P58006
PR
Gene name |
Sesn1 |
Protein name |
Sestrin-1 |
Names |
|
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:140742 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P58006
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P58006-F1 | Predicted | AlphaFoldDB |
15 variants for P58006
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3400486718 | 17 | V>F | No | EVA | |
| rs221041578 | 30 | R>C | No | EVA | |
| rs3389070463 | 102 | Q>P | No | EVA | |
| rs3400513907 | 109 | D>E | No | EVA | |
| rs3401145659 | 116 | Y>* | No | EVA | |
| rs252193219 | 227 | C>F | No | EVA | |
| rs3389098733 | 257 | Q>* | No | EVA | |
| rs3389089605 | 276 | L>H | No | EVA | |
| rs3389098726 | 280 | M>I | No | EVA | |
| rs3412920161 | 308 | S>I | No | EVA | |
| rs3389103112 | 309 | M>T | No | EVA | |
| rs3389075675 | 342 | H>L | No | EVA | |
| rs3389097587 | 408 | Y>F | No | EVA | |
| rs3389097545 | 432 | S>N | No | EVA | |
| rs3389107329 | 476 | M>I | No | EVA |
No associated diseases with P58006
No regional properties for P58006
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for P58006 | |||
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| fibrillar center | A structure found most metazoan nucleoli, but not usually found in lower eukaryotes; surrounded by the dense fibrillar component; the zone of transcription from multiple copies of the pre-rRNA genes is in the border region between these two structures. |
| GATOR2 complex | A multiprotein subcomplex of the GATOR complex that regulates TORC1 signaling by interacting with the Rag GTPase. In human, this complex consists of WDR24, WDR59, MIOS, SEH1L, and SEC13. In S. cerevisiae, this complex is referred to as SEACAT and contains the Sea2p, Sea3p, Sea4p, Seh1p, Sec13p proteins. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| leucine binding | Binding to 2-amino-4-methylpentanoic acid. |
| oxidoreductase activity, acting on peroxide as acceptor | Catalysis of an oxidation-reduction (redox) reaction in which the peroxide group acts as a hydrogen or electron acceptor. |
12 GO annotations of biological process
| Name | Definition |
|---|---|
| cellular oxidant detoxification | Any process carried out at the cellular level that reduces or removes the toxicity superoxide radicals or hydrogen peroxide. |
| cellular response to amino acid starvation | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of amino acids. |
| cellular response to amino acid stimulus | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups. |
| cellular response to glucose starvation | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of glucose. |
| cellular response to leucine | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leucine stimulus. |
| cellular response to leucine starvation | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of leucine. |
| negative regulation of cell growth | Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth. |
| negative regulation of TORC1 signaling | Any process that stops, prevents or reduces the frequency, rate or extent of TORC1 signaling. |
| positive regulation of macroautophagy | Any process, such as recognition of nutrient depletion, that activates or increases the rate of macroautophagy to bring cytosolic macromolecules to the vacuole/lysosome for degradation. |
| reactive oxygen species metabolic process | The chemical reactions and pathways involving a reactive oxygen species, any molecules or ions formed by the incomplete one-electron reduction of oxygen. They contribute to the microbicidal activity of phagocytes, regulation of signal transduction and gene expression, and the oxidative damage to biopolymers. |
| regulation of protein kinase B signaling | Any process that modulates the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B. |
| regulation of response to reactive oxygen species | Any process that modulates the frequency, rate or extent of response to reactive oxygen species. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MRLAAASNEA | YAASLAVSEL | LSCHQCGGDR | GQDEELGIRI | PRPLGHGPSR | FIPEKEMLQV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GSEDAQMHAL | FADSFAALGR | LDNITLVMVF | HPQYLESFLK | TQHYLLQMDG | PLPLHYRHYI |
| 130 | 140 | 150 | 160 | 170 | 180 |
| GIMAAARHQC | SYLVNLHVSD | FLHVGGDPKW | LNGLENAPQK | LQNLGELNKV | LAHRPWLITK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| EHIEGLLKAE | EHSWSLAELV | HAVVLLTHYH | SLASFTFGCG | ISPEIHCDGG | HTFRPPSVSN |
| 250 | 260 | 270 | 280 | 290 | 300 |
| YCICDITNGN | HSVDEMQVNS | AGNASVSDSF | FEVEALMEKM | RQLQECREEE | EASQEEMASR |
| 310 | 320 | 330 | 340 | 350 | 360 |
| FEMEKRESMF | VFSSDDDEVT | PARDVSRHFE | DTSYGYKDFS | RHGMHVPTFR | VQDYCWEDHG |
| 370 | 380 | 390 | 400 | 410 | 420 |
| YSLVNRLYPD | VGQLIDEKFH | IAYNLTYNTM | AMHKDVDTSM | LRRAIWNYIH | CMFGIRYDDY |
| 430 | 440 | 450 | 460 | 470 | 480 |
| DYGEINQLLD | RSFKVYIKTV | VCTPEKVTKR | MYDSFWRQFK | HSEKVHVNLL | LIEARMQAEL |
| 490 | |||||
| LYALRAITRY | MT |