P31232

PR
Gene name
Tagln (Sm22)
Protein name
Transgelin
Names
Smooth muscle protein 22-alpha, SM22-alpha
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:25123
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-52 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P31232

Entry ID Method Resolution Chain Position Source
AF-P31232-F1 Predicted AlphaFoldDB

No variants for P31232

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P31232

No associated diseases with P31232

2 regional properties for P31232

Type Name Position InterPro Accession
repeat Calponin repeat 175 - 200 IPR000557
domain Calponin homology domain 24 - 137 IPR001715

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytoskeleton A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.

2 GO annotations of molecular function

Name Definition
actin filament binding Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits.
protein-macromolecule adaptor activity The binding activity of a protein that brings together two or more macromolecules in contact, permitting those molecules to function in a coordinated way. The adaptor can bring together two proteins, or a protein and another macromolecule such as a lipid or a nucleic acid.

1 GO annotations of biological process

Name Definition
epithelial cell differentiation The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q01995 TAGLN Transgelin Homo sapiens (Human) PR
Q9WVA4 Tagln2 Transgelin-2 Mus musculus (Mouse) PR
P37804 Tagln Transgelin Mus musculus (Mouse) PR
10 20 30 40 50 60
MANKGPSYGM SREVQSKIEK KYDEELEERL VEWIVMQCGP DVGRPDRGRL GFQVWLKNGV
70 80 90 100 110 120
ILSKLVNSLY PEGSKPVKVP ENPPSMVFKQ MEQVAQFLKA AEDYGVTKTD MFQTVDLFEG
130 140 150 160 170 180
KDMAAVQRTV MALGSLAVTK NDGHYRGDPN WFMKKAQEHK REFTDSQLQE GKHVIGLQMG
190 200
SNRGASQAGM TGYGRPRQII S