P17625

PR
Gene name
Gys2
Protein name
Glycogen [starch] synthase, liver
Names
Species
Rattus norvegicus (Rat)
KEGG Pathway
EC number
2.4.1.11: Hexosyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

596-698 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P17625

Entry ID Method Resolution Chain Position Source
AF-P17625-F1 Predicted AlphaFoldDB

No variants for P17625

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P17625

No associated diseases with P17625

No regional properties for P17625

Type Name Position InterPro Accession
No domain, repeats, and functional sites for P17625

Functions

Description
EC Number 2.4.1.11 Hexosyltransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

6 GO annotations of cellular component

Name Definition
cell cortex The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.
cortical actin cytoskeleton The portion of the actin cytoskeleton, comprising filamentous actin and associated proteins, that lies just beneath the plasma membrane.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytoskeleton A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
ectoplasm Granule free cytoplasm, lying immediately below the plasma membrane.

2 GO annotations of molecular function

Name Definition
glucose binding Binding to D- or L-enantiomers of glucose.
glycogen (starch) synthase activity Catalysis of the reaction: UDP-glucose + (1,4)-alpha-D-glucosyl(n) = UDP + (1,4)-alpha-D-glucosyl(n+1).

3 GO annotations of biological process

Name Definition
glycogen biosynthetic process The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues.
glycogen metabolic process The chemical reactions and pathways involving glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues in alpha-(1->4) glycosidic linkage, joined together by alpha-(1->6) glycosidic linkages.
response to glucose Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P54840 GYS2 Glycogen [starch] synthase, liver Homo sapiens (Human) PR
Q9Z1E4 Gys1 Glycogen [starch] synthase, muscle Mus musculus (Mouse) PR
Q8VCB3 Gys2 Glycogen [starch] synthase, liver Mus musculus (Mouse) PR
10 20 30 40 50 60
MLRGRSLSVT SLGGLPAWEA ERLPVEDLLL FEVSWEVTNK VGGICTVIQS KAKTTANEWG
70 80 90 100 110 120
ENYFLIGPYF EHNVKTQVEP CEPANDAVRK AVDAMNKHGC QVHFGRWLIE GSPYVVLFDI
130 140 150 160 170 180
SSSVWNLDRW KGDFWEACGV GIPHDDREAN DMLIFGSLTA WFLKEVTDHA DGKHVIAQFH
190 200 210 220 230 240
EWQAGTGLIL SRARKLPIAT IFTTHATLLG RYLCAANIDF YNQLDKFNID KEAGERQIYH
250 260 270 280 290 300
RYCMERASVH CAHVFTTVSE ITAIEADHML KRKPDVVTPN GLNVKKFSAV HEFQNLHATY
310 320 330 340 350 360
KARIQDFVRG HFYGHLDFDL EKTLFLFIAG RYEFSNKGAD IFLESLSRLN FLLRMHKSNV
370 380 390 400 410 420
TVVVFFIMPA KTNNFNVETL KGQAVRKQLW DTVHCMKEKF GKKLYDGLLR GEIPDMNSIL
430 440 450 460 470 480
DRDDLTIMKR AIFSTQRHSL PPVTTHNMID DSTDPILSTI RRIGLFNNRT DRVKVILHPE
490 500 510 520 530 540
FLSSTSPLLP MDYEEFVRGC HLGVFPSYYE PWGYTPAECT VMGIPSVTTN LSGFGCFMQE
550 560 570 580 590 600
HVADPTAYGI YIVDRRFRSP DDSCNQLTQF LYGFCKQSRR QRIIQRNRTE RLSDLLDWRY
610 620 630 640 650 660
LGRYYQHARH LTLSRAFPDK FHLEPTSPPT TDGFKYPRPS SVPPSPSGSQ TSSPQSSDVE
670 680 690 700
NEGDEDERYD EEEEAERDRL NIKSPFSLNH IPKGKKKLHG EYKN