AiPD: Autoinhibited Protein Database

Q9Y581

Gene name	INSL6 (RIF1)
Protein name	Insulin-like peptide INSL6
Names	Insulin-like peptide 6, Relaxin/insulin-like factor 1
Species	Homo sapiens (Human)
KEGG Pathway	hsa:11172
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-188 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-188 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q9Y581

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q9Y581-F1	Predicted				AlphaFoldDB

303 variants for Q9Y581

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs144566910 CA4972719	2	P>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA4972716 rs142813719	2	P>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA372831739 rs142813719	2	P>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs142813719 CA4972717	2	P>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs144566910 CA4972718	2	P>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA4972713 rs758608116	3	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
COSM287379 CA4972714 rs373690238	3	R>W	lung Variant assessed as Somatic; 0.0 impact. large_intestine [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
rs752714146 CA188453813	4	L>H		No	ClinGen ExAC gnomAD
rs752714146 CA4972712	4	L>R		No	ClinGen ExAC gnomAD
CA372831734 rs1488209484	4	L>V		No	ClinGen TOPMed
CA4972710 rs779233270	5	L>F		No	ClinGen ExAC TOPMed gnomAD
CA372831731 rs779233270	5	L>V		No	ClinGen ExAC TOPMed gnomAD
rs755134539 CA4972709	6	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs576555591 CA4972706	8	S>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs576555591 CA372831712	8	S>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs144087410 CA4972708	8	S>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs576555591 CA4972707	8	S>Y		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA4972702 rs942662495	9	L>V		No	ClinGen TOPMed gnomAD
CA4972699 rs748921712	10	L>P		No	ClinGen ExAC TOPMed gnomAD
CA188453739 rs748921712	10	L>R		No	ClinGen ExAC TOPMed gnomAD
CA188453720 rs367825102 CA372831698	11	W>C		No	ClinGen ESP
rs779920842 CA188453721	11	W>R		No	ClinGen Ensembl
rs35211475 CA4972697	12	L>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs200449001 CA4972696	12	L>P		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs35211475 CA372831697	12	L>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA372831692 rs771364584	13	G>*		No	ClinGen ExAC gnomAD
CA4972694 rs747364118	13	G>E		No	ClinGen ExAC gnomAD
CA4972695 rs771364584	13	G>R		No	ClinGen ExAC gnomAD
CA4972692 rs200880390	14	L>F		No	ClinGen 1000Genomes ExAC gnomAD
rs200880390 CA188453690	14	L>V		No	ClinGen 1000Genomes ExAC gnomAD
rs1036028390 CA188453679	15	L>R		No	ClinGen Ensembl
CA372831685 rs778810658	15	L>V		No	ClinGen ExAC TOPMed gnomAD
CA4972688 rs137949046	16	L>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs553705920 CA4972687	17	V>A	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA gnomAD
rs553705920 CA372831674	17	V>D		No	ClinGen 1000Genomes ExAC gnomAD
rs201600640 CA4972685	18	R>P		No	ClinGen 1000Genomes ExAC gnomAD
rs757105790 CA4972686	18	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1586884373 CA372831667	19	F>V		No	ClinGen Ensembl
CA4972684 rs202140762	19	F>Y		No	ClinGen ESP ExAC TOPMed gnomAD
rs1327336666 CA372831659	20	S>F		No	ClinGen TOPMed gnomAD
CA4972683 rs150295768	21	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs1344986306 CA372831652	21	R>L		No	ClinGen TOPMed gnomAD
rs1386057916 CA372831646	22	E>D		No	ClinGen gnomAD
CA4972681 rs199592186	22	E>G		No	ClinGen ExAC TOPMed gnomAD
rs1368941917 CA372831643	23	L>V		No	ClinGen gnomAD
COSM608741 CA4972680 rs759236184	24	S>R	lung [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs969714285 CA188453623	25	D>E		No	ClinGen TOPMed
rs1457875713 CA372831628	25	D>G		No	ClinGen TOPMed
rs776204889 CA372831619	26	I>M		No	ClinGen ExAC TOPMed gnomAD
CA372831609 rs1373367064	28	S>G		No	ClinGen gnomAD
CA372831607 rs1172473325	28	S>N		No	ClinGen TOPMed gnomAD
CA4972677 rs761160232 CA372831591	30	R>S		No	ClinGen ExAC TOPMed gnomAD
CA372831595 rs1379081740	30	R>W		No	ClinGen TOPMed
CA4972676 rs148371933	31	K>E		No	ClinGen ESP ExAC TOPMed gnomAD
rs368461380 CA4972674	31	K>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA4972675 rs368461380	31	K>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA188453576 rs755672520	32	L>P		No	ClinGen Ensembl
CA4972673 rs774494634	32	L>V		No	ClinGen ExAC TOPMed gnomAD
rs749377607 CA4972671	34	G>D		No	ClinGen ExAC TOPMed gnomAD
rs749377607 CA372831568	34	G>V		No	ClinGen ExAC TOPMed gnomAD
rs374288687 CA372831562	35	R>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1366288951 CA372831566	35	R>W		No	ClinGen gnomAD
CA372831558 rs1323409412	36	Y>D		No	ClinGen gnomAD
CA188453548 rs926839323	37	L>F		No	ClinGen TOPMed
CA372831537 rs1564059792	39	K>R		No	ClinGen Ensembl
rs866666085 CA188453547	40	E>K		No	ClinGen Ensembl
CA4972669 rs756300946	41	I>V		No	ClinGen ExAC gnomAD
TCGA novel	42	E>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA188453540 rs981410441	44	L>F		No	ClinGen TOPMed gnomAD
CA372831502 rs981410441	44	L>V		No	ClinGen TOPMed gnomAD
rs62637621 CA4972668	45	C>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA4972665 rs758358190	46	G>S		No	ClinGen ExAC TOPMed gnomAD
CA4972664 rs752515931	47	H>R		No	ClinGen ExAC TOPMed gnomAD
rs62620190 CA4972663	48	A>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1427922118 CA372831479	48	A>T		No	ClinGen Ensembl
rs62620190 CA4972662	48	A>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA372831471 rs753365466	49	N>I		No	ClinGen ExAC TOPMed gnomAD
CA372831470 rs1177002915 CA372831469	49	N>K		No	ClinGen gnomAD
CA4972661 rs753365466	49	N>S		No	ClinGen ExAC TOPMed gnomAD
CA372831461 rs1424279175	50	W>*		No	ClinGen TOPMed
CA372831459 rs1481136336	50	W>*		No	ClinGen gnomAD
rs1032405198 CA188453448	51	S>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
CA372831442 rs1361521231	52	Q>E		No	ClinGen gnomAD
CA4972660 rs766180898	52	Q>P		No	ClinGen ExAC gnomAD
CA372831437 rs766180898	52	Q>R		No	ClinGen ExAC gnomAD
rs888935699 CA188453443	53	F>L		No	ClinGen TOPMed gnomAD
rs1000971406 CA188453444	53	F>L		No	ClinGen Ensembl
TCGA novel	54	R>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4972659 rs760356380	54	R>G		No	ClinGen ExAC TOPMed gnomAD
rs773745265 CA372831416	54	R>H		No	ClinGen ExAC
rs773745265 CA4972658	54	R>P		No	ClinGen ExAC
rs1253150884 CA372831401	55	F>L		No	ClinGen TOPMed gnomAD
CA188453431 rs867229131	57	E>*		No	ClinGen TOPMed gnomAD
CA372831376 rs767708471	58	E>*		No	ClinGen ExAC gnomAD
CA4972655 rs762395288	58	E>G		No	ClinGen ExAC gnomAD
CA4972656 rs767708471	58	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA4972654 rs745317622	59	T>I		No	ClinGen ExAC TOPMed gnomAD
rs769204929 CA4972653	60	P>L		No	ClinGen ExAC gnomAD
CA372831354 rs769204929	60	P>R		No	ClinGen ExAC gnomAD
CA4972652 rs749369990	61	F>C		No	ClinGen ExAC gnomAD
CA4972651 rs775528701	61	F>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA188453396 rs780760292	63	R>G		No	ClinGen ExAC TOPMed gnomAD
rs375327208 CA372831328	63	R>L		No	ClinGen ExAC gnomAD
rs375327208 CA4972649	63	R>Q		No	ClinGen ExAC gnomAD
CA4972650 rs780760292	63	R>W		No	ClinGen ExAC TOPMed gnomAD
CA372831323 rs1217263780	64	L>S		No	ClinGen TOPMed
CA372831306 rs1450203028	65	I>M		No	ClinGen TOPMed gnomAD
CA4972648 rs777554114	67	Q>R		No	ClinGen ExAC gnomAD
rs552133251 CA4972646	68	A>T		No	ClinGen 1000Genomes ExAC gnomAD
CA188453360 rs1036248385	68	A>V		No	ClinGen Ensembl
rs1157454272 CA372831271	69	S>W		No	ClinGen gnomAD
CA188453336 rs1048870190	71	K>E		No	ClinGen TOPMed
rs753418629 CA372831243 CA4972643	71	K>N		No	ClinGen ExAC TOPMed gnomAD
CA4972642 rs373895718	72	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA4972639 rs767186616	73	E>D		No	ClinGen ExAC gnomAD
rs539770695 CA4972640	73	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA188453290 rs201962912	74	A>G		No	ClinGen TOPMed gnomAD
rs762155136 CA4972638	74	A>S		No	ClinGen ExAC gnomAD
rs201962912 CA188453285	74	A>V		No	ClinGen TOPMed gnomAD
rs763403590 CA4972635	75	Y>C		No	ClinGen ExAC gnomAD
CA4972636 rs764559997	75	Y>H		No	ClinGen ExAC gnomAD
CA372831213 rs764559997	75	Y>N		No	ClinGen ExAC gnomAD
CA4972634 rs758780998	76	S>G		No	ClinGen ExAC gnomAD
rs759594828 CA4972633	76	S>I		No	ClinGen ExAC TOPMed gnomAD
rs759594828 CA372831198	76	S>N		No	ClinGen ExAC TOPMed gnomAD
rs759594828 CA4972632	76	S>T		No	ClinGen ExAC TOPMed gnomAD
CA4972631 rs201847389	77	P>A		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA188453211 rs201847389	77	P>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA4972628 rs778719232	78	Y>*		No	ClinGen ExAC gnomAD
rs1317097109 CA372831177	78	Y>C		No	ClinGen gnomAD
CA4972629 rs747940213	78	Y>N		No	ClinGen ExAC TOPMed gnomAD
rs140609583 CA4972627	79	Q>*		No	ClinGen ESP ExAC TOPMed gnomAD
CA4972626 rs140609583	79	Q>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA372831165 rs1586884112	79	Q>H		No	ClinGen Ensembl
CA4972625 rs145724246	79	Q>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA4972624 rs2149554 VAR_024329	80	F>L		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA188453146 rs971310807	81	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
CA4972621 rs756914318	82	S>R		No	ClinGen ExAC gnomAD
rs780751879 CA4972622	82	S>T		No	ClinGen ExAC gnomAD
rs764449120 CA4972619	83	P>L		No	ClinGen ExAC TOPMed gnomAD
CA4972620 rs764449120	83	P>Q		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	84	Q>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4972615 rs759652062	84	Q>H		No	ClinGen ExAC gnomAD
rs776750067 CA372831100	85	T>I		No	ClinGen ExAC TOPMed gnomAD
rs776750067 CA188453090	85	T>N		No	ClinGen ExAC TOPMed gnomAD
rs776750067 CA4972614	85	T>S		No	ClinGen ExAC TOPMed gnomAD
CA4972611 rs774022065	86	A>S		No	ClinGen ExAC gnomAD
CA372831083 rs1001340090	87	S>F		No	ClinGen TOPMed
CA188453070 rs1032372618	87	S>T		No	ClinGen Ensembl
CA188453069 rs1001340090	87	S>Y		No	ClinGen TOPMed
rs587783069 RCV000144677	88	P>missing		No	ClinVar dbSNP
CA372831077 rs754042711	88	P>L		No	ClinGen ExAC gnomAD
rs754042711 CA4972609	88	P>R		No	ClinGen ExAC gnomAD
CA372831079 rs1229810864	88	P>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs866705752 CA188453023	89	A>D		No	ClinGen Ensembl
CA372831073 rs144467909	89	A>P		No	ClinGen ESP ExAC TOPMed gnomAD
CA4972608 rs144467909	89	A>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA188453036 rs144467909	89	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA372831067 rs140515241	90	R>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs780707256 CA4972605	90	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA4972606 rs140515241	90	R>W		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA372831050 rs1404023755	92	R>K		No	ClinGen gnomAD
CA372831046 rs1365795277	92	R>S		No	ClinGen gnomAD
rs531827751 CA4972604	93	G>V		No	ClinGen 1000Genomes ExAC gnomAD
CA4972602 rs777275112	95	N>H		No	ClinGen ExAC
rs760888692 CA188452977	96	P>S		No	ClinGen TOPMed
rs201363703 CA4972601	97	V>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA372832509 rs1452228380	98	S>F		No	ClinGen gnomAD
rs1404284561 CA372832513	98	S>P		No	ClinGen gnomAD
CA4972565 rs147189972	99	T>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA372832505 rs1361017976	99	T>I		No	ClinGen gnomAD
CA4972564 rs147189972	99	T>P		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs147189972 CA372832508	99	T>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs779264313 CA4972561	101	W>*		No	ClinGen ExAC TOPMed gnomAD
rs747730569 CA4972562	101	W>L		No	ClinGen ExAC gnomAD
TCGA novel	102	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA188485988 rs997608073	102	E>K		No	ClinGen TOPMed gnomAD
CA372832491 rs997608073	102	E>Q		No	ClinGen TOPMed gnomAD
rs769124888 CA372832476	104	A>P		No	ClinGen ExAC gnomAD
rs769124888 CA4972560	104	A>T		No	ClinGen ExAC gnomAD
rs749611216 CA4972559	104	A>V		No	ClinGen ExAC gnomAD
rs754591383 CA4972557	105	V>A		No	ClinGen ExAC TOPMed gnomAD
CA372832472 rs1483516582	105	V>I		No	ClinGen gnomAD
CA372832465 rs1564049614	106	N>H		No	ClinGen Ensembl
rs1213024127 CA372832463	106	N>S		No	ClinGen gnomAD
rs781383014 CA4972555	107	S>C		No	ClinGen ExAC gnomAD
CA4972554 rs757560259	107	S>N		No	ClinGen ExAC gnomAD
CA372832447 rs1254937211	108	W>*		No	ClinGen TOPMed
CA372832449 rs1231495874	108	W>S		No	ClinGen TOPMed
rs1564049595 CA372832441	109	E>G		No	ClinGen Ensembl
CA372832444 rs1381072524	109	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA188485914 rs148422893	111	Q>H		No	ClinGen ESP TOPMed gnomAD
rs373169579 CA4972551	112	S>L		No	ClinGen ESP ExAC gnomAD
CA372832412 rs1197201073	113	L>P		No	ClinGen TOPMed
CA188485908 rs566868714	115	E>D		No	ClinGen 1000Genomes gnomAD
CA372832395 rs1470531899	116	Y>C		No	ClinGen TOPMed gnomAD
rs753550479 CA4972549	116	Y>H		No	ClinGen ExAC gnomAD
rs753550479 CA4972548	116	Y>N		No	ClinGen ExAC gnomAD
CA4972546 rs760489584	117	K>E		No	ClinGen ExAC gnomAD
CA372832388 rs1586870909	117	K>R		No	ClinGen Ensembl
rs771512233 CA4972544	118	D>E		No	ClinGen ExAC gnomAD
CA4972545 rs369136600	118	D>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs1457206008 COSM1554966 CA372832382	118	D>Y	lung Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA TOPMed
CA372832350 rs1424390942	122	Y>*		No	ClinGen gnomAD
CA372832355 rs1411874410	122	Y>H		No	ClinGen gnomAD
CA4972543 rs761301478	123	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA4972541 rs768162857	126	G>D		No	ClinGen ExAC gnomAD
CA372832330 rs1470846896	126	G>R		No	ClinGen gnomAD
rs768162857 CA188485865	126	G>V		No	ClinGen ExAC gnomAD
CA372832311 rs1564049541	129	R>K		No	ClinGen Ensembl
rs780234860 CA4972538	130	E>K		No	ClinGen ExAC TOPMed gnomAD
rs1356786590 CA372832289	132	S>A		No	ClinGen gnomAD
rs1291595676 CA372832287	132	S>C		No	ClinGen gnomAD
rs34832229 CA4972536 RCV000967114	135	H>R		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs746313746 CA4972535	137	I>T		No	ClinGen ExAC TOPMed gnomAD
CA188485800 rs994783034	137	I>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA372832246 rs757475664	138	N>K		No	ClinGen ExAC TOPMed gnomAD
CA372832234 rs1164392086	140	Y>C		No	ClinGen gnomAD
rs949882923 CA188485731	141	I>F		No	ClinGen TOPMed gnomAD
CA188485740 rs949882923	141	I>V		No	ClinGen TOPMed gnomAD
rs532468526 CA372832225	142	H>D		No	ClinGen 1000Genomes ExAC gnomAD
rs532468526 CA4972530	142	H>Y		No	ClinGen 1000Genomes ExAC gnomAD
COSM275573 rs913059616 CA188485726	143	E>D	large_intestine [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
rs1316901192 CA372832216	143	E>G		No	ClinGen TOPMed
CA4972529 rs753696096	144	N>K		No	ClinGen ExAC gnomAD
CA372832208 rs1427829667	144	N>S		No	ClinGen gnomAD
rs753136515 CA188485715	145	A>T		No	ClinGen Ensembl
rs1195208164 CA372832182	148	Q>*		No	ClinGen TOPMed gnomAD
rs565291208 CA4972528	148	Q>L		No	ClinGen 1000Genomes ExAC gnomAD
CA188485712 rs935917390	151	R>C		No	ClinGen TOPMed gnomAD
CA4972527 rs34567633	151	R>H		No	ClinGen ExAC TOPMed gnomAD
CA372832159 rs34567633	151	R>L		No	ClinGen ExAC TOPMed gnomAD
CA188485711 rs34567633	151	R>P		No	ClinGen ExAC TOPMed gnomAD
CA188485702 rs750419451	152	R>K		No	ClinGen ExAC TOPMed gnomAD
CA4972526 rs750419451	152	R>T		No	ClinGen ExAC TOPMed gnomAD
rs140593025 CA372832147	153	N>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA372832141 rs138452027	154	K>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA4972524 rs138452027	154	K>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs1319201154 CA372832137	155	I>V		No	ClinGen gnomAD
rs1167310866 CA372832124	156	K>N		No	ClinGen TOPMed
CA4972523 rs773830804	157	T>S		No	ClinGen ExAC TOPMed gnomAD
rs765861093 CA4972521	159	S>R		No	ClinGen ExAC TOPMed gnomAD
CA4972520 rs145774751	160	N>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA4972519 rs372626636	161	L>F		No	ClinGen ESP ExAC TOPMed gnomAD
CA4972517 rs777314219	163	W>*		No	ClinGen ExAC gnomAD
rs202029159 CA4972516	163	W>*		No	ClinGen ESP ExAC TOPMed gnomAD
rs368362599 CA372832075	164	G>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs368362599 CA4972515	164	G>W		No	ClinGen ESP ExAC TOPMed gnomAD
CA4972513 rs758649480	166	H>D		No	ClinGen ExAC gnomAD
TCGA novel	166	H>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA188485599 rs1015081490	167	P>L		No	ClinGen Ensembl
CA372832049 rs1248939122	168	Q>*		No	ClinGen gnomAD
rs755970119 CA372832047	168	Q>L		No	ClinGen ExAC gnomAD
CA4972510 rs755970119	168	Q>R		No	ClinGen ExAC gnomAD
rs1564049386 CA372832041	169	R>T		No	ClinGen Ensembl
rs767494322 CA4972508	171	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1322949204 CA372832027	171	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs757138594 CA4972507	172	R>G		No	ClinGen ExAC TOPMed gnomAD
CA372832022 rs1243775002	172	R>T		No	ClinGen TOPMed
rs1334200577 CA372832016	173	G>E		No	ClinGen gnomAD
rs751114432 CA4972506	173	G>R		No	ClinGen ExAC gnomAD
CA372832009 rs763447972	174	Y>C		No	ClinGen ExAC gnomAD
CA4972505 rs763447972	174	Y>F		No	ClinGen ExAC gnomAD
CA4972504 rs762683628	176	E>G		No	ClinGen ExAC gnomAD
rs1352713018 CA372832000	176	E>K		No	ClinGen TOPMed
rs775067226 CA4972503	177	K>E		No	ClinGen ExAC gnomAD
CA188485522 rs755562723	178	C>Y		No	ClinGen gnomAD
CA4972502 rs764909150	179	C>G		No	ClinGen ExAC gnomAD
rs952307781 CA188485507	180	L>V		No	ClinGen TOPMed gnomAD
CA4972500 rs777085197	181	T>I		No	ClinGen ExAC gnomAD
CA372831956 rs1440736559	183	C>G		No	ClinGen TOPMed gnomAD
rs140629472 CA4972498	183	C>Y		No	ClinGen ESP ExAC TOPMed gnomAD
rs1182345729 CA372831949	184	T>A		No	ClinGen gnomAD
CA372831942 rs1279506935	185	K>E		No	ClinGen gnomAD
rs773353870 CA4972497	185	K>R		No	ClinGen ExAC gnomAD
rs748253897 CA4972495	187	E>K		No	ClinGen ExAC gnomAD
CA4972494 rs180824328	188	L>V		No	ClinGen 1000Genomes ExAC
CA4972492 rs755172710	190	I>V		No	ClinGen ExAC gnomAD
CA372831902 rs970807459	191	A>P		No	ClinGen TOPMed
CA372831901 rs970807459	191	A>S		No	ClinGen TOPMed
rs970807459 CA188485456	191	A>T		No	ClinGen TOPMed
CA372831892 rs1311140046	192	C>F		No	ClinGen gnomAD
rs1386693144 CA372831887	193	L>F		No	ClinGen gnomAD
rs780928550 CA4972490	193	L>P		No	ClinGen ExAC gnomAD
rs751399042 CA4972488	194	P>A		No	ClinGen ExAC
CA372831875 rs1415683524	195	Y>C		No	ClinGen gnomAD
TCGA novel	196	I>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1382095521 CA372831870	196	I>V		No	ClinGen gnomAD
rs757883461 COSM1109367 CA4972486	198	F>L	endometrium [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
TCGA novel	198	F>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4972484 rs765000491	200	R>K		No	ClinGen ExAC TOPMed
TCGA novel	201	L>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs754257221 CA4972482	202	K>M		No	ClinGen ExAC TOPMed gnomAD
CA372831816 rs1564049277	203	E>D		No	ClinGen Ensembl
CA188485410 rs373708383	204	K>E		No	ClinGen ESP TOPMed gnomAD
CA4972481 rs766790610	205	R>K		No	ClinGen ExAC TOPMed gnomAD
rs766790610 CA372831806	205	R>T		No	ClinGen ExAC TOPMed gnomAD
rs1395278205 CA372831799	206	S>*		No	ClinGen TOPMed
rs761107037 CA4972479	207	S>L		No	ClinGen ExAC gnomAD
CA188485389 rs372996592	209	V>L		No	ClinGen gnomAD
rs772600588 CA4972477	211	K>R		No	ClinGen ExAC gnomAD
CA372831766 rs1355294638	212	I>V		No	ClinGen TOPMed gnomAD
CA4972476 rs761848417	213	Y>H		No	ClinGen ExAC gnomAD

No associated diseases with Q9Y581

2 regional properties for Q9Y581

Type	Name	Position	InterPro Accession
domain	Insulin-like	30 - 192	IPR016179
conserved_site	Insulin, conserved site	178 - 192	IPR022353

Functions

		Description
EC Number
Subcellular Localization	Secreted
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

1 GO annotations of cellular component

Name	Definition
extracellular region	The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.

1 GO annotations of molecular function

Name	Definition
hormone activity	The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process.

No GO annotations of biological process

Name	Definition
No GO annotations for biological process

2 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q9QY05	Insl6	Insulin-like peptide INSL6	Mus musculus (Mouse)	PR
Q9WV41	Insl6	Insulin-like peptide INSL6	Rattus norvegicus (Rat)	PR

10	20	30	40	50	60
MPRLLRLSLL	WLGLLLVRFS	RELSDISSAR	KLCGRYLVKE	IEKLCGHANW	SQFRFEEETP
70	80	90	100	110	120
FSRLIAQASE	KVEAYSPYQF	ESPQTASPAR	GRGTNPVSTS	WEEAVNSWEM	QSLPEYKDKK
130	140	150	160	170	180
GYSPLGKTRE	FSSSHNINVY	IHENAKFQKK	RRNKIKTLSN	LFWGHHPQRK	RRGYSEKCCL
190	200	210
TGCTKEELSI	ACLPYIDFKR	LKEKRSSLVT	KIY