AiPD: Autoinhibited Protein Database

Q9Y5B9

Gene name	SUPT16H (FACT140, FACTP140)
Protein name	FACT complex subunit SPT16
Names	Chromatin-specific transcription elongation factor 140 kDa subunit, FACT 140 kDa subunit, FACTp140, Facilitates chromatin transcription complex subunit SPT16, hSPT16
Species	Homo sapiens (Human)
KEGG Pathway	hsa:11198
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

943-1047 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

943-1047 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

10 structures for Q9Y5B9

Entry ID	Method	Resolution	Chain	Position	Source
4Z2M	X-ray	298 A	B	644-930	PDB
4Z2N	X-ray	192 A	A	644-930	PDB
5E5B	X-ray	184 A	A	2-432	PDB
5UMT	X-ray	209 A	A	1-434	PDB
5UMU	X-ray	190 A	A/B	649-926	PDB
5XM2	X-ray	219 A	A/B	1-437	PDB
6UPK	EM	490 A	G	2-925	PDB
6UPL	EM	740 A	G	2-925	PDB
8I17	X-ray	198 A	C/F/I	926-965	PDB
AF-Q9Y5B9-F1	Predicted				AlphaFoldDB

433 variants for Q9Y5B9

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
VAR_086185	162	I>V	NEDDFAC; unknown pathological significance [UniProt]	Yes	UniProt
VAR_086186	432	L>P	NEDDFAC; unknown pathological significance [UniProt]	Yes	UniProt
VAR_086187	571	N>S	NEDDFAC; unknown pathological significance [UniProt]	Yes	UniProt
VAR_086188	734	R>W	NEDDFAC; unknown pathological significance [UniProt]	Yes	UniProt
rs771404867 CA7090495	2	A>P		No	ClinGen ExAC TOPMed gnomAD
CA388873849 rs771404867	2	A>T		No	ClinGen ExAC TOPMed gnomAD
rs1355366612 CA388873806	5	L>P		No	ClinGen TOPMed gnomAD
CA388873784 rs1173028066	6	D>E		No	ClinGen gnomAD
CA388873770 rs1432988431	7	K>I		No	ClinGen gnomAD
rs1594315861 CA388873704	14	V>G		No	ClinGen Ensembl
rs1396782293 CA388873709	14	V>M		No	ClinGen gnomAD
CA388873703 rs1174261451	15	K>Q		No	ClinGen gnomAD
CA7090491 rs148988336	19	S>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs772638192 CA7090490	20	N>S		No	ClinGen ExAC TOPMed gnomAD
CA257582338 rs757130398	22	R>W		No	ClinGen Ensembl
rs1415988028 CA388873009	23	K>N		No	ClinGen gnomAD
CA388873004 rs1425573358	24	G>A		No	ClinGen TOPMed
rs1183653965 CA388872989	26	D>V		No	ClinGen gnomAD
CA257572702 rs1021439676	28	Y>F		No	ClinGen TOPMed gnomAD
rs1566392884 CA388872967	29	A>G		No	ClinGen Ensembl
CA388872960 rs1268483121	30	N>I		No	ClinGen gnomAD
CA388872963 rs1448676222	30	N>Y		No	ClinGen gnomAD
rs201996123 COSM1368971 CA7090420	31	V>I	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	33	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA257572685 rs1002792311	36	V>A		No	ClinGen Ensembl
CA388872925 rs1228388314	36	V>I		No	ClinGen gnomAD
CA388872908 rs1267907992	39	G>S		No	ClinGen gnomAD
CA388872901 rs1429151466	40	V>L		No	ClinGen gnomAD
CA388872892 rs1368016564	41	D>G		No	ClinGen gnomAD
CA388872880 rs1408212063	43	E>K		No	ClinGen TOPMed
CA388872790 rs1437320146	54	T>S		No	ClinGen TOPMed
rs1413068820 CA388872782	55	W>S		No	ClinGen gnomAD
rs751843434 CA7090392	57	F>C		No	ClinGen ExAC gnomAD
rs1361421511 CA388872732	62	T>I		No	ClinGen TOPMed
CA388872720 rs1452777108	64	T>N		No	ClinGen gnomAD
CA7090390 rs762651134	65	I>V		No	ClinGen ExAC TOPMed gnomAD
rs1566391791 CA388872710	66	M>V		No	ClinGen Ensembl
rs1052417413 CA257571773	69	C>Y		No	ClinGen TOPMed
CA7090387 rs761769909	74	I>T		No	ClinGen ExAC TOPMed gnomAD
rs141099957 CA7090388	74	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA257571745 rs1033244422	75	F>S		No	ClinGen Ensembl
TCGA novel	76	M>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA257571743 rs866020920	78	S>R		No	ClinGen Ensembl
CA388872591 rs1209319438	82	V>L		No	ClinGen TOPMed
CA388872525 rs1332902149	91	T>A		No	ClinGen TOPMed gnomAD
CA257571714 rs1043811060	91	T>S		No	ClinGen TOPMed
TCGA novel	92	K>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1183178234 CA388872503	94	N>S		No	ClinGen TOPMed
TCGA novel	95	E>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1594307532 CA388872455	101	P>S		No	ClinGen Ensembl
rs374390465 CA7090384	102	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA7090383 rs775004031	102	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA7090381 rs749596910	107	I>V		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	108	R>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA388872416 rs1459266554	108	R>Q		No	ClinGen TOPMed
rs774344417 CA388871847	111	N>S		No	ClinGen ExAC TOPMed gnomAD
rs774344417 CA7090354	111	N>T		No	ClinGen ExAC TOPMed gnomAD
rs186052263 CA7090352	113	S>C		No	ClinGen 1000Genomes ExAC gnomAD
rs780214689 CA7090351	113	S>N		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	117	S>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1388855903 CA388871778	120	K>R		No	ClinGen gnomAD
rs746117621 CA7090349	121	M>I		No	ClinGen ExAC gnomAD
rs1450658265 CA388871770	121	M>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs533962767 CA257570401	121	M>V		No	ClinGen gnomAD
CA7090347 rs757044451	124	A>V		No	ClinGen ExAC TOPMed gnomAD
CA388871736 rs1268381692	126	K>R		No	ClinGen gnomAD
rs1195296128 CA388871719	128	S>N		No	ClinGen gnomAD
CA257570382 rs904516441	129	K>N		No	ClinGen TOPMed gnomAD
CA257570374 rs868462703	132	K>E		No	ClinGen Ensembl
rs1276879508 CA388871684	133	K>R		No	ClinGen gnomAD
CA257570330 rs1044454188	138	S>G		No	ClinGen gnomAD
COSM4136241 CA388871651 rs1044454188	138	S>R	pancreas [Cosmic]	No	ClinGen cosmic curated gnomAD
CA257570321 rs1012987475	139	K>R		No	ClinGen Ensembl
CA7090344 rs756121962	142	F>Y		No	ClinGen ExAC TOPMed gnomAD
rs1305937666 CA388871568	149	S>C		No	ClinGen gnomAD
CA388871570 rs1305937666	149	S>R		No	ClinGen gnomAD
rs1235671196 CA388871563	149	S>R		No	ClinGen TOPMed
TCGA novel	150	W>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1057228105 CA257570292	153	C>Y		No	ClinGen TOPMed
CA388871528 rs1407442585	154	L>F		No	ClinGen TOPMed gnomAD
rs1407442585 CA388871529	154	L>V		No	ClinGen TOPMed gnomAD
CA257570287 rs940159670	155	N>D		No	ClinGen Ensembl
CA7090343 rs377180638	156	K>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA388871441 rs1239138721	164	I>T		No	ClinGen gnomAD
TCGA novel	165	S>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs762735296 CA7090321	167	V>A		No	ClinGen ExAC gnomAD
rs766106280 CA7090322	167	V>I		No	ClinGen ExAC TOPMed gnomAD
rs766106280 CA388871424	167	V>L		No	ClinGen ExAC TOPMed gnomAD
rs1235655027 CA388871397	171	T>I		No	ClinGen gnomAD
CA388871387 rs764567155	173	A>S		No	ClinGen ExAC TOPMed gnomAD
rs764567155 CA7090319	173	A>T		No	ClinGen ExAC TOPMed gnomAD
CA7090318 rs761022577	176	E>D		No	ClinGen ExAC gnomAD
rs201067558 CA257569750	177	D>G		No	ClinGen 1000Genomes
TCGA novel	178	G>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA7090316 rs376183523	180	L>F		No	ClinGen ESP ExAC TOPMed gnomAD
CA7090315 rs376183523	180	L>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA257569710 rs866587435	181	N>S		No	ClinGen TOPMed gnomAD
rs866587435 CA388871333	181	N>T		No	ClinGen TOPMed gnomAD
rs771105762 CA7090312	183	M>T		No	ClinGen ExAC gnomAD
CA7090313 rs373052146	183	M>V		No	ClinGen ESP ExAC gnomAD
rs749530193 CA7090311	186	A>G		No	ClinGen ExAC
CA257569686 rs992076600	188	S>N		No	ClinGen TOPMed gnomAD
rs777482561 CA7090310	190	T>A		No	ClinGen ExAC gnomAD
TCGA novel	193	V>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs781173989 CA7090307	195	N>K		No	ClinGen ExAC gnomAD
CA388871082 rs1263208665	202	V>L		No	ClinGen TOPMed
rs1486628749 CA388871074	203	M>V		No	ClinGen TOPMed
CA7090303 rs758066968	208	A>T		No	ClinGen ExAC gnomAD
CA388870988 rs1473057609	208	A>V		No	ClinGen gnomAD
TCGA novel	209	D>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	210	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1201352548 CA388870430	211	K>E		No	ClinGen gnomAD
CA388870415 rs1477550186	213	R>Q		No	ClinGen TOPMed
CA388870401 rs1449585974	215	S>N		No	ClinGen gnomAD
rs745430204 CA388870396	216	K>E		No	ClinGen ExAC gnomAD
CA7090283 rs745430204	216	K>Q		No	ClinGen ExAC gnomAD
CA388870394 rs1189214449	216	K>T		No	ClinGen TOPMed
rs1344978423 CA388870333	225	I>T		No	ClinGen gnomAD
rs148675721 CA7090282	225	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs1219064278 CA388870322	227	E>K		No	ClinGen gnomAD
CA7090281 rs756902968	228	K>N		No	ClinGen ExAC gnomAD
rs1276900909 CA388870246	238	T>A		No	ClinGen gnomAD
rs1265664724 CA388870182	247	I>V		No	ClinGen gnomAD
CA388870165 rs1369953425	249	S>N		No	ClinGen gnomAD
CA388870141 rs1306290670	252	N>K		No	ClinGen gnomAD
rs753068656 CA7090280	253	Y>C		No	ClinGen ExAC gnomAD
rs767798718 CA7090279	254	N>S		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	256	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1228377964 CA388870116	256	K>R		No	ClinGen gnomAD
CA7090278 rs755415943	259	V>M		No	ClinGen ExAC gnomAD
CA388870045 rs1482579002	264	N>S		No	ClinGen gnomAD
CA388870038 rs1181332226	265	H>R		No	ClinGen TOPMed
CA388870039 rs1483888873	265	H>Y		No	ClinGen TOPMed
rs201324303 CA257568191	266	M>I		No	ClinGen TOPMed
CA388870032 rs4402461 CA257568203	266	M>L		No	ClinGen Ensembl
rs749985907 CA257568199	266	M>T		No	ClinGen gnomAD
CA388870021 rs1441776635	267	H>Q		No	ClinGen TOPMed
rs1179506704 CA388870002	270	A>G		No	ClinGen TOPMed
rs201776136 CA257568159	270	A>T		No	ClinGen 1000Genomes
CA388870000 rs934106728	271	I>L		No	ClinGen TOPMed gnomAD
CA257568151 rs934106728	271	I>V		No	ClinGen TOPMed gnomAD
TCGA novel	273	C>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA7090259 rs780519589	277	I>V		No	ClinGen ExAC gnomAD
RCV001291800 rs1470319697	278	R>C		No	ClinVar dbSNP
CA388869948 rs1328707311	278	R>H		No	ClinGen gnomAD
CA388869953 rs1470319697	278	R>S		No	ClinGen gnomAD
rs758945136 CA7090258	284	S>A		No	ClinGen ExAC gnomAD
CA388869906 rs1417102510	284	S>C		No	ClinGen TOPMed
CA257568119 rs978695498	288	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs1381280819 CA388869865	291	M>V		No	ClinGen TOPMed gnomAD
TCGA novel	296	Q>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	299	Q>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1385996390 CA388869787	301	N>K		No	ClinGen gnomAD
CA7090255 rs762027957	301	N>S		No	ClinGen ExAC gnomAD
rs1034583243 CA257568091	302	Y>D		No	ClinGen TOPMed
TCGA novel	303	N>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
COSM1514907 CA7090254 rs754001146	303	N>T	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs1457457175 CA388869772	304	F>I		No	ClinGen gnomAD
CA388869719 rs1162114539	311	E>*		No	ClinGen gnomAD
CA388869716 rs1422556670	311	E>V		No	ClinGen gnomAD
rs200742721 CA257568072	313	L>P		No	ClinGen 1000Genomes
rs1276482358 CA388869124	322	I>M		No	ClinGen TOPMed gnomAD
rs1025018963 CA257567044	323	C>R		No	ClinGen gnomAD
rs1388164662 CA388869090	325	V>G		No	ClinGen gnomAD
CA7090222 rs201123027	325	V>L		No	ClinGen ExAC TOPMed gnomAD
rs201123027 CA7090223	325	V>M		No	ClinGen ExAC TOPMed gnomAD
rs769398370 CA7090221	326	Y>F		No	ClinGen ExAC TOPMed gnomAD
rs1329124047 CA388869076	327	N>D		No	ClinGen TOPMed
rs780339751 CA388869061	328	A>S		No	ClinGen ExAC gnomAD
rs780339751 CA7090219	328	A>T		No	ClinGen ExAC gnomAD
rs772318526 CA7090218	329	V>I		No	ClinGen ExAC gnomAD
CA388869035 CA7090217 rs746301647	330	M>I		No	ClinGen ExAC gnomAD
rs1217972261 CA388869042	330	M>L		No	ClinGen gnomAD
rs1377274032 CA388869027	331	D>G		No	ClinGen gnomAD
CA388869031 rs1462877487	331	D>N		No	ClinGen gnomAD
rs200651162 CA257567001	332	V>M		No	ClinGen TOPMed gnomAD
rs773336274 CA257566992	333	V>I		No	ClinGen Ensembl
rs201435159 CA257566986	334	K>R		No	ClinGen 1000Genomes
CA7090215 rs757820802	335	K>Q		No	ClinGen ExAC gnomAD
rs1181610185 CA388868966	336	Q>H		No	ClinGen gnomAD
CA257566976 rs199598876	337	K>R		No	ClinGen 1000Genomes
rs778018603 CA7090213	338	P>L		No	ClinGen ExAC gnomAD
CA388868949 rs1265148576	338	P>T		No	ClinGen TOPMed
rs149497176 CA7090211	346	K>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA388868295 rs1218797405	352	M>V		No	ClinGen TOPMed
CA388868268 rs1330537200	354	I>V		No	ClinGen gnomAD
rs1269610740 CA388868185	360	S>T		No	ClinGen TOPMed
CA7090200 rs575783306	362	V>L		No	ClinGen 1000Genomes ExAC gnomAD
rs139418140 CA7090198	363	I>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA257565927 rs888333552	364	N>S		No	ClinGen TOPMed gnomAD
CA388868077 rs1320057477	367	N>S		No	ClinGen TOPMed gnomAD
CA388868079 rs1320057477	367	N>T		No	ClinGen TOPMed gnomAD
TCGA novel	368	Q>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA388868034 rs1407091454	370	K>E		No	ClinGen gnomAD
rs749733101 CA7090178	375	M>T		No	ClinGen ExAC gnomAD
rs773845920 CA7090177	379	I>V		No	ClinGen ExAC gnomAD
rs373401934 CA7090175	380	N>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs373401934 CA7090176	380	N>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs1197532273 CA388867825	381	L>V		No	ClinGen gnomAD
TCGA novel	383	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs781366991 CA7090174	385	D>E		No	ClinGen ExAC gnomAD
rs1472797773 CA388867724	388	N>I		No	ClinGen TOPMed
rs1555309667 CA388867714	389	K>*		No	ClinGen Ensembl
TCGA novel rs1555309667 CA388867717	389	K>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA Ensembl
rs747270908 CA7090169	391	G>R		No	ClinGen ExAC gnomAD
rs779648070 CA7090168	392	K>E	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA388867659 rs1375960239	392	K>N		No	ClinGen Ensembl
CA388867644 rs1271051222	393	K>N		No	ClinGen gnomAD
rs1329349317 CA388867600	396	E>D		No	ClinGen TOPMed gnomAD
CA388867606 rs1436047803	396	E>G		No	ClinGen TOPMed gnomAD
rs1386782784 CA388867598	397	K>Q		No	ClinGen TOPMed
rs750267986 CA7090166	402	F>L		No	ClinGen ExAC TOPMed gnomAD
rs1358436626 CA388867492	404	G>V		No	ClinGen TOPMed
rs369263621 CA257565642	407	V>M		No	ClinGen ESP TOPMed
rs948357750 CA257565616	409	V>L		No	ClinGen Ensembl
CA388867412 rs1419974764	410	D>G		No	ClinGen gnomAD
CA388867260 rs1209919756	412	D>G		No	ClinGen gnomAD
CA257564628 rs947399622	414	P>L		No	ClinGen gnomAD
rs61739513 CA7090139	415	A>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1224364897 CA388867229	415	A>P		No	ClinGen gnomAD
rs765711186 CA7090138	418	L>V		No	ClinGen ExAC
CA388867172 rs1374030903	420	S>P		No	ClinGen gnomAD
rs374015871 CA7090136	423	K>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs769101274 CA7090135	424	K>Q		No	ClinGen ExAC gnomAD
rs1407827671 CA388867104	425	V>L		No	ClinGen gnomAD
rs775462571 CA7090133	428	V>M		No	ClinGen ExAC TOPMed gnomAD
CA388866782 rs1482315974	434	N>S		No	ClinGen gnomAD
CA7090108 rs749082552	438	E>D		No	ClinGen ExAC gnomAD
rs373644416 CA7090107	440	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA7090106 rs373644416	440	E>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs899497065 CA257564474	442	E>G		No	ClinGen gnomAD
rs1348506398 CA388866712	443	E>V		No	ClinGen TOPMed
rs780784005 CA7090103	444	K>R		No	ClinGen ExAC gnomAD
CA7090102 rs754533043	448	E>D		No	ClinGen ExAC TOPMed gnomAD
CA388866654 rs1566385993	451	L>F		No	ClinGen Ensembl
CA388866645 rs1249411947	453	R>G		No	ClinGen TOPMed
TCGA novel	453	R>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA388866639 rs1361895907	454	G>S		No	ClinGen gnomAD
CA7090100 rs779831190	456	R>Q		No	ClinGen ExAC gnomAD
rs1368047680 CA388866626	456	R>W		No	ClinGen gnomAD
CA388866616 rs1371715129	458	A>T		No	ClinGen gnomAD
rs199842481 CA257564463	462	E>G		No	ClinGen 1000Genomes
COSM1300482 CA7090075 rs756418970	474	R>Q	Variant assessed as Somatic; 0.0 impact. urinary_tract [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
TCGA novel	475	R>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA7090074 rs753105637	476	A>V		No	ClinGen ExAC gnomAD
CA388866456 rs1309567695	479	K>R		No	ClinGen gnomAD
CA257564288 rs868595377	482	A>G		No	ClinGen gnomAD
COSM1228016 rs868595377 CA388866435	482	A>V	large_intestine [Cosmic]	No	ClinGen cosmic curated gnomAD
CA388866434 rs1334902610	483	A>T		No	ClinGen gnomAD
rs1307205423 CA388866410	486	N>S		No	ClinGen TOPMed gnomAD
TCGA novel	487	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	487	E>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs766384670 CA7090070	488	E>D		No	ClinGen ExAC gnomAD
CA388866354 rs1158581147	494	T>S		No	ClinGen gnomAD
rs201675046 CA7090068	496	Q>P		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA7090067 rs201675046	496	Q>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA388866315 rs1365529627	500	Q>E		No	ClinGen gnomAD
rs1383099672 CA388866257	506	R>C		No	ClinGen gnomAD
CA388866255 COSM3690012 rs1185247895	506	R>H	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
rs939891893 CA257564198	510	V>M		No	ClinGen TOPMed
rs1190384424 CA388866143	522	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1213472003 CA388866140	523	H>Y		No	ClinGen TOPMed
CA7090045 rs753627159	525	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA7090046 rs776919364	525	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs763986189 CA7090044	527	M>I		No	ClinGen ExAC gnomAD
CA257564116 rs974334937	532	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
rs1490923939 CA388865831	540	M>I		No	ClinGen gnomAD
CA7090039 rs773940603 COSM1368968	542	V>M	large_intestine Variant assessed as Somatic; 4.682e-05 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs748955388 CA7090038	545	I>S		No	ClinGen ExAC gnomAD
CA7090037 rs748955388	545	I>T		No	ClinGen ExAC gnomAD
rs964676596 CA257564075	547	T>A		No	ClinGen TOPMed
rs769008038 CA7090035	547	T>I		No	ClinGen ExAC gnomAD
TCGA novel	548	P>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	549	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs758986272 CA7090032	554	I>V		No	ClinGen ExAC gnomAD
rs1011043946 CA257563481	557	I>V		No	ClinGen TOPMed
CA7090008 rs756434202	558	S>C		No	ClinGen ExAC gnomAD
TCGA novel	558	S>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	561	V>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	562	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	569	R>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA7090001 rs749975441	579	L>V		No	ClinGen ExAC gnomAD
CA257563432 rs538206878	584	G>S		No	ClinGen Ensembl
rs764831935 CA7090000	586	I>V		No	ClinGen ExAC gnomAD
rs761551385 CA7089999	588	P>S		No	ClinGen ExAC gnomAD
rs147751566 CA7089998	590	P>S		No	ClinGen ESP ExAC gnomAD
rs1239184644 COSM954405 CA388864983	592	A>V	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
CA388864273 rs1172616437	607	A>P		No	ClinGen gnomAD
rs1478150435 CA388864255	608	P>S		No	ClinGen gnomAD
CA7089956 rs745799925	609	G>R		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	612	T>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA257562354 rs866400832	615	A>S		No	ClinGen Ensembl
rs753327668 CA7089953	615	A>V		No	ClinGen ExAC gnomAD
TCGA novel	619	Q>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA388864019 rs1252636532	621	A>V		No	ClinGen gnomAD
CA7089951 rs755741220	624	I>V		No	ClinGen ExAC
TCGA novel	626	K>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1566384325	627	E>Y	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs1232266295 CA388863850	631	R>H		No	ClinGen TOPMed gnomAD
TCGA novel	632	Y>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1240960339 CA388863527	646	V>I		No	ClinGen gnomAD
rs762249289 CA7089926	654	N>S		No	ClinGen ExAC TOPMed gnomAD
CA388863436 rs1331871974	659	N>S		No	ClinGen TOPMed
rs928978769 CA388863400	664	D>E		No	ClinGen TOPMed gnomAD
CA388863393 rs1302830215	666	Y>H		No	ClinGen TOPMed
CA257562122 rs1037870133	673	Q>K		No	ClinGen Ensembl
rs1241398603 CA388863316	676	M>I		No	ClinGen gnomAD
CA257562121 rs941860562	676	M>L		No	ClinGen Ensembl
CA388863223 rs1478476745	688	R>H		No	ClinGen gnomAD
CA388863208 rs1194985643	690	T>I		No	ClinGen gnomAD
TCGA novel	696	K>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA257561700 rs77133783	700	L>F		No	ClinGen Ensembl
TCGA novel	702	N>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA7089899 rs147874876	708	L>F		No	ClinGen ESP ExAC TOPMed gnomAD
CA257561672 rs941813882	716	M>I		No	ClinGen Ensembl
TCGA novel	718	I>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA388863006 rs1202651310	719	V>F		No	ClinGen gnomAD
rs1219751593 CA388862775	732	K>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs776215631 CA7089875	744	V>A		No	ClinGen ExAC gnomAD
rs1449749820 CA388862626	745	G>R		No	ClinGen gnomAD
TCGA novel	746	E>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA388862607 rs1353930026	747	I>R		No	ClinGen TOPMed
CA7089873 rs555039355	749	T>M		No	ClinGen 1000Genomes ExAC gnomAD
rs935976589 CA257560898	758	H>R		No	ClinGen TOPMed
TCGA novel	759	D>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA257560891 rs926070813	760	R>*		No	ClinGen TOPMed
TCGA novel	762	D>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	765	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA7089856 rs760062405	770	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA257560202 rs79499533	774	H>Q		No	ClinGen Ensembl
CA388861941 rs1416028307	782	N>S		No	ClinGen gnomAD
rs775087323 CA7089855	784	I>L		No	ClinGen ExAC gnomAD
CA388861905 rs1260859611	787	V>A		No	ClinGen gnomAD
rs771566204 CA7089854	787	V>I		No	ClinGen ExAC gnomAD
rs1289950095 CA388861892	789	A>S		No	ClinGen TOPMed
rs774055437 CA7089852	790	L>V		No	ClinGen ExAC gnomAD
TCGA novel	791	T>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1361932846 CA388861853	795	L>V		No	ClinGen TOPMed
rs1242121033 CA388861819	800	P>T		No	ClinGen gnomAD
rs1432956262 CA388861803	802	R>K		No	ClinGen TOPMed
CA257560074 rs867431583	808	G>R		No	ClinGen Ensembl
CA388861619 rs1385390051	811	Y>C		No	ClinGen gnomAD
TCGA novel	813	S>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	817	L>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA7089831 rs770612956	820	T>S		No	ClinGen ExAC gnomAD
rs1331884064 CA388861472	822	S>G		No	ClinGen gnomAD
rs762127740 CA7089830	823	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA257560044 rs974718874	830	W>*		No	ClinGen Ensembl
TCGA novel	832	P>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA7089797 rs777914683	838	D>G		No	ClinGen ExAC gnomAD
rs764942806 CA257559712	843	I>V		No	ClinGen Ensembl
CA7089791 rs369898452	860	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA257559675 rs967954743	866	K>R		No	ClinGen TOPMed gnomAD
TCGA novel	869	T>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA257559670 rs77117349	870	M>I		No	ClinGen Ensembl
rs1594298006 CA388861068	870	M>V		No	ClinGen Ensembl
CA257559666 rs534521870	872	N>S		No	ClinGen 1000Genomes
CA388861046 rs764849621	873	A>S		No	ClinGen ExAC TOPMed gnomAD
rs764849621 CA7089787	873	A>T		No	ClinGen ExAC TOPMed gnomAD
rs1424730344 CA388861041	874	I>V		No	ClinGen TOPMed
CA388861027 rs1594297982	876	V>L		No	ClinGen Ensembl
rs1257394167 CA388860991	882	I>V		No	ClinGen gnomAD
rs1300504299 CA388860419	890	D>N		No	ClinGen TOPMed
rs200551095 CA257555778	901	N>S		No	ClinGen 1000Genomes
rs370518325 CA257555768	903	T>A		No	ClinGen ESP TOPMed
CA388860200 rs1305896840	909	I>V		No	ClinGen TOPMed
rs201031732 CA257555763	911	D>G		No	ClinGen 1000Genomes
rs945446737 CA257555760	915	G>A		No	ClinGen Ensembl
TCGA novel	915	G>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs767031188 CA7089762	918	E>K		No	ClinGen ExAC gnomAD
rs1435405382 CA388860092	918	E>V		No	ClinGen gnomAD
CA257555692 rs199875206	926	E>G		No	ClinGen 1000Genomes
CA7089760 rs773189447 COSM3793562	928	E>K	urinary_tract Variant assessed as Somatic; 4.621e-05 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs569192537 CA7089737	937	G>R		No	ClinGen 1000Genomes ExAC gnomAD
CA388859837 rs1379848579	939	S>L		No	ClinGen gnomAD
CA388859826 rs1459105444	941	S>A		No	ClinGen gnomAD
rs1233550969 CA388859810	943	I>T		No	ClinGen gnomAD
CA7089735 rs750452954	946	E>K		No	ClinGen ExAC gnomAD
rs765228041 CA7089734	953	D>E		No	ClinGen ExAC gnomAD
rs762011472 CA7089733	955	Y>C		No	ClinGen ExAC gnomAD
CA388859711 rs1376732204	957	E>Q		No	ClinGen gnomAD
CA7089730 rs760424796	960	E>K		No	ClinGen ExAC gnomAD
rs773988222	960	E>missing	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
CA7089725 rs143874908	970	A>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA7089724 rs143874908	970	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA257555274 rs937342683	972	E>G		No	ClinGen TOPMed
CA388859601 rs1435667815	972	E>Q		No	ClinGen gnomAD
CA7089699 rs758668522	975	Y>C		No	ClinGen ExAC
CA257555150 rs149446959	977	K>N		No	ClinGen ESP
CA7089698 rs560749506	979	S>L		No	ClinGen 1000Genomes ExAC gnomAD
rs757786394 CA7089696	980	L>F		No	ClinGen ExAC gnomAD
rs753859968 CA7089695	982	S>N		No	ClinGen ExAC gnomAD
TCGA novel	986	S>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs759202482 CA257555113	987	G>R		No	ClinGen Ensembl
TCGA novel	994	E>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs752836768 CA7089692	998	R>Q		No	ClinGen ExAC gnomAD
CA388859191 rs1373550950	1000	A>G		No	ClinGen gnomAD
rs756151775 CA7089671	1002	R>*		No	ClinGen ExAC TOPMed gnomAD
rs1398232340 CA388859171	1002	R>Q		No	ClinGen gnomAD
CA7089669 rs767585887	1004	S>C		No	ClinGen ExAC gnomAD
rs755239634 CA7089668	1005	R>H		No	ClinGen ExAC gnomAD
rs1189468427 CA388859116 COSM954399	1007	E>K	large_intestine Variant assessed as Somatic; impact. endometrium [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA TOPMed
rs766274563 CA7089666	1011	E>Q		No	ClinGen ExAC TOPMed gnomAD
rs762901559 CA7089664	1014	R>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA388859018 rs1239510187	1014	R>Q		No	ClinGen gnomAD
rs773261513 CA7089663	1015	S>G		No	ClinGen ExAC TOPMed gnomAD
rs773261513 CA388859016	1015	S>R		No	ClinGen ExAC TOPMed gnomAD
rs1481279879 CA388859007	1015	S>R		No	ClinGen TOPMed gnomAD
CA7089661 rs761192331	1018	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA7089662 rs562835058	1018	R>W		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1304382530 CA388858940	1021	K>E		No	ClinGen gnomAD
rs775059544 CA7089657	1023	S>F		No	ClinGen ExAC gnomAD
rs1401488251 CA388858892	1025	H>Q		No	ClinGen gnomAD
CA7089656 rs373781982	1026	S>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs749689647 CA7089655	1027	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs756636080 COSM1368962 CA7089653	1029	R>C	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA7089652 rs748118048	1029	R>H		No	ClinGen ExAC TOPMed gnomAD
CA388858831 rs1381614412	1031	S>F		No	ClinGen gnomAD
CA7089651 rs781334536	1033	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA7089650 rs150316403	1033	R>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA7089649 rs751795382	1034	G>S		No	ClinGen ExAC TOPMed gnomAD
rs1256005421 CA388858792	1035	S>C		No	ClinGen gnomAD
rs780473200 CA388858785	1036	R>K		No	ClinGen ExAC gnomAD
rs780473200 CA7089648	1036	R>T		No	ClinGen ExAC gnomAD
CA7089646 rs750278650	1037	H>Q		No	ClinGen ExAC gnomAD
CA7089644 rs200675076	1042	P>A		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA388858712 rs1239770576	1042	P>L		No	ClinGen gnomAD
CA388858713 rs1239770576	1042	P>R		No	ClinGen gnomAD
CA388858717 rs200675076	1042	P>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA7089643 rs200675076	1042	P>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	1043	K>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	1043	K>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA257554511 rs200233088	1045	K>R		No	ClinGen TOPMed gnomAD

1 associated diseases with Q9Y5B9

[MIM: 619480]: Neurodevelopmental disorder with dysmorphic facies and thin corpus callosum (NEDDFAC)

An autosomal dominant disorder characterized by global developmental delay, impaired intellectual development with poor or absent speech and language, and autistic-like behaviors. Corpus callosum anomalies are visible on brain imaging. Most patients have dysmorphic features including tall forehead, down-slanting palpebral fissures, ear anomalies and broad nasal bridge. Other variably present clinical features include seizures, sleeping difficulties and precocious puberty. {ECO:0000269|PubMed:31924697}. Note=The disease may be caused by variants affecting the gene represented in this entry.

Without disease ID

An autosomal dominant disorder characterized by global developmental delay, impaired intellectual development with poor or absent speech and language, and autistic-like behaviors. Corpus callosum anomalies are visible on brain imaging. Most patients have dysmorphic features including tall forehead, down-slanting palpebral fissures, ear anomalies and broad nasal bridge. Other variably present clinical features include seizures, sleeping difficulties and precocious puberty. {ECO:0000269|PubMed:31924697}. Note=The disease may be caused by variants affecting the gene represented in this entry.

5 regional properties for Q9Y5B9

Type	Name	Position	InterPro Accession
domain	Peptidase M24	182 - 411	IPR000994
domain	Histone chaperone RTT106/FACT complex subunit SPT16-like, middle domain	806 - 896	IPR013719
domain	FACT complex subunit Spt16 domain	529 - 689	IPR013953
domain	FACT complex subunit Spt16, N-terminal lobe domain	5 - 168	IPR029148
domain	FACT complex subunit Spt16, peptidase M24-like domain	180 - 420	IPR033825

Functions

		Description
EC Number
Subcellular Localization	Nucleus Chromosome	Colocalizes with RNA polymerase II on chromatin Recruited to actively transcribed loci
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

3 GO annotations of cellular component

Name	Definition
FACT complex	A histone chaperone complex that facilitates nucleosome disassembly and reassembly upon DNA or RNA polymerase passage.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

2 GO annotations of molecular function

Name	Definition
nucleosome binding	Binding to a nucleosome, a complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures.
RNA binding	Binding to an RNA molecule or a portion thereof.

8 GO annotations of biological process

Name	Definition
DNA repair	The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.
DNA replication	The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.
nucleosome assembly	The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA.
nucleosome disassembly	The controlled breakdown of nucleosomes, the beadlike structural units of eukaryotic chromatin composed of histones and DNA.
positive regulation of DNA-templated transcription, elongation	Any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase.
positive regulation of transcription elongation by RNA polymerase II	Any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II.
transcription by RNA polymerase II	The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).
transcription elongation by RNA polymerase II promoter	The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase II promoter by the addition of ribonucleotides catalyzed by RNA polymerase II.

4 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P32558	SPT16	FACT complex subunit SPT16	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
Q8H6B1	SPT16	FACT complex subunit SPT16	Zea mays (Maize)	PR
Q7X923	SPT16	FACT complex subunit SPT16	Oryza sativa subsp japonica (Rice)	PR
O82491	SPT16	FACT complex subunit SPT16	Arabidopsis thaliana (Mouse-ear cress)	PR

10	20	30	40	50	60
MAVTLDKDAY	YRRVKRLYSN	WRKGEDEYAN	VDAIVVSVGV	DEEIVYAKST	ALQTWLFGYE
70	80	90	100	110	120
LTDTIMVFCD	DKIIFMASKK	KVEFLKQIAN	TKGNENANGA	PAITLLIREK	NESNKSSFDK
130	140	150	160	170	180
MIEAIKESKN	GKKIGVFSKD	KFPGEFMKSW	NDCLNKEGFD	KIDISAVVAY	TIAVKEDGEL
190	200	210	220	230	240
NLMKKAASIT	SEVFNKFFKE	RVMEIVDADE	KVRHSKLAES	VEKAIEEKKY	LAGADPSTVE
250	260	270	280	290	300
MCYPPIIQSG	GNYNLKFSVV	SDKNHMHFGA	ITCAMGIRFK	SYCSNLVRTL	MVDPSQEVQE
310	320	330	340	350	360
NYNFLLQLQE	ELLKELRHGV	KICDVYNAVM	DVVKKQKPEL	LNKITKNLGF	GMGIEFREGS
370	380	390	400	410	420
LVINSKNQYK	LKKGMVFSIN	LGFSDLTNKE	GKKPEEKTYA	LFIGDTVLVD	EDGPATVLTS
430	440	450	460	470	480
VKKKVKNVGI	FLKNEDEEEE	EEEKDEAEDL	LGRGSRAALL	TERTRNEMTA	EEKRRAHQKE
490	500	510	520	530	540
LAAQLNEEAK	RRLTEQKGEQ	QIQKARKSNV	SYKNPSLMPK	EPHIREMKIY	IDKKYETVIM
550	560	570	580	590	600
PVFGIATPFH	IATIKNISMS	VEGDYTYLRI	NFYCPGSALG	RNEGNIFPNP	EATFVKEITY
610	620	630	640	650	660
RASNIKAPGE	QTVPALNLQN	AFRIIKEVQK	RYKTREAEEK	EKEGIVKQDS	LVINLNRSNP
670	680	690	700	710	720
KLKDLYIRPN	IAQKRMQGSL	EAHVNGFRFT	SVRGDKVDIL	YNNIKHALFQ	PCDGEMIIVL
730	740	750	760	770	780
HFHLKNAIMF	GKKRHTDVQF	YTEVGEITTD	LGKHQHMHDR	DDLYAEQMER	EMRHKLKTAF
790	800	810	820	830	840
KNFIEKVEAL	TKEELEFEVP	FRDLGFNGAP	YRSTCLLQPT	SSALVNATEW	PPFVVTLDEV
850	860	870	880	890	900
ELIHFERVQF	HLKNFDMVIV	YKDYSKKVTM	INAIPVASLD	PIKEWLNSCD	LKYTEGVQSL
910	920	930	940	950	960
NWTKIMKTIV	DDPEGFFEQG	GWSFLEPEGE	GSDAEEGDSE	SEIEDETFNP	SEDDYEEEEE
970	980	990	1000	1010	1020
DSDEDYSSEA	EESDYSKESL	GSEEESGKDW	DELEEEARKA	DRESRYEEEE	EQSRSMSRKR
1030	1040
KASVHSSGRG	SNRGSRHSSA	PPKKKRK