AiPD: Autoinhibited Protein Database

Q9Y6P5

Gene name	SESN1
Protein name	Sestrin-1
Names	p53-regulated protein PA26
Species	Homo sapiens (Human)
KEGG Pathway	hsa:27244
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

252-352 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

252-352 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q9Y6P5

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q9Y6P5-F1	Predicted				AlphaFoldDB

341 variants for Q9Y6P5

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs1330134273 CA365186465	4	A>V		No	ClinGen TOPMed
rs1269990209 CA365186453	6	A>V		No	ClinGen gnomAD
CA145040450 rs867105017	7	A>V		No	ClinGen Ensembl
rs896154275 CA365186440	8	N>K		No	ClinGen TOPMed gnomAD
CA365186437 rs1345847077	9	E>*		No	ClinGen TOPMed
CA145040437 rs868222731	9	E>G		No	ClinGen gnomAD
CA3950597 rs142983751	10	A>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA365186427 rs1257862514	11	Y>N		No	ClinGen Ensembl
CA365186418 rs1278393227	12	T>A		No	ClinGen TOPMed gnomAD
TCGA novel	14	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1295341800 CA365186405	14	P>T		No	ClinGen gnomAD
CA365186379 rs1324549257	18	S>*		No	ClinGen gnomAD
CA365186372 rs1298149118	19	G>E		No	ClinGen gnomAD
CA3950596 rs755639093	22	G>S		No	ClinGen ExAC gnomAD
CA365186335 rs1490247771	25	Q>R		No	ClinGen TOPMed
rs748685243 CA3950595	26	C>G		No	ClinGen ExAC
CA365186325 rs1213232905	26	C>W		No	ClinGen gnomAD
CA145040400 rs771298906	27	G>S		No	ClinGen TOPMed gnomAD
rs1208056055 CA365186315	28	G>E		No	ClinGen Ensembl
TCGA novel	28	G>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs781592728 CA3950594	29	G>D		No	ClinGen ExAC TOPMed gnomAD
rs1361817251 CA365186301	31	D>N		No	ClinGen gnomAD
CA145040379 rs887608622	32	Q>*		No	ClinGen Ensembl
rs887330063 CA365186261	33	D>E		No	ClinGen TOPMed gnomAD
CA145040377 rs1048916111	33	D>G		No	ClinGen Ensembl
CA365186256 rs1249653928	34	E>*		No	ClinGen gnomAD
CA365186250 rs1191728782	34	E>V		No	ClinGen gnomAD
CA365191158 rs1171482262	36	L>F		No	ClinGen gnomAD
CA3950586 rs146922968	37	G>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs1253602779 CA365191121	42	R>*		No	ClinGen gnomAD
CA3950585 rs767306041	42	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA3950584 rs2273668 VAR_014210	44	L>I		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs2273668 CA145065764	44	L>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs147845692 CA3950583	45	G>A		No	ClinGen ESP ExAC
rs1418622558 CA365191081	49	S>N		No	ClinGen TOPMed gnomAD
CA365191072 rs1196032474	50	R>S		No	ClinGen gnomAD
CA3950582 rs552659231	50	R>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs748926614 CA365191064 CA3950581	51	F>L		No	ClinGen ExAC gnomAD
CA365191058 rs1278673127	52	I>S		No	ClinGen gnomAD
rs772807801 CA3950580	53	P>S		No	ClinGen ExAC TOPMed gnomAD
CA3950579 rs369021558	56	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA365191013 rs1583265368	57	I>N		No	ClinGen Ensembl
rs775940697 CA3950555	58	L>R		No	ClinGen ExAC gnomAD
rs1415613973 CA365190990	61	G>R		No	ClinGen gnomAD
CA365190981 rs1375852932	62	S>N		No	ClinGen TOPMed gnomAD
rs774482265 CA145065068	62	S>R		No	ClinGen gnomAD
CA145065065 rs1005093051	63	E>K		No	ClinGen TOPMed gnomAD
CA3950552 rs376950903	65	A>P		No	ClinGen ESP ExAC gnomAD
COSM1225322 CA3950553 rs376950903	65	A>T	large_intestine [Cosmic]	No	ClinGen cosmic curated ESP ExAC gnomAD
CA365190958 rs1374465320	66	Q>*		No	ClinGen Ensembl
CA365190940 rs1399505254	68	H>D		No	ClinGen TOPMed
CA3950551 rs772540397	68	H>R		No	ClinGen ExAC TOPMed gnomAD
rs1186849805 CA365190932	69	A>S		No	ClinGen gnomAD
rs149726227 CA3950550	72	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
COSM1071948 CA3950549 rs779364145	74	S>Y	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA3950548 rs757353675	75	F>Y		No	ClinGen ExAC gnomAD
rs749478685 CA145065031	76	A>V		No	ClinGen Ensembl
rs756253993 CA3950545	80	R>C		No	ClinGen ExAC TOPMed gnomAD
rs371591680 CA3950544	80	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA365190856 rs1272563178	81	L>W		No	ClinGen gnomAD
CA3950543 rs766355196	82	D>N		No	ClinGen ExAC gnomAD
CA3950542 rs762972224	85	T>M		No	ClinGen ExAC gnomAD
CA365190829 rs1381565272	85	T>S		No	ClinGen gnomAD
CA3950540 rs765087833	87	V>L		No	ClinGen ExAC gnomAD
CA145064976 rs11556938	89	V>A		No	ClinGen Ensembl
rs776488244 CA3950538	93	Q>R		No	ClinGen ExAC gnomAD
TCGA novel	96	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1163492427 CA365190753	96	E>G		No	ClinGen gnomAD
rs768245807 CA365190756	96	E>K		No	ClinGen ExAC TOPMed gnomAD
CA3950537 rs768245807	96	E>Q		No	ClinGen ExAC TOPMed gnomAD
CA3950536 rs760307290	97	S>C		No	ClinGen ExAC gnomAD
rs1429037232 CA365190747	97	S>N		No	ClinGen TOPMed
TCGA novel	98	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1184378999 CA365190704	103	H>Y		No	ClinGen gnomAD
rs1243042829 CA365190694	104	Y>C		No	ClinGen TOPMed gnomAD
CA365190693 rs1243042829	104	Y>S		No	ClinGen TOPMed gnomAD
CA3950532 rs201465645	108	M>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA3950533 rs746389602	108	M>V		No	ClinGen ExAC gnomAD
rs1252484837 CA365190660	109	D>G		No	ClinGen gnomAD
CA365190654 rs1214343983	110	G>R		No	ClinGen gnomAD
rs1271196492 CA365190646	111	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA3950531 rs771384645	111	P>S		No	ClinGen ExAC gnomAD
CA3950529 rs778011237	115	H>R		No	ClinGen ExAC TOPMed gnomAD
CA365190627 rs1437191840	115	H>Y		No	ClinGen gnomAD
rs769935193 CA3950528	117	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs748178740 CA3950527	117	R>H		No	ClinGen ExAC TOPMed gnomAD
rs79832046 CA3950525	118	H>Q		No	ClinGen ExAC TOPMed
CA3950526 rs781284555	118	H>R		No	ClinGen ExAC TOPMed gnomAD
rs1167959734 CA365190594	120	I>L		No	ClinGen TOPMed gnomAD
rs151284724 CA3950524	120	I>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs1167959734 CA365190593	120	I>V		No	ClinGen TOPMed gnomAD
CA3950505 rs745757510	125	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1562455891 CA365190530	128	H>D		No	ClinGen Ensembl
rs368711688 CA3950503	128	H>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs1405886915 CA365190527	128	H>R		No	ClinGen gnomAD
CA145064323 rs1047353354	129	Q>H		No	ClinGen Ensembl
rs930318022 CA145064313	130	C>R		No	ClinGen Ensembl
CA3950502 rs753622961	132	Y>*		No	ClinGen ExAC gnomAD
CA3950501 rs764014847	133	L>F		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	133	L>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA3950500 rs755780757	135	N>T		No	ClinGen ExAC gnomAD
CA365190477 rs1218494361	136	L>M		No	ClinGen TOPMed
CA3950498 rs375028635	137	H>R		No	ClinGen ESP ExAC gnomAD
CA3950497 rs759152035	139	N>S		No	ClinGen ExAC gnomAD
rs200097683 CA145064286	142	L>P		No	ClinGen TOPMed
rs374094607 CA145064250	143	H>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA3950495 rs374094607	143	H>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA3950496 rs774705909	143	H>Y		No	ClinGen ExAC TOPMed gnomAD
CA145064219 rs984736083	145	G>D		No	ClinGen TOPMed
CA3950494 rs773524051	145	G>R		No	ClinGen ExAC TOPMed gnomAD
rs773524051 CA3950493	145	G>S		No	ClinGen ExAC TOPMed gnomAD
rs770163426 CA3950492	146	G>R		No	ClinGen ExAC gnomAD
rs974512964 CA145064200	147	D>N		No	ClinGen Ensembl
rs140062020 CA3950491	148	P>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA3950490 rs776948785	149	K>R		No	ClinGen ExAC TOPMed gnomAD
CA365190398 rs776948785	149	K>T		No	ClinGen ExAC TOPMed gnomAD
rs1375235139 CA365190391	150	W>*		No	ClinGen gnomAD
CA3950489 rs760197100	152	N>S		No	ClinGen ExAC TOPMed gnomAD
rs747056609 CA3950488	153	G>S		No	ClinGen ExAC gnomAD
CA145064183 rs987716314	155	E>V		No	ClinGen Ensembl
rs1343896583 CA365190350	156	N>S		No	ClinGen gnomAD
TCGA novel	158	P>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA3950486 rs770954026	158	P>S		No	ClinGen ExAC gnomAD
CA3950485 rs749261620	159	Q>E		No	ClinGen ExAC gnomAD
TCGA novel	162	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1279209258 CA365190296	164	L>S		No	ClinGen TOPMed
CA365190291 rs1348552399	165	G>R		No	ClinGen TOPMed
CA365190284 rs1032022376	166	E>*		No	ClinGen gnomAD
COSM739725 CA145064165 rs1032022376	166	E>K	lung Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs1182185267 CA365190274	167	L>P		No	ClinGen gnomAD
CA3950483 rs756014265	168	N>K		No	ClinGen ExAC gnomAD
rs961520823 CA145064161	168	N>S		No	ClinGen TOPMed
TCGA novel	169	K>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1461253100 CA365190250	171	L>S		No	ClinGen TOPMed
rs549678440 CA3950481	173	H>N		No	ClinGen 1000Genomes ExAC gnomAD
CA365190236 rs1269416704	173	H>R		No	ClinGen gnomAD
rs1008424804 CA145064151	174	R>S		No	ClinGen TOPMed
rs751013218 CA3950479	175	P>T		No	ClinGen ExAC gnomAD
CA3950477 rs763399693	178	I>V		No	ClinGen ExAC gnomAD
CA365190200 rs1398205221	179	T>A		No	ClinGen gnomAD
rs776876641 CA3950473	183	I>T		No	ClinGen ExAC TOPMed gnomAD
CA3950474 rs371392243	183	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA365190119 rs1391212122	189	A>T		No	ClinGen TOPMed
rs1436299259 CA365190116	189	A>V		No	ClinGen TOPMed
rs977464045 CA145063087	190	E>K		No	ClinGen Ensembl
CA365190106 rs1479431236	191	E>K		No	ClinGen gnomAD
CA365190020 rs1397460744	197	A>G		No	ClinGen TOPMed
rs1376515862 CA365190024	197	A>T		No	ClinGen TOPMed
CA365189986 rs1344722599	200	V>L		No	ClinGen gnomAD
CA365189973 rs1234180002	201	H>P		No	ClinGen gnomAD
CA365189975 rs1234180002	201	H>R		No	ClinGen gnomAD
rs376971427 CA3950445	202	A>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA145063067 rs369712213	205	L>V		No	ClinGen ESP TOPMed
rs373895777 CA145063052	210	H>D		No	ClinGen ESP
CA365189884 rs1254092400	210	H>R		No	ClinGen TOPMed
CA145063037 rs35697331	214	S>*		No	ClinGen ExAC TOPMed gnomAD
CA3950441 rs35697331	214	S>L		No	ClinGen ExAC TOPMed gnomAD
CA365189823 rs1472309889	216	T>I		No	ClinGen TOPMed
rs1377729830 CA365189821	217	F>I		No	ClinGen TOPMed gnomAD
CA365189820 rs1377729830	217	F>L		No	ClinGen TOPMed gnomAD
rs1220310443 CA365189808	218	G>S		No	ClinGen Ensembl
rs1416772262 CA365189781	220	G>A		No	ClinGen gnomAD
rs369355631 CA3950438	222	S>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA3950437 rs768383429	223	P>L		No	ClinGen ExAC gnomAD
TCGA novel	223	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA3950436 rs746639044	224	E>A		No	ClinGen ExAC gnomAD
TCGA novel	228	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs779744842 CA3950435 COSM1071947	232	T>I	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs757886717 CA3950434	233	F>Y		No	ClinGen ExAC gnomAD
CA3950433 rs745320994	234	R>G		No	ClinGen ExAC gnomAD
CA365189635 rs1349913754	234	R>T		No	ClinGen gnomAD
rs1467217774 CA365189610	237	S>P		No	ClinGen TOPMed
rs553986577 CA3950431	238	V>I		No	ClinGen 1000Genomes ExAC gnomAD
CA365189575 rs1310807543	240	N>I		No	ClinGen gnomAD
CA365189577 rs1310807543	240	N>S		No	ClinGen gnomAD
rs1310807543 CA365189578	240	N>T		No	ClinGen gnomAD
rs375753083 CA3950430	241	Y>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA365189556 rs1402890371	242	C>S		No	ClinGen gnomAD
rs754354528 CA3950429	243	I>T		No	ClinGen ExAC gnomAD
CA3950427 rs756502932	248	N>S		No	ClinGen ExAC TOPMed gnomAD
rs748655496 CA145062920	250	N>S		No	ClinGen gnomAD
CA365189475 rs1562455024	251	H>P		No	ClinGen Ensembl
rs1255881041 CA365189472	251	H>Q		No	ClinGen gnomAD
rs1261941152 CA365189476	251	H>Y		No	ClinGen gnomAD
CA3950425 rs767789452	252	S>G		No	ClinGen ExAC gnomAD
CA365189464 rs1443331379	252	S>R		No	ClinGen TOPMed gnomAD
rs548806605 CA3950424	253	V>M		No	ClinGen 1000Genomes ExAC gnomAD
rs1034106509 CA145062887	254	D>A		No	ClinGen Ensembl
CA3950423 rs138898747	255	E>D		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA145062861 rs904434135	256	M>I		No	ClinGen TOPMed
rs1328647386 CA365189440	256	M>T		No	ClinGen gnomAD
rs150654249 CA3950421	257	P>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA3950422 rs150654249	257	P>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1283800278 CA365189419	259	N>K		No	ClinGen gnomAD
CA3950419 rs143545521	259	N>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA365189405 rs1447071069	262	E>K		No	ClinGen gnomAD
rs746834049 CA365189383	265	S>A		No	ClinGen ExAC gnomAD
rs746834049 CA3950418	265	S>P		No	ClinGen ExAC gnomAD
CA145060433 rs535710671	266	V>G		No	ClinGen gnomAD
rs200255805 CA3950404	267	S>N		No	ClinGen 1000Genomes ExAC gnomAD
CA145060427 rs112563275	267	S>R		No	ClinGen TOPMed gnomAD
TCGA novel	267	S>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA365189349 rs1191054545	269	S>P		No	ClinGen gnomAD
rs1057129965 CA145060396	275	A>V		No	ClinGen Ensembl
rs763876525 CA3950400	277	M>I		No	ClinGen ExAC gnomAD
rs958191694 CA145060389	277	M>V		No	ClinGen TOPMed
CA365189248 rs75780557	283	L>I		No	ClinGen TOPMed
rs75780557 CA145060388	283	L>V		No	ClinGen TOPMed
rs1291786157 CA365189235	284	Q>H		No	ClinGen gnomAD
CA145060384 rs757704028	286	C>S		No	ClinGen TOPMed gnomAD
TCGA novel	287	R>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1218235551 CA365189219	287	R>G		No	ClinGen TOPMed
CA365189217 rs1341157600	287	R>Q		No	ClinGen gnomAD
CA3950398 rs760701656	288	D>H		No	ClinGen ExAC TOPMed gnomAD
rs1048535718 CA145060355	290	E>Q		No	ClinGen TOPMed gnomAD
rs759161337 CA3950394	293	S>N		No	ClinGen ExAC gnomAD
rs1305765392 CA365189166	294	Q>R		No	ClinGen gnomAD
rs1429593576 CA365189142	297	M>R		No	ClinGen TOPMed gnomAD
rs1429593576 CA365189143	297	M>T		No	ClinGen TOPMed gnomAD
rs1554262797 CA3950392	299	S>L		No	ClinGen Ensembl
TCGA novel	304	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	306	R>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA365189079 rs903300709	306	R>I		No	ClinGen TOPMed gnomAD
CA145060303 rs903300709	306	R>K		No	ClinGen TOPMed gnomAD
CA3950390 rs770462649	307	E>G		No	ClinGen ExAC TOPMed gnomAD
rs760878307 CA145060302	307	E>K		No	ClinGen gnomAD
rs371879536 CA3950389	308	S>C		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	308	S>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	309	M>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs768870908 CA145060284	310	F>L		No	ClinGen Ensembl
rs777341294 CA3950386	310	F>S		No	ClinGen ExAC gnomAD
CA145060282 rs1020343983	311	V>A		No	ClinGen TOPMed
rs1361261634 CA365189048	311	V>I		No	ClinGen TOPMed
rs1278575875 CA365189034	313	S>P		No	ClinGen TOPMed
CA365189032 rs1231430248	313	S>Y		No	ClinGen gnomAD
rs770423654 CA3950370	317	E>D		No	ClinGen ExAC TOPMed gnomAD
rs934016829 CA145059040	317	E>G		No	ClinGen Ensembl
rs762697538 CA365188986	318	E>A		No	ClinGen ExAC gnomAD
CA3950368 rs772548122	318	E>D		No	ClinGen ExAC gnomAD
rs762697538 CA3950369	318	E>V		No	ClinGen ExAC gnomAD
rs769392905 CA3950367	319	V>A		No	ClinGen ExAC
rs1284575951 CA365188977	320	T>A		No	ClinGen TOPMed
rs968168864 CA145059008	320	T>R		No	ClinGen Ensembl
rs748633348 CA3950365	321	P>L		No	ClinGen ExAC
rs1273995657 CA365188971	321	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA365188968 rs1394690343	322	A>T		No	ClinGen TOPMed gnomAD
rs781780594 CA3950364	326	S>A		No	ClinGen ExAC
CA3950362 rs557313505	327	R>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs780468161 CA3950361	327	R>H		No	ClinGen ExAC TOPMed gnomAD
rs750711133 CA3950359	334	Y>H		No	ClinGen ExAC gnomAD
rs757397697 CA3950357	336	Y>C		No	ClinGen ExAC gnomAD
rs1421897691 CA365188823	336	Y>H		No	ClinGen gnomAD
CA365188811 rs1182383634	337	K>E		No	ClinGen gnomAD
CA365188799 rs201225098	338	D>H		No	ClinGen gnomAD
rs201225098 CA145058939	338	D>N		No	ClinGen gnomAD
CA365188767 rs752619167	341	R>G		No	ClinGen ExAC TOPMed gnomAD
rs767386298 CA3950355	343	G>R		No	ClinGen ExAC
CA3950354 rs759474520	345	H>P		No	ClinGen ExAC gnomAD
rs370356794 CA3950353	347	P>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA3950352 rs199611315 COSM3766885	350	R>C	liver [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs772956928 CA3950351	350	R>H		No	ClinGen ExAC TOPMed gnomAD
rs772956928 CA3950350	350	R>L		No	ClinGen ExAC TOPMed gnomAD
CA3950349 rs377481017	351	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs766055393 CA3950335	354	Y>H		No	ClinGen ExAC gnomAD
CA3950333 rs750027141	356	W>G		No	ClinGen ExAC gnomAD
rs764922603 CA3950332	357	E>D		No	ClinGen ExAC
CA365188453 rs1391783010	357	E>K		No	ClinGen gnomAD
CA3950331 rs761558481	359	H>N		No	ClinGen ExAC gnomAD
CA3950330 rs776238078	359	H>R		No	ClinGen ExAC gnomAD
rs761059613 CA3950328	362	S>A		No	ClinGen ExAC gnomAD
rs1475851538 CA365188391	366	R>C		No	ClinGen TOPMed gnomAD
CA145057162 rs937114076	368	Y>F		No	ClinGen TOPMed
CA365188368 rs1238842417	369	P>L		No	ClinGen TOPMed
CA365188325 rs201020606	376	D>H		No	ClinGen ExAC TOPMed gnomAD
CA3950327 rs201020606	376	D>N		No	ClinGen ExAC TOPMed gnomAD
CA365188312 rs1196069006	377	E>D		No	ClinGen gnomAD
CA145057156 rs927070728	378	K>E		No	ClinGen TOPMed gnomAD
rs772314185 CA3950326	379	F>V		No	ClinGen ExAC
rs746187351 CA3950325	381	I>V		No	ClinGen ExAC gnomAD
CA365188277 rs1261981726	382	A>V		No	ClinGen TOPMed
CA3950324 rs774585259	384	N>D		No	ClinGen ExAC gnomAD
CA365188267 rs774585259	384	N>H		No	ClinGen ExAC gnomAD
rs1482287006 CA365188265	384	N>S		No	ClinGen gnomAD
rs757974485 CA145057143	388	N>S		No	ClinGen Ensembl
rs1206545392 CA365188222	390	M>I		No	ClinGen gnomAD
CA365188211 rs1254750453	392	M>T		No	ClinGen gnomAD
CA3950322 rs749534099	392	M>V		No	ClinGen ExAC TOPMed gnomAD
rs777807556 CA3950321	394	K>E		No	ClinGen ExAC gnomAD
rs1331747916 CA365188189	395	D>H		No	ClinGen TOPMed gnomAD
TCGA novel	400	M>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA3950320 rs756225119	400	M>V		No	ClinGen ExAC gnomAD
CA3950319 rs777845724	403	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1473700910 CA365188097	408	Y>C		No	ClinGen TOPMed
CA3950318 rs369330706	410	H>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA3950317 rs758278301	411	C>R		No	ClinGen ExAC gnomAD
CA3950316 CA365188067 rs750161025	412	M>I		No	ClinGen ExAC TOPMed gnomAD
CA145057128 rs1016537660	412	M>V		No	ClinGen TOPMed gnomAD
CA365188053 rs1356056565	414	G>A		No	ClinGen gnomAD
CA145057124 rs918537818	416	R>K		No	ClinGen Ensembl
CA365187850 rs146939598	417	Y>*		No	ClinGen ESP ExAC TOPMed gnomAD
CA3950300 rs773489599	418	D>G		No	ClinGen ExAC TOPMed gnomAD
CA365187845 rs1373901982	418	D>Y		No	ClinGen TOPMed
CA145055764 rs370303610	421	D>N		No	ClinGen Ensembl
CA3950297 rs748198330	422	Y>C		No	ClinGen ExAC TOPMed gnomAD
rs1269074691 CA365187766	424	E>V		No	ClinGen gnomAD
CA3950292 rs757187967	431	R>C	Variant assessed as Somatic; 0.0003743 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA3950291 rs369093694	431	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA365187686 rs369093694	431	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA3950289 COSM1672662 rs755727138	436	Y>D	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
TCGA novel	437	I>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1387254019 CA365187615	437	I>N		No	ClinGen gnomAD
rs1387254019 CA365187617	437	I>S		No	ClinGen gnomAD
TCGA novel	439	T>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	441	V>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1473317780 CA365187520	450	R>T		No	ClinGen gnomAD
CA365187512 rs1387678283	451	M>T		No	ClinGen gnomAD
rs1448953598 CA365187495	453	D>G		No	ClinGen gnomAD
rs773577159 CA3950282	457	R>K		No	ClinGen ExAC gnomAD
rs1209067119 CA569152513	463	E>A*		No	ClinGen gnomAD
CA365187412 rs1583255529	464	K>E		No	ClinGen Ensembl
rs1306510376 CA365187392	465	V>F		No	ClinGen gnomAD
CA365187380 rs1266402509	467	V>I		No	ClinGen TOPMed
rs3799831 CA145055239	468	N>I		No	ClinGen Ensembl
rs201885358 CA3950267	472	I>T		No	ClinGen ExAC TOPMed gnomAD
rs1485777558 CA365187349	472	I>V		No	ClinGen TOPMed
CA365187328 rs1583254669	475	R>K		No	ClinGen Ensembl
rs766813574 CA3950266	477	Q>*		No	ClinGen ExAC TOPMed gnomAD
rs916523363 CA145055220	481	L>I		No	ClinGen Ensembl
CA365187268 rs1412902067	483	A>V		No	ClinGen gnomAD
CA145055207 rs960349001	485	R>S		No	ClinGen TOPMed gnomAD
rs750741495 CA3950264	486	A>T		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	486	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1482587346 CA365187246	487	I>M		No	ClinGen TOPMed gnomAD
rs762070609 CA3950262	487	I>T		No	ClinGen ExAC gnomAD
rs1442130633 CA365187244	488	T>A		No	ClinGen gnomAD
rs1233452635 CA365187241	488	T>N		No	ClinGen gnomAD
rs776788098 CA3950261	489	R>C		No	ClinGen ExAC TOPMed gnomAD
rs760783455 CA3950259	489	R>H		No	ClinGen ExAC TOPMed gnomAD
rs760783455 CA3950260	489	R>L		No	ClinGen ExAC TOPMed gnomAD
TCGA novel CA145055157 rs868221814	491	M>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA ClinGen Ensembl
rs1212255665 CA365187208	493	T>W		No	ClinGen gnomAD

No associated diseases with Q9Y6P5

No regional properties for Q9Y6P5

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for Q9Y6P5

Functions

		Description
EC Number
Subcellular Localization	Nucleus Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

5 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
fibrillar center	A structure found most metazoan nucleoli, but not usually found in lower eukaryotes; surrounded by the dense fibrillar component; the zone of transcription from multiple copies of the pre-rRNA genes is in the border region between these two structures.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

2 GO annotations of molecular function

Name	Definition
leucine binding	Binding to 2-amino-4-methylpentanoic acid.
oxidoreductase activity, acting on peroxide as acceptor	Catalysis of an oxidation-reduction (redox) reaction in which the peroxide group acts as a hydrogen or electron acceptor.

9 GO annotations of biological process

Name	Definition
cellular oxidant detoxification	Any process carried out at the cellular level that reduces or removes the toxicity superoxide radicals or hydrogen peroxide.
cellular response to amino acid starvation	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of amino acids.
cellular response to glucose starvation	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of glucose.
cellular response to leucine	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leucine stimulus.
cellular response to leucine starvation	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of leucine.
negative regulation of TORC1 signaling	Any process that stops, prevents or reduces the frequency, rate or extent of TORC1 signaling.
positive regulation of macroautophagy	Any process, such as recognition of nutrient depletion, that activates or increases the rate of macroautophagy to bring cytosolic macromolecules to the vacuole/lysosome for degradation.
reactive oxygen species metabolic process	The chemical reactions and pathways involving a reactive oxygen species, any molecules or ions formed by the incomplete one-electron reduction of oxygen. They contribute to the microbicidal activity of phagocytes, regulation of signal transduction and gene expression, and the oxidative damage to biopolymers.
regulation of response to reactive oxygen species	Any process that modulates the frequency, rate or extent of response to reactive oxygen species.

3 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P58005	SESN3	Sestrin-3	Homo sapiens (Human)	PR
P58006	Sesn1	Sestrin-1	Mus musculus (Mouse)	PR
Q9N4D6	sesn-1	Sestrin homolog	Caenorhabditis elegans	PR

10	20	30	40	50	60
MRLAAAANEA	YTAPLAVSGL	LGCKQCGGGR	DQDEELGIRI	PRPLGQGPSR	FIPEKEILQV
70	80	90	100	110	120
GSEDAQMHAL	FADSFAALGR	LDNITLVMVF	HPQYLESFLK	TQHYLLQMDG	PLPLHYRHYI
130	140	150	160	170	180
GIMAAARHQC	SYLVNLHVND	FLHVGGDPKW	LNGLENAPQK	LQNLGELNKV	LAHRPWLITK
190	200	210	220	230	240
EHIEGLLKAE	EHSWSLAELV	HAVVLLTHYH	SLASFTFGCG	ISPEIHCDGG	HTFRPPSVSN
250	260	270	280	290	300
YCICDITNGN	HSVDEMPVNS	AENVSVSDSF	FEVEALMEKM	RQLQECRDEE	EASQEEMASR
310	320	330	340	350	360
FEIEKRESMF	VFSSDDEEVT	PARAVSRHFE	DTSYGYKDFS	RHGMHVPTFR	VQDYCWEDHG
370	380	390	400	410	420
YSLVNRLYPD	VGQLIDEKFH	IAYNLTYNTM	AMHKDVDTSM	LRRAIWNYIH	CMFGIRYDDY
430	440	450	460	470	480
DYGEINQLLD	RSFKVYIKTV	VCTPEKVTKR	MYDSFWRQFK	HSEKVHVNLL	LIEARMQAEL
490
LYALRAITRY	MT