AiPD: Autoinhibited Protein Database

Q9Y478

Gene name	PRKAB1 (AMPK)
Protein name	5'-AMP-activated protein kinase subunit beta-1
Names	AMPK subunit beta-1, AMPKb
Species	Homo sapiens (Human)
KEGG Pathway	hsa:5564
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-71 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-71 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

12 structures for Q9Y478

Entry ID	Method	Resolution	Chain	Position	Source
4CFE	X-ray	302 A	B/D	1-270	PDB
4CFF	X-ray	392 A	B/D	1-270	PDB
4ZHX	X-ray	299 A	B/D	1-270	PDB
5EZV	X-ray	299 A	B/D	1-270	PDB
5ISO	X-ray	263 A	B/D	1-270	PDB
6B1U	X-ray	277 A	B/D	1-270	PDB
6C9F	X-ray	292 A	B	68-270	PDB
6C9G	X-ray	270 A	B	67-270	PDB
6C9H	X-ray	265 A	B	68-270	PDB
6C9J	X-ray	305 A	B	68-270	PDB
7MYJ	X-ray	295 A	B/D	1-270	PDB
AF-Q9Y478-F1	Predicted				AlphaFoldDB

184 variants for Q9Y478

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs761521273 CA6820320	2	G>D		No	ClinGen ExAC gnomAD
CA6820323 rs758106654	8	R>H		No	ClinGen ExAC gnomAD
CA386533222 rs1413108299	9	A>T		No	ClinGen TOPMed
CA244358548 rs375442599	10	A>T		No	ClinGen ESP TOPMed gnomAD
CA386533239 rs1296222598	11	L>P		No	ClinGen gnomAD
CA6820328 rs749595403	11	L>V		No	ClinGen ExAC gnomAD
rs1460006507 CA386533248	12	E>D		No	ClinGen TOPMed gnomAD
rs779157494 COSM1578177 CA6820330	13	R>L	lung [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs1221817266 CA386533258	14	H>R		No	ClinGen TOPMed
rs1248282313 CA386533256	14	H>Y		No	ClinGen TOPMed
CA6820331 rs746047315	15	G>R		No	ClinGen ExAC gnomAD
rs772385438 CA6820333	17	H>P		No	ClinGen ExAC TOPMed gnomAD
rs772385438 CA6820332	17	H>R		No	ClinGen ExAC TOPMed gnomAD
rs1043354 CA244358653	20	P>A		No	ClinGen gnomAD
rs1259291845 CA386533318	20	P>H		No	ClinGen gnomAD
CA386533311 rs1043354	20	P>S		No	ClinGen gnomAD
rs61756440 CA6820335	22	R>K		No	ClinGen ExAC gnomAD
CA6820336 rs78433950	25	S>P		No	ClinGen 1000Genomes ESP TOPMed gnomAD
rs776725274 CA6820340	26	G>R		No	ClinGen ExAC gnomAD
CA6820343 rs61748075	27	G>D		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA6820341 rs761626973	27	G>S		No	ClinGen ExAC gnomAD
CA6820342 rs61748075	27	G>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs765766033	28	T>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
CA386533442 rs1397133422	28	T>I		No	ClinGen TOPMed gnomAD
CA244358765 rs913104801	30	D>G		No	ClinGen TOPMed
rs1452797908 CA386533465	30	D>N		No	ClinGen gnomAD
CA386533508 rs1295679130	31	G>E		No	ClinGen TOPMed
CA6820345 rs766087073	31	G>R		No	ClinGen ExAC TOPMed gnomAD
rs373680495 CA6820346	32	D>E		No	ClinGen ESP ExAC TOPMed gnomAD
rs568284871 CA6820348	35	K>E		No	ClinGen 1000Genomes ExAC gnomAD
rs1305152539 CA386533598	35	K>M		No	ClinGen gnomAD
TCGA novel	35	K>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1316621420 CA386533621	36	I>T		No	ClinGen TOPMed gnomAD
rs1489993872 CA386533654	37	L>R		No	ClinGen gnomAD
CA6820352 rs371815177	38	M>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs1458877382 CA386533677	38	M>R		No	ClinGen TOPMed
rs757824708 CA6820351	38	M>V		No	ClinGen ExAC gnomAD
CA386533712 rs1158296874	39	D>G		No	ClinGen TOPMed
rs772422545 COSM3687986 CA6820354	41	P>S	large_intestine Variant assessed as Somatic; 9.274e-05 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
TCGA novel	42	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1422624494 CA386533934	46	L>P		No	ClinGen gnomAD
rs768882714 CA6820357	48	H>R		No	ClinGen ExAC TOPMed gnomAD
rs1593328452 CA386534017	49	S>P		No	ClinGen Ensembl
CA6820383 rs1139637	56	E>*		No	ClinGen ESP ExAC TOPMed gnomAD
CA386536194 rs1139637	56	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs1320928464 CA386536230	57	K>E		No	ClinGen gnomAD
CA6820384 rs377700666	57	K>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs774859004 CA6820386	59	E>K		No	ClinGen ExAC gnomAD
TCGA novel	60	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6820387 rs760241080	63	W>G		No	ClinGen ExAC gnomAD
CA244362708 rs946688613	64	Q>K		No	ClinGen TOPMed gnomAD
CA244362713 rs1042433129	64	Q>R		No	ClinGen TOPMed gnomAD
rs1484910309 CA386536466	65	H>R		No	ClinGen TOPMed
CA244362714 rs902211689	68	E>K		No	ClinGen TOPMed
rs1195908214 CA386536529	69	V>L		No	ClinGen gnomAD
CA386536557 rs1427338706	71	D>H		No	ClinGen gnomAD
CA6820388 rs80330613	75	A>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs774770783 CA6820389	77	A>V		No	ClinGen ExAC gnomAD
rs371073735 CA6820391	78	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA6820390 rs758798418	78	R>W		No	ClinGen ExAC TOPMed gnomAD
CA386536707 rs1277129635	80	T>A		No	ClinGen TOPMed
rs755243236 CA6820393	80	T>M		No	ClinGen ExAC TOPMed gnomAD
rs941647796 CA244362824	82	F>S		No	ClinGen Ensembl
rs1299449930 CA386536746	83	R>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA6820395 rs201397246	83	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA386536768 rs1302934070	84	W>*		No	ClinGen TOPMed
CA6820396 rs756238637	85	T>M		No	ClinGen ExAC TOPMed
CA386536787 CA6820399 rs770905581	86	G>R		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	87	G>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6820401 rs745730456	87	G>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA244362884 rs745730456	87	G>S		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	88	G>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel CA6820403 rs375579154 COSM430474	88	G>R	Variant assessed as Somatic; 0.0 impact. breast Variant assessed as Somatic; impact. [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
rs557732890 CA6820404	89	K>E		No	ClinGen 1000Genomes ExAC gnomAD
CA6820405 rs768247950	89	K>R		No	ClinGen ExAC gnomAD
rs776051030 CA6820406	92	Y>C		No	ClinGen ExAC gnomAD
rs199606165 CA386536882	94	S>F		No	ClinGen ESP ExAC TOPMed gnomAD
rs1565875622 CA386536878	94	S>T		No	ClinGen Ensembl
rs199606165 CA6820407	94	S>Y		No	ClinGen ESP ExAC TOPMed gnomAD
rs767055560 CA6820408	100	W>*		No	ClinGen ExAC TOPMed gnomAD
CA386536994 rs1468852044	102	K>I		No	ClinGen gnomAD
rs751902416 CA6820409	104	P>L		No	ClinGen ExAC TOPMed gnomAD
CA386537018 rs1444126229	104	P>T		No	ClinGen TOPMed
CA6820410 rs759992306	105	L>F		No	ClinGen ExAC gnomAD
CA386537870 rs1377282629	109	H>R		No	ClinGen gnomAD
rs1372064326 CA386537987	112	F>L		No	ClinGen gnomAD
rs767890601 CA6820432	113	V>L		No	ClinGen ExAC gnomAD
CA386538031 rs1245467754	114	A>G		No	ClinGen gnomAD
CA6820436 rs764289933	117	D>E		No	ClinGen ExAC TOPMed gnomAD
CA6820434 rs760939482	117	D>V		No	ClinGen ExAC gnomAD
TCGA novel	118	L>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6820437 rs757346466	119	P>L		No	ClinGen ExAC TOPMed gnomAD
rs1459304732 CA386538214	119	P>S		No	ClinGen gnomAD
CA6820439 rs750394660	120	E>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs758310763 CA6820440	122	E>K		No	ClinGen ExAC gnomAD
rs758310763 CA386538306	122	E>Q		No	ClinGen ExAC gnomAD
CA386538351 rs1474143796	123	H>Q		No	ClinGen gnomAD
CA6820442 rs202243548	126	K>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	127	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6820443 rs74516777	128	F>S		No	ClinGen 1000Genomes ExAC gnomAD
rs781002487 CA6820444	134	T>M		No	ClinGen ExAC TOPMed gnomAD
CA244364404 rs11546695	135	H>L		No	ClinGen Ensembl
CA386538710 rs1401257819	135	H>Y		No	ClinGen TOPMed gnomAD
rs373505242 CA6820447	136	D>N		No	ClinGen ExAC gnomAD
CA244364414 rs193278535	137	P>L		No	ClinGen 1000Genomes gnomAD
CA6820450 rs368579544	139	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA6820464 rs200872060	141	I>M		No	ClinGen ExAC gnomAD
rs755879464 CA6820465	144	S>C		No	ClinGen ExAC gnomAD
CA386539033 rs755879464	144	S>G		No	ClinGen ExAC gnomAD
rs932755946 CA244364612	148	T>R		No	ClinGen TOPMed
rs777409087 CA6820466	149	V>A		No	ClinGen ExAC TOPMed gnomAD
rs777409087 CA386539135	149	V>D		No	ClinGen ExAC TOPMed gnomAD
CA386539163 rs1353581988	150	N>T		No	ClinGen gnomAD
rs894074129 CA244364632	151	N>H		No	ClinGen Ensembl
rs748816878 CA6820468	152	I>M		No	ClinGen ExAC gnomAD
rs772565745 CA6820469	153	I>F		No	ClinGen ExAC gnomAD
rs775877182 CA6820470	155	V>M		No	ClinGen ExAC gnomAD
rs1021577649 CA244364640	157	K>T		No	ClinGen Ensembl
CA6820471 rs747352974	161	E>Q		No	ClinGen ExAC gnomAD
rs970785786 CA244364657	162	V>E		No	ClinGen Ensembl
rs769042774 CA6820472	164	D>E		No	ClinGen ExAC gnomAD
CA386539508 rs1390477889	167	M>V		No	ClinGen TOPMed
CA6820473 rs139810340	168	V>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs867491740 CA244364669	170	S>F		No	ClinGen Ensembl
CA386539642 rs1177928762	173	C>S		No	ClinGen TOPMed gnomAD
CA6820474 COSM174615 rs762004648	175	D>N	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs773272756 CA6820476	176	V>L		No	ClinGen ExAC gnomAD
rs762954063 CA6820477	177	S>C		No	ClinGen ExAC TOPMed gnomAD
rs762954063 CA386539782	177	S>F		No	ClinGen ExAC TOPMed gnomAD
CA386539790 rs1293078878	178	E>Q		No	ClinGen gnomAD
TCGA novel	181	S>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs773326833 CA6820496	182	S>F		No	ClinGen ExAC TOPMed gnomAD
rs1199018613 CA386541076	184	P>L		No	ClinGen gnomAD
CA386541103 rs1466090595	185	G>E		No	ClinGen TOPMed
rs1471748180 CA386541294	191	P>T		No	ClinGen gnomAD
CA6820499 COSM935751 rs746242433	193	V>I	endometrium [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA244366736 rs111872676	195	K>R		No	ClinGen Ensembl
CA6820501 rs368860400	197	E>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1346259116 CA386541535	198	E>Q		No	ClinGen TOPMed
CA6820502 rs752474474	199	R>C	Variant assessed as Somatic; 4.619e-05 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs143112563 CA6820503	199	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA386541606 rs1298865227	200	F>L		No	ClinGen TOPMed
rs1303940089 CA386541634	201	R>Q		No	ClinGen TOPMed gnomAD
COSM935752 CA6820506 rs756977389	201	R>W	Variant assessed as Somatic; 0.0 impact. endometrium breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA6820507 rs778268813	205	I>V		No	ClinGen ExAC TOPMed gnomAD
rs749996019 CA386541844	208	P>L		No	ClinGen ExAC TOPMed gnomAD
rs749996019 CA6820508	208	P>Q		No	ClinGen ExAC TOPMed gnomAD
rs749996019 CA244366797	208	P>R		No	ClinGen ExAC TOPMed gnomAD
rs781670874 CA6820510	213	V>I		No	ClinGen ExAC gnomAD
rs1259699799 CA386541996	214	I>V		No	ClinGen gnomAD
CA386542098 rs1451040977	217	K>E		No	ClinGen TOPMed
CA6820512 rs770171767	218	D>N		No	ClinGen ExAC gnomAD
rs373173905 CA6820513	219	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs749447280 CA6820514	221	I>T		No	ClinGen ExAC gnomAD
CA6820547 rs756574271	223	C>R		No	ClinGen ExAC gnomAD
rs764667443 CA6820548	226	A>T		No	ClinGen ExAC gnomAD
rs779238721 CA6820551	234	V>I		No	ClinGen ExAC TOPMed gnomAD
CA6820553 rs758745155	237	N>D		No	ClinGen ExAC gnomAD
CA244370186 rs758745155	237	N>Y		No	ClinGen ExAC gnomAD
rs568377821 CA6820558	241	A>E		No	ClinGen ExAC TOPMed gnomAD
CA6820556 rs768414478	241	A>T		No	ClinGen ExAC TOPMed gnomAD
rs568377821 COSM935754 CA6820557	241	A>V	large_intestine endometrium Variant assessed as Somatic; 9.239e-05 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA6820562 rs773037341	243	S>C		No	ClinGen ExAC gnomAD
CA386544306 rs1409527311	249	M>T		No	ClinGen gnomAD
rs1330379731 CA386544341	251	L>V		No	ClinGen gnomAD
CA6820577 rs781167231	253	A>T		No	ClinGen ExAC TOPMed gnomAD
CA6820578 rs748094351	254	T>A		No	ClinGen ExAC gnomAD
CA386544404 rs1319163692	256	R>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA244370452 rs901746495	259	K>R		No	ClinGen TOPMed gnomAD
CA386544458 rs1313399814	260	K>E		No	ClinGen gnomAD
rs770259028	260	K>missing	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
CA386544467 rs1593333710	261	Y>H		No	ClinGen Ensembl
rs1218272618 CA386544490	262	V>F		No	ClinGen TOPMed gnomAD
rs1218272618 CA386544486	262	V>I		No	ClinGen TOPMed gnomAD
CA386544500 rs539558322	263	T>A		No	ClinGen ExAC gnomAD
rs539558322 CA6820582	263	T>P		No	ClinGen ExAC gnomAD
TCGA novel	264	T>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA386544578 rs1447633858	267	Y>*		No	ClinGen TOPMed
rs997448515 CA244370504	267	Y>F		No	ClinGen TOPMed
CA6820584 rs774014433	267	Y>H		No	ClinGen ExAC TOPMed gnomAD
rs758929575 CA6820585	269	P>R		No	ClinGen ExAC TOPMed gnomAD
rs771581050 CA6820586	270	I>M		No	ClinGen ExAC gnomAD
CA244370538 rs199990839	270	I>T		No	ClinGen 1000Genomes gnomAD
CA244370530 rs375188670	270	I>V		No	ClinGen ESP TOPMed

No associated diseases with Q9Y478

2 regional properties for Q9Y478

Type	Name	Position	InterPro Accession
domain	Association with the SNF1 complex (ASC) domain	180 - 270	IPR006828
domain	AMP-activated protein kinase, glycogen-binding domain	79 - 160	IPR032640

Functions

		Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

5 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleotide-activated protein kinase complex	A protein complex that possesses nucleotide-dependent protein kinase activity. The nucleotide can be AMP (in S. pombe and human) or ADP (in S. cerevisiae).
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

2 GO annotations of molecular function

Name	Definition
protein kinase activity	Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
protein kinase binding	Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.

8 GO annotations of biological process

Name	Definition
cellular response to nutrient levels	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients.
fatty acid biosynthetic process	The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes.
nail development	The process whose specific outcome is the progression of a nail over time, from its formation to the mature structure. A nail is a horn-like envelope covering the outer end of a finger or toe, and consists of the nail plate, the nail matrix and the nail bed below it, and the grooves surrounding it. [GOC:bf, ISBN:0323025781, UBERON:0001705, Wikipedia:Nail_(anatomy)]
positive regulation of cold-induced thermogenesis	Any process that activates or increases the frequency, rate or extent of cold-induced thermogenesis.
positive regulation of gene expression	Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
protein phosphorylation	The process of introducing a phosphate group on to a protein.
regulation of catalytic activity	Any process that modulates the activity of an enzyme.
signal transduction	The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

6 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q5BIS9	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	Bos taurus (Bovine)	PR
O43741	PRKAB2	5'-AMP-activated protein kinase subunit beta-2	Homo sapiens (Human)	PR
Q6PAM0	Prkab2	5'-AMP-activated protein kinase subunit beta-2	Mus musculus (Mouse)	PR
Q9R078	Prkab1	5'-AMP-activated protein kinase subunit beta-1	Mus musculus (Mouse)	PR
Q9QZH4	Prkab2	5'-AMP-activated protein kinase subunit beta-2	Rattus norvegicus (Rat)	PR
P80386	Prkab1	5'-AMP-activated protein kinase subunit beta-1	Rattus norvegicus (Rat)	PR

10	20	30	40	50	60
MGNTSSERAA	LERHGGHKTP	RRDSSGGTKD	GDRPKILMDS	PEDADLFHSE	EIKAPEKEEF
70	80	90	100	110	120
LAWQHDLEVN	DKAPAQARPT	VFRWTGGGKE	VYLSGSFNNW	SKLPLTRSHN	NFVAILDLPE
130	140	150	160	170	180
GEHQYKFFVD	GQWTHDPSEP	IVTSQLGTVN	NIIQVKKTDF	EVFDALMVDS	QKCSDVSELS
190	200	210	220	230	240
SSPPGPYHQE	PYVCKPEERF	RAPPILPPHL	LQVILNKDTG	ISCDPALLPE	PNHVMLNHLY
250	260
ALSIKDGVMV	LSATHRYKKK	YVTTLLYKPI