Q8BPM2
Gene name |
Map4k5 |
Protein name |
Mitogen-activated protein kinase kinase kinase kinase 5 |
Names |
MAPK/ERK kinase kinase kinase 5, MEK kinase kinase 5, MEKKK 5 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:399510 |
EC number |
2.7.11.1: Protein-serine/threonine kinases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
157-180 (Activation loop from InterPro)
Target domain |
20-277 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
Autoinhibited structure
Activated structure
1 structures for Q8BPM2
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8BPM2-F1 | Predicted | AlphaFoldDB |
33 variants for Q8BPM2
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389252156 | 49 | K>N | No | EVA | |
| rs3389236967 | 111 | P>S | No | EVA | |
| rs3389252195 | 117 | I>K | No | EVA | |
| rs3389239846 | 173 | K>M | No | EVA | |
| rs3389215930 | 263 | K>E | No | EVA | |
| rs3389209453 | 320 | T>A | No | EVA | |
| rs3389202481 | 357 | E>D | No | EVA | |
| rs3389209518 | 388 | I>K | No | EVA | |
| rs3389215944 | 422 | E>G | No | EVA | |
| rs264475894 | 437 | C>F | No | EVA | |
| rs37037959 | 441 | A>V | No | EVA | |
| rs3389243692 | 447 | I>T | No | EVA | |
| rs3389244864 | 460 | N>* | No | EVA | |
| rs3389244800 | 460 | N>I | No | EVA | |
| rs3389244800 | 460 | N>S | No | EVA | |
| rs3389238675 | 461 | T>P | No | EVA | |
| rs3389238675 | 461 | T>S | No | EVA | |
| rs3389255511 | 462 | E>G | No | EVA | |
| rs3389227660 | 542 | L>P | No | EVA | |
| rs3389243715 | 549 | Q>R | No | EVA | |
| rs864286498 | 586 | E>* | No | EVA | |
| rs3389239855 | 606 | I>N | No | EVA | |
| rs3389209532 | 629 | V>D | No | EVA | |
| rs3389243728 | 632 | P>L | No | EVA | |
| rs3389236989 | 726 | Q>H | No | EVA | |
| rs3389244844 | 735 | L>S | No | EVA | |
| rs3389239784 | 739 | T>I | No | EVA | |
| rs3389240906 | 745 | D>Y | No | EVA | |
| rs13460549 | 758 | K>N | No | EVA | |
| rs3389238692 | 795 | S>G | No | EVA | |
| rs3389244836 | 804 | E>D | No | EVA | |
| rs3389244877 | 810 | R>K | No | EVA | |
| rs3389252127 | 815 | L>M | No | EVA |
No associated diseases with Q8BPM2
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.1 | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| MAP kinase kinase kinase kinase activity | Catalysis of the phosphorylation of serine and threonine residues in a mitogen-activated protein kinase kinase kinase (MAPKKK), resulting in activation of MAPKKK. MAPKKK signaling pathways relay, amplify and integrate signals from the plasma membrane to the nucleus in response to a diverse range of extracellular stimuli. |
| protein serine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. |
| protein serine/threonine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| intracellular signal transduction | The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. |
| protein phosphorylation | The process of introducing a phosphate group on to a protein. |
15 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q12851 | MAP4K2 | Mitogen-activated protein kinase kinase kinase kinase 2 | Homo sapiens (Human) | EV |
| Q8IVH8 | MAP4K3 | Mitogen-activated protein kinase kinase kinase kinase 3 | Homo sapiens (Human) | SS |
| Q92918 | MAP4K1 | Mitogen-activated protein kinase kinase kinase kinase 1 | Homo sapiens (Human) | EV |
| Q9Y4K4 | MAP4K5 | Mitogen-activated protein kinase kinase kinase kinase 5 | Homo sapiens (Human) | PR |
| Q61161 | Map4k2 | Mitogen-activated protein kinase kinase kinase kinase 2 | Mus musculus (Mouse) | SS |
| P70218 | Map4k1 | Mitogen-activated protein kinase kinase kinase kinase 1 | Mus musculus (Mouse) | PR |
| Q99JP0 | Map4k3 | Mitogen-activated protein kinase kinase kinase kinase 3 | Mus musculus (Mouse) | SS |
| O54988 | Slk | STE20-like serine/threonine-protein kinase | Mus musculus (Mouse) | PR |
| O55098 | Stk10 | Serine/threonine-protein kinase 10 | Mus musculus (Mouse) | PR |
| Q6P9R2 | Oxsr1 | Serine/threonine-protein kinase OSR1 | Mus musculus (Mouse) | PR |
| Q9Z1W9 | Stk39 | STE20/SPS1-related proline-alanine-rich protein kinase | Mus musculus (Mouse) | PR |
| Q99JT2 | Stk26 | Serine/threonine-protein kinase 26 | Mus musculus (Mouse) | PR |
| Q99KH8 | Stk24 | Serine/threonine-protein kinase 24 | Mus musculus (Mouse) | PR |
| Q9Z2W1 | Stk25 | Serine/threonine-protein kinase 25 | Mus musculus (Mouse) | PR |
| Q924I2 | Map4k3 | Mitogen-activated protein kinase kinase kinase kinase 3 | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEAPLRPAAD | ILRRNPQHDY | ELVQRVGSGT | YGDVYKARNV | HTGELAAVKI | IKLEPGDDFS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LIQQEIFMVK | ECKHCNIVAY | FGSYLSREKL | WICMEYCGGG | SLQDIYHVTG | PLSEMQIAYV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| CRETLQGLAY | LHTKGKMHRD | IKGANILLTD | HGDVKLADFG | VAAKITATIA | KRKSFIGTPY |
| 190 | 200 | 210 | 220 | 230 | 240 |
| WMAPEVAAVE | KNGGYNQLCD | IWAVGITAIE | LGELQPPMFD | LHPMRALFLM | SKSNFQPPKL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| KDKTKWSSTF | HNFVKIALTK | NPKKRPTAER | LLTHTFVGQP | GLSRALAVEL | LDKVSNPDNH |
| 310 | 320 | 330 | 340 | 350 | 360 |
| APYSEGDEDD | LEPHAIIRHT | IRSTNRNSRA | ERTASEINFD | KLQFEPPLRK | ETEARDEMGL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| SSEPNFILHW | NPFVDGANTG | RSTSKRAIPP | PLPPKPRVNT | YPEDSLPDEE | KSSTIKRCPD |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LEARAPQVLR | RQSSPSCVPV | AETSSSIGNG | DGISKLISEN | TEGSAQAPQL | PRKKDKRDFP |
| 490 | 500 | 510 | 520 | 530 | 540 |
| KPTINGLPPT | PKVLMGACFS | KVFDGCPLKI | NCATSWIHPD | TKDQYIIFGT | EDGIYTLNLN |
| 550 | 560 | 570 | 580 | 590 | 600 |
| ELHEATMEQL | FPRKCTWLYV | INNTLMSLSE | GKTFQLYSHN | LIALFEQAKK | PGLAAHIQTH |
| 610 | 620 | 630 | 640 | 650 | 660 |
| RFPDRILPRK | FALTTKIPDT | KGCHKCCIVR | NPYTGHKYLC | GALQSGIVLL | QWYEPMQKFM |
| 670 | 680 | 690 | 700 | 710 | 720 |
| LIKHFDFPLP | SPLNVFEMLV | IPEQEYPMVC | VAISKGSDSS | QVVQFETINL | NSASSWFTEI |
| 730 | 740 | 750 | 760 | 770 | 780 |
| GAGSQQLDSI | HVTQLERDTV | LVCLDKFVKI | VNLQGKLKSS | KKLASELSFD | FRIESVVCLQ |
| 790 | 800 | 810 | 820 | 830 | 840 |
| DSVLAFWKHG | MQGKSFKSDE | VTQEISDETR | VFRLLGSDRV | VVLESRPTEN | PAAHSNLYIL |
| AGHENSY |