Q9Y4K4
Gene name |
MAP4K5 |
Protein name |
Mitogen-activated protein kinase kinase kinase kinase 5 |
Names |
Kinase homologous to SPS1/STE20, KHS, MAPK/ERK kinase kinase kinase 5, MEK kinase kinase 5, MEKKK 5 |
Species |
Homo sapiens (Human) |
KEGG Pathway |
hsa:11183 |
EC number |
2.7.11.1: Protein-serine/threonine kinases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
157-180 (Activation loop from InterPro)
Target domain |
20-277 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
Autoinhibited structure
Activated structure
1 structures for Q9Y4K4
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9Y4K4-F1 | Predicted | AlphaFoldDB |
7 variants for Q9Y4K4
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
|
CA7180083 VAR_057102 rs34726242 |
41 | H>Y | No |
ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
|
VAR_040747 rs12881869 CA7179853 |
334 | A>T | No |
ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
|
CA7179771 rs34818002 VAR_040748 |
407 | P>L | No |
ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
|
VAR_040749 rs55815015 CA7179754 |
446 | I>V | No |
ClinGen UniProt 1000Genomes TOPMed dbSNP |
|
|
CA7179730 rs35768475 VAR_040750 |
473 | K>N | No |
ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
|
VAR_040751 rs55997280 CA7179643 |
552 | R>Q | No |
ClinGen UniProt ESP ExAC TOPMed dbSNP gnomAD |
|
|
rs17780143 CA7179550 VAR_040752 |
633 | T>M | No |
ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
No associated diseases with Q9Y4K4
4 regional properties for Q9Y4K4
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Protein kinase domain | 14 - 272 | IPR000719 |
| active_site | Serine/threonine-protein kinase, active site | 132 - 144 | IPR008271 |
| domain | Calcium/calmodulin-dependent protein kinase II, association-domain | 346 - 473 | IPR013543 |
| binding_site | Protein kinase, ATP binding site | 20 - 43 | IPR017441 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.1 | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| MAP kinase kinase kinase kinase activity | Catalysis of the phosphorylation of serine and threonine residues in a mitogen-activated protein kinase kinase kinase (MAPKKK), resulting in activation of MAPKKK. MAPKKK signaling pathways relay, amplify and integrate signals from the plasma membrane to the nucleus in response to a diverse range of extracellular stimuli. |
| protein kinase activity | Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. |
| protein serine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. |
| protein serine/threonine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| intracellular signal transduction | The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. |
| protein phosphorylation | The process of introducing a phosphate group on to a protein. |
15 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9H2G2 | SLK | STE20-like serine/threonine-protein kinase | Homo sapiens (Human) | PR |
| O94804 | STK10 | Serine/threonine-protein kinase 10 | Homo sapiens (Human) | PR |
| O95747 | OXSR1 | Serine/threonine-protein kinase OSR1 | Homo sapiens (Human) | PR |
| Q9UEW8 | STK39 | STE20/SPS1-related proline-alanine-rich protein kinase | Homo sapiens (Human) | PR |
| Q92918 | MAP4K1 | Mitogen-activated protein kinase kinase kinase kinase 1 | Homo sapiens (Human) | EV |
| Q12851 | MAP4K2 | Mitogen-activated protein kinase kinase kinase kinase 2 | Homo sapiens (Human) | EV |
| Q8IVH8 | MAP4K3 | Mitogen-activated protein kinase kinase kinase kinase 3 | Homo sapiens (Human) | SS |
| Q9P289 | STK26 | Serine/threonine-protein kinase 26 | Homo sapiens (Human) | PR |
| Q9Y6E0 | STK24 | Serine/threonine-protein kinase 24 | Homo sapiens (Human) | PR |
| O00506 | STK25 | Serine/threonine-protein kinase 25 | Homo sapiens (Human) | PR |
| Q99JP0 | Map4k3 | Mitogen-activated protein kinase kinase kinase kinase 3 | Mus musculus (Mouse) | SS |
| Q61161 | Map4k2 | Mitogen-activated protein kinase kinase kinase kinase 2 | Mus musculus (Mouse) | SS |
| P70218 | Map4k1 | Mitogen-activated protein kinase kinase kinase kinase 1 | Mus musculus (Mouse) | PR |
| Q8BPM2 | Map4k5 | Mitogen-activated protein kinase kinase kinase kinase 5 | Mus musculus (Mouse) | PR |
| Q924I2 | Map4k3 | Mitogen-activated protein kinase kinase kinase kinase 3 | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEAPLRPAAD | ILRRNPQQDY | ELVQRVGSGT | YGDVYKARNV | HTGELAAVKI | IKLEPGDDFS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LIQQEIFMVK | ECKHCNIVAY | FGSYLSREKL | WICMEYCGGG | SLQDIYHVTG | PLSELQIAYV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| CRETLQGLAY | LHTKGKMHRD | IKGANILLTD | HGDVKLADFG | VAAKITATIA | KRKSFIGTPY |
| 190 | 200 | 210 | 220 | 230 | 240 |
| WMAPEVAAVE | KNGGYNQLCD | IWAVGITAIE | LGELQPPMFD | LHPMRALFLM | SKSNFQPPKL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| KDKTKWSSTF | HNFVKIALTK | NPKKRPTAER | LLTHTFVAQP | GLSRALAVEL | LDKVNNPDNH |
| 310 | 320 | 330 | 340 | 350 | 360 |
| AHYTEADDDD | FEPHAIIRHT | IRSTNRNARA | ERTASEINFD | KLQFEPPLRK | ETEARDEMGL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| SSDPNFMLQW | NPFVDGANTG | KSTSKRAIPP | PLPPKPRISS | YPEDNFPDEE | KASTIKHCPD |
| 430 | 440 | 450 | 460 | 470 | 480 |
| SESRAPQILR | RQSSPSCGPV | AETSSIGNGD | GISKLMSENT | EGSAQAPQLP | RKKDKRDFPK |
| 490 | 500 | 510 | 520 | 530 | 540 |
| PAINGLPPTP | KVLMGACFSK | VFDGCPLKIN | CATSWIHPDT | KDQYIIFGTE | DGIYTLNLNE |
| 550 | 560 | 570 | 580 | 590 | 600 |
| LHEATMEQLF | PRKCTWLYVI | NNTLMSLSVG | KTFQLYSHNL | IALFEHAKKP | GLAAHIQTHR |
| 610 | 620 | 630 | 640 | 650 | 660 |
| FPDRILPRKF | ALTTKIPDTK | GCHKCCIVRN | PYTGHKYLCG | ALQSGIVLLQ | WYEPMQKFML |
| 670 | 680 | 690 | 700 | 710 | 720 |
| IKHFDFPLPS | PLNVFEMLVI | PEQEYPMVCV | AISKGTESNQ | VVQFETINLN | SASSWFTEIG |
| 730 | 740 | 750 | 760 | 770 | 780 |
| AGSQQLDSIH | VTQLERDTVL | VCLDKFVKIV | NLQGKLKSSK | KLASELSFDF | RIESVVCLQD |
| 790 | 800 | 810 | 820 | 830 | 840 |
| SVLAFWKHGM | QGKSFKSDEV | TQEISDETRV | FRLLGSDRVV | VLESRPTENP | TAHSNLYILA |
| GHENSY |