P80386
PR
Gene name |
Prkab1 |
Protein name |
5'-AMP-activated protein kinase subunit beta-1 |
Names |
AMPK subunit beta-1, AMPKb, 5'-AMP-activated protein kinase 40 kDa subunit |
Species |
Rattus norvegicus (Rat) |
KEGG Pathway |
rno:83803 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
16 structures for P80386
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 1Z0M | X-ray | 191 A | A/B/C | 68-163 | PDB |
| 1Z0N | X-ray | 149 A | A/B/C | 68-163 | PDB |
| 4EAG | X-ray | 270 A | B | 187-270 | PDB |
| 4EAK | X-ray | 250 A | B | 200-270 | PDB |
| 4EAL | X-ray | 251 A | B | 200-270 | PDB |
| 4QFG | X-ray | 346 A | B | 68-270 | PDB |
| 4QFR | X-ray | 334 A | B | 68-270 | PDB |
| 4QFS | X-ray | 355 A | B | 68-270 | PDB |
| 4YEF | X-ray | 172 A | A/B/C/D/E/F/G | 76-156 | PDB |
| 5KQ5 | X-ray | 341 A | B | 68-270 | PDB |
| 5T5T | X-ray | 346 A | B | 68-270 | PDB |
| 5UFU | X-ray | 345 A | B | 67-270 | PDB |
| 6E4T | X-ray | 340 A | B | 67-270 | PDB |
| 6E4U | X-ray | 327 A | B | 67-270 | PDB |
| 6E4W | X-ray | 335 A | B | 67-270 | PDB |
| AF-P80386-F1 | Predicted | AlphaFoldDB |
1 variants for P80386
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs8154950 | 26 | G>E | No | EVA |
No associated diseases with P80386
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| nucleotide-activated protein kinase complex | A protein complex that possesses nucleotide-dependent protein kinase activity. The nucleotide can be AMP (in S. pombe and human) or ADP (in S. cerevisiae). |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| protein-containing complex | A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| protein kinase activity | Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. |
| protein kinase binding | Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate. |
8 GO annotations of biological process
| Name | Definition |
|---|---|
| cellular response to nutrient levels | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients. |
| fatty acid biosynthetic process | The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. |
| nail development | The process whose specific outcome is the progression of a nail over time, from its formation to the mature structure. A nail is a horn-like envelope covering the outer end of a finger or toe, and consists of the nail plate, the nail matrix and the nail bed below it, and the grooves surrounding it. [GOC:bf, ISBN:0323025781, UBERON:0001705, Wikipedia:Nail_(anatomy)] |
| positive regulation of cold-induced thermogenesis | Any process that activates or increases the frequency, rate or extent of cold-induced thermogenesis. |
| positive regulation of gene expression | Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). |
| protein phosphorylation | The process of introducing a phosphate group on to a protein. |
| regulation of catalytic activity | Any process that modulates the activity of an enzyme. |
| signal transduction | The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. |
6 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q5BIS9 | PRKAB1 | 5'-AMP-activated protein kinase subunit beta-1 | Bos taurus (Bovine) | PR |
| O43741 | PRKAB2 | 5'-AMP-activated protein kinase subunit beta-2 | Homo sapiens (Human) | PR |
| Q9Y478 | PRKAB1 | 5'-AMP-activated protein kinase subunit beta-1 | Homo sapiens (Human) | PR |
| Q6PAM0 | Prkab2 | 5'-AMP-activated protein kinase subunit beta-2 | Mus musculus (Mouse) | PR |
| Q9R078 | Prkab1 | 5'-AMP-activated protein kinase subunit beta-1 | Mus musculus (Mouse) | PR |
| Q9QZH4 | Prkab2 | 5'-AMP-activated protein kinase subunit beta-2 | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGNTSSERAA | LERQAGHKTP | RRDSSGGTKD | GDRPKILMDS | PEDADIFHTE | EMKAPEKEEF |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LAWQHDLEVN | EKAPAQARPT | VFRWTGGGKE | VYLSGSFNNW | SKLPLTRSQN | NFVAILDLPE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| GEHQYKFFVD | GQWTHDPSEP | IVTSQLGTVN | NIIQVKKTDF | EVFDALMVDS | QKCSDVSELS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SSPPGPYHQE | PYISKPEERF | KAPPILPPHL | LQVILNKDTG | ISCDPALLPE | PNHVMLNHLY |
| 250 | 260 | ||||
| ALSIKDGVMV | LSATHRYKKK | YVTTLLYKPI |