Q8VCB3
Gene name |
Gys2 |
Protein name |
Glycogen [starch] synthase, liver |
Names |
|
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:232493 |
EC number |
2.4.1.11: Hexosyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8VCB3
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8VCB3-F1 | Predicted | AlphaFoldDB |
42 variants for Q8VCB3
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388853302 | 2 | L>P | No | EVA | |
| rs3388868966 | 24 | P>L | No | EVA | |
| rs3388862522 | 30 | L>P | No | EVA | |
| rs3388868515 | 43 | G>D | No | EVA | |
| rs3388872265 | 56 | A>V | No | EVA | |
| rs265889866 | 92 | V>M | No | EVA | |
| rs3388872304 | 133 | D>E | No | EVA | |
| rs3388850651 | 179 | F>Y | No | EVA | |
| rs3388868988 | 204 | T>S | No | EVA | |
| rs3388846599 | 213 | L>I | No | EVA | |
| rs3388830864 | 266 | A>E | No | EVA | |
| rs3388850642 | 269 | M>I | No | EVA | |
| rs32172839 | 271 | K>Q | No | EVA | |
| rs3388862578 | 279 | P>Q | No | EVA | |
| rs3388830883 | 405 | Y>F | No | EVA | |
| rs3388862585 | 413 | I>N | No | EVA | |
| rs3388850613 | 431 | A>P | No | EVA | |
| rs3388869034 | 432 | I>N | No | EVA | |
| rs3388875632 | 442 | P>L | No | EVA | |
| rs3388869020 | 452 | S>P | No | EVA | |
| rs3388866730 | 465 | L>P | No | EVA | |
| rs3388830940 | 479 | P>S | No | EVA | |
| rs3388862892 | 487 | P>S | No | EVA | |
| rs3388844400 | 491 | M>L | No | EVA | |
| rs32174624 | 538 | V>M | No | EVA | |
| rs3388867079 | 539 | Q>S | No | EVA | |
| rs3388867038 | 540 | E>G | No | EVA | |
| rs239381443 | 630 | T>M | No | EVA | |
| rs3388867072 | 631 | T>M | No | EVA | |
| rs3388844476 | 635 | K>N | No | EVA | |
| rs3388868570 | 639 | P>S | No | EVA | |
| rs3388868494 | 641 | S>* | No | EVA | |
| rs3388875649 | 643 | P>A | No | EVA | |
| rs3388875672 | 653 | S>G | No | EVA | |
| rs32172034 | 656 | C>S | No | EVA | |
| rs225244459 | 659 | A>V | No | EVA | |
| rs32170912 | 661 | D>E | No | EVA | |
| rs3388862569 | 682 | I>T | No | EVA | |
| rs3388853309 | 685 | P>S | No | EVA | |
| rs3388865618 | 695 | K>E | No | EVA | |
| rs3397270820 | 702 | Y>H | No | EVA | |
| rs3388872333 | 705 | N>R | No | EVA |
No associated diseases with Q8VCB3
No regional properties for Q8VCB3
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q8VCB3 | |||
Functions
| Description | ||
|---|---|---|
| EC Number | 2.4.1.11 | Hexosyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| cell cortex | The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins. |
| cortical actin cytoskeleton | The portion of the actin cytoskeleton, comprising filamentous actin and associated proteins, that lies just beneath the plasma membrane. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytoskeleton | A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| ectoplasm | Granule free cytoplasm, lying immediately below the plasma membrane. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| glucose binding | Binding to D- or L-enantiomers of glucose. |
| glycogen (starch) synthase activity | Catalysis of the reaction: UDP-glucose + (1,4)-alpha-D-glucosyl(n) = UDP + (1,4)-alpha-D-glucosyl(n+1). |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| glycogen biosynthetic process | The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. |
| glycogen metabolic process | The chemical reactions and pathways involving glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues in alpha-(1->4) glycosidic linkage, joined together by alpha-(1->6) glycosidic linkages. |
| response to glucose | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MLRGRSLSVT | SLGGLPVWEA | ERLPVEDLLL | FEVSWEVTNK | VGGICTVIQT | KAKTTADEWG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| ENYFLIGPYF | EHNMKTQVEQ | CEPTNDAVRK | AVDAMNKHGC | QVHFGRWLIE | GSPYVVLFDI |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SSSAWNLDRW | KGDFWEACGV | GIPHHDREAN | DMLIFGSLTA | WFLKEVTDHA | DGKHVIAQFH |
| 190 | 200 | 210 | 220 | 230 | 240 |
| EWQAGTGLIL | SRARKLPIAT | VFTTHATLLG | RYLCAANIDF | YNQLDKFDID | KEAGERQIYH |
| 250 | 260 | 270 | 280 | 290 | 300 |
| RYCMERASVH | CAHVFTTVSE | ITAIEAEHML | KRKPDVVTPN | GLNVKKFSAV | HEFQNLHAMY |
| 310 | 320 | 330 | 340 | 350 | 360 |
| KARIQDFVRG | HFYGHLDFDL | EKTLFLFIAG | RYEFSNKGAD | IFLESLSRLN | FLLRMHKSNV |
| 370 | 380 | 390 | 400 | 410 | 420 |
| TVVVFFIMPA | KTNNFNVETL | KGQAVRKQLW | DTVHCLKEKF | GKKLYDGLLR | GEIPDMNSIL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| DRDDLTIMKR | AIFSTQRQSL | PPVTTHNMID | DSTDPILSTI | RRIGLFNNRA | DRVKVILHPE |
| 490 | 500 | 510 | 520 | 530 | 540 |
| FLSSTSPLLP | MDYEEFVRGC | HLGVFPSYYE | PWGYTPAECT | VMGIPSVTTN | LSGFGCFVQE |
| 550 | 560 | 570 | 580 | 590 | 600 |
| HVADPTAYGI | YIVDRRFRSP | DDSCNQLTQF | LYGFCKQSRR | QRIIQRNRTE | RLSDLLDWRY |
| 610 | 620 | 630 | 640 | 650 | 660 |
| LGRYYQHARH | LTLSRAFPDK | FHLEPTSPPT | TDGFKYPRPS | SVPPSPSGSQ | ASSPQCSDAE |
| 670 | 680 | 690 | 700 | ||
| DEEDEDERYD | EEEEAERDRL | NIKSPFSLNH | FPKGKKKLHG | EYKN |