AiPD: Autoinhibited Protein Database

O43741

Gene name	PRKAB2
Protein name	5'-AMP-activated protein kinase subunit beta-2
Names	AMPK subunit beta-2
Species	Homo sapiens (Human)
KEGG Pathway	hsa:5565
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-77 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-77 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

18 structures for O43741

Entry ID	Method	Resolution	Chain	Position	Source
2F15	X-ray	200 A	A	69-163	PDB
2V8Q	X-ray	210 A	B	187-272	PDB
2V92	X-ray	240 A	B	187-272	PDB
2V9J	X-ray	253 A	B	187-272	PDB
2Y8L	X-ray	250 A	B	187-272	PDB
2Y8Q	X-ray	280 A	B	187-270	PDB
2YA3	X-ray	251 A	B	187-272	PDB
4CFH	X-ray	324 A	B	187-272	PDB
4EAI	X-ray	228 A	B	189-272	PDB
4EAJ	X-ray	261 A	B	189-272	PDB
4RER	X-ray	405 A	B	76-272	PDB
4REW	X-ray	458 A	B	76-272	PDB
6B2E	X-ray	380 A	B	1-272	PDB
7JHG	EM	347 A	B	75-272	PDB
7JHH	EM	392 A	B	75-272	PDB
7JIJ	X-ray	550 A	B	75-272	PDB
7M74	EM	393 A	B	75-272	PDB
AF-O43741-F1	Predicted				AlphaFoldDB

187 variants for O43741

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
TCGA novel	2	G>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1062300 rs782609266	4	T>A		No	ClinGen ExAC gnomAD
CA342197264 rs1553914549	4	T>I		No	ClinGen gnomAD
CA342197265 rs1553914549	4	T>S		No	ClinGen gnomAD
rs1361038188 CA342197255	6	S>G		No	ClinGen TOPMed
rs782497242 CA1062299	9	V>L		No	ClinGen ExAC TOPMed gnomAD
CA342197235 rs782497242	9	V>M		No	ClinGen ExAC TOPMed gnomAD
rs1553914536 CA342197227	10	S>F		No	ClinGen gnomAD
CA342197224 rs1449590190	11	G>R		No	ClinGen TOPMed gnomAD
CA342197222 rs1449590190	11	G>W		No	ClinGen TOPMed gnomAD
rs1553914531 CA342197207	13	R>H		No	ClinGen gnomAD
rs782065025 CA1062296	16	A>T		No	ClinGen ExAC gnomAD
rs1553914527 CA342197186	16	A>V		No	ClinGen gnomAD
CA342197177 rs369329867	18	A>S		No	ClinGen ESP ExAC TOPMed
CA1062295 rs369329867	18	A>T		No	ClinGen ESP ExAC TOPMed
CA342197174 rs1553914523	18	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA342197172 rs1553914521	19	A>T		No	ClinGen gnomAD
rs1041418907 CA342197165	20	R>C		No	ClinGen gnomAD
CA29881779 rs1041418907	20	R>G		No	ClinGen gnomAD
rs782386477 CA1062291	22	E>D		No	ClinGen ExAC TOPMed gnomAD
rs782174803 CA1062290	23	G>V		No	ClinGen ExAC gnomAD
CA342197137 rs1553914516	25	G>S		No	ClinGen gnomAD
rs782333885 CA1062288	26	G>R		No	ClinGen ExAC TOPMed gnomAD
CA342197127 rs1388853518	26	G>V		No	ClinGen TOPMed gnomAD
rs1553914514 CA342197123	27	H>R		No	ClinGen gnomAD
CA342197115 rs782619139	28	A>G		No	ClinGen ExAC gnomAD
rs587635949 CA1062287	28	A>S		No	ClinGen 1000Genomes ExAC gnomAD
CA342197117 rs587635949	28	A>T		No	ClinGen 1000Genomes ExAC gnomAD
CA1062286 rs782619139	28	A>V		No	ClinGen ExAC gnomAD
CA1062285 rs782351168	29	P>L		No	ClinGen ExAC TOPMed gnomAD
CA342197111 rs782351168	29	P>Q		No	ClinGen ExAC TOPMed gnomAD
CA1062284 rs782351168	29	P>R		No	ClinGen ExAC TOPMed gnomAD
rs1553914505 CA342197112	29	P>S		No	ClinGen gnomAD
TCGA novel	30	G>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA342197088 rs1553914495	33	H>N		No	ClinGen gnomAD
rs1445188647 CA342197084	33	H>R		No	ClinGen TOPMed gnomAD
CA342197086 rs1553914495	33	H>Y		No	ClinGen gnomAD
CA342197060 rs1553914493	36	M>I		No	ClinGen gnomAD
COSM3801679 CA1062282 rs782544337	36	M>V	Variant assessed as Somatic; 0.0 impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA1062281 rs587670454	38	G>R		No	ClinGen 1000Genomes ExAC gnomAD
rs1553914490 CA342197035	39	S>N		No	ClinGen gnomAD
CA1062279 rs782482886	40	T>R		No	ClinGen ExAC gnomAD
CA342197017 rs1553914487	41	D>N		No	ClinGen gnomAD
rs1553914480 CA342197006	41	D>V		No	ClinGen gnomAD
CA1062278 rs781820097	42	D>G		No	ClinGen ExAC gnomAD
rs920476994 CA29881693	42	D>H		No	ClinGen gnomAD
rs920476994 CA342196998	42	D>N		No	ClinGen gnomAD
CA342196978 rs1553914475	43	P>L		No	ClinGen gnomAD
rs1553914475 CA342196980	43	P>R		No	ClinGen gnomAD
rs782119609 CA1062276	43	P>S		No	ClinGen ExAC TOPMed gnomAD
CA342196952 rs1553914471	45	V>E		No	ClinGen gnomAD
rs1553914469 CA342196911	48	L>F		No	ClinGen gnomAD
rs1273411499 CA342196900	49	P>A		No	ClinGen TOPMed
CA342196894 rs1437063769	49	P>R		No	ClinGen TOPMed gnomAD
CA1062272 rs781923727	50	D>G		No	ClinGen ExAC gnomAD
CA342196890 rs1553914467	50	D>N		No	ClinGen gnomAD
CA1062271 rs782363488	51	S>P		No	ClinGen ExAC gnomAD
rs1571064992 CA342195853	54	P>A		No	ClinGen Ensembl
CA342195850 rs1185974915	54	P>L		No	ClinGen TOPMed gnomAD
CA342195849 rs1185974915	54	P>R		No	ClinGen TOPMed gnomAD
CA1062251 rs79025532	55	G>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	57	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	58	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs953619284 CA29879645	58	E>A		No	ClinGen Ensembl
CA29879642 rs149699645	60	V>L		No	ClinGen ESP TOPMed
rs1194575401 CA342195792 COSM1333631	63	Q>*	large_intestine Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA TOPMed
CA342195780 rs1553913884	64	Q>R		No	ClinGen gnomAD
rs1553913883 CA342195763	66	L>F		No	ClinGen gnomAD
rs1553913881 CA342195752	68	D>H		No	ClinGen gnomAD
CA1062249 rs782714734 COSM3704933	70	V>I	liver Variant assessed as Somatic; 4.622e-05 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA342195710 rs1553913878	74	Q>R		No	ClinGen gnomAD
CA342195696 rs1553913877	76	A>S		No	ClinGen gnomAD
rs782337644 CA1062247	76	A>V		No	ClinGen ExAC gnomAD
rs782427423 CA342195692	77	R>P		No	ClinGen ExAC TOPMed gnomAD
rs782427423 CA1062244	77	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA1062245 rs781976127	77	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	80	V>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1553913875 CA342195669	81	I>S		No	ClinGen gnomAD
rs782281504 CA1062243	82	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA1062242 rs587727942 COSM1333630	82	R>H	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA526255978 rs1559612319	83	W>*		No	ClinGen Ensembl
CA342195642 rs1559612310	85	E>G		No	ClinGen Ensembl
CA342195636 rs1553913872	86	G>*		No	ClinGen gnomAD
CA342195635 rs1553913871	86	G>E		No	ClinGen gnomAD
rs1553913865 CA342195603	91	F>L		No	ClinGen Ensembl
CA342195578 rs1217293914	94	G>V		No	ClinGen TOPMed gnomAD
rs1553913863 CA342195576	95	S>A		No	ClinGen gnomAD
rs1308932871 CA342195552	98	N>S		No	ClinGen TOPMed
CA1062238 rs782522876	98	N>Y		No	ClinGen ExAC gnomAD
rs1317425942 CA342195540	99	W>C		No	ClinGen TOPMed
CA1062235 rs782455277	101	T>S		No	ClinGen ExAC gnomAD
CA29879565 rs970372018	105	L>P		No	ClinGen Ensembl
rs782261120 CA342195462	109	H>D		No	ClinGen ExAC TOPMed gnomAD
CA1062220 rs782636288	109	H>R		No	ClinGen ExAC TOPMed gnomAD
rs782261120 CA1062221	109	H>Y		No	ClinGen ExAC TOPMed gnomAD
rs990471621 CA29879318	110	N>D		No	ClinGen gnomAD
TCGA novel	113	V>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA342195416 rs182440872	115	I>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	116	L>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA29879287 rs782809042	118	L>F		No	ClinGen TOPMed
rs752565266 CA29879273	120	E>K		No	ClinGen Ensembl
CA1062217 rs782569228	122	E>Q		No	ClinGen ExAC TOPMed gnomAD
CA1062216 rs782477214	125	Y>C		No	ClinGen ExAC gnomAD
CA342195342 rs782448525	126	K>N		No	ClinGen TOPMed gnomAD
CA1062215 rs781818815	126	K>R		No	ClinGen ExAC gnomAD
rs781818815 CA342195345	126	K>T		No	ClinGen ExAC gnomAD
rs1553913770 CA342195315	130	D>G		No	ClinGen gnomAD
CA342195319 rs1553913771	130	D>N		No	ClinGen gnomAD
rs781895843 CA1062213	132	Q>P		No	ClinGen ExAC gnomAD
rs781895843 CA1062212	132	Q>R		No	ClinGen ExAC gnomAD
rs1553913768 CA342195299	133	W>R		No	ClinGen gnomAD
CA29879241 rs111520419	134	V>A		No	ClinGen Ensembl
CA342195286 rs111520419	134	V>G		No	ClinGen Ensembl
CA1062211 rs782790004	136	D>G		No	ClinGen ExAC gnomAD
rs782075104 CA1062210	137	P>S		No	ClinGen ExAC gnomAD
CA342195170 rs1366648133	140	P>S		No	ClinGen TOPMed
CA1062195 rs782236292	143	T>A		No	ClinGen ExAC TOPMed gnomAD
CA342195102 rs782522047	145	Q>H		No	ClinGen ExAC gnomAD
CA342195111 rs1559611527	145	Q>P		No	ClinGen Ensembl
TCGA novel	145	Q>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1062192 rs781814045	148	T>I		No	ClinGen ExAC gnomAD
TCGA novel	151	N>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1062191 rs782750105	151	N>H		No	ClinGen ExAC TOPMed gnomAD
CA1062190 rs782491363	152	L>F		No	ClinGen ExAC gnomAD
CA1062189 rs34137344	155	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs776140258 CA29879108	161	E>K		No	ClinGen Ensembl
CA1062187 rs782517115	163	F>L		No	ClinGen ExAC gnomAD
rs1266369550 CA342194918	164	D>E		No	ClinGen TOPMed
CA1062185 rs782809221	167	K>R		No	ClinGen ExAC TOPMed gnomAD
CA342194880 rs1553913722	168	L>S		No	ClinGen gnomAD
rs782045932 CA1062184	170	S>F		No	ClinGen ExAC gnomAD
CA342194792 rs1222679915	174	S>F		No	ClinGen TOPMed
CA342194737 rs1553913719	178	C>F		No	ClinGen gnomAD
rs1553913719 CA342194740	178	C>Y		No	ClinGen gnomAD
CA1062183 COSM1221992 rs781971645	179	R>G	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA1062167 rs368553229	183	S>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA342193924 rs368553229	183	S>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs1553913213 CA342193908	184	S>L		No	ClinGen Ensembl
CA342193903 rs1553913212	185	P>T		No	ClinGen gnomAD
TCGA novel	186	P>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs142003739 CA1062166	186	P>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA342193898 rs1553913206	186	P>T		No	ClinGen gnomAD
rs1553913204 CA342193882	187	G>V		No	ClinGen gnomAD
CA29877553 rs901551927	188	P>L		No	ClinGen Ensembl
CA342193868 rs1317018433	188	P>S		No	ClinGen TOPMed
CA342193813 rs1553913202	191	Q>E		No	ClinGen gnomAD
CA1062165 rs781869751 COSM1320026	193	M>I	ovary Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA342193766 rs1341011127	193	M>T		No	ClinGen TOPMed
CA342193739 rs1553913197	194	Y>C		No	ClinGen gnomAD
rs1553913199 CA342193753	194	Y>D		No	ClinGen gnomAD
rs587771645 CA1062164 COSM1333629	195	A>V	pancreas large_intestine [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD
rs782092808 CA29877536	197	R>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
CA1062162 rs149396746	197	R>L		No	ClinGen ESP ExAC gnomAD
CA1062161 rs149396746	197	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA gnomAD
rs1341715440 CA342193656	198	S>P		No	ClinGen TOPMed
rs782054210 CA1062160	198	S>Y		No	ClinGen ExAC gnomAD
rs781985939 CA1062156	201	R>K		No	ClinGen ExAC gnomAD
TCGA novel	203	K>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs782423302 CA1062155	205	P>L		No	ClinGen ExAC TOPMed
rs1553913195 CA342193414	210	P>H		No	ClinGen gnomAD
TCGA novel	210	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA29877483 rs1048051	211	H>Y		No	ClinGen Ensembl
rs1456686975 CA342193363	213	L>F		No	ClinGen TOPMed
rs782280646 CA1062154	218	N>S		No	ClinGen ExAC gnomAD
CA1062153 rs782578573	221	T>I		No	ClinGen ExAC gnomAD
TCGA novel	230	L>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1062128 rs782668351	235	H>Q		No	ClinGen ExAC gnomAD
CA1062129 rs200135639	235	H>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1553913101 CA342192835	238	L>P		No	ClinGen gnomAD
rs1010644738 CA29877061 COSM1600720	240	H>L	liver [Cosmic]	No	ClinGen cosmic curated Ensembl
rs1415435693 CA342192809	242	Y>C		No	ClinGen TOPMed
CA342192746 rs1158596181	249	S>T		No	ClinGen TOPMed
CA342192729 rs1553912847	251	M>I		No	ClinGen gnomAD
rs1559607209 CA342192735	251	M>V		No	ClinGen Ensembl
rs1553912845 CA342192715	254	S>G		No	ClinGen gnomAD
CA1062091 rs782046955 COSM3934070	255	A>T	Variant assessed as Somatic; 0.0 impact. oesophagus [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs1166173385 CA342192692	257	H>R		No	ClinGen TOPMed gnomAD
CA342192683 rs1394360718	258	R>C		No	ClinGen TOPMed gnomAD
CA342192680 rs1553912834	258	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1553912831 CA342192664	259	Y>C		No	ClinGen gnomAD
rs1553912833 CA342192673	259	Y>H		No	ClinGen gnomAD
rs1439387336 CA342192626	261	K>R		No	ClinGen TOPMed gnomAD
CA342192609 rs1553912830	262	K>R		No	ClinGen gnomAD
CA1062088 rs782734240	266	T>A		No	ClinGen ExAC TOPMed gnomAD
rs1571051182 CA342192507	269	Y>*		No	ClinGen Ensembl
TCGA novel	271	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA342192472 rs1333692181	272	I>T		No	ClinGen TOPMed

No associated diseases with O43741

2 regional properties for O43741

Type	Name	Position	InterPro Accession
domain	Association with the SNF1 complex (ASC) domain	182 - 272	IPR006828
domain	AMP-activated protein kinase, glycogen-binding domain	78 - 161	IPR032640

Functions

		Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

5 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleotide-activated protein kinase complex	A protein complex that possesses nucleotide-dependent protein kinase activity. The nucleotide can be AMP (in S. pombe and human) or ADP (in S. cerevisiae).
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

1 GO annotations of molecular function

Name	Definition
protein kinase binding	Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.

5 GO annotations of biological process

Name	Definition
cellular response to nutrient levels	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients.
fatty acid biosynthetic process	The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes.
positive regulation of cold-induced thermogenesis	Any process that activates or increases the frequency, rate or extent of cold-induced thermogenesis.
regulation of catalytic activity	Any process that modulates the activity of an enzyme.
signal transduction	The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

6 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q5BIS9	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	Bos taurus (Bovine)	PR
Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	Homo sapiens (Human)	PR
Q9R078	Prkab1	5'-AMP-activated protein kinase subunit beta-1	Mus musculus (Mouse)	PR
Q6PAM0	Prkab2	5'-AMP-activated protein kinase subunit beta-2	Mus musculus (Mouse)	PR
P80386	Prkab1	5'-AMP-activated protein kinase subunit beta-1	Rattus norvegicus (Rat)	PR
Q9QZH4	Prkab2	5'-AMP-activated protein kinase subunit beta-2	Rattus norvegicus (Rat)	PR

10	20	30	40	50	60
MGNTTSDRVS	GERHGAKAAR	SEGAGGHAPG	KEHKIMVGST	DDPSVFSLPD	SKLPGDKEFV
70	80	90	100	110	120
SWQQDLEDSV	KPTQQARPTV	IRWSEGGKEV	FISGSFNNWS	TKIPLIKSHN	DFVAILDLPE
130	140	150	160	170	180
GEHQYKFFVD	GQWVHDPSEP	VVTSQLGTIN	NLIHVKKSDF	EVFDALKLDS	MESSETSCRD
190	200	210	220	230	240
LSSSPPGPYG	QEMYAFRSEE	RFKSPPILPP	HLLQVILNKD	TNISCDPALL	PEPNHVMLNH
250	260	270
LYALSIKDSV	MVLSATHRYK	KKYVTTLLYK	PI