSLVLVNK VFFSLNSQDL PEFFEDNINT
250 260 270 280 290 300
WMGAFIQQLA ADVPSLRTAD DEDAGVLEHL RAQVCENICL YAKKYDEEFK PFMEQFVTAV
310 320 330 340 350 360
WELLVKTSLH TKYDSLVSHA LQFLSVVADR QHYQSIFENP EILAQICDKV VIPNLDIRPS
370 380 390 400 410 420
DEEIFEDSPE EYIRRDIEGS DIDTRRRAAC DLVKTLSINF EQKIFGIFGQ YLERLLTKYK
430 440 450 460 470 480
ENPATNWRSK DTAIYLVTSW ASRGGTQKHG ITQTSELVPL PEFCAQQIIP ELERPNINEF
490 500 510 520 530 540
PVLKAAAIKY VMVFRSILGP QVLASCLPQL IRHLPAESSV VHSYAACSVE KILSMRDASN
550 560 570 580 590 600
AIVFGPQILA PYTTELISGL FATLSLPGSG ENEYVMKAIM RSFSVLQSAA MPFMGVALPR
610 620 630 640 650 660
LTEILTQVAK NPSRPQFNHY LFETLALCIK IVCHADSSAV SSFEEALFPV FQGILQQDIV
670 680 690 700 710 720
EFMPYVFQML SVLLEMREGT GTIPEPYWAL FPCLLSPALW DRTGNVTPLI RLISAFIKQG
730 740 750 760 770 780
SAQIQALGKL SGILGIFQKM IASKANDHEG FYLLQNLLSY YPPAEIQTNL RQIFGLLFQR
790 800 810 820 830 840
LSLSKTPKYL SGIIIFFSFY VIKFSGSQMA QLIDEIQPNL FGMLLDRVFI TEMGKIPKEQ
850 860 870 880 890 900
DRKMVAVGVT KLLTETPEIL QQQYATFWPR LLHSLIDLFE RPPEKLMGLE IGETAGVAED
910 920 930 940 950 960
PDAGYQVAFA QLTHAQPNQQ DHLAEIKDAR QFLATSLSKF AQARAGEFST LLSPLEPEYK
970
QVLQKYCDQA GVRIA