P26045
PR
Gene name |
PTPN3 (PTPH1) |
Protein name |
Tyrosine-protein phosphatase non-receptor type 3 |
Names |
Protein-tyrosine phosphatase H1, PTP-H1 |
Species |
Homo sapiens (Human) |
KEGG Pathway |
hsa:5774 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
14 structures for P26045
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 2B49 | X-ray | 154 A | A | 628-913 | PDB |
| 4QUM | X-ray | 252 A | A | 628-909 | PDB |
| 4QUN | X-ray | 186 A | A/B | 628-909 | PDB |
| 4RH5 | X-ray | 160 A | A | 628-909 | PDB |
| 4RH9 | X-ray | 160 A | A | 628-909 | PDB |
| 4RHG | X-ray | 158 A | A | 628-909 | PDB |
| 4RI4 | X-ray | 160 A | A/B | 628-909 | PDB |
| 4RI5 | X-ray | 126 A | A/B | 628-909 | PDB |
| 4S0G | X-ray | 172 A | A | 628-909 | PDB |
| 6HKS | X-ray | 219 A | A/B/C/D/E/F | 489-597 | PDB |
| 6T36 | X-ray | 186 A | A | 1-913 | PDB |
| 8CQY | X-ray | 170 A | A | 489-597 | PDB |
| 8OEP | X-ray | 187 A | A/C | 489-597 | PDB |
| AF-P26045-F1 | Predicted | AlphaFoldDB |
755 variants for P26045
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
|
CA174287 RCV000149070 rs193920798 |
211 | A>V | Malignant tumor of prostate Variant assessed as Somatic; 0.0 impact. [ClinVar, NCI-TCGA] | Yes |
ClinGen ClinVar 1000Genomes ExAC NCI-TCGA TOPMed dbSNP gnomAD |
|
CA5179515 rs765688707 |
4 | R>Q | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA374663071 rs371966999 |
4 | R>W | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA5179513 rs147740778 |
6 | R>C | Variant assessed as Somatic; 4.637e-05 impact. [NCI-TCGA] | No |
ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD |
|
CA5179512 rs777253098 |
6 | R>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA198007146 rs949617108 |
7 | A>V | No |
ClinGen TOPMed gnomAD |
|
|
CA374663049 rs1477805413 |
8 | L>S | No |
ClinGen TOPMed |
|
|
CA374663043 rs1378349248 |
9 | G>C | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
rs761116560 CA5179510 |
9 | G>D | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 11 | R>K | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA198007142 rs908792391 |
12 | I>V | No |
ClinGen TOPMed |
|
| TCGA novel | 14 | N>S | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA5179507 rs200407136 |
16 | R>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs540108445 CA5179506 |
16 | R>H | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA374662998 rs200407136 |
16 | R>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA5179505 rs774623127 |
17 | T>S | No |
ClinGen ExAC gnomAD |
|
|
CA198007138 rs748202983 |
18 | S>A | No |
ClinGen Ensembl |
|
|
CA5179504 rs769548418 |
18 | S>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs780989989 CA5179502 |
19 | E>G | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 19 | E>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs970950405 CA198007134 |
21 | P>S | No |
ClinGen TOPMed gnomAD |
|
| TCGA novel | 21 | P>T | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs754873186 CA5179501 |
26 | R>* | No |
ClinGen ExAC gnomAD |
|
|
CA374662934 rs539799147 |
26 | R>L | No |
ClinGen ExAC gnomAD |
|
|
CA5179500 rs539799147 |
26 | R>P | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
CA374662935 rs539799147 |
26 | R>Q | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
rs1445915930 CA374662932 |
27 | S>P | No |
ClinGen gnomAD |
|
|
rs1299051378 CA374662926 |
28 | E>* | No |
ClinGen gnomAD |
|
|
rs757908209 CA5179498 |
28 | E>V | No |
ClinGen ExAC gnomAD |
|
|
CA374662911 rs1325335791 |
30 | I>V | No |
ClinGen TOPMed |
|
|
CA374662884 rs1358360962 |
33 | I>M | No |
ClinGen gnomAD |
|
|
rs1564465788 CA374662880 |
34 | H>R | No |
ClinGen Ensembl |
|
|
CA5179497 rs750058407 |
34 | H>Y | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs765028676 CA5179496 |
35 | F>C | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 36 | L>F | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1415960960 CA374662861 |
37 | D>H | No |
ClinGen gnomAD |
|
|
rs547988784 CA5179495 |
38 | G>D | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen 1000Genomes ExAC NCI-TCGA gnomAD |
|
rs567366920 CA5179493 |
39 | V>M | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs374221054 CA5179492 |
41 | Q>* | No |
ClinGen ESP ExAC gnomAD |
|
|
CA5179491 rs753202614 |
41 | Q>R | No |
ClinGen ExAC gnomAD |
|
|
CA374662828 rs1284307153 |
42 | T>S | No |
ClinGen gnomAD |
|
|
CA374662818 rs1206944228 |
44 | K>Q | No |
ClinGen TOPMed |
|
|
CA5179490 rs767630494 |
46 | T>A | No |
ClinGen ExAC gnomAD |
|
|
CA5179471 rs753217745 |
49 | D>V | No |
ClinGen ExAC gnomAD |
|
|
CA374662756 rs1316228398 |
50 | T>A | No |
ClinGen gnomAD |
|
|
CA198005857 rs780210174 |
50 | T>S | No |
ClinGen Ensembl |
|
|
rs906855815 CA374662748 |
51 | G>D | No |
ClinGen gnomAD |
|
|
rs906855815 CA198005855 |
51 | G>V | No |
ClinGen gnomAD |
|
|
CA374662742 rs760112728 |
52 | Q>H | No |
ClinGen ExAC gnomAD |
|
|
CA5179470 rs767960364 |
52 | Q>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA198005852 rs751601039 |
53 | V>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs751601039 CA5179468 |
53 | V>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA374662736 rs1443872548 |
54 | L>I | No |
ClinGen TOPMed |
|
|
CA198005849 rs1023996538 |
55 | L>V | No |
ClinGen Ensembl |
|
|
rs1475658796 CA374662724 |
56 | D>G | No |
ClinGen TOPMed |
|
|
rs372676217 CA198005848 |
56 | D>H | No |
ClinGen ESP TOPMed |
|
|
CA374662715 rs1463617929 |
57 | M>T | No |
ClinGen gnomAD |
|
|
CA5179466 rs763107205 |
59 | H>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA374662700 rs1417570390 |
59 | H>R | No |
ClinGen TOPMed |
|
|
rs773485522 CA5179465 |
60 | N>K | No |
ClinGen ExAC gnomAD |
|
|
CA5179464 rs768462820 |
61 | H>Q | No |
ClinGen ExAC gnomAD |
|
|
CA198005842 rs1014250582 |
63 | G>D | No |
ClinGen TOPMed |
|
|
rs760432550 CA5179463 |
64 | V>A | No |
ClinGen ExAC gnomAD |
|
|
rs559268858 CA5179462 |
65 | T>P | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA374662651 rs1239326002 |
67 | K>R | No |
ClinGen gnomAD |
|
| TCGA novel | 69 | Y>F | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1456520846 CA374662639 |
69 | Y>H | No |
ClinGen TOPMed gnomAD |
|
|
rs1440734460 CA374662609 |
73 | Q>E | No |
ClinGen Ensembl |
|
|
rs574197123 CA5179460 CA5179459 |
73 | Q>H | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD NCI-TCGA |
|
rs1327373433 CA374662600 |
74 | H>R | No |
ClinGen TOPMed |
|
|
CA198005837 rs866419010 |
75 | D>N | No |
ClinGen Ensembl |
|
|
CA5179456 VAR_055252 rs35285139 |
77 | D>N | No |
ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
|
rs576352362 CA5179454 |
79 | V>M | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs1443884202 CA374662559 |
80 | D>G | No |
ClinGen gnomAD |
|
|
CA5179453 rs781644795 |
80 | D>N | No |
ClinGen ExAC gnomAD |
|
|
CA5179451 rs752077556 |
81 | S>F | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA5179452 rs755413839 |
81 | S>P | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs150709588 CA5179438 |
83 | R>K | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs1406359837 CA374662517 |
84 | W>C | No |
ClinGen TOPMed |
|
|
CA374662516 rs1335156311 |
85 | L>M | No |
ClinGen gnomAD |
|
|
CA5179437 rs769293135 |
86 | E>Q | No |
ClinGen ExAC gnomAD |
|
|
rs1413295712 CA374662502 |
87 | A>T | No |
ClinGen TOPMed gnomAD |
|
|
CA5179436 rs747844269 |
88 | S>C | No |
ClinGen ExAC gnomAD |
|
|
CA5179435 VAR_055253 rs3793524 |
90 | A>P | No |
ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
|
CA374662480 rs3793524 |
90 | A>S | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs3793524 CA374662481 |
90 | A>T | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA5179434 rs755397460 |
91 | I>V | No |
ClinGen ExAC gnomAD |
|
|
rs780583300 CA5179433 |
92 | R>S | No |
ClinGen ExAC gnomAD |
|
|
rs141057944 CA5179431 |
95 | L>I | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1418395124 CA374662434 |
97 | G>R | No |
ClinGen gnomAD |
|
|
rs756417887 CA5179405 |
97 | G>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs751331910 CA5179404 |
98 | G>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA374662409 rs1326179927 |
99 | F>C | No |
ClinGen gnomAD |
|
|
rs766307216 CA5179402 |
101 | C>S | No |
ClinGen ExAC gnomAD |
|
|
rs1439565420 CA374662384 |
102 | T>I | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed |
|
CA374662381 rs1325231345 |
103 | L>P | No |
ClinGen gnomAD |
|
|
CA374662377 rs1314936162 |
104 | H>D | No |
ClinGen gnomAD |
|
| TCGA novel | 104 | H>N | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA5179398 rs761449301 |
106 | R>* | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA |
|
rs1425996648 CA374662361 |
106 | R>Q | No |
ClinGen gnomAD |
|
|
rs1564457972 CA374662350 |
108 | R>K | No |
ClinGen Ensembl |
|
| TCGA novel | 110 | F>L | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA5179395 rs760355107 |
112 | P>L | No |
ClinGen ExAC gnomAD |
|
|
rs760355107 CA374662318 |
112 | P>R | No |
ClinGen ExAC gnomAD |
|
|
rs775786259 CA5179394 |
113 | D>E | No |
ClinGen ExAC gnomAD |
|
|
rs1252310900 CA374662310 |
114 | P>T | No |
ClinGen gnomAD |
|
|
CA5179393 rs772476130 |
115 | N>K | No |
ClinGen ExAC gnomAD |
|
|
CA5179392 rs746331303 |
116 | T>A | No |
ClinGen ExAC gnomAD |
|
|
CA374662285 rs1319868670 |
118 | Q>* | No |
ClinGen TOPMed |
|
|
rs1361499086 CA374662280 |
118 | Q>H | No |
ClinGen gnomAD |
|
|
rs1318826839 CA374662277 |
119 | Q>* | No |
ClinGen gnomAD |
|
|
rs770901957 CA5179390 |
123 | R>G | No |
ClinGen ExAC gnomAD |
|
|
rs1421432832 CA374662224 |
124 | H>R | No |
ClinGen gnomAD |
|
|
CA374662226 rs1159086976 |
124 | H>Y | No |
ClinGen gnomAD |
|
|
rs537605429 CA5179353 |
126 | Y>C | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA374662212 rs1405707044 |
126 | Y>H | No |
ClinGen gnomAD |
|
|
rs1425049227 CA374662189 |
129 | Q>K | No |
ClinGen TOPMed |
|
|
CA198004090 rs570615503 |
131 | K>R | No |
ClinGen 1000Genomes gnomAD |
|
|
CA5179350 rs552251645 |
132 | M>I | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA5179351 rs758110531 |
132 | M>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs200472346 CA5179348 |
136 | E>K | Variant assessed as Somatic; 0.0002338 impact. [NCI-TCGA] | No |
ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD |
|
rs753825128 CA5179347 |
136 | E>V | No |
ClinGen ExAC gnomAD |
|
|
CA5179346 rs763818081 |
137 | G>E | No |
ClinGen ExAC gnomAD |
|
|
rs139361478 CA374662112 |
138 | R>S | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1261105027 CA374662110 |
139 | L>I | No |
ClinGen TOPMed |
|
|
rs749220165 CA5179329 |
140 | T>P | No |
ClinGen ExAC gnomAD |
|
|
CA5179327 rs756059630 |
144 | N>D | No |
ClinGen ExAC gnomAD |
|
|
rs1400514873 CA374662049 |
148 | V>A | No |
ClinGen gnomAD |
|
|
rs1396094033 CA374662044 |
149 | L>P | No |
ClinGen TOPMed |
|
|
CA5179325 rs766966545 |
150 | A>V | No |
ClinGen ExAC gnomAD |
|
|
rs751217227 CA5179323 |
152 | Y>C | No |
ClinGen ExAC gnomAD |
|
|
CA198003456 rs988763524 |
153 | A>V | No |
ClinGen TOPMed gnomAD |
|
|
CA5179321 rs138810032 |
154 | V>I | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs752000585 CA198003452 |
155 | Q>E | No |
ClinGen Ensembl |
|
|
CA374662005 rs1258847302 |
156 | S>P | No |
ClinGen gnomAD |
|
|
rs765723127 CA5179297 |
159 | G>R | No |
ClinGen ExAC gnomAD |
|
|
rs1275704877 CA374443242 |
161 | Y>C | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed |
|
CA374443244 rs1438319042 |
161 | Y>H | No |
ClinGen TOPMed |
|
|
rs1482693832 CA374443220 |
164 | S>C | No |
ClinGen gnomAD |
|
|
rs1588427065 CA374443223 |
164 | S>T | No |
ClinGen Ensembl |
|
|
CA197622364 rs943528133 |
165 | I>V | No |
ClinGen TOPMed |
|
|
rs754346304 CA5179295 |
166 | H>Q | No |
ClinGen ExAC gnomAD |
|
|
CA374443209 rs1381479156 |
166 | H>Y | No |
ClinGen gnomAD |
|
|
rs760725973 CA5179293 |
167 | H>N | No |
ClinGen ExAC gnomAD |
|
|
rs760725973 CA5179294 |
167 | H>Y | No |
ClinGen ExAC gnomAD |
|
|
rs867565254 CA197622353 |
168 | P>L | No |
ClinGen Ensembl |
|
|
rs1250037030 CA374443190 |
169 | G>D | No |
ClinGen gnomAD |
|
|
CA197622350 rs776045957 |
170 | Y>C | No |
ClinGen Ensembl |
|
|
rs889297900 CA197622348 |
172 | S>F | No |
ClinGen TOPMed |
|
|
CA5179290 rs370903570 |
173 | D>G | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs772217385 CA5179291 |
173 | D>N | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
rs772943029 CA5179289 |
174 | S>G | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 176 | F>S | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs145013735 CA5179288 |
177 | I>V | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs781054586 CA5179287 |
178 | P>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs781054586 CA5179286 |
178 | P>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs746441964 CA5179284 |
179 | D>N | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
| TCGA novel | 180 | Q>R | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA374443073 rs1234737632 |
186 | T>K | No |
ClinGen gnomAD |
|
|
rs750154089 CA5179281 |
188 | V>L | No |
ClinGen ExAC gnomAD |
|
|
CA197622311 rs200331488 |
189 | E>* | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA5179277 rs200331488 |
189 | E>K | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs1291179084 CA374443041 |
191 | L>P | No |
ClinGen gnomAD |
|
|
CA374443003 rs761249070 |
196 | S>I | No |
ClinGen ExAC gnomAD |
|
|
CA5179276 rs761249070 |
196 | S>N | No |
ClinGen ExAC gnomAD |
|
|
CA374442973 rs1169857756 |
199 | K>R | No |
ClinGen TOPMed |
|
|
CA5179250 rs764002258 |
202 | E>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA374442951 rs764002258 |
202 | E>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA5179249 rs760502129 |
203 | A>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA5179248 rs565991205 |
206 | C>W | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA374442913 rs1198861166 |
208 | I>V | No |
ClinGen gnomAD |
|
|
rs1341115721 CA374442893 |
210 | I>M | No |
ClinGen gnomAD |
|
|
rs770450233 CA5179245 |
212 | R>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA5179246 rs529250315 |
212 | R>W | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen 1000Genomes ExAC NCI-TCGA gnomAD |
|
rs748993613 CA5179244 |
214 | L>F | No |
ClinGen ExAC gnomAD |
|
|
rs777977887 CA5179243 |
215 | D>N | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
CA374442859 rs1483402466 |
216 | F>L | No |
ClinGen gnomAD |
|
|
CA5179242 rs768746739 |
217 | Y>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1564440301 CA374442848 |
218 | G>A | No |
ClinGen Ensembl |
|
|
CA374442844 rs1398915152 |
219 | V>I | No |
ClinGen gnomAD |
|
|
rs1461318097 CA374442834 |
220 | E>V | No |
ClinGen TOPMed gnomAD |
|
|
CA374442820 rs1272430134 |
222 | H>R | No |
ClinGen TOPMed |
|
|
rs1211349830 CA374442803 |
224 | G>V | No |
ClinGen TOPMed |
|
|
CA5179226 rs578110556 |
226 | D>H | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs578110556 CA197620466 |
226 | D>N | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs770040661 CA5179225 |
229 | N>D | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA5179222 rs769107972 |
238 | S>F | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
rs1352896334 CA374442696 |
239 | A>T | No |
ClinGen TOPMed gnomAD |
|
|
CA374442693 rs1345596937 |
239 | A>V | No |
ClinGen TOPMed |
|
|
CA374442662 rs1275876007 |
244 | Y>S | No |
ClinGen TOPMed |
|
|
CA374442658 rs149073049 |
245 | R>* | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD |
|
CA5179219 rs149073049 |
245 | R>G | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA5179218 rs750600179 |
245 | R>Q | No |
ClinGen ExAC gnomAD |
|
|
rs757558303 CA5179216 |
247 | Y>C | No |
ClinGen ExAC gnomAD |
|
|
CA5179217 rs145005611 |
247 | Y>H | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs752503078 CA5179215 |
248 | I>N | No |
ClinGen ExAC gnomAD |
|
|
CA374442640 rs1318853785 |
248 | I>V | No |
ClinGen TOPMed gnomAD |
|
|
CA5179214 rs767443683 |
249 | C>F | No |
ClinGen ExAC gnomAD |
|
|
rs1157552054 CA374442628 |
250 | T>S | No |
ClinGen gnomAD |
|
| TCGA novel | 252 | F>L | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA5179199 rs747020559 |
258 | I>S | No |
ClinGen ExAC gnomAD |
|
|
rs192064945 CA5179200 |
258 | I>V | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA374442549 rs1413514797 |
259 | L>F | No |
ClinGen gnomAD |
|
|
rs199956141 CA197618861 |
259 | L>P | No |
ClinGen 1000Genomes |
|
|
rs1187541117 CA374442534 |
261 | I>T | No |
ClinGen gnomAD |
|
| TCGA novel | 262 | S>Y | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs757508296 CA5179198 |
263 | F>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA5179197 rs146954653 |
265 | R>T | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1185598358 CA374442489 |
267 | K>N | No |
ClinGen gnomAD |
|
|
rs1564431249 CA374442482 |
268 | F>L | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen Ensembl NCI-TCGA |
| TCGA novel | 268 | F>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1187955331 CA374442461 |
271 | H>R | No |
ClinGen TOPMed gnomAD |
|
|
CA5179196 rs781102733 |
273 | R>* | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
rs141258824 CA5179195 |
273 | R>Q | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1047132115 CA197618849 |
275 | K>E | No |
ClinGen TOPMed |
|
|
rs536550850 CA197618289 |
277 | A>G | No |
ClinGen 1000Genomes |
|
|
CA5179169 rs376928867 |
278 | E>D | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA5179167 rs569015635 |
282 | H>L | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs569015635 CA5179168 |
282 | H>R | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA5179165 rs775876677 |
283 | I>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs765711319 CA197618276 |
283 | I>V | No |
ClinGen Ensembl |
|
|
CA374442365 rs1432707870 |
284 | V>M | No |
ClinGen gnomAD |
|
|
CA374442334 rs1171817575 |
288 | M>T | No |
ClinGen TOPMed |
|
|
rs1466430590 CA374442336 |
288 | M>V | No |
ClinGen TOPMed |
|
|
CA374442328 rs1161511203 |
289 | L>V | No |
ClinGen gnomAD |
|
|
rs767821078 CA5179164 |
292 | R>* | No |
ClinGen ExAC gnomAD |
|
|
rs374370776 CA374442306 |
292 | R>L | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA5179163 rs374370776 |
292 | R>Q | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD |
|
CA5179162 rs774785506 |
293 | S>P | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA374442293 rs1250799438 |
294 | C>W | No |
ClinGen gnomAD |
|
|
CA374442275 rs771119485 |
297 | L>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs372409514 CA5179160 |
298 | W>R | No |
ClinGen ESP ExAC gnomAD |
|
|
CA5179158 rs147767465 |
301 | C>S | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs147767465 CA5179157 |
301 | C>Y | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA5179156 rs368204104 |
302 | V>I | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1188108366 CA374442227 |
304 | H>N | No |
ClinGen TOPMed gnomAD |
|
|
rs1188108366 CA374442228 |
304 | H>Y | No |
ClinGen TOPMed gnomAD |
|
|
CA197618258 rs867698058 |
306 | T>M | No |
ClinGen Ensembl |
|
|
rs745807232 CA5179154 |
308 | F>L | No |
ClinGen ExAC gnomAD |
|
|
CA197618254 rs1036248168 |
310 | A>P | No |
ClinGen gnomAD |
|
|
CA5179153 rs778767083 |
311 | K>E | No |
ClinGen ExAC gnomAD |
|
|
rs757195571 CA5179152 |
311 | K>N | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
CA197618236 rs374798614 |
313 | L>V | No |
ClinGen ESP |
|
|
CA5179150 rs777288597 |
315 | P>S | No |
ClinGen ExAC gnomAD |
|
|
rs1345848069 CA374442134 |
318 | K>E | No |
ClinGen gnomAD |
|
|
rs1161464165 CA374442128 |
318 | K>N | No |
ClinGen gnomAD |
|
|
rs61736875 CA5179149 |
319 | N>S | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA5179148 rs752334142 |
320 | V>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1188337664 CA374442105 |
322 | S>F | No |
ClinGen gnomAD |
|
|
CA5179147 rs767921182 |
323 | Q>R | No |
ClinGen ExAC gnomAD |
|
|
CA5179146 rs759874495 |
327 | M>V | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA5179144 rs766926594 |
330 | R>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA5179145 rs370526852 |
330 | R>W | No |
ClinGen ESP ExAC gnomAD |
|
|
CA5179142 rs773373501 |
334 | K>T | No |
ClinGen ExAC gnomAD |
|
|
CA5179118 rs376647767 |
335 | S>L | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD |
|
rs926725860 CA197616852 |
336 | V>L | No |
ClinGen TOPMed gnomAD |
|
|
rs1415582981 CA374441767 |
338 | N>K | No |
ClinGen TOPMed |
|
|
CA374441763 rs1194965008 |
339 | Q>* | No |
ClinGen gnomAD |
|
|
CA5179115 rs201919688 |
340 | Y>* | No |
ClinGen ExAC gnomAD |
|
|
CA374441748 rs1176036462 |
341 | C>G | No |
ClinGen Ensembl |
|
|
rs1266263961 CA374441742 |
342 | K>E | No |
ClinGen gnomAD |
|
|
rs151104500 CA5179113 |
343 | K>R | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
| TCGA novel | 343 | K>R | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA5179109 rs142980957 |
347 | G>R | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs761447839 CA197616822 |
348 | M>I | No |
ClinGen TOPMed gnomAD |
|
|
rs369138815 CA5179108 |
349 | V>M | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA374441683 rs1392233871 |
350 | W>C | No |
ClinGen gnomAD |
|
|
CA374441677 rs1588394175 |
351 | N>T | No |
ClinGen Ensembl |
|
|
rs1398348939 CA374441672 |
352 | P>A | No |
ClinGen TOPMed gnomAD |
|
|
CA5179105 rs750950689 |
354 | M>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs568051655 CA5179106 |
354 | M>T | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs774062306 CA5179102 |
355 | R>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA5179104 rs757816656 |
355 | R>W | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
| TCGA novel | 356 | R>I | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA374441639 rs1182062128 |
357 | S>F | No |
ClinGen gnomAD |
|
|
rs760856001 CA5179101 |
360 | V>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs760856001 CA5179100 |
360 | V>M | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 361 | E>Q | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA5179099 rs775757603 |
362 | H>P | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 363 | L>* | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1034193429 CA197616791 |
363 | L>V | No |
ClinGen Ensembl |
|
|
rs1191259093 CA374441574 |
367 | S>N | No |
ClinGen TOPMed |
|
|
CA5179098 rs766150478 |
368 | L>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA374441565 rs1281706002 |
369 | P>S | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
rs576273524 CA197616783 |
370 | S>A | No |
ClinGen Ensembl |
|
|
CA374441553 rs1237196580 |
371 | R>C | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed gnomAD |
|
CA374441554 rs1237196580 |
371 | R>G | No |
ClinGen TOPMed gnomAD |
|
|
CA197616780 rs371270540 |
371 | R>H | No |
ClinGen ESP TOPMed gnomAD |
|
|
CA5179097 rs762680641 |
372 | S>C | No |
ClinGen ExAC gnomAD |
|
|
CA197616773 rs1001421869 |
374 | P>A | No |
ClinGen TOPMed |
|
|
rs1337759399 CA374441537 |
374 | P>H | No |
ClinGen gnomAD |
|
|
rs1286166339 CA374441533 |
375 | I>V | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
CA197616770 rs964435781 |
377 | P>S | No |
ClinGen TOPMed |
|
|
CA5179094 rs148558305 |
378 | N>S | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA5179064 rs144812815 |
379 | W>C | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA374441391 rs185821807 |
380 | R>* | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD |
|
rs771804289 CA5179062 |
380 | R>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1274751670 CA374441371 |
383 | R>Q | No |
ClinGen gnomAD |
|
|
rs558168795 CA5179061 |
383 | R>W | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA197616137 rs201397922 |
385 | R>Q | No |
ClinGen gnomAD |
|
|
rs749745979 CA5179058 |
385 | R>W | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
CA374441359 rs1588389319 |
386 | H>Y | No |
ClinGen Ensembl |
|
|
CA197616130 rs980443001 |
387 | E>D | No |
ClinGen Ensembl |
|
|
rs756619933 CA5179056 |
387 | E>K | No |
ClinGen ExAC gnomAD |
|
|
rs1396543362 CA374441341 |
388 | I>M | No |
ClinGen TOPMed |
|
|
rs969028888 CA197616126 |
388 | I>V | No |
ClinGen gnomAD |
|
|
CA5179055 rs752731768 |
389 | R>* | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
rs752731768 CA374441340 |
389 | R>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs539842793 CA5179054 |
389 | R>Q | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs140094288 CA5179052 |
392 | R>H | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA5179053 rs140094288 |
392 | R>L | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1413580101 CA374441310 |
394 | S>P | No |
ClinGen gnomAD |
|
|
rs761723063 CA5179050 |
396 | A>P | No |
ClinGen ExAC gnomAD |
|
|
rs761723063 CA197616114 |
396 | A>S | No |
ClinGen ExAC gnomAD |
|
|
CA374441291 rs1469346763 |
397 | D>G | No |
ClinGen TOPMed |
|
|
rs1188017444 CA374441285 |
398 | N>Y | No |
ClinGen gnomAD |
|
|
CA5179048 rs573117768 |
400 | A>E | No |
ClinGen 1000Genomes ExAC gnomAD |
|
| TCGA novel | 400 | A>P | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 402 | E>* | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1031861146 CA197616113 |
402 | E>K | No |
ClinGen TOPMed |
|
|
CA5179046 rs775121164 |
403 | M>I | No |
ClinGen ExAC |
|
|
CA5179047 rs760714392 |
403 | M>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs771752925 CA5179045 |
405 | Y>H | No |
ClinGen ExAC gnomAD |
|
|
CA5179044 rs774111449 |
406 | I>N | No |
ClinGen ExAC gnomAD |
|
|
CA5179043 rs774111449 |
406 | I>T | No |
ClinGen ExAC gnomAD |
|
|
rs1427954288 CA374441233 |
406 | I>V | No |
ClinGen TOPMed gnomAD |
|
|
rs770505018 CA5179042 |
407 | T>M | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
VAR_055254 CA5179040 rs10979858 |
409 | T>A | No |
ClinGen UniProt ExAC dbSNP gnomAD |
|
|
rs770235117 CA5179039 |
409 | T>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1471294067 CA374441209 |
410 | E>* | No |
ClinGen Ensembl |
|
|
rs1414137618 CA374441198 |
411 | D>G | No |
ClinGen gnomAD |
|
|
rs1423417342 CA374441195 |
412 | V>I | No |
ClinGen gnomAD |
|
|
CA5179035 rs181688303 |
413 | F>L | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs368525928 CA5179033 |
414 | Y>C | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs751714294 CA5179034 |
414 | Y>H | No |
ClinGen ExAC gnomAD |
|
|
rs751714294 CA374441182 |
414 | Y>N | No |
ClinGen ExAC gnomAD |
|
|
CA5179032 rs536512105 |
415 | T>M | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs1427412162 CA374441170 |
416 | Y>H | No |
ClinGen gnomAD |
|
|
rs1292862142 CA374441162 |
417 | K>E | No |
ClinGen TOPMed |
|
|
rs760662743 CA5179029 |
417 | K>R | No |
ClinGen ExAC gnomAD |
|
|
rs760662743 CA374441160 |
417 | K>T | No |
ClinGen ExAC gnomAD |
|
|
CA5179028 rs752752824 |
418 | G>C | No |
ClinGen ExAC gnomAD |
|
|
rs752752824 CA374441156 |
418 | G>S | No |
ClinGen ExAC gnomAD |
|
|
CA374441148 rs1388330646 |
419 | S>Y | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed |
|
rs374202196 CA5179027 |
420 | L>V | No |
ClinGen ESP ExAC gnomAD |
|
|
CA374441139 rs1207054092 |
421 | A>S | No |
ClinGen gnomAD |
|
|
rs1482005343 CA374441130 |
422 | P>L | No |
ClinGen TOPMed gnomAD |
|
|
rs1481762603 CA374441133 |
422 | P>S | No |
ClinGen TOPMed gnomAD |
|
|
rs1273870302 CA374441128 |
423 | Q>E | No |
ClinGen gnomAD |
|
|
CA374441116 rs1211562107 |
424 | D>V | No |
ClinGen TOPMed gnomAD |
|
|
rs367948677 CA374441108 |
425 | S>R | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA5179026 rs372151791 |
425 | S>T | No |
ClinGen ESP ExAC gnomAD |
|
|
rs770579571 CA5179024 |
426 | D>N | No |
ClinGen ExAC gnomAD |
|
|
rs1588388728 CA374441075 |
430 | S>F | No |
ClinGen Ensembl |
|
|
CA374441071 rs1280450078 |
431 | Q>* | No |
ClinGen TOPMed gnomAD |
|
|
rs1412097270 CA374441069 |
431 | Q>R | No |
ClinGen gnomAD |
|
|
rs1204707512 CA374441060 |
432 | N>I | No |
ClinGen gnomAD |
|
|
rs375004037 CA5179023 |
433 | R>* | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs370298571 CA5179022 |
433 | R>Q | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs770183844 CA5179021 |
434 | S>N | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1435949343 CA374441054 |
434 | S>R | No |
ClinGen gnomAD |
|
|
CA374441051 rs770183844 |
434 | S>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs748644877 CA5179020 |
435 | P>L | No |
ClinGen ExAC gnomAD |
|
|
CA5179017 rs200101992 |
436 | H>Y | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA374440746 rs1032516473 |
439 | S>I | No |
ClinGen TOPMed gnomAD |
|
|
CA197612884 rs1032516473 |
439 | S>N | No |
ClinGen TOPMed gnomAD |
|
|
rs1188401986 CA374440744 |
439 | S>R | No |
ClinGen gnomAD |
|
|
rs141809051 CA5179003 |
442 | E>K | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA5179002 rs141809051 |
442 | E>Q | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1181246688 CA374440720 |
443 | N>S | No |
ClinGen gnomAD |
|
|
rs769164037 CA5179001 |
444 | N>S | No |
ClinGen ExAC gnomAD |
|
|
rs775609338 CA5178999 |
445 | P>L | No |
ClinGen ExAC gnomAD |
|
|
rs775609338 CA374440707 |
445 | P>Q | No |
ClinGen ExAC gnomAD |
|
|
CA5179000 rs747521000 |
445 | P>S | No |
ClinGen ExAC gnomAD |
|
|
rs868723910 CA197612867 |
446 | A>T | No |
ClinGen TOPMed |
|
|
rs1405201984 CA374440698 |
447 | Q>* | No |
ClinGen TOPMed |
|
|
rs746075257 CA5178997 |
448 | S>N | No |
ClinGen ExAC gnomAD |
|
|
CA374440681 rs1246015001 |
449 | Y>C | No |
ClinGen gnomAD |
|
|
CA374440664 rs1473865260 |
452 | Q>* | No |
ClinGen gnomAD |
|
| TCGA novel | 452 | Q>H | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA374440638 rs780874349 |
456 | S>C | No |
ClinGen ExAC gnomAD |
|
|
rs780874349 CA5178993 |
456 | S>G | No |
ClinGen ExAC gnomAD |
|
|
rs780874349 CA5178994 |
456 | S>R | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 457 | S>Y | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1251959448 CA374440615 |
459 | S>F | No |
ClinGen gnomAD |
|
|
rs1366009855 CA374440620 |
459 | S>P | No |
ClinGen gnomAD |
|
|
rs765866650 CA197612851 |
462 | S>* | No |
ClinGen Ensembl |
|
|
rs754919153 CA5178992 |
467 | S>F | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
rs1459216154 CA374440570 |
467 | S>P | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
rs1163920014 CA374440564 |
468 | C>S | No |
ClinGen gnomAD |
|
|
CA197612844 rs987070083 |
469 | S>L | No |
ClinGen Ensembl |
|
|
rs765905557 CA5178990 |
471 | D>H | No |
ClinGen ExAC gnomAD |
|
|
CA374440539 rs750357031 |
472 | G>C | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA5178988 rs750357031 |
472 | G>S | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
rs769409923 CA197612834 |
472 | G>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen Ensembl NCI-TCGA |
|
rs138707755 CA197612831 |
473 | V>A | No |
ClinGen ESP TOPMed gnomAD |
|
|
CA374440535 rs141350094 |
473 | V>F | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA5178986 rs141350094 |
473 | V>I | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA197612829 rs933352971 |
474 | D>V | No |
ClinGen TOPMed |
|
|
CA5178985 rs564550303 |
475 | Q>E | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA197612824 rs545853964 |
475 | Q>R | No |
ClinGen 1000Genomes |
|
|
rs375545706 CA5178983 |
476 | Q>R | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs775920120 CA5178982 |
477 | L>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs759626144 CA5178980 |
479 | D>G | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
rs772651505 CA374440500 |
479 | D>H | No |
ClinGen ExAC gnomAD |
|
|
CA5178981 rs772651505 |
479 | D>Y | No |
ClinGen ExAC gnomAD |
|
|
rs774607981 CA5178979 |
481 | F>L | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA5178977 rs147174947 |
482 | H>Q | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs1033977712 CA197612810 |
484 | V>E | No |
ClinGen TOPMed |
|
|
CA5178976 rs781006029 |
485 | T>N | No |
ClinGen ExAC gnomAD |
|
|
CA374440459 rs1430318145 |
485 | T>P | No |
ClinGen gnomAD |
|
|
CA374440454 rs1448306112 |
486 | K>E | No |
ClinGen gnomAD |
|
|
CA197612803 rs571664661 |
488 | G>S | No |
ClinGen TOPMed gnomAD |
|
|
rs779797357 CA5178973 |
488 | G>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs373058480 CA5178969 |
491 | E>K | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA5178968 rs756874632 |
492 | D>A | No |
ClinGen ExAC gnomAD |
|
|
rs1304765065 CA374440418 |
492 | D>N | No |
ClinGen gnomAD |
|
|
rs764506355 CA5178966 |
493 | A>G | No |
ClinGen ExAC gnomAD |
|
|
rs753503028 CA5178967 |
493 | A>P | No |
ClinGen ExAC gnomAD |
|
|
rs753503028 CA374440411 |
493 | A>T | No |
ClinGen ExAC gnomAD |
|
|
CA374440397 rs1240258245 |
495 | Q>* | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen Ensembl NCI-TCGA |
|
CA374440384 rs145875554 |
496 | Y>* | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1564406551 CA374440358 |
500 | K>E | No |
ClinGen Ensembl |
|
|
CA374440333 rs1406121051 |
501 | N>K | No |
ClinGen TOPMed |
|
|
CA5178936 rs775242064 |
501 | N>S | No |
ClinGen ExAC gnomAD |
|
|
rs368144041 CA5178934 |
502 | D>E | No |
ClinGen ESP ExAC gnomAD |
|
|
rs372363344 CA5178935 |
502 | D>N | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA374440331 rs372363344 |
502 | D>Y | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs774216839 CA5178933 |
503 | N>S | No |
ClinGen ExAC gnomAD |
|
|
CA374440313 rs1265989836 |
505 | D>N | No |
ClinGen gnomAD |
|
|
rs770860303 CA5178932 |
506 | S>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1382567071 CA374440301 |
506 | S>I | No |
ClinGen TOPMed |
|
|
rs748710824 CA5178931 |
507 | Y>S | No |
ClinGen ExAC gnomAD |
|
|
rs113237352 CA197612711 |
509 | V>A | No |
ClinGen Ensembl |
|
| TCGA novel | 510 | L>F | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA5178930 rs376855050 |
510 | L>V | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA374440267 rs371910658 |
511 | I>M | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA5178928 rs747877274 |
512 | R>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs189241432 CA5178927 |
512 | R>H | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs1400451714 CA374440241 |
516 | D>N | No |
ClinGen gnomAD |
|
|
CA374440213 rs1415006028 |
520 | K>E | No |
ClinGen gnomAD |
|
|
rs751982221 CA5178925 |
520 | K>N | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1244333910 CA374440209 |
520 | K>R | No |
ClinGen TOPMed |
|
|
CA374440172 rs1186266889 |
525 | L>P | No |
ClinGen TOPMed |
|
|
CA374440164 rs1472097416 |
526 | K>N | No |
ClinGen gnomAD |
|
|
rs780929393 CA5178903 |
527 | G>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA5178901 rs754678211 |
529 | V>M | No |
ClinGen ExAC gnomAD |
|
|
CA374440114 rs1219170613 |
532 | K>T | No |
ClinGen gnomAD |
|
|
CA374440107 rs1275217930 |
533 | M>L | No |
ClinGen gnomAD |
|
|
rs1207238288 CA374440093 |
535 | L>I | No |
ClinGen gnomAD |
|
|
CA5178899 rs183458658 |
536 | V>M | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs758807392 CA5178898 |
538 | S>T | No |
ClinGen ExAC gnomAD |
|
|
CA5178895 rs144915998 |
539 | R>K | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA5178894 rs753919338 |
542 | P>S | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 543 | E>A | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs765177743 CA5178867 |
546 | A>T | No |
ClinGen ExAC gnomAD |
|
|
rs1249778129 CA374440011 |
546 | A>V | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed gnomAD |
|
CA374439998 rs1226417769 |
548 | T>S | No |
ClinGen TOPMed |
|
|
rs919588386 CA374439955 |
554 | N>K | No |
ClinGen TOPMed gnomAD |
|
|
CA5178864 rs140628740 |
555 | E>K | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA5178863 rs760397382 |
556 | G>R | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 557 | D>G | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1230669336 CA374439922 |
559 | I>T | No |
ClinGen gnomAD |
|
|
rs996210738 CA197606992 |
560 | V>M | No |
ClinGen TOPMed gnomAD |
|
|
rs966412863 CA197606987 |
564 | G>S | No |
ClinGen Ensembl |
|
|
rs181792746 CA5178860 |
565 | R>Q | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs771629529 CA5178861 |
565 | R>W | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs761380062 CA197606973 |
567 | I>T | No |
ClinGen Ensembl |
|
|
rs59324117 CA5178858 |
569 | E>Q | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs749839684 CA5178857 |
571 | T>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs749839684 CA374439845 |
571 | T>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA374439840 rs1322259022 |
572 | H>R | No |
ClinGen gnomAD |
|
|
CA5178855 rs140140279 |
573 | D>E | No |
ClinGen ESP ExAC |
|
|
rs748314105 CA197606964 |
577 | M>I | No |
ClinGen Ensembl |
|
|
CA5178854 rs146077461 |
578 | F>S | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA5178853 rs781406036 |
579 | I>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA5178852 rs201209769 |
580 | K>R | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA5178851 rs750181035 |
581 | A>V | No |
ClinGen ExAC gnomAD |
|
|
CA5178850 rs764989133 |
583 | R>Q | No |
ClinGen ExAC gnomAD |
|
|
rs1465045994 CA374439767 |
583 | R>W | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
CA197606946 rs994658902 |
584 | E>K | No |
ClinGen Ensembl |
|
|
rs144304313 CA5178848 |
586 | H>R | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs757229146 CA5178849 |
586 | H>Y | No |
ClinGen ExAC gnomAD |
|
|
rs199759803 CA5178846 |
588 | R>Q | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA197606937 rs1055256981 |
588 | R>W | No |
ClinGen TOPMed |
|
|
rs760198715 CA5178845 |
589 | E>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1300027680 CA374439691 |
596 | R>K | No |
ClinGen gnomAD |
|
|
rs1383970512 CA374439677 |
598 | A>T | No |
ClinGen gnomAD |
|
|
CA374439662 rs1254631084 |
598 | A>V | No |
ClinGen TOPMed |
|
|
rs148505458 CA5178818 |
600 | R>C | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs759723246 CA5178817 |
600 | R>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA197605978 rs148505458 |
600 | R>S | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs748649101 CA5178815 |
602 | F>I | No |
ClinGen ExAC gnomAD |
|
|
rs748649101 CA374439646 |
602 | F>L | No |
ClinGen ExAC gnomAD |
|
|
rs949371683 CA197605946 |
602 | F>S | No |
ClinGen TOPMed gnomAD |
|
|
rs748649101 CA374439645 |
602 | F>V | No |
ClinGen ExAC gnomAD |
|
|
rs949371683 CA374439644 |
602 | F>Y | No |
ClinGen TOPMed gnomAD |
|
|
rs913841009 CA197605944 |
605 | F>I | No |
ClinGen Ensembl |
|
|
CA5178813 CA5178814 rs7859962 VAR_055255 |
605 | F>L | No |
ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
|
rs1199238578 CA374439617 |
606 | K>R | No |
ClinGen TOPMed gnomAD |
|
|
rs568449195 CA5178812 |
609 | D>E | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs1254044349 CA374439590 |
610 | E>* | No |
ClinGen gnomAD |
|
|
CA5178811 rs780364886 |
610 | E>A | No |
ClinGen ExAC gnomAD |
|
|
rs1254044349 CA374439592 |
610 | E>K | No |
ClinGen gnomAD |
|
|
rs1300673033 CA374439577 |
612 | N>T | No |
ClinGen TOPMed |
|
|
rs749042366 CA5178809 |
613 | Q>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1235716126 CA374439559 |
615 | F>L | No |
ClinGen gnomAD |
|
|
CA5178808 rs777761915 |
616 | P>L | No |
ClinGen ExAC gnomAD |
|
|
CA374439549 rs1297459785 |
616 | P>S | No |
ClinGen TOPMed |
|
|
rs752646788 CA5178806 |
617 | E>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs754391577 CA374439533 |
619 | I>L | No |
ClinGen ExAC gnomAD |
|
|
rs754391577 CA5178804 |
619 | I>V | No |
ClinGen ExAC gnomAD |
|
|
rs150353247 CA5178803 |
620 | F>L | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs1173905364 CA374439492 |
624 | P>L | No |
ClinGen gnomAD |
|
|
rs750761638 CA5178800 |
626 | G>A | No |
ClinGen ExAC gnomAD |
|
|
CA374439474 rs1473188936 |
627 | G>E | No |
ClinGen gnomAD |
|
|
CA374439477 rs1396835414 |
627 | G>R | No |
ClinGen TOPMed gnomAD |
|
|
CA374439470 rs1235067905 |
628 | D>N | No |
ClinGen TOPMed gnomAD |
|
|
rs765628886 CA5178799 |
629 | T>A | No |
ClinGen ExAC gnomAD |
|
|
CA5178798 rs762374942 |
630 | L>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1205044185 CA374439452 |
631 | E>Q | No |
ClinGen TOPMed |
|
|
CA374439439 rs1460195840 |
633 | S>A | No |
ClinGen gnomAD |
|
|
rs1228819752 CA374439431 |
634 | M>L | No |
ClinGen gnomAD |
|
|
rs1330988411 CA374439429 |
634 | M>T | No |
ClinGen gnomAD |
|
|
rs1277649633 CA374439422 |
635 | A>T | No |
ClinGen gnomAD |
|
|
CA374439414 rs1182764872 |
636 | Q>R | No |
ClinGen TOPMed |
|
|
CA5178795 rs770897495 |
638 | K>N | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA5178793 rs772402348 |
640 | G>D | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs761872639 CA197605838 |
641 | L>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA5178792 rs761872639 |
641 | L>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs777708935 CA5178791 |
642 | E>K | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA374439371 rs1458053605 |
643 | S>N | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
rs1470134595 CA374439364 |
644 | G>E | No |
ClinGen gnomAD |
|
|
rs763071949 CA5178790 |
644 | G>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1361970381 CA374439356 |
645 | T>M | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed |
| TCGA novel | 647 | L>P | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1185550682 CA374439337 |
649 | Q>* | No |
ClinGen gnomAD |
|
|
rs780927849 CA5178788 |
649 | Q>L | No |
ClinGen ExAC gnomAD |
|
|
CA197605826 rs948316466 |
650 | F>L | No |
ClinGen TOPMed gnomAD |
|
|
CA5178766 rs745395808 |
652 | Q>R | No |
ClinGen ExAC gnomAD |
|
|
CA374438794 rs1358021866 |
653 | L>F | No |
ClinGen gnomAD |
|
|
rs753827129 CA197597888 |
655 | R>K | No |
ClinGen Ensembl |
|
|
CA5178764 rs573531360 |
657 | K>R | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
| rs1564381860 | 658 | P>A | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA5178762 rs371372947 |
659 | G>S | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
| TCGA novel | 661 | A>T | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA5178761 rs756685970 |
662 | I>V | No |
ClinGen ExAC gnomAD |
|
|
CA374438683 rs1268755429 |
663 | T>M | No |
ClinGen gnomAD |
|
|
rs768153874 CA5178759 |
666 | K>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA5178756 rs766460015 |
671 | L>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA197597831 rs766460015 |
671 | L>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1411842017 CA374438624 |
672 | D>V | No |
ClinGen gnomAD |
|
|
rs763280816 CA5178755 |
675 | R>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA374438601 rs763280816 |
675 | R>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs377718578 CA197597813 |
676 | Y>C | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs377718578 CA5178754 |
676 | Y>F | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA197597817 rs760664305 |
676 | Y>H | No |
ClinGen Ensembl |
|
|
rs1270790665 CA374438586 |
678 | D>N | No |
ClinGen gnomAD |
|
| TCGA novel | 679 | V>A | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA5178753 rs768560669 |
679 | V>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1418149010 CA374438569 |
680 | L>R | No |
ClinGen TOPMed |
|
|
CA374438525 rs1161114494 |
685 | T>N | No |
ClinGen gnomAD |
|
|
CA374438520 rs1406587220 |
686 | R>Q | No |
ClinGen gnomAD |
|
|
rs755576588 CA5178717 |
686 | R>W | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1181982614 CA374438516 |
687 | V>L | No |
ClinGen gnomAD |
|
|
rs1045080214 CA197597472 |
690 | Q>P | No |
ClinGen gnomAD |
|
|
CA374438495 rs1045080214 |
690 | Q>R | No |
ClinGen gnomAD |
|
|
rs1202657887 CA374438491 |
691 | G>* | No |
ClinGen gnomAD |
|
|
rs946909301 CA197597468 |
692 | N>D | No |
ClinGen TOPMed gnomAD |
|
| TCGA novel | 692 | N>M | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1261753929 CA374438482 |
692 | N>S | No |
ClinGen gnomAD |
|
|
CA197597467 rs866921746 |
693 | E>K | No |
ClinGen Ensembl |
|
|
CA5178715 rs759379733 |
696 | I>T | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
CA5178714 rs138839766 |
700 | Y>* | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA5178712 rs762489165 |
701 | V>M | No |
ClinGen ExAC gnomAD |
|
|
rs1385111987 CA374438414 |
702 | N>D | No |
ClinGen gnomAD |
|
|
CA197597423 rs145864054 |
702 | N>S | No |
ClinGen ESP TOPMed gnomAD |
|
|
CA5178691 rs764903987 |
704 | E>K | No |
ClinGen ExAC gnomAD |
|
|
rs1200771518 CA374438360 |
708 | A>S | No |
ClinGen TOPMed gnomAD |
|
|
rs1200771518 CA374438362 |
708 | A>T | No |
ClinGen TOPMed gnomAD |
|
|
rs768195763 CA5178689 |
712 | N>I | No |
ClinGen ExAC gnomAD |
|
|
CA5178688 rs768195763 |
712 | N>S | No |
ClinGen ExAC gnomAD |
|
|
CA374438313 rs1183157679 |
715 | I>V | No |
ClinGen TOPMed |
|
|
CA197595852 rs763936455 |
716 | A>T | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
CA5178686 rs775738603 |
718 | Q>R | No |
ClinGen ExAC gnomAD |
|
|
rs1225526021 CA374438287 |
719 | G>E | No |
ClinGen TOPMed gnomAD |
|
|
CA197595847 rs989608249 |
719 | G>R | No |
ClinGen Ensembl |
|
| TCGA novel | 721 | L>A | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs778951184 CA5178682 |
722 | P>A | No |
ClinGen ExAC gnomAD |
|
|
rs189256306 CA5178681 |
722 | P>L | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA197595808 rs189256306 |
722 | P>R | No |
ClinGen 1000Genomes ExAC gnomAD |
|
| TCGA novel | 722 | P>S | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA5178678 rs143462283 |
723 | H>R | No |
ClinGen 1000Genomes ESP TOPMed gnomAD |
|
| TCGA novel | 727 | Q>* | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs965273332 CA197595792 |
727 | Q>R | No |
ClinGen Ensembl |
|
|
CA197595785 rs1015472740 |
728 | F>I | No |
ClinGen gnomAD |
|
|
CA374438214 rs1177658483 |
730 | Q>H | No |
ClinGen gnomAD |
|
|
rs1423335793 CA374438217 |
730 | Q>P | No |
ClinGen gnomAD |
|
|
rs1481687336 CA374438205 |
732 | V>F | No |
ClinGen gnomAD |
|
|
CA374438197 rs1353022762 |
733 | W>* | No |
ClinGen TOPMed |
|
|
CA374438184 rs1427766434 |
734 | D>E | No |
ClinGen gnomAD |
|
|
rs1467760394 CA374438189 |
734 | D>N | No |
ClinGen TOPMed |
|
|
rs536342787 CA5178675 |
735 | Q>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA5178673 rs751351405 |
737 | L>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA197595753 rs569359098 |
740 | I>T | No |
ClinGen Ensembl |
|
|
rs758348142 CA5178671 |
741 | V>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs750440450 CA5178670 |
744 | T>M | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
CA5178668 rs761338097 |
749 | R>* | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
rs776311554 CA5178667 |
749 | R>Q | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA197595698 rs1027223044 |
751 | R>G | No |
ClinGen Ensembl |
|
|
CA5178665 rs760293572 |
751 | R>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA5178643 rs759856464 |
752 | T>I | No |
ClinGen ExAC gnomAD |
|
|
rs1564371426 CA374437641 |
753 | K>E | No |
ClinGen Ensembl |
|
|
rs774723037 CA5178642 |
753 | K>T | No |
ClinGen ExAC gnomAD |
|
|
rs771408438 CA5178641 |
755 | H>Q | No |
ClinGen ExAC |
|
|
CA5178639 rs773333531 |
759 | P>T | No |
ClinGen ExAC gnomAD |
|
|
rs375763821 CA5178638 |
761 | P>A | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs748270076 CA5178637 |
761 | P>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs748270076 CA374437535 |
761 | P>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs748270076 CA197590478 |
761 | P>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs375763821 CA374437538 |
761 | P>S | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
VAR_055256 CA5178633 rs10116806 |
763 | D>N | No |
ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
|
CA5178631 rs753778510 |
764 | V>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1400002705 CA374437498 |
765 | M>V | No |
ClinGen gnomAD |
|
|
rs755513213 CA5178630 |
766 | N>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA374437464 rs373493427 |
767 | H>Q | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA374437456 rs1413287687 |
768 | G>A | No |
ClinGen gnomAD |
|
| TCGA novel | 768 | G>A | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA374437462 rs767031759 |
768 | G>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA5178627 rs767031759 |
768 | G>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1003787838 CA374437452 |
769 | G>C | No |
ClinGen TOPMed gnomAD |
|
|
rs1003787838 CA197590383 |
769 | G>S | No |
ClinGen TOPMed gnomAD |
|
|
rs751894907 CA5178625 |
771 | H>D | No |
ClinGen ExAC gnomAD |
|
|
rs1203916643 CA374437424 |
773 | Q>E | No |
ClinGen TOPMed gnomAD |
|
|
rs150008661 CA374437417 |
774 | C>G | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA374437418 rs150008661 |
774 | C>R | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs150008661 CA5178624 |
774 | C>S | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs570425717 CA5178622 |
777 | E>K | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs1423284098 CA374437379 |
777 | E>V | No |
ClinGen Ensembl |
|
|
CA5178621 rs770336003 |
778 | D>G | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
rs761756497 CA5178620 |
779 | C>R | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 781 | I>N | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA374437343 rs1210977615 |
781 | I>V | No |
ClinGen TOPMed |
|
|
rs370019146 CA5178618 |
782 | A>T | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD |
|
rs747274167 CA5178617 |
783 | Y>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA374437315 rs747274167 |
783 | Y>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA374437317 rs747274167 |
783 | Y>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA5178615 rs770792229 |
786 | R>* | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
CA374437285 rs749113031 |
786 | R>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA5178614 rs749113031 |
786 | R>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA374437277 rs1349383875 |
787 | E>G | No |
ClinGen gnomAD |
|
|
rs777530030 CA5178613 |
787 | E>K | No |
ClinGen ExAC gnomAD |
|
|
CA374437236 rs1346167071 |
791 | T>A | No |
ClinGen gnomAD |
|
|
CA374437227 rs139321235 |
792 | N>D | No |
ClinGen ESP TOPMed gnomAD |
|
|
CA197590312 rs139321235 |
792 | N>H | No |
ClinGen ESP TOPMed gnomAD |
|
|
CA374437210 rs780717989 |
793 | T>P | No |
ClinGen ExAC gnomAD |
|
|
CA5178610 rs780717989 |
793 | T>S | No |
ClinGen ExAC gnomAD |
|
|
CA197590285 rs574451296 |
794 | Q>E | No |
ClinGen 1000Genomes TOPMed gnomAD |
|
|
CA374437196 rs1431289892 |
794 | Q>H | No |
ClinGen gnomAD |
|
|
rs759615816 CA197589292 |
795 | T>= | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen Ensembl NCI-TCGA |
|
CA5178595 rs769584100 |
796 | G>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1265458936 CA374436719 |
797 | E>K | Variant assessed as Somatic; 4.624e-05 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
rs1332380627 CA374436689 |
799 | H>Y | No |
ClinGen TOPMed |
|
|
rs780662928 CA5178593 |
800 | T>I | No |
ClinGen ExAC gnomAD |
|
|
rs887120621 CA197589267 |
801 | V>A | No |
ClinGen Ensembl |
|
|
CA5178591 rs746530947 |
803 | H>L | No |
ClinGen ExAC gnomAD |
|
|
CA374436640 rs1225490459 |
803 | H>Y | No |
ClinGen gnomAD |
|
|
rs1436573360 CA374436632 |
804 | L>V | No |
ClinGen TOPMed |
|
|
CA5178589 rs750732370 |
807 | V>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA5178588 rs750732370 |
807 | V>I | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA374436587 rs995426157 |
808 | A>S | No |
ClinGen TOPMed gnomAD |
|
|
rs995426157 CA197589236 |
808 | A>T | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed gnomAD |
|
CA374436583 rs1334505404 |
808 | A>V | No |
ClinGen gnomAD |
|
|
CA374436555 rs764701966 |
811 | D>H | No |
ClinGen ExAC gnomAD |
|
|
CA5178584 rs764701966 |
811 | D>N | No |
ClinGen ExAC gnomAD |
|
|
CA5178582 rs775732806 |
812 | H>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA5178581 rs767610399 |
813 | G>D | No |
ClinGen ExAC gnomAD |
|
|
CA5178577 rs747913041 |
816 | D>E | No |
ClinGen ExAC |
|
|
rs769685005 CA5178579 |
816 | D>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs769685005 CA5178578 |
816 | D>N | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA5178575 rs768615392 |
817 | D>G | No |
ClinGen ExAC gnomAD |
|
|
rs371886206 CA5178576 |
817 | D>Y | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
| TCGA novel | 819 | S>F | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs571043610 CA197589148 |
820 | D>E | No |
ClinGen Ensembl |
|
|
rs757957361 CA5178572 |
820 | D>N | No |
ClinGen ExAC TOPMed |
|
|
CA5178569 rs779132573 |
824 | F>L | No |
ClinGen ExAC gnomAD |
|
|
CA374436411 rs1564369362 |
825 | V>A | No |
ClinGen Ensembl |
|
|
CA5178567 rs375434242 |
826 | N>Y | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA5178566 rs778374111 |
827 | Y>C | No |
ClinGen ExAC gnomAD |
|
|
rs1310882886 CA374436384 |
828 | V>M | No |
ClinGen gnomAD |
|
|
CA5178565 rs756732632 |
830 | S>C | No |
ClinGen ExAC gnomAD |
|
|
rs767699817 CA374436328 |
833 | V>E | No |
ClinGen ExAC gnomAD |
|
|
rs767699817 CA5178561 |
833 | V>G | No |
ClinGen ExAC gnomAD |
|
|
CA5178559 rs374209870 |
834 | D>G | No |
ClinGen ESP ExAC gnomAD |
|
|
CA374436321 rs1411637197 |
834 | D>H | No |
ClinGen TOPMed |
|
|
rs1382955023 CA374436288 |
836 | E>D | No |
ClinGen gnomAD |
|
|
rs1236617838 CA374436293 |
836 | E>G | No |
ClinGen TOPMed |
|
|
CA5178558 rs147420952 |
836 | E>K | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA374436287 rs761559374 |
837 | P>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs761559374 CA5178557 |
837 | P>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs138828543 CA5178554 |
838 | V>I | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA374436241 rs1262530911 |
841 | H>R | No |
ClinGen gnomAD |
|
|
rs773780893 CA5178531 |
846 | I>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA374435903 rs1287578970 |
847 | G>R | No |
ClinGen gnomAD |
|
|
rs1398139979 CA374435897 |
848 | R>* | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
CA5178530 rs372894176 |
848 | R>Q | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA5178528 rs778265977 |
850 | G>S | No |
ClinGen ExAC gnomAD |
|
|
rs767866017 CA5178527 |
852 | L>S | No |
ClinGen ExAC gnomAD |
|
|
CA5178526 rs748523184 |
854 | T>I | No |
ClinGen ExAC gnomAD |
|
|
rs781698299 CA5178525 |
855 | M>V | No |
ClinGen ExAC gnomAD |
|
|
rs1419778123 CA374435849 |
856 | E>A | No |
ClinGen gnomAD |
|
|
rs1419778123 CA374435848 |
856 | E>G | No |
ClinGen gnomAD |
|
|
rs370374314 CA5178524 |
857 | T>I | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ESP ExAC NCI-TCGA gnomAD |
|
CA5178523 rs747093162 |
858 | A>T | No |
ClinGen ExAC gnomAD |
|
|
CA5178520 rs750704291 |
859 | M>T | No |
ClinGen ExAC gnomAD |
|
|
rs758617675 CA5178521 |
859 | M>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA374435818 rs1243668040 |
861 | L>V | No |
ClinGen TOPMed |
|
|
rs765458684 CA5178519 |
864 | R>G | No |
ClinGen ExAC gnomAD |
|
|
CA5178517 rs752456729 |
865 | N>S | No |
ClinGen ExAC gnomAD |
|
|
CA374435781 rs1306544426 |
867 | P>A | No |
ClinGen TOPMed gnomAD |
|
|
CA5178515 rs759429073 |
868 | I>V | No |
ClinGen ExAC gnomAD |
|
|
CA197588333 rs1054234573 |
871 | L>R | No |
ClinGen TOPMed gnomAD |
|
|
CA374435740 rs1398272676 |
873 | I>T | No |
ClinGen gnomAD |
|
|
rs1337857096 CA374435742 |
873 | I>V | No |
ClinGen gnomAD |
|
|
CA374435737 rs1444967868 |
874 | V>I | No |
ClinGen gnomAD |
|
|
rs1400639923 CA374435730 |
875 | R>* | No |
ClinGen gnomAD |
|
|
rs554596041 CA5178514 |
875 | R>Q | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD |
|
rs1588280309 CA374435715 |
877 | M>T | No |
ClinGen Ensembl |
|
|
rs201209437 CA5178512 |
878 | R>* | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD |
|
CA374435709 rs1382323139 |
878 | R>Q | No |
ClinGen gnomAD |
|
|
rs1157069163 CA374435700 |
879 | D>E | No |
ClinGen gnomAD |
|
|
CA197588292 rs757558061 |
880 | Q>R | No |
ClinGen Ensembl |
|
|
rs1439374015 CA374435689 |
881 | R>C | No |
ClinGen TOPMed gnomAD |
|
|
CA374435690 rs1439374015 |
881 | R>G | No |
ClinGen TOPMed gnomAD |
|
|
CA5178511 rs772929268 |
881 | R>H | No |
ClinGen ExAC gnomAD |
|
|
rs201640227 CA5178509 |
882 | A>T | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs1255310697 CA374435675 |
883 | M>I | No |
ClinGen gnomAD |
|
|
rs200077324 CA197588270 |
883 | M>T | No |
ClinGen 1000Genomes TOPMed |
|
|
CA5178508 rs776911389 |
884 | M>I | No |
ClinGen ExAC gnomAD |
|
|
rs769178303 CA5178507 CA374435664 |
885 | V>L | No |
ClinGen ExAC gnomAD |
|
|
CA5178483 rs778922967 |
892 | K>N | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs761116253 CA5178484 |
892 | K>T | No |
ClinGen ExAC gnomAD |
|
|
rs149479153 CA5178482 |
894 | V>A | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1242761360 CA374434845 |
894 | V>L | No |
ClinGen TOPMed |
|
|
CA5178481 rs531502072 |
897 | A>V | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs771178217 CA5178479 |
899 | L>F | No |
ClinGen ExAC gnomAD |
|
|
CA5178477 rs778066954 |
900 | R>C | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA5178476 rs754659379 |
900 | R>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs754659379 CA374434761 |
900 | R>P | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA5178474 rs780087068 |
902 | Y>C | Variant assessed as Somatic; 0.0002772 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
rs1256648740 CA374434691 |
905 | G>D | No |
ClinGen TOPMed gnomAD |
|
|
rs962382044 CA197586428 |
905 | G>S | No |
ClinGen TOPMed gnomAD |
|
|
rs150328766 CA5178472 |
911 | D>G | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA374434597 rs1276734659 |
912 | P>S | No |
ClinGen gnomAD |
|
|
CA374434581 rs1434540553 |
913 | S>N | No |
ClinGen gnomAD |
No associated diseases with P26045
13 regional properties for P26045
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Tyrosine-specific protein phosphatase, PTPase domain | 645 - 903 | IPR000242 |
| domain | FERM domain | 29 - 312 | IPR000299 |
| domain | Tyrosine-specific protein phosphatases domain | 819 - 892 | IPR000387 |
| domain | PDZ domain | 510 - 598 | IPR001478 |
| domain | Protein-tyrosine phosphatase, catalytic | 800 - 900 | IPR003595 |
| active_site | Protein-tyrosine phosphatase, active site | 840 - 850 | IPR016130 |
| domain | FERM, N-terminal | 33 - 96 | IPR018979 |
| domain | FERM, C-terminal PH-like domain | 226 - 316 | IPR018980 |
| conserved_site | FERM conserved site | 84 - 113 | IPR019747-1 |
| conserved_site | FERM conserved site | 192 - 221 | IPR019747-2 |
| domain | FERM central domain | 114 - 222 | IPR019748 |
| domain | Band 4.1 domain | 25 - 222 | IPR019749 |
| domain | PTPN3/4, FERM domain C-lobe | 216 - 309 | IPR041783 |
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytoplasmic side of plasma membrane | The leaflet the plasma membrane that faces the cytoplasm and any proteins embedded or anchored in it or attached to its surface. |
| cytoskeleton | A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATPase binding | Binding to an ATPase, any enzyme that catalyzes the hydrolysis of ATP. |
| cytoskeletal protein binding | Binding to a protein component of a cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton). |
| phosphotyrosine residue binding | Binding to a phosphorylated tyrosine residue within a protein. |
| protein tyrosine phosphatase activity | Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. |
| sodium channel regulator activity | Binds to and modulates the activity of a sodium channel. |
8 GO annotations of biological process
| Name | Definition |
|---|---|
| liver regeneration | The regrowth of lost or destroyed liver. |
| MAPK cascade | An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain an additional tiers: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell. |
| negative regulation of epidermal growth factor receptor signaling pathway | Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity. |
| negative regulation of membrane protein ectodomain proteolysis | Any process that stops, prevents, or reduces the frequency, rate or extent of membrane protein ectodomain proteolysis. |
| negative regulation of mitotic cell cycle | Any process that stops, prevents or reduces the rate or extent of progression through the mitotic cell cycle. |
| protein dephosphorylation | The process of removing one or more phosphoric residues from a protein. |
| regulation of membrane depolarization during action potential | Any process that modulates the rate, frequency or extent of membrane depolarization during an action potential. Membrane depolarization is the process in which membrane potential changes in the depolarizing direction from the resting potential. |
| regulation of sodium ion transmembrane transporter activity | Any process that modulates the frequency, rate or extent of sodium ion transmembrane transporter activity. |
3 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q15678 | PTPN14 | Tyrosine-protein phosphatase non-receptor type 14 | Homo sapiens (Human) | PR |
| P29074 | PTPN4 | Tyrosine-protein phosphatase non-receptor type 4 | Homo sapiens (Human) | PR |
| Q9WU22 | Ptpn4 | Tyrosine-protein phosphatase non-receptor type 4 | Mus musculus (Mouse) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MTSRLRALGG | RINNIRTSEL | PKEKTRSEVI | CSIHFLDGVV | QTFKVTKQDT | GQVLLDMVHN |
| 70 | 80 | 90 | 100 | 110 | 120 |
| HLGVTEKEYF | GLQHDDDSVD | SPRWLEASKA | IRKQLKGGFP | CTLHFRVRFF | IPDPNTLQQE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| QTRHLYFLQL | KMDICEGRLT | CPLNSAVVLA | SYAVQSHFGD | YNSSIHHPGY | LSDSHFIPDQ |
| 190 | 200 | 210 | 220 | 230 | 240 |
| NEDFLTKVES | LHEQHSGLKQ | SEAESCYINI | ARTLDFYGVE | LHSGRDLHNL | DLMIGIASAG |
| 250 | 260 | 270 | 280 | 290 | 300 |
| VAVYRKYICT | SFYPWVNILK | ISFKRKKFFI | HQRQKQAESR | EHIVAFNMLN | YRSCKNLWKS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| CVEHHTFFQA | KKLLPQEKNV | LSQYWTMGSR | NTKKSVNNQY | CKKVIGGMVW | NPAMRRSLSV |
| 370 | 380 | 390 | 400 | 410 | 420 |
| EHLETKSLPS | RSPPITPNWR | SPRLRHEIRK | PRHSSADNLA | NEMTYITETE | DVFYTYKGSL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| APQDSDSEVS | QNRSPHQESL | SENNPAQSYL | TQKSSSSVSP | SSNAPGSCSP | DGVDQQLLDD |
| 490 | 500 | 510 | 520 | 530 | 540 |
| FHRVTKGGST | EDASQYYCDK | NDNGDSYLVL | IRITPDEDGK | FGFNLKGGVD | QKMPLVVSRI |
| 550 | 560 | 570 | 580 | 590 | 600 |
| NPESPADTCI | PKLNEGDQIV | LINGRDISEH | THDQVVMFIK | ASRESHSREL | ALVIRRRAVR |
| 610 | 620 | 630 | 640 | 650 | 660 |
| SFADFKSEDE | LNQLFPEAIF | PMCPEGGDTL | EGSMAQLKKG | LESGTVLIQF | EQLYRKKPGL |
| 670 | 680 | 690 | 700 | 710 | 720 |
| AITFAKLPQN | LDKNRYKDVL | PYDTTRVLLQ | GNEDYINASY | VNMEIPAANL | VNKYIATQGP |
| 730 | 740 | 750 | 760 | 770 | 780 |
| LPHTCAQFWQ | VVWDQKLSLI | VMLTTLTERG | RTKCHQYWPD | PPDVMNHGGF | HIQCQSEDCT |
| 790 | 800 | 810 | 820 | 830 | 840 |
| IAYVSREMLV | TNTQTGEEHT | VTHLQYVAWP | DHGVPDDSSD | FLEFVNYVRS | LRVDSEPVLV |
| 850 | 860 | 870 | 880 | 890 | 900 |
| HCSAGIGRTG | VLVTMETAMC | LTERNLPIYP | LDIVRKMRDQ | RAMMVQTSSQ | YKFVCEAILR |
| 910 | |||||
| VYEEGLVQML | DPS |