AiPD: Autoinhibited Protein Database

Gene name	Il1rl1 (Ly84, St2, Ste2)
Protein name	Interleukin-1 receptor-like 1
Names	Interleukin-33 receptor alpha chain, Lymphocyte antigen 84, Protein ST2, Protein T1
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:17082
EC number	3.2.2.6: Hydrolyzing N-glycosyl compounds
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

34-103 (Predicted disordered autoinhibitory region) PR

34-103 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
5VI4	X-ray	279 A	B/E	26-326	PDB
AF-P14719-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs1133019593	5	Q>R		No	EVA
rs1133847496	16	T>A		No	EVA
rs1132357396	19	M>V		No	EVA
rs3388467130	35	N>D		No	EVA
rs260927391	44	Q>K		No	EVA
rs3388465063	69	N>Y		No	EVA
rs3388465058	131	S>L		No	EVA
rs260943543	192	A>S		No	EVA
rs51401641	192	A>V	strain: C3H/He [UniProt]	No	EVA
rs3388465104	203	T>N		No	EVA
rs3388465503	252	A>V		No	EVA
rs3388465577	253	D>G		No	EVA
rs3388466604	261	T>A		No	EVA
rs3388466809	266	F>C		No	EVA
rs3388467076	266	F>L		No	EVA
rs1134458377	300	K>Q		No	EVA
rs3388466520	306	Y>C		No	EVA
rs3388466826	324	R>S		No	EVA
rs3388466198	338	V>I		No	EVA
rs3388467359	355	L>F		No	EVA
rs259636271	368	D>G		No	EVA
rs1133996513	376	R>W		No	EVA
rs214759597	400	H>R		No	EVA
rs47001137	413	V>I		No	EVA
rs3389887408	433	Q>P		No	EVA
rs52008393	445	N>S		No	EVA
rs252948089	460	S>N		No	EVA
rs3388465576	463	F>V		No	EVA
rs236413291	492	E>K		No	EVA
rs3388467540	493	A>T		No	EVA
rs3388466926	516	K>E		No	EVA
rs3388466399	532	F>L		No	EVA
rs261337760	549	T>M		No	EVA

Type	Name	Position	InterPro Accession
domain	STAG	225 - 343	IPR013721
domain	Stromalin conservative domain	367 - 457	IPR020839

		Description
EC Number	3.2.2.6	Hydrolyzing N-glycosyl compounds
Subcellular Localization	Cell membrane; Single-pass type I membrane protein ;
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cell surface	The external part of the cell wall and/or plasma membrane.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
external side of plasma membrane	The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
extracellular space	That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
focal adhesion	A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ).
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Name	Definition
interleukin-1 receptor activity	Combining with interleukin-1 to initiate a change in cell activity. Interleukin-1 is produced mainly by activated macrophages and is involved in the inflammatory response.
interleukin-33 binding	Binding to interleukin-33.
interleukin-33 receptor activity	Combining with interleukin-33 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
NAD(P)+ nucleosidase activity	Catalysis of the reaction: NAD(P)+ + H2O = ADP-ribose(P) + nicotinamide.
NAD+ nucleotidase, cyclic ADP-ribose generating	Catalysis of the reaction: NAD+ + H2O = nicotinamide + ADP-ribose that proceeds in a stepwise fashion by ADP-ribosyl cyclase activity followed by cyclic ADP-ribose hydrolase activity.

Name	Definition
negative regulation of cell population proliferation	Any process that stops, prevents or reduces the rate or extent of cell proliferation.
negative regulation of interferon-gamma production	Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon.
negative regulation of T-helper 1 type immune response	Any process that stops, prevents, or reduces the frequency, rate, or extent of a T-helper 1 type immune response.
positive regulation of chemokine production	Any process that activates or increases the frequency, rate, or extent of chemokine production.
positive regulation of inflammatory response	Any process that activates or increases the frequency, rate or extent of the inflammatory response.
positive regulation of interleukin-5 production	Any process that activates or increases the frequency, rate, or extent of interleukin-5 production.
positive regulation of macrophage activation	Any process that stimulates, induces or increases the rate of macrophage activation.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P14778	IL1R1	Interleukin-1 receptor type 1	Homo sapiens (Human)	PR
P27930	IL1R2	Interleukin-1 receptor type 2	Homo sapiens (Human)	PR
Q9NPH3	IL1RAP	Interleukin-1 receptor accessory protein	Homo sapiens (Human)	PR
Q61730	Il1rap	Interleukin-1 receptor accessory protein	Mus musculus (Mouse)	PR
Q9Z2B1	Il18rap	Interleukin-18 receptor accessory protein	Mus musculus (Mouse)	PR
P13504	Il1r1	Interleukin-1 receptor type 1	Mus musculus (Mouse)	PR