Q9WVA4

PR
Gene name
Tagln2 (Kiaa0120)
Protein name
Transgelin-2
Names
SM22-beta
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:21346
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

142-199 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9WVA4

Entry ID Method Resolution Chain Position Source
AF-Q9WVA4-F1 Predicted AlphaFoldDB

7 variants for Q9WVA4

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3388517751 40 E>K No EVA
rs227566539 54 K>N No EVA
rs3388513158 75 A>V No EVA
rs230659896 82 A>S No EVA
rs245717543 84 S>L No EVA
rs3388515247 123 A>T No EVA
rs3388517380 194 M>I No EVA

No associated diseases with Q9WVA4

2 regional properties for Q9WVA4

Type Name Position InterPro Accession
repeat Calponin repeat 174 - 199 IPR000557
domain Calponin homology domain 24 - 136 IPR001715

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoskeleton A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

1 GO annotations of biological process

Name Definition
epithelial cell differentiation The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q01995 TAGLN Transgelin Homo sapiens (Human) PR
P37804 Tagln Transgelin Mus musculus (Mouse) PR
P31232 Tagln Transgelin Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MANRGPSYGL SREVQQKIEK QYDADLEQIL IQWITTQCRE DVGQPQPGRE NFQKWLKDGT
70 80 90 100 110 120
VLCKLINSLY PEGQAPVKKI QASSMAFKQM EQISQFLQAA ERYGINTTDI FQTVDLWEGK
130 140 150 160 170 180
NMACVQRTLM NLGGLAVARD DGLFSGDPNW FPKKSKENPR NFSDNQLQEG KNVIGLQMGT
190
NRGASQAGMT GYGMPRQIL