Q9Z321
Gene name |
Top3b (Top3b1) |
Protein name |
DNA topoisomerase 3-beta-1 |
Names |
DNA topoisomerase III beta-1 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:21976 |
EC number |
5.6.2.1: Enzymes altering nucleic acid conformation |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9Z321
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9Z321-F1 | Predicted | AlphaFoldDB |
42 variants for Q9Z321
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389395587 | 21 | L>P | No | EVA | |
| rs3389318922 | 29 | H>N | No | EVA | |
| rs3389399585 | 47 | G>V | No | EVA | |
| rs3389406340 | 57 | V>L | No | EVA | |
| rs3389418725 | 106 | G>D | No | EVA | |
| rs3389397416 | 128 | E>G | No | EVA | |
| rs3389402053 | 138 | N>S | No | EVA | |
| rs3389397475 | 233 | Q>* | No | EVA | |
| rs3389318921 | 264 | V>A | No | EVA | |
| rs45916605 | 267 | W>R | No | EVA | |
| rs3389393552 | 293 | K>* | No | EVA | |
| rs3389318941 | 356 | Q>E | No | EVA | |
| rs3406377078 | 362 | Y>F | No | EVA | |
| rs3406651277 | 377 | R>LSEGG* | No | EVA | |
| rs3405753174 | 378 | P>L | No | EVA | |
| rs3406715234 | 436 | G>V | No | EVA | |
| rs3389397423 | 474 | D>H | No | EVA | |
| rs3389402046 | 483 | M>K | No | EVA | |
| rs3406865489 | 483 | M>V | No | EVA | |
| rs3389381785 | 484 | L>I | No | EVA | |
| rs3389418733 | 509 | G>W | No | EVA | |
| rs3389381799 | 521 | I>M | No | EVA | |
| rs3389399984 | 546 | H>Q | No | EVA | |
| rs3389363094 | 554 | E>G | No | EVA | |
| rs3389397447 | 565 | E>* | No | EVA | |
| rs3406635114 | 567 | Q>H | No | EVA | |
| rs212077091 | 583 | G>D | No | EVA | |
| rs3389418732 | 616 | A>T | No | EVA | |
| rs3389411744 | 639 | S>R | No | EVA | |
| rs3389318918 | 646 | C>S | No | EVA | |
| rs3389402055 | 647 | D>N | No | EVA | |
| rs3389318870 | 648 | E>* | No | EVA | |
| rs3389381779 | 721 | L>M | No | EVA | |
| rs3389318860 | 772 | N>K | No | EVA | |
| rs3389318914 | 784 | N>K | No | EVA | |
| rs3389363137 | 784 | N>S | No | EVA | |
| rs3389402088 | 789 | P>S | No | EVA | |
| rs250234982 | 805 | P>H | No | EVA | |
| rs3389402117 | 821 | P>T | No | EVA | |
| rs3389372255 | 853 | K>E | No | EVA | |
| rs3389406390 | 861 | F>S | No | EVA | |
| rs3389399970 | 862 | V>A | No | EVA |
No associated diseases with Q9Z321
Functions
| Description | ||
|---|---|---|
| EC Number | 5.6.2.1 | Enzymes altering nucleic acid conformation |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| condensed chromosome | A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct structure. |
| DNA topoisomerase III-beta-TDRD3 complex | A protein complex that has DNA topoisomerase type I and RNA topoisomerase activities. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
| DNA topoisomerase activity | Catalysis of the transient cleavage and passage of individual DNA strands or double helices through one another, resulting a topological transformation in double-stranded DNA. |
| DNA topoisomerase type I (single strand cut, ATP-independent) activity | Catalysis of a DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the linking number by +1 per catalytic cycle. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| chromosome segregation | The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles. |
| DNA topological change | The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MKTVLMVAEK | PSLAQSIAKI | LSRGNMSSHK | GLNGACSVHK | YTGTFAGQPV | HFKMTSVCGH |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VMTLDFLGKY | NKWDKVDPAE | LFSQAPTEKK | EANPKLNMVK | FLQVEGRGCD | YVVLWLDCDK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| EGENICFEVL | DAVLPVMNNA | HNGEKTVFRA | RFSSITDTDI | CNAMTRLSEP | DHNEALSVDA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| RQELDLRIGC | AFTRFQTKYF | QGKYGDLDSS | LISFGPCQTP | TLGFCVERHD | KIQSFKPETY |
| 250 | 260 | 270 | 280 | 290 | 300 |
| WVLQAKVHTD | KEESLLLDWD | RVRVFDWEIA | QMFLNMTKLE | KEAWVEATSR | KEKAKQRPLA |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LNTVEMLRVA | SSALGMGPQH | AMQIAERLYT | QGYISYPRTE | TTHYPENFDL | KGSLRQQANH |
| 370 | 380 | 390 | 400 | 410 | 420 |
| PYWADSVKQL | LAEGINRPRK | GHDAGDHPPI | TPMKSATEAE | LGGDAWRLYE | YITRHFIATV |
| 430 | 440 | 450 | 460 | 470 | 480 |
| SHDCKYLQST | ISFRIGPEHF | TCMGKTVISP | GFTEIMPWQS | VPLEESLPTC | QKGDTFTVGE |
| 490 | 500 | 510 | 520 | 530 | 540 |
| VKMLEKQTSP | PDYLTEAELI | TLMEKHGIGT | DASIPVHINN | ICQRNYVTVE | SGRRLKPTNL |
| 550 | 560 | 570 | 580 | 590 | 600 |
| GIVLVHGYYK | IDAELVLPTI | RSAVEKQLNL | IAQGKADYHQ | VLGHTLDIFK | RKFHYFVDSI |
| 610 | 620 | 630 | 640 | 650 | 660 |
| AGMDELMEVS | FSPLAATGKP | LSRCGKCHRF | MKYIQAKPSR | LHCSHCDETY | TLPQNGTIKL |
| 670 | 680 | 690 | 700 | 710 | 720 |
| YKELRCPLDD | FELVLWSSGS | RGKSYPLCPY | CYNHPPFRDM | KKGMGCNECT | HPTCQHSLSM |
| 730 | 740 | 750 | 760 | 770 | 780 |
| LGIGQCVECE | NGVLVLDPTS | GPKWKVACNT | CNVVAHCFEN | AHRVRVSADT | CNTCEAALLD |
| 790 | 800 | 810 | 820 | 830 | 840 |
| VDFNKAKSPL | PGNETQHTGC | IFCDPVFQEL | VELKHAASCH | PMHRGGPGRR | QGRGRGRGRR |
| 850 | 860 | ||||
| PPGKPNPRRP | KDKMSALAAY | FV |