F4ISQ7
Gene name |
At2g32000 (F22D22.25) |
Protein name |
DNA topoisomerase 3-beta |
Names |
|
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT2G32000 |
EC number |
5.6.2.1: Enzymes altering nucleic acid conformation |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for F4ISQ7
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-F4ISQ7-F1 | Predicted | AlphaFoldDB |
45 variants for F4ISQ7
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH05641710 | 34 | G>C | No | 1000Genomes | |
| ENSVATH05641710 | 34 | G>S | No | 1000Genomes | |
| tmp_2_13621051_T_C | 51 | H>R | No | 1000Genomes | |
| tmp_2_13620446_C_T | 112 | V>M | No | 1000Genomes | |
| ENSVATH13501132 | 135 | D>N | No | 1000Genomes | |
| ENSVATH14577049 | 138 | D>G | No | 1000Genomes | |
| ENSVATH05641697 | 142 | K>N | No | 1000Genomes | |
| tmp_2_13619913_G_C | 172 | L>V | No | 1000Genomes | |
| ENSVATH13501131 | 197 | Q>E | No | 1000Genomes | |
| tmp_2_13619120_T_A | 242 | Y>F | No | 1000Genomes | |
| ENSVATH13501114 | 276 | R>I | No | 1000Genomes | |
| tmp_2_13618917_G_T | 277 | T>N | No | 1000Genomes | |
| tmp_2_13618915_C_T | 278 | A>T | No | 1000Genomes | |
| tmp_2_13618910_T_G | 279 | K>N | No | 1000Genomes | |
| ENSVATH05641687 | 326 | Q>R | No | 1000Genomes | |
| tmp_2_13618141_G_A | 332 | P>S | No | 1000Genomes | |
| tmp_2_13618085_T_A | 350 | R>S | No | 1000Genomes | |
| tmp_2_13618068_G_A | 356 | P>L | No | 1000Genomes | |
| ENSVATH13501109 | 385 | I>V | No | 1000Genomes | |
| ENSVATH01936636 | 390 | A>V | No | 1000Genomes | |
| ENSVATH14577045 | 397 | G>R | No | 1000Genomes | |
| ENSVATH05641679 | 407 | V>I | No | 1000Genomes | |
| tmp_2_13617901_G_A | 412 | L>F | No | 1000Genomes | |
| ENSVATH13501107 | 419 | C>F | No | 1000Genomes | |
| tmp_2_13617686_G_A | 452 | P>L | No | 1000Genomes | |
| tmp_2_13617459_A_G | 487 | Y>H | No | 1000Genomes | |
| tmp_2_13617160_A_T | 544 | C>* | No | 1000Genomes | |
| ENSVATH05641673 | 548 | D>G | No | 1000Genomes | |
| ENSVATH01936629 | 596 | H>Q | No | 1000Genomes | |
| tmp_2_13616773_C_G | 638 | G>A | No | 1000Genomes | |
| ENSVATH13501086 | 695 | I>R | No | 1000Genomes | |
| tmp_2_13616511_C_A | 696 | D>Y | No | 1000Genomes | |
| tmp_2_13616500_A_C | 699 | F>L | No | 1000Genomes | |
| ENSVATH05641669 | 709 | A>T | No | 1000Genomes | |
| tmp_2_13616350_G_T | 749 | D>E | No | 1000Genomes | |
| tmp_2_13616348_G_A | 750 | P>L | No | 1000Genomes | |
| tmp_2_13616286_C_A | 771 | E>* | No | 1000Genomes | |
| ENSVATH13501073 | 782 | R>H | No | 1000Genomes | |
| ENSVATH05641668 | 785 | E>K | No | 1000Genomes | |
| ENSVATH13501071 | 790 | I>V | No | 1000Genomes | |
| tmp_2_13616198_G_A | 800 | T>I | No | 1000Genomes | |
| tmp_2_13616147_T_C | 817 | E>G | No | 1000Genomes | |
| tmp_2_13616096_C_T | 834 | R>H | No | 1000Genomes | |
| tmp_2_13616057_C_T | 847 | R>K | No | 1000Genomes | |
| ENSVATH14577032 | 856 | V>I | No | 1000Genomes |
No associated diseases with F4ISQ7
No regional properties for F4ISQ7
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for F4ISQ7 | |||
Functions
| Description | ||
|---|---|---|
| EC Number | 5.6.2.1 | Enzymes altering nucleic acid conformation |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
| DNA topoisomerase activity | Catalysis of the transient cleavage and passage of individual DNA strands or double helices through one another, resulting a topological transformation in double-stranded DNA. |
| DNA topoisomerase type I (single strand cut, ATP-independent) activity | Catalysis of a DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the linking number by +1 per catalytic cycle. |
| metal ion binding | Binding to a metal ion. |
| mRNA binding | Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| DNA topological change | The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MANLLRVLMV | AEKPSIALSI | ASVLSHGQMS | TRRGSTEVHE | FDGMFRGFKA | HYRVTSVIGH |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VFSVDFPEKY | QNWATIDPQD | LFDAPIIKKE | SNPKAHICRH | LSNEARGCSY | MVLWLDCDRE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| GENICFEVIE | STGFDMKDSK | RKVYRARFSS | VTEKDISKAM | DNLVEPNRDE | ALAVDARQEI |
| 190 | 200 | 210 | 220 | 230 | 240 |
| DLKVGVAFSR | FQTSYFQGKY | QNLDCRVISY | GPCQTPTLGF | CVQRYMHINT | FKPEKFWALR |
| 250 | 260 | 270 | 280 | 290 | 300 |
| PYIRKDGYEL | QLEWERRRLF | DLEAATVFQK | LVVEGRTAKV | MDVSEKQEVK | GRPAGLNTVN |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LLKVASSALG | FGPQTAMHLA | ERLYTQGFIS | YPRTESTAYP | SSFDFTDTLR | AQVSNPVWGG |
| 370 | 380 | 390 | 400 | 410 | 420 |
| YVQRLLSDGF | HMPKSGTDAG | DHPPITPMRA | ATEVMVGGDA | WRLYQYVCQH | FLGTVSPNCK |
| 430 | 440 | 450 | 460 | 470 | 480 |
| YIRTKVELSI | GGETFHCTGQ | RVTEKGFTAI | MPWSAVDEKK | LPSFLKGERI | EVLRVELYEG |
| 490 | 500 | 510 | 520 | 530 | 540 |
| NTAPPDYLTE | SELISLMEKH | GIGTDASIAV | HINNIGERNY | VQVQSGRKMV | PTALGITLIR |
| 550 | 560 | 570 | 580 | 590 | 600 |
| GYQCIDPDLC | LPDIRSFIEQ | QITLVAKGQA | DHSHVVQHVI | QQFRRKFSYF | VQQIEHMDAL |
| 610 | 620 | 630 | 640 | 650 | 660 |
| FEAQFSPLAD | SGRALSKCGK | CLRYMKHITA | VPPRLFCGTC | EEVYYLPQKG | TVKLYKELTC |
| 670 | 680 | 690 | 700 | 710 | 720 |
| PLDNFELVIY | SVPGPEGKSF | PLCPYCYNSP | PFEGIDTLFG | ASKTPNAPAK | TKTGAGMPCS |
| 730 | 740 | 750 | 760 | 770 | 780 |
| LCPHPTCQHS | VRNQGVCACP | ECEGTLVLDP | VSFPKWKLNC | NLCSCIVLLP | EGAHRITTTS |
| 790 | 800 | 810 | 820 | 830 | 840 |
| NRCPECDSAI | IEIDFNKKTT | PLENGATLHQ | GCVLCDELLL | SLVEVKHGRS | FVRRGGRGRG |
| 850 | 860 | ||||
| RGRGRGRGGR | RGSKSVDPKM | SFRDF |