O82491
PR
Gene name |
SPT16 (At4g10710, T12H20.3) |
Protein name |
FACT complex subunit SPT16 |
Names |
Facilitates chromatin transcription complex subunit SPT16 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT4G10710 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O82491
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O82491-F1 | Predicted | AlphaFoldDB |
31 variants for O82491
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH02779520 | 35 | A>T | No | 1000Genomes | |
| tmp_4_6605315_T_A | 46 | S>C | No | 1000Genomes | |
| tmp_4_6605309_C_T | 48 | D>N | No | 1000Genomes | |
| ENSVATH14126769 | 94 | K>M | No | 1000Genomes | |
| ENSVATH11465224 | 97 | H>Q | No | 1000Genomes | |
| tmp_4_6605044_C_T | 136 | G>E | No | 1000Genomes | |
| ENSVATH06607846 | 140 | A>T | No | 1000Genomes | |
| ENSVATH11465223 | 142 | F>L | No | 1000Genomes | |
| ENSVATH06607845 | 143 | R>C | No | 1000Genomes | |
| ENSVATH06607844 | 146 | R>C | No | 1000Genomes | |
| tmp_4_6605005_G_T | 149 | S>Y | No | 1000Genomes | |
| tmp_4_6604478_A_G | 325 | S>P | No | 1000Genomes | |
| ENSVATH11465220 | 345 | L>F | No | 1000Genomes | |
| ENSVATH14126768 | 365 | N>S | No | 1000Genomes | |
| ENSVATH06607837 | 402 | P>S | No | 1000Genomes | |
| tmp_4_6604199_C_G | 418 | E>Q | No | 1000Genomes | |
| ENSVATH14126766 | 450 | S>A | No | 1000Genomes | |
| tmp_4_6604046_G_A | 469 | P>S | No | 1000Genomes | |
| ENSVATH11465216 | 481 | Y>F | No | 1000Genomes | |
| ENSVATH14126765 | 512 | N>I | No | 1000Genomes | |
| tmp_4_6603874_G_A | 526 | A>V | No | 1000Genomes | |
| tmp_4_6603857_T_C | 532 | T>A | No | 1000Genomes | |
| ENSVATH14126724 | 544 | N>S | No | 1000Genomes | |
| ENSVATH06607830 | 619 | A>S | No | 1000Genomes | |
| tmp_4_6603535_G_A | 639 | T>I | No | 1000Genomes | |
| tmp_4_6603520_G_C | 644 | T>S | No | 1000Genomes | |
| ENSVATH06607828 | 699 | L>V | No | 1000Genomes | |
| ENSVATH11465152 | 792 | D>E | No | 1000Genomes | |
| ENSVATH06607819 | 962 | G>C | No | 1000Genomes | |
| tmp_4_6602356_T_C | 1032 | E>G | No | 1000Genomes | |
| tmp_4_6602249_G_C | 1068 | P>A | No | 1000Genomes |
No associated diseases with O82491
5 regional properties for O82491
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Peptidase M24 | 208 - 440 | IPR000994 |
| domain | Histone chaperone RTT106/FACT complex subunit SPT16-like, middle domain | 833 - 923 | IPR013719 |
| domain | FACT complex subunit Spt16 domain | 555 - 708 | IPR013953 |
| domain | FACT complex subunit Spt16, N-terminal lobe domain | 26 - 193 | IPR029148 |
| domain | FACT complex subunit Spt16, peptidase M24-like domain | 208 - 448 | IPR033825 |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| euchromatin | A dispersed and relatively uncompacted form of chromatin that is in a transcription-competent conformation. |
| FACT complex | A histone chaperone complex that facilitates nucleosome disassembly and reassembly upon DNA or RNA polymerase passage. |
| nucleolus | A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| nucleosome binding | Binding to a nucleosome, a complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| DNA repair | The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. |
| DNA replication | The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA. |
| positive regulation of transcription elongation by RNA polymerase II | Any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II. |
| transcription elongation by RNA polymerase II promoter | The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase II promoter by the addition of ribonucleotides catalyzed by RNA polymerase II. |
| vegetative to reproductive phase transition of meristem | The process involved in transforming a meristem that produces vegetative structures, such as leaves, into a meristem that produces reproductive structures, such as a flower or an inflorescence. |
4 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P32558 | SPT16 | FACT complex subunit SPT16 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q9Y5B9 | SUPT16H | FACT complex subunit SPT16 | Homo sapiens (Human) | PR |
| Q8H6B1 | SPT16 | FACT complex subunit SPT16 | Zea mays (Maize) | PR |
| Q7X923 | SPT16 | FACT complex subunit SPT16 | Oryza sativa subsp japonica (Rice) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MADSRNGNAR | APPSGVPPKA | GNTYSIDVKN | FISRARALYE | HWKKHSADLW | GSADALAIAT |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PPASDDLRYL | KSSALNIWLL | GYEFPDTIMV | FTKKQIHFLC | SRNKASLLEV | VKKPAHDELK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LDVIMHVKPK | GDDGTGLMDA | IFRAIRDLSR | GDGNDSQVVG | HIAREAPEGK | LLETWTERLK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| NANFQFVDIT | GGLSDLFAVK | DDTEVMSVKK | AAYLAYSVMK | NVVVPNLESA | IDEEKDVTHS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| ALMDLTEKAI | LEPTKASVKL | KPENVDICYP | PIFQSGGKFD | LKPSAASNDE | LLTYDPASII |
| 310 | 320 | 330 | 340 | 350 | 360 |
| ICAVGARYNS | YCSNVARTYL | IDATSLQSKA | YEVLLKAHEA | AIDALRSGRK | INTVYQAALS |
| 370 | 380 | 390 | 400 | 410 | 420 |
| VVEKNAPEFV | DKLTKSAGTG | IGLEFRESGL | NINAKNDKVL | RPKMAFNVSL | GFQNLECESE |
| 430 | 440 | 450 | 460 | 470 | 480 |
| SRSKNKKFSL | LLADTVLVTD | QKPELLTKCS | KSVKDVAYSF | KEDEEEEKPR | KKARTSGSEN |
| 490 | 500 | 510 | 520 | 530 | 540 |
| YITKTALRSD | DHVVSKEELR | KQHQAELARQ | KNEETARRLA | GDSSGAGDSR | STAKTSADVV |
| 550 | 560 | 570 | 580 | 590 | 600 |
| AYKNVNDMPH | KELMIQVDTR | NEAVLLPIYG | SLVPFHVATI | RTVSGNQDTN | RNCYIRIIFN |
| 610 | 620 | 630 | 640 | 650 | 660 |
| VPGTPFNPHD | SNSLKNQGAI | YLKEVSFRTK | DSRHSSEVTQ | QIKTLRRQVM | ARESERAERA |
| 670 | 680 | 690 | 700 | 710 | 720 |
| TLVTQEKLQL | AGNKFKPLRL | SELWIRPPFS | GRKKIPGTLE | AHANGFRYST | TRPDERVDVL |
| 730 | 740 | 750 | 760 | 770 | 780 |
| FANIKHAFFQ | PAEKEMITLL | HFHLHNHIMV | GTKKTKDVQF | YVEVMDVVQS | LGGGRRSAYD |
| 790 | 800 | 810 | 820 | 830 | 840 |
| PDEIDEEQRE | RDRKNKINMD | FNHFANRVND | MWQLPQFASL | DLEFDQPLRE | LGFHGVPHKT |
| 850 | 860 | 870 | 880 | 890 | 900 |
| SAFIIPTSSC | LVELIEYPFL | VVSLSEIEIV | NLERVGFGQK | NFDMAIIFKD | FKKDVLRVDS |
| 910 | 920 | 930 | 940 | 950 | 960 |
| VPTSSLEGIK | EWLDTTDIKY | YESKLNLNWR | QILKTITDDP | QSFIDDGGWE | FLNLDGSDSE |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| SGGSEESDKG | YEPSDVEVES | ESEDEASESE | SLVESDDDEE | EDSEQESEEE | KGKTWDELER |
| 1030 | 1040 | 1050 | 1060 | 1070 | |
| EATNADREHG | VESDSEEERK | RRKMKAFGKS | RPGTSGGGGS | SSMKNMPPSK | RKHR |