Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

Autoinhibited structure

Activated structure

1 structures for Q9XVS7

Entry ID Method Resolution Chain Position Source
AF-Q9XVS7-F1 Predicted AlphaFoldDB

No variants for Q9XVS7

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9XVS7

No associated diseases with Q9XVS7

3 regional properties for Q9XVS7

Type Name Position InterPro Accession
domain TAP C-terminal (TAP-C) domain 568 - 628 IPR005637
domain Nuclear RNA export factor Tap, RNA-binding domain 108 - 179 IPR015245
domain Nuclear transport factor 2, eukaryote 365 - 526 IPR018222

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
  • Shuttle protein that accumulates in the nucleoplasm and at the nuclear rim
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

6 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nuclear envelope The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).
nuclear pore A protein complex providing a discrete opening in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined.
nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

1 GO annotations of molecular function

Name Definition
RNA binding Binding to an RNA molecule or a portion thereof.

1 GO annotations of biological process

Name Definition
poly(A)+ mRNA export from nucleus The directed movement of poly(A)+ mRNA out of the nucleus into the cytoplasm.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q1RMS5 NXF1 Nuclear RNA export factor 1 Bos taurus (Bovine) PR
Q9UBU9 NXF1 Nuclear RNA export factor 1 Homo sapiens (Human) PR
Q99JX7 Nxf1 Nuclear RNA export factor 1 Mus musculus (Mouse) PR
10 20 30 40 50 60
MERDGCFGNC WLRRWEKSDM NRKGFGGHRD AKQLSRTKNR FARLDPDTQS RYEDDDEPAV
70 80 90 100 110 120
PVRASLTSAS SRGRGGSSRG FGQSAASIAN TGVRNADIVY KCRATGAAKK VDAKWLIKQL
130 140 150 160 170 180
NQIIENFKPL LWTDNARGDF EWYVRDEDTA STIRANNRRV VHKESGTRVE FYTSKVPAPW
190 200 210 220 230 240
MKLKREEIEI IHRVVDKRHN AENRVLDLSN FHEDEEFKAK DMMMNLTKGN VMLTVLDHID
250 260 270 280 290 300
DKYGNIVALS LSNNRIRHLD YASALVSIAK FVMELDLSHN HISTEKELEK FAGLPVERFF
310 320 330 340 350 360
FEGNPVVESF TQRAAYISYI HQSFPRCNML DGVEVQPLVV GPDLDIHDAM PFRAGYYPNP
370 380 390 400 410 420
QIRVLVEQFV TSYFDFYDGP DGQRTRRNLH NAYDADASTF SLTIEHLRGS SHARHHNDEC
430 440 450 460 470 480
FAQYAGVSHN VLKQERFARH RASRSARGAM DIAVALSKLP TSSHMRDTFI VDVFLQSNDL
490 500 510 520 530 540
LGFTVQGLFC DGDLTQTPSP SFFSRSFLVS PRENDSVAVI SDQLFITVAS LDRLEKFKKL
550 560 570 580 590 600
YDQSIANGAA VEQVSAVQIA QIGVNGMGFD GAPALPIREE MIKAMCQFSG MIPPFSEKCL
610 620
ADCAWNFDFA CQKFNEIKSS VPAEAFAH