P37804

PR
Gene name
Tagln (Sm22, Sm22a)
Protein name
Transgelin
Names
Actin-associated protein p27, Smooth muscle protein 22-alpha, SM22-alpha
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:21345
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-51 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

2 structures for P37804

Entry ID Method Resolution Chain Position Source
1UJO NMR - A 24-154 PDB
AF-P37804-F1 Predicted AlphaFoldDB

12 variants for P37804

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3389043135 9 G>D No EVA
rs3389030166 26 L>M No EVA
rs3389015560 28 E>V No EVA
rs13475075 33 W>R No EVA
rs3389049025 57 K>T No EVA
rs3389041588 91 M>K No EVA
rs3389039152 99 K>* No EVA
rs3389021308 111 M>I No EVA
rs213861276 118 Y>F No EVA
rs3400092345 132 A>FGHSQTAQSH* No EVA
rs3389041624 145 Y>H No EVA
rs3389041609 167 Q>R No EVA

No associated diseases with P37804

2 regional properties for P37804

Type Name Position InterPro Accession
repeat Calponin repeat 175 - 200 IPR000557
domain Calponin homology domain 24 - 137 IPR001715

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytoskeleton A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.

1 GO annotations of molecular function

Name Definition
actin filament binding Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits.

1 GO annotations of biological process

Name Definition
epithelial cell differentiation The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q01995 TAGLN Transgelin Homo sapiens (Human) PR
Q9WVA4 Tagln2 Transgelin-2 Mus musculus (Mouse) PR
P31232 Tagln Transgelin Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MANKGPSYGM SREVQSKIEK KYDEELEERL VEWIVVQCGP DVGRPDRGRL GFQVWLKNGV
70 80 90 100 110 120
ILSKLVNSLY PEGSKPVKVP ENPPSMVFKQ MEQVAQFLKA AEDYGVIKTD MFQTVDLYEG
130 140 150 160 170 180
KDMAAVQRTL MALGSLAVTK NDGNYRGDPN WFMKKAQEHK RDFTDSQLQE GKHVIGLQMG
190 200
SNRGASQAGM TGYGRPRQII S