Q9Z2B1
PR
Gene name |
Il18rap |
Protein name |
Interleukin-18 receptor accessory protein |
Names |
|
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:16174 |
EC number |
3.2.2.6: Hydrolyzing N-glycosyl compounds |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9Z2B1
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9Z2B1-F1 | Predicted | AlphaFoldDB |
40 variants for Q9Z2B1
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388467139 | 48 | L>I | No | EVA | |
| rs233504840 | 59 | A>T | No | EVA | |
| rs251195252 | 59 | A>V | No | EVA | |
| rs3388466288 | 64 | P>S | No | EVA | |
| rs45722513 | 67 | S>G | No | EVA | |
| rs3388467414 | 78 | K>N | No | EVA | |
| rs241672679 | 94 | P>S | No | EVA | |
| rs255927537 | 96 | E>K | No | EVA | |
| rs239445093 | 105 | M>V | No | EVA | |
| rs222133593 | 108 | E>K | No | EVA | |
| rs3388465591 | 117 | Q>H | No | EVA | |
| rs240823878 | 118 | T>M | No | EVA | |
| rs49948977 | 120 | S>G | No | EVA | |
| rs233491736 | 131 | R>G | No | EVA | |
| rs3388467337 | 346 | T>I | No | EVA | |
| rs213336099 | 350 | R>Q | No | EVA | |
| rs227851881 | 353 | K>R | No | EVA | |
| rs217172728 | 356 | E>D | No | EVA | |
| rs246224328 | 356 | E>G | No | EVA | |
| rs3388467067 | 398 | D>Y | No | EVA | |
| rs3388465513 | 401 | L>M | No | EVA | |
| rs219677915 | 414 | S>W | No | EVA | |
| rs256699006 | 424 | V>M | No | EVA | |
| rs3388465584 | 425 | G>* | No | EVA | |
| rs3388466266 | 431 | H>R | No | EVA | |
| rs220173301 | 431 | H>Y | No | EVA | |
| rs249788823 | 435 | N>K | No | EVA | |
| rs3388465830 | 438 | P>T | No | EVA | |
| rs239409979 | 443 | D>N | No | EVA | |
| rs3388466541 | 528 | K>R | No | EVA | |
| rs3388467399 | 531 | R>Q | No | EVA | |
| rs256942902 | 544 | V>A | No | EVA | |
| rs3389895324 | 550 | F>I | No | EVA | |
| rs3389883902 | 550 | F>S | No | EVA | |
| rs264295564 | 570 | G>W | No | EVA | |
| rs233814535 | 586 | T>I | No | EVA | |
| rs250128240 | 595 | K>N | No | EVA | |
| rs212363602 | 599 | D>G | No | EVA | |
| rs244219091 | 608 | Y>S | No | EVA | |
| rs215986132 | 613 | R>G | No | EVA |
No associated diseases with Q9Z2B1
7 regional properties for Q9Z2B1
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Toll/interleukin-1 receptor homology (TIR) domain | 405 - 567 | IPR000157 |
| domain | Immunoglobulin subtype | 159 - 240 | IPR003599-1 |
| domain | Immunoglobulin subtype | 257 - 354 | IPR003599-2 |
| domain | Immunoglobulin-like domain | 148 - 234 | IPR007110-1 |
| domain | Immunoglobulin-like domain | 250 - 352 | IPR007110-2 |
| domain | Immunoglobulin | 257 - 348 | IPR013151 |
| domain | IL-1Ra-like, immunoglobulin domain | 36 - 164 | IPR041416 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.2.2.6 | Hydrolyzing N-glycosyl compounds |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| interleukin-18 receptor complex | A protein complex that binds interleukin-18; comprises an alpha and a beta subunit. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| interleukin-1 receptor activity | Combining with interleukin-1 to initiate a change in cell activity. Interleukin-1 is produced mainly by activated macrophages and is involved in the inflammatory response. |
| interleukin-18 receptor activity | Combining with interleukin-18 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| NAD(P)+ nucleosidase activity | Catalysis of the reaction: NAD(P)+ + H2O = ADP-ribose(P) + nicotinamide. |
| NAD+ nucleotidase, cyclic ADP-ribose generating | Catalysis of the reaction: NAD+ + H2O = nicotinamide + ADP-ribose that proceeds in a stepwise fashion by ADP-ribosyl cyclase activity followed by cyclic ADP-ribose hydrolase activity. |
8 GO annotations of biological process
| Name | Definition |
|---|---|
| cell population proliferation | The multiplication or reproduction of cells, resulting in the expansion of a cell population. |
| cellular response to hydrogen peroxide | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus. |
| cellular response to interleukin-18 | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-18 stimulus. |
| inflammatory response | The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages. |
| interleukin-18-mediated signaling pathway | The series of molecular signals initiated by interleukin-18 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. |
| neutrophil activation | The change in morphology and behavior of a neutrophil resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor. |
| positive regulation of natural killer cell mediated cytotoxicity | Any process that activates or increases the frequency, rate or extent of natural killer cell mediated cytotoxicity. |
| positive regulation of NF-kappaB transcription factor activity | Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB. |
6 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P27930 | IL1R2 | Interleukin-1 receptor type 2 | Homo sapiens (Human) | PR |
| P14778 | IL1R1 | Interleukin-1 receptor type 1 | Homo sapiens (Human) | PR |
| Q9NPH3 | IL1RAP | Interleukin-1 receptor accessory protein | Homo sapiens (Human) | PR |
| Q61730 | Il1rap | Interleukin-1 receptor accessory protein | Mus musculus (Mouse) | PR |
| P13504 | Il1r1 | Interleukin-1 receptor type 1 | Mus musculus (Mouse) | PR |
| P14719 | Il1rl1 | Interleukin-1 receptor-like 1 | Mus musculus (Mouse) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MLCLGWVFLW | FVAGEKTTGF | NHSACATKKL | LWTYSARGAE | NFVLFCDLQE | LQEQKFSHAS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| QLSPTQSPAH | KPCSGSQKDL | SDVQWYMQPR | SGSPLEEISR | NSPHMQSEGM | LHILAPQTNS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| IWSYICRPRI | RSPQDMACCI | KTVLEVKPQR | NVSCGNTAQD | EQVLLLGSTG | SIHCPSLSCQ |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SDVQSPEMTW | YKDGRLLPEH | KKNPIEMADI | YVFNQGLYVC | DYTQSDNVSS | WTVRAVVKVR |
| 250 | 260 | 270 | 280 | 290 | 300 |
| TIGKDINVKP | EILDPITDTL | DVELGKPLTL | PCRVQFGFQR | LSKPVIKWYV | KESTQEWEMS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| VFEEKRIQST | FKNEVIERTI | FLREVTQRDL | SRKFVCFAQN | SIGNTTRTIR | LRKKEEVVFV |
| 370 | 380 | 390 | 400 | 410 | 420 |
| YILLGTALML | VGVLVAAAFL | YWYWIEVVLL | CRTYKNKDET | LGDKKEFDAF | VSYSNWSSPE |
| 430 | 440 | 450 | 460 | 470 | 480 |
| TDAVGSLSEE | HLALNLFPEV | LEDTYGYRLC | LLDRDVTPGG | VYADDIVSII | KKSRRGIFIL |
| 490 | 500 | 510 | 520 | 530 | 540 |
| SPSYLNGPRV | FELQAAVNLA | LVDQTLKLIL | IKFCSFQEPE | SLPYLVKKAL | RVLPTVTWKG |
| 550 | 560 | 570 | 580 | 590 | 600 |
| LKSVHASSRF | WTQIRYHMPV | KNSNRFMFNG | LRIFLKGFSP | EKDLVTQKPL | EGMPKSGNDH |
| 610 | |||||
| GAQNLLLYSD | QKRC |