Q9XGR4
Gene name |
B''ALPHA (At5g44090, MLN1.1) |
Protein name |
Serine/threonine protein phosphatase 2A regulatory subunit B''alpha |
Names |
AtB''alpha, PP2A, B'' subunit, alpha isoform |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT5G44090 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9XGR4
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9XGR4-F1 | Predicted | AlphaFoldDB |
31 variants for Q9XGR4
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| tmp_5_17747900_C_T | 4 | D>N | No | 1000Genomes | |
| ENSVATH00704270 | 26 | S>A | No | 1000Genomes | |
| ENSVATH03345435 | 71 | T>S | No | 1000Genomes | |
| ENSVATH00704262 | 105 | S>L | No | 1000Genomes | |
| tmp_5_17747082_T_A | 107 | Q>L | No | 1000Genomes | |
| tmp_5_17747039_C_G | 121 | R>S | No | 1000Genomes | |
| ENSVATH07327399 | 125 | R>H | No | 1000Genomes | |
| ENSVATH14584246 | 134 | Q>K | No | 1000Genomes | |
| tmp_5_17746618_C_T | 145 | E>K | No | 1000Genomes | |
| tmp_5_17746614_T_A | 146 | Q>L | No | 1000Genomes | |
| tmp_5_17746602_A_C | 150 | M>R | No | 1000Genomes | |
| ENSVATH07327389 | 154 | F>L | No | 1000Genomes | |
| ENSVATH07327388 | 155 | F>V | No | 1000Genomes | |
| tmp_5_17746578_T_A | 158 | Y>F | No | 1000Genomes | |
| tmp_5_17746572_T_C | 160 | D>G | No | 1000Genomes | |
| tmp_5_17746378_T_C | 191 | T>A | No | 1000Genomes | |
| tmp_5_17746377_G_A | 191 | T>M | No | 1000Genomes | |
| tmp_5_17746368_G_A | 194 | T>I | No | 1000Genomes | |
| tmp_5_17745870_G_T | 210 | H>N | No | 1000Genomes | |
| ENSVATH14584221 | 224 | L>F | No | 1000Genomes | |
| tmp_5_17745205_T_C | 275 | Y>C | No | 1000Genomes | |
| tmp_5_17745143_T_A | 296 | T>S | No | 1000Genomes | |
| ENSVATH00704250 | 300 | Q>K | No | 1000Genomes | |
| ENSVATH12486487 | 303 | E>G | No | 1000Genomes | |
| ENSVATH14584217 | 397 | Y>F | No | 1000Genomes | |
| tmp_5_17743992_G_T | 399 | F>L | No | 1000Genomes | |
| tmp_5_17743966_C_A | 408 | G>V | No | 1000Genomes | |
| ENSVATH07327345 | 448 | K>N | No | 1000Genomes | |
| ENSVATH00704240 | 498 | T>R | No | 1000Genomes | |
| tmp_5_17743316_A_T,G | 522 | V>A | No | 1000Genomes | |
| tmp_5_17743316_A_T,G | 522 | V>D | No | 1000Genomes |
No associated diseases with Q9XGR4
4 regional properties for Q9XGR4
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | EF-hand domain | 177 - 208 | IPR002048-1 |
| domain | EF-hand domain | 319 - 425 | IPR002048-2 |
| binding_site | EF-Hand 1, calcium-binding site | 403 - 415 | IPR018247 |
| domain | PP2A regulatory subunit B'', EF-hand domain | 215 - 304 | IPR041534 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
| protein phosphatase type 2A complex | A protein complex that has protein serine/threonine phosphatase activity that is polycation-stimulated (PCS), being directly stimulated by protamine, polylysine, or histone H1; it constitutes a subclass of several enzymes activated by different histones and polylysine, and consists of catalytic, scaffolding, and regulatory subunits. The catalytic and scaffolding subunits form the core enzyme, and the holoenzyme also includes the regulatory subunit. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| calcium ion binding | Binding to a calcium ion (Ca2+). |
| protein phosphatase regulator activity | Binds to and modulates the activity of a protein phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a protein substrate molecule. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| protein dephosphorylation | The process of removing one or more phosphoric residues from a protein. |
3 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9SLI8 | B''DELTA | Probable serine/threonine protein phosphatase 2A regulatory subunit B''delta | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q84JI6 | B''EPSILON | Probable serine/threonine protein phosphatase 2A regulatory subunit B''epsilon | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q803V3 | ppp2r3c | Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEIDGGNDVQ | ILDPELLQLP | GLSPVSLKEN | PHIAEELFSQ | WLSLPETGRL | VKSLIDDTKS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| STPVSVSKNC | TSLNVACGSA | LPSVFLNSGT | PPLSPRGSPG | SPRFSRQKTS | PSLQSPLKSV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| REPKRQLIPQ | FYFQHGRPPA | KELREQCISM | VDQFFSNYID | GLHMDEFKSI | TKEVCKLPSF |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LSSVLFRKID | TSGTGIVTRD | AFIKYWVDGH | MLAMDVASQI | YNILRQPGCK | YLRQADFKPV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LDELLTTHPG | LEFLRNTPEF | QERYAETVIY | RIFYYINRSG | TGCITLRELK | RGNLITAMQQ |
| 310 | 320 | 330 | 340 | 350 | 360 |
| VDEEDDINKV | IRYFSYEHFY | VIYCRFWELD | GDHDFLIDKE | NLIKYGNHAL | TYRIVDRIFS |
| 370 | 380 | 390 | 400 | 410 | 420 |
| QVPRKFTSKV | EGKMSYEDFA | YFILAEEDKS | SEPSLEYWFK | CIDLDGDGVI | TPNEMQFFYE |
| 430 | 440 | 450 | 460 | 470 | 480 |
| EQLHRMECIT | QEPVLFEDIL | CQIFDMIKPE | KENCITLQDL | KASKLSGNIF | NILFNLNKFM |
| 490 | 500 | 510 | 520 | 530 | |
| AFETRDPFLI | RQERENPTLT | EWDRFAQREY | VRLSMEEDVE | EVSNGSADVW | DEPLESPF |