Q99JX7
PR
Gene name |
Nxf1 (Tap) |
Protein name |
Nuclear RNA export factor 1 |
Names |
Tip-associated protein, Tip-associating protein, mRNA export factor TAP |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:53319 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q99JX7
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q99JX7-F1 | Predicted | AlphaFoldDB |
38 variants for Q99JX7
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389535847 | 19 | Q>* | No | EVA | |
| rs3389527900 | 41 | R>I | No | EVA | |
| rs3389527926 | 42 | G>A | No | EVA | |
| rs3389533546 | 43 | G>S | No | EVA | |
| rs3389522106 | 45 | G>D | No | EVA | |
| rs215083738 | 48 | S>P | No | EVA | |
| rs3389516783 | 63 | P>S | No | EVA | |
| rs3389525477 | 64 | Q>K | No | EVA | |
| rs261280310 | 102 | A>P | No | EVA | |
| rs3389525503 | 103 | E>V | No | EVA | |
| rs3389503730 | 106 | G>R | No | EVA | |
| rs3389525548 | 147 | N>S | No | EVA | |
| rs3389516741 | 152 | H>R | No | EVA | |
| rs3389481498 | 167 | T>N | No | EVA | |
| rs3389489830 | 173 | G>A | No | EVA | |
| rs3389527921 | 207 | Q>* | No | EVA | |
| rs3389481554 | 211 | L>F | No | EVA | |
| rs260534646 | 271 | L>M | No | EVA | |
| rs3389525554 | 282 | M>L | No | EVA | |
| rs3389503701 | 335 | S>C | No | EVA | |
| rs3389517269 | 349 | R>H | No | EVA | |
| rs3389481513 | 359 | I>F | No | EVA | |
| rs3389481516 | 363 | V>I | No | EVA | |
| rs3389503694 | 368 | M>L | No | EVA | |
| rs3389517771 | 372 | C>R | No | EVA | |
| rs3389481555 | 409 | Y>F | No | EVA | |
| rs3389431184 | 412 | G>S | No | EVA | |
| rs3389517711 | 422 | N>I | No | EVA | |
| rs265928198 | 426 | P>S | No | EVA | |
| rs3389503685 | 447 | P>A | No | EVA | |
| rs3389516768 | 487 | S>N | No | EVA | |
| rs3389489808 | 489 | L>I | No | EVA | |
| rs3389524262 | 497 | V>L | No | EVA | |
| rs3389523261 | 512 | F>Y | No | EVA | |
| rs3389516794 | 552 | P>R | No | EVA | |
| rs3389527884 | 562 | L>P | No | EVA | |
| rs3389516733 | 576 | Q>P | No | EVA | |
| rs246218030 | 610 | E>G | No | EVA |
No associated diseases with Q99JX7
6 regional properties for Q99JX7
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| repeat | Leucine-rich repeat | 265 - 286 | IPR001611-1 |
| repeat | Leucine-rich repeat | 291 - 312 | IPR001611-2 |
| domain | Nuclear transport factor 2 domain | 386 - 534 | IPR002075 |
| domain | TAP C-terminal (TAP-C) domain | 555 - 618 | IPR005637 |
| domain | Nuclear RNA export factor Tap, RNA-binding domain | 118 - 197 | IPR015245 |
| domain | Nuclear transport factor 2, eukaryote | 381 - 537 | IPR018222 |
Functions
9 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytoplasmic stress granule | A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress. |
| nuclear inclusion body | An intranuclear focus at which aggregated proteins have been sequestered. |
| nuclear pore | A protein complex providing a discrete opening in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined. |
| nuclear RNA export factor complex | A protein complex that contains two proteins (know in several organisms, including Drosophila, as NXF1 and NXF2) and is required for the export of the majority of mRNAs from the nucleus to the cytoplasm; localized in the nucleoplasm and at both the nucleoplasmic and cytoplasmic faces of the nuclear pore complex; shuttles between the nucleus and the cytoplasm. |
| nuclear speck | A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| transcription export complex | The transcription export (TREX) complex couples transcription elongation by RNA polymerase II to mRNA export. The complex associates with the polymerase and travels with it along the length of the transcribed gene. TREX is composed of the THO transcription elongation complex as well as other proteins that couple THO to mRNA export proteins. The TREX complex is known to be found in a wide range of eukaryotes, including S. cerevisiae and metazoans. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| mRNA binding | Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns. |
| RNA binding | Binding to an RNA molecule or a portion thereof. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| mRNA export from nucleus | The directed movement of mRNA from the nucleus to the cytoplasm. |
| poly(A)+ mRNA export from nucleus | The directed movement of poly(A)+ mRNA out of the nucleus into the cytoplasm. |
| protein transport | The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| RNA export from nucleus | The directed movement of RNA from the nucleus to the cytoplasm. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MADEGKSYNE | HDDRVSFPQR | RKKGRGPFRW | KCGEGNRRSG | RGGSGVQSSR | FEEDDGDVAM |
| 70 | 80 | 90 | 100 | 110 | 120 |
| NDPQDGPRVR | YNPYTNRPNR | RGDGWHDRDR | IHITVRRDRA | PAERGGAGTS | QDGTTKNWFK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ITIPYGRKYD | KTWLLSMIQS | KCSVPFNPIE | FHYENTRAHF | FVEDATTASA | LKGVNHKIQD |
| 190 | 200 | 210 | 220 | 230 | 240 |
| RENRRISIII | NASAPPYTVQ | NELKPEQIEQ | LKLIMSKRYD | GNQQALDLKG | LRSDPDLVAQ |
| 250 | 260 | 270 | 280 | 290 | 300 |
| NIDVVLNRRS | CMAATLRIIE | ENIPELLSLN | LSSNRLYKLD | DMSSIVQKAP | NLKTLNLSGN |
| 310 | 320 | 330 | 340 | 350 | 360 |
| ELKTERELDK | IKGLKLEELW | LDRNPMCDNF | GDQSSYISAI | RERFPKLLRL | DGHELPPPIS |
| 370 | 380 | 390 | 400 | 410 | 420 |
| FDVEAPTMLP | PCKGSYFGTE | NLKSLVLRFL | QQYYVIYDSG | DRQGLLYAYH | DGACCSLSIP |
| 430 | 440 | 450 | 460 | 470 | 480 |
| YNPQNPVRKN | LAEYVKDSRN | VKKLKEPTQR | FRLLKHTRLN | VVAFLNELPK | TQHDVNAFVV |
| 490 | 500 | 510 | 520 | 530 | 540 |
| DISAQTSTLL | CFSVNGVFKE | VDGKSRDSLR | AFTRTFIAVP | ASNSGLCIVN | DELFVRNASP |
| 550 | 560 | 570 | 580 | 590 | 600 |
| EEIQRAFAMS | APTPSSSPVP | TLSPEQQEML | QAFSTQSGMN | LEWSQKCLQD | NNWDYTRSAQ |
| 610 | |||||
| AFTLLKAKGE | IPEVAFMK |