AiPD: Autoinhibited Protein Database

Gene name	Gys1 (Gys, Gys3)
Protein name	Glycogen [starch] synthase, muscle
Names
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:14936
EC number	2.4.1.11: Hexosyltransferases
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

670-738 (Predicted disordered autoinhibitory region) PR

670-738 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q9Z1E4-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3412562627	75	T>M	No	EVA
rs3388888272	81	E>G	No	EVA
rs3388867181	111	G>A	No	EVA
rs3388896667	121	A>T	No	EVA
rs3388867211	127	E>D	No	EVA
rs31966686	173	P>L	No	EVA
rs3388907196	188	L>M	No	EVA
rs3388882189	223	N>S	No	EVA
rs3397711532	292	E>A	No	EVA
rs3388909394	321	D>V	No	EVA
rs3388909354	325	Y>*	No	EVA
rs3388912765	328	I>T	No	EVA
rs3388910964	347	A>P	No	EVA
rs3388910979	354	R>G	No	EVA
rs3388907243	385	V>M	No	EVA
rs3388909404	426	T>N	No	EVA
rs3388909404	426	T>S	No	EVA
rs3388907274	450	D>Y	No	EVA
rs3388909333	474	K>M	No	EVA
rs1133774799	475	V>E	No	EVA
rs3388907438	480	E>G	No	EVA
rs3388890998	503	G>A	No	EVA
rs3388906213	553	L>P	No	EVA
rs3388867126	574	F>L	No	EVA
rs3388896694	611	M>L	No	EVA
rs3388900143	637	P>Q	No	EVA
rs3388896653	646	P>S	No	EVA
rs3388896662	672	S>C	No	EVA
rs257125169	699	C>S	No	EVA
rs3388906145	710	N>K	No	EVA
rs3388867159	727	L>P	No	EVA

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for Q9Z1E4

		Description
EC Number	2.4.1.11	Hexosyltransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
inclusion body	A discrete intracellular part formed of aggregated molecules such as proteins or other biopolymers.

Name	Definition
glucose binding	Binding to D- or L-enantiomers of glucose.
glycogen (starch) synthase activity	Catalysis of the reaction: UDP-glucose + (1,4)-alpha-D-glucosyl(n) = UDP + (1,4)-alpha-D-glucosyl(n+1).
glycogen synthase activity, transferring glucose-1-phosphate	Catalysis of the reaction: UDP-glucose + (1,4)-alpha-D-glucosyl(n) = UMP + (1,4)-alpha-D-glucosyl(n)-glucose-1-phosphate.
protein kinase binding	Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.

Name	Definition
glycogen biosynthetic process	The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues.
glycogen metabolic process	The chemical reactions and pathways involving glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues in alpha-(1->4) glycosidic linkage, joined together by alpha-(1->6) glycosidic linkages.
heart development	The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P54840	GYS2	Glycogen [starch] synthase, liver	Homo sapiens (Human)	PR
Q8VCB3	Gys2	Glycogen [starch] synthase, liver	Mus musculus (Mouse)	PR
P17625	Gys2	Glycogen [starch] synthase, liver	Rattus norvegicus (Rat)	PR