Q1RMS5

PR
Gene name
NXF1
Protein name
Nuclear RNA export factor 1
Names
Species
Bos taurus (Bovine)
KEGG Pathway
bta:512136
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-66 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q1RMS5

Entry ID Method Resolution Chain Position Source
AF-Q1RMS5-F1 Predicted AlphaFoldDB

119 variants for Q1RMS5

Variant ID(s) Position Change Description Diseaes Association Provenance
rs483217151 2 A>V No EVA
rs446045268 3 D>E No EVA
rs464543867 3 D>Y No EVA
rs478140430 8 Y>S No EVA
rs447502663 9 N>K No EVA
rs459444752 9 N>S No EVA
rs454747844 10 E>D No EVA
rs469147320 17 F>L No EVA
rs450509996 21 R>T No EVA
rs464947272 27 P>A No EVA
rs449434778 30 W>G No EVA
rs463819270 34 E>G No EVA
rs471773853 36 N>K No EVA
rs438905313 36 N>T No EVA
rs459772527 37 R>Q No EVA
rs440308448 38 R>M No EVA
rs473338301 38 R>S No EVA
rs454716797 39 S>A No EVA
rs436152399 39 S>F No EVA
rs475612339 40 G>* No EVA
rs432081322 41 R>I No EVA
rs464781731 42 G>A No EVA
rs452819055 43 G>V No EVA
rs467866771 45 S>R No EVA
rs470386811 47 R>Q No EVA
rs482442694 47 R>W No EVA
rs459733920 51 L>P No EVA
rs441285535 52 E>G No EVA
rs480626569 53 D>G No EVA
rs461199961 55 D>A No EVA
rs475611675 59 A>G No EVA
rs457111442 61 S>G No EVA
rs457111442 61 S>R No EVA
rs438463266 61 S>R No EVA
rs452897319 62 D>E No EVA
rs471358449 62 D>G No EVA
rs467222868 64 Q>E No EVA
rs455979922 65 D>E No EVA
rs437516770 66 A>V No EVA
rs466228383 69 V>G No EVA
rs480587752 71 Y>N No EVA
rs464578806 72 T>P No EVA
rs445081808 73 P>S No EVA
rs477934461 75 A>P No EVA
rs459379092 78 P>L No EVA
rs443338332 84 N>D No EVA
rs476172509 84 N>S No EVA
rs457778245 89 T>A No EVA
rs454312225 92 H>Q No EVA
rs438123433 98 R>P No EVA
rs464501506 102 S>A No EVA
rs453206756 105 E>K No EVA
rs447498376 109 A>G No EVA
rs465859001 109 A>P No EVA
rs468414964 111 T>S No EVA
rs449689152 113 Q>* No EVA
rs482800804 113 Q>H No EVA
rs457728191 114 D>Y No EVA
rs439499342 115 G>R No EVA
rs478614817 120 W>R No EVA
rs460815350 121 F>I No EVA
rs475192968 124 T>A No EVA
rs468964674 130 K>E No EVA
rs451166945 130 K>R No EVA
rs477536143 131 Y>D No EVA
rs447045755 132 D>A No EVA
rs479827609 134 S>* No EVA
rs442920275 139 V>G No EVA
rs461406236 139 V>M No EVA
rs482236386 140 I>N No EVA
rs463745378 141 Q>H No EVA
rs444343288 142 S>R No EVA
rs452431661 144 C>F No EVA
rs470922656 144 C>G No EVA
rs440182032 144 C>W No EVA
rs473204753 145 S>T No EVA
rs454575395 146 V>G No EVA
rs436122476 147 P>T No EVA
rs468982094 149 T>I No EVA
rs478199540 165 E>A No EVA
rs458800707 166 D>G No EVA
rs455902990 175 A>D No EVA
rs435767780 177 N>D No EVA
rs440347357 179 K>R No EVA
rs473213814 180 I>M No EVA
rs454673070 184 E>D No EVA
rs442505171 185 N>D No EVA
rs471195212 232 G>S No EVA
rs452835544 232 G>V No EVA
rs521795410 276 N>S No EVA
rs447632213 286 S>R No EVA
rs378781167 325 G>R No EVA
rs471350349 339 I>S No EVA
rs479803478 395 Y>H No EVA
rs448959750 396 Y>* No EVA
rs467394477 396 Y>H No EVA
rs481830935 401 S>A No EVA
rs719943407 406 R>Q No EVA
rs463259723 407 L>P No EVA
rs438478827 408 L>Q No EVA
rs477833366 411 Y>S No EVA
rs459393134 417 C>W No EVA
rs441479436 420 S>G No EVA
rs474479201 420 S>R No EVA
rs456032512 422 P>S No EVA
rs467458280 462 N>K No EVA
rs449120533 475 H>Q No EVA
rs469835547 497 N>S No EVA
rs468224514 509 D>A No EVA
rs468224514 509 D>G No EVA
rs208493690 515 T>S No EVA
rs437558527 517 T>A No EVA
rs384900272 519 V>I No EVA
rs450895545 550 A>G No EVA
rs477594341 551 M>L No EVA
rs460402140 556 P>T No EVA
rs441977087 558 S>P No EVA
rs474780960 563 T>P No EVA
rs462797412 582 N>H No EVA

No associated diseases with Q1RMS5

6 regional properties for Q1RMS5

Type Name Position InterPro Accession
repeat Leucine-rich repeat 267 - 288 IPR001611-1
repeat Leucine-rich repeat 293 - 314 IPR001611-2
domain Nuclear transport factor 2 domain 388 - 536 IPR002075
domain TAP C-terminal (TAP-C) domain 557 - 620 IPR005637
domain Nuclear RNA export factor Tap, RNA-binding domain 120 - 199 IPR015245
domain Nuclear transport factor 2, eukaryote 383 - 539 IPR018222

Functions

Description
EC Number
Subcellular Localization
  • Nucleus, nucleoplasm
  • Nucleus speckle
  • Cytoplasm
  • Nucleus
  • Localized predominantly in the nucleoplasm and at both the nucleoplasmic and cytoplasmic faces of the nuclear pore complex
  • Shuttles between the nucleus and the cytoplasm
  • Travels to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA
  • The association with the TREX complex seems to occur in regions surrounding nuclear speckles known as perispeckles
  • Nucleus; nuclear rim
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nuclear speck A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

1 GO annotations of molecular function

Name Definition
RNA binding Binding to an RNA molecule or a portion thereof.

2 GO annotations of biological process

Name Definition
mRNA export from nucleus The directed movement of mRNA from the nucleus to the cytoplasm.
poly(A)+ mRNA export from nucleus The directed movement of poly(A)+ mRNA out of the nucleus into the cytoplasm.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9UBU9 NXF1 Nuclear RNA export factor 1 Homo sapiens (Human) PR
Q99JX7 Nxf1 Nuclear RNA export factor 1 Mus musculus (Mouse) PR
Q9XVS7 nxf-1 Nuclear RNA export factor 1 Caenorhabditis elegans PR
10 20 30 40 50 60
MADEGKSYNE HDDRVSFPQR RKKGRGPFRW KSGEGNRRSG RGGSSVRSSR LEDDDRDVAM
70 80 90 100 110 120
SDVQDAPRVR YTPYAARPNR RGDNWNERTR IHVTLPLRRD RSAAERGGAG TSQDGTSKNW
130 140 150 160 170 180
FKITIPYGRK YDKSWLLNVI QSKCSVPFTP IEFHYENTRA QFFVEDASTA SALKAVNYKI
190 200 210 220 230 240
LDRENRRISI IINSSSPPHS VQNELKPEQV EQLKLIMSKR YDGSQQALDL KGLRSDPDLV
250 260 270 280 290 300
AQNIDVVLNR RSCMAATLRI IEENIPELLS LNLSNNKLYR LDDLSSIVQK APNLKILNLS
310 320 330 340 350 360
GNELKSEREL DKIKGLKLEE LWLDGNTLCD TFRDQSTYIS AVRERFPKLL RLDGHELPPP
370 380 390 400 410 420
IAFDVEAPTT LPPCKGSYFG TETLKNLVLH FLQQYYAVYD SGDRQRLLDA YHDGACCSLS
430 440 450 460 470 480
IPFTPQNPAR SNLAEYFKDS RNVKKLKDPT LRFRLLKHTR LNVVAFLNEL PKTQHDINSF
490 500 510 520 530 540
VVDISAQTST LLCFSVNGVF KEVDGKSRDS LRAFTRTFVA VPASNSGLCI VNDELFVRNA
550 560 570 580 590 600
SADEIQRAFA MPAPTPSSSP VPTLSPEQQE MLQAFSTQSG MNLEWSQKCL QDNNWDYTRS
610
AQAFTHLKAK GEIPEVAFMK