AiPD: Autoinhibited Protein Database

Gene name	Ptpn4
Protein name	Tyrosine-protein phosphatase non-receptor type 4
Names	Testis-enriched protein tyrosine phosphatase
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:19258
EC number	3.1.3.48: Phosphoric monoester hydrolases
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

339-519 (Predicted disordered autoinhibitory region) PR

339-519 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q9WU22-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3388494799	8	P>A	No	EVA
rs1134625137	80	D>H	No	EVA
rs3388492111	123	R>K	No	EVA
rs3388490888	205	F>L	No	EVA
rs30683353	212	R>L	No	EVA
rs3388494859	225	R>W	No	EVA
rs3388494824	245	K>N	No	EVA
rs230476906	322	A>T	No	EVA
rs3388490903	397	P>R	No	EVA
rs3388494612	521	K>N	No	EVA
rs3388493728	558	P>H	No	EVA
rs3388494070	566	V>E	No	EVA
rs3388494132	587	K>T	No	EVA
rs3388493807	589	S>N	No	EVA
rs3388492623	590	C>R	No	EVA
rs3388495822	658	Q>R	No	EVA
rs3388490867	660	D>Y	No	EVA
rs1132831897	690	P>A	No	EVA
rs3388493190	738	W>G	No	EVA
rs3388490844	768	P>L	No	EVA
rs3388493727	773	S>I	No	EVA
rs3388494951	778	C>R	No	EVA
rs3390547105	784	H>R	No	EVA
rs3388492093	789	N>I	No	EVA
rs3388494791	795	R>G	No	EVA
rs3388494925	797	M>V	No	EVA
rs3388495656	807	S>I	No	EVA
rs3388490875	813	I>V	No	EVA
rs241034502	835	C>Y	No	EVA
rs3388494053	852	C>*	No	EVA
rs3388493769	853	S>I	No	EVA
rs3388492503	854	A>V	No	EVA
rs3390505306	859	T>I	No	EVA
rs3388494816	860	G>W	No	EVA
rs3388492641	871	L>H	No	EVA
rs3388493169	874	C>Y	No	EVA
rs3390490226	897	T>I	No	EVA

Type	Name	Position	InterPro Accession
domain	Tyrosine-specific protein phosphatase, PTPase domain	654 - 913	IPR000242
domain	FERM domain	29 - 312	IPR000299
domain	Tyrosine-specific protein phosphatases domain	828 - 902	IPR000387
domain	PDZ domain	517 - 605	IPR001478
domain	Protein-tyrosine phosphatase, catalytic	809 - 910	IPR003595
domain	FERM adjacent	322 - 368	IPR014847
active_site	Protein-tyrosine phosphatase, active site	850 - 860	IPR016130
domain	FERM, N-terminal	33 - 96	IPR018979
domain	FERM, C-terminal PH-like domain	226 - 316	IPR018980
conserved_site	FERM conserved site	84 - 113	IPR019747-1
conserved_site	FERM conserved site	192 - 221	IPR019747-2
domain	FERM central domain	114 - 222	IPR019748
domain	Band 4.1 domain	25 - 222	IPR019749
domain	PTPN3/4, FERM domain C-lobe	216 - 310	IPR041783

		Description
EC Number	3.1.3.48	Phosphoric monoester hydrolases
Subcellular Localization	Cell membrane ; Peripheral membrane protein ; Cytoplasmic side Cytoplasm, cytoskeleton
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytoplasmic side of plasma membrane	The leaflet the plasma membrane that faces the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
cytoskeleton	A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
membrane	A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.

Name	Definition
cytoskeletal protein binding	Binding to a protein component of a cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton).
glutamate receptor binding	Binding to a glutamate receptor.
non-membrane spanning protein tyrosine phosphatase activity	Catalysis of the reaction: non-membrane spanning protein tyrosine phosphate + H2O = non-membrane spanning protein tyrosine + phosphate.
protein tyrosine phosphatase activity	Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Name	Definition
peptidyl-tyrosine phosphorylation	The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine.
protein dephosphorylation	The process of removing one or more phosphoric residues from a protein.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P26045	PTPN3	Tyrosine-protein phosphatase non-receptor type 3	Homo sapiens (Human)	PR
P29074	PTPN4	Tyrosine-protein phosphatase non-receptor type 4	Homo sapiens (Human)	PR
Q15678	PTPN14	Tyrosine-protein phosphatase non-receptor type 14	Homo sapiens (Human)	PR