Q9QY05

PR
Gene name
Insl6
Protein name
Insulin-like peptide INSL6
Names
Insulin-like peptide 6
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:27356
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-179 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9QY05

Entry ID Method Resolution Chain Position Source
AF-Q9QY05-F1 Predicted AlphaFoldDB

5 variants for Q9QY05

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3389535092 41 V>A No EVA
rs222088037 57 E>K No EVA
rs237549022 98 K>T No EVA
rs213885995 117 T>A No EVA
rs3389543071 142 K>E No EVA

No associated diseases with Q9QY05

2 regional properties for Q9QY05

Type Name Position InterPro Accession
domain Insulin-like 30 - 185 IPR016179
conserved_site Insulin, conserved site 171 - 185 IPR022353

Functions

Description
EC Number
Subcellular Localization
  • Secreted
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.

1 GO annotations of molecular function

Name Definition
hormone activity The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process.

10 GO annotations of biological process

Name Definition
apoptotic process A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
ectopic germ cell programmed cell death Programmed cell death of an errant germ line cell that is outside the normal migratory path or ectopic to the gonad. This is an important mechanism of regulating germ cell survival within the embryo.
fertilization The union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy).
flagellated sperm motility The directed, self-propelled movement of a cilium (aka flagellum) that contributes to the movement of a flagellated sperm.
male gonad development The process whose specific outcome is the progression of the male gonad over time, from its formation to the mature structure.
negative regulation of apoptotic process Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
negative regulation of developmental process Any process that stops, prevents or reduces the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).
negative regulation of reproductive process Any process that stops, prevents, or reduces the frequency, rate or extent of reproductive process.
spermatid development The process whose specific outcome is the progression of a spermatid over time, from its formation to the mature structure.
spermatogenesis The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9Y581 INSL6 Insulin-like peptide INSL6 Homo sapiens (Human) PR
Q9WV41 Insl6 Insulin-like peptide INSL6 Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MKQLCCSCLL WLGLLLTPFS REEEEESRPR KLCGRHLLIE VIKLCGQSDW SRFEMEEQSP
70 80 90 100 110 120
MTQFFPHYSR KGKAFNPHPS SSAWRRFTNP VPAGVSQKKG THTWEPQSLP DYQFEKTELL
130 140 150 160 170 180
PKARVFSYHS GKPYVKSVQL QKKSTNKMNT FRSLFWGNHS QRKRRGFADK CCVIGCTKEE
190
MAVACLPFVD F