P70218

PR
Gene name
Map4k1 (Hpk1)
Protein name
Mitogen-activated protein kinase kinase kinase kinase 1
Names
Hematopoietic progenitor kinase, HPK, MAPK/ERK kinase kinase kinase 1, MEK kinase kinase 1, MEKKK 1
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:26411
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

263-516 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

154-177 (Activation loop from InterPro)

Target domain

17-274 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

2 structures for P70218

Entry ID Method Resolution Chain Position Source
1UTI X-ray 150 A D 465-480 PDB
AF-P70218-F1 Predicted AlphaFoldDB

44 variants for P70218

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3412824826 11 K>* No EVA
rs3388891688 14 R>P No EVA
rs3388892947 26 G>E No EVA
rs3388896750 41 D>N No EVA
rs3388896713 90 C>Y No EVA
rs3388882559 109 L>V No EVA
rs3388895669 124 G>E No EVA
rs3388854101 130 S>T No EVA
rs3388877303 141 A>S No EVA
rs3388882578 150 E>K No EVA
rs3388895160 177 Y>* No EVA
rs3388869800 190 G>D No EVA
rs3388895177 191 G>R No EVA
rs3388896795 193 N>S No EVA
rs3388869788 209 A>T No EVA
rs3388890508 212 Q>H No EVA
rs3388877324 236 R>L No EVA
rs3388877323 273 L>M No EVA
rs3388891752 330 D>G No EVA
rs3397307693 352 A>D No EVA
rs3388896721 359 P>S No EVA
rs243193247 364 G>R No EVA
rs3388875266 425 R>Q No EVA
rs3388885643 440 P>S No EVA
rs31155356 444 C>R No EVA
rs3388892989 468 P>Q No EVA
rs3388892980 480 K>N No EVA
rs3388877322 482 E>Q No EVA
rs3388885669 494 V>L No EVA
rs3388869793 504 I>M No EVA
rs3396933886 520 L>M No EVA
rs3388895735 528 I>N No EVA
rs264692411 566 P>S No EVA
rs3388887616 609 D>E No EVA
rs3388869776 663 L>P No EVA
rs259613735 687 Q>H No EVA
rs3388892931 690 K>R No EVA
rs3388885667 697 V>E No EVA
rs3388895209 705 W>* No EVA
rs3388875296 755 M>L No EVA
rs31836292 807 V>I No EVA
rs46422041 808 V>E No EVA
rs3388869799 813 P>H No EVA
rs3388898049 819 A>P No EVA

No associated diseases with P70218

1 regional properties for P70218

Type Name Position InterPro Accession
domain Chemokine interleukin-8-like domain 28 - 90 IPR001811

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
MAP kinase kinase kinase kinase activity Catalysis of the phosphorylation of serine and threonine residues in a mitogen-activated protein kinase kinase kinase (MAPKKK), resulting in activation of MAPKKK. MAPKKK signaling pathways relay, amplify and integrate signals from the plasma membrane to the nucleus in response to a diverse range of extracellular stimuli.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

8 GO annotations of biological process

Name Definition
cell population proliferation The multiplication or reproduction of cells, resulting in the expansion of a cell population.
cellular response to phorbol 13-acetate 12-myristate Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a phorbol 13-acetate 12-myristate stimulus.
intracellular signal transduction The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
JNK cascade An intracellular protein kinase cascade containing at least a JNK (a MAPK), a JNKK (a MAPKK) and a JUN3K (a MAP3K). The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell.
peptidyl-serine phosphorylation The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.
positive regulation of MAPK cascade Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade.
protein autophosphorylation The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
protein phosphorylation The process of introducing a phosphate group on to a protein.

15 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q12851 MAP4K2 Mitogen-activated protein kinase kinase kinase kinase 2 Homo sapiens (Human) EV
Q8IVH8 MAP4K3 Mitogen-activated protein kinase kinase kinase kinase 3 Homo sapiens (Human) SS
Q9Y4K4 MAP4K5 Mitogen-activated protein kinase kinase kinase kinase 5 Homo sapiens (Human) PR
Q92918 MAP4K1 Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens (Human) EV
Q61161 Map4k2 Mitogen-activated protein kinase kinase kinase kinase 2 Mus musculus (Mouse) SS
Q99JP0 Map4k3 Mitogen-activated protein kinase kinase kinase kinase 3 Mus musculus (Mouse) SS
O54988 Slk STE20-like serine/threonine-protein kinase Mus musculus (Mouse) PR
O55098 Stk10 Serine/threonine-protein kinase 10 Mus musculus (Mouse) PR
Q6P9R2 Oxsr1 Serine/threonine-protein kinase OSR1 Mus musculus (Mouse) PR
Q9Z1W9 Stk39 STE20/SPS1-related proline-alanine-rich protein kinase Mus musculus (Mouse) PR
Q99JT2 Stk26 Serine/threonine-protein kinase 26 Mus musculus (Mouse) PR
Q99KH8 Stk24 Serine/threonine-protein kinase 24 Mus musculus (Mouse) PR
Q9Z2W1 Stk25 Serine/threonine-protein kinase 25 Mus musculus (Mouse) PR
Q8BPM2 Map4k5 Mitogen-activated protein kinase kinase kinase kinase 5 Mus musculus (Mouse) PR
Q924I2 Map4k3 Mitogen-activated protein kinase kinase kinase kinase 3 Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MALVDPDIFN KDPREHYDLL QRLGGGTYGE VFKARDKVSK DLVALKMVKM EPDDDVATLQ
70 80 90 100 110 120
KEILMLKTCR HANIVAYHGS YLWLQKLWIC MEFCGAGSLQ DIYQVTGSLS ELQISYVCRE
130 140 150 160 170 180
VLQGLAYLHS EKKIHRDIKG ANILINDCGE VKLADFGISA QIGATLARRL SFIGTPYWMA
190 200 210 220 230 240
PEVAAVALKG GYNELCDIWS LGITAIELAE LQPPLFDVHP LRVLFLMTKS GYQPPRLKEK
250 260 270 280 290 300
SRWSSSFHNF VKVTLTKNSK KRPSATKMLS HQLVSQPGLN RGLILDLLDK MKNPGKGLPV
310 320 330 340 350 360
DIEDEEPEPP PAIPRRIRST YRASSLGIPD ADCCRRQMEF QRPRCVDCRP QAETVRLYPP
370 380 390 400 410 420
AHFGSTSPRS QLSDSDDDYD DVDIPAPSEN IPPPLPPKPK FRSPSDDGSG GIRDDGQLSP
430 440 450 460 470 480
GVLVRCASGP PPRTPRPGPP PATCSPHLTA RSDPSLWNPA APEPGQPPLV PPRKEKMRGK
490 500 510 520 530 540
MENEKRREKY PLLVKLFNGC PLQIHSTAAW THPSTKDQNL LLGAEEGIFI LNRNDQEATL
550 560 570 580 590 600
EMIFPGRTTW LYCINNLLMS LSGKTPYLYS HSILGLLERK DGRTGSPIAH ISPHRLLARK
610 620 630 640 650 660
NMVSSKIQDT KGCRACCVAE SASSGGPFLC GALETSVVLL QWYQPMNKFL LVRQVLFPLP
670 680 690 700 710 720
TPLPVFTLLT TPGSELPAVC IGVSPGQAAK SVLFHTVRFG ALSCWLDDSS TEHKGPVQVI
730 740 750 760 770 780
QVKEDMVMVL MDGSLKLVTP EGAPAPGLRT PEIPMTEAVE AVAMVEDRLE AFWKHGVQVW
790 800 810 820
APGLKQPLQE LRDPTLTFRL LCSPRPVVVE TRPTDDPTAP SNLYIQE