Q9W4D2

PR
Gene name
Rnp4F
Protein name
RNA-binding protein 4F
Names
Species
Drosophila melanogaster (Fruit fly)
KEGG Pathway
dme:Dmel_CG3312
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-180 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9W4D2

Entry ID Method Resolution Chain Position Source
AF-Q9W4D2-F1 Predicted AlphaFoldDB

88 variants for Q9W4D2

Variant ID(s) Position Change Description Diseaes Association Provenance
9 R>G RNA edited version [UniProt] No
13 K>R RNA edited version [UniProt] No
17 E>G RNA edited version [UniProt] No
21 E>G RNA edited version [UniProt] No
31 Y>C RNA edited version [UniProt] No
41 K>G RNA edited version [UniProt] No
46 Q>R RNA edited version [UniProt] No
50 E>G RNA edited version [UniProt] No
54 Q>R RNA edited version [UniProt] No
57 E>G RNA edited version [UniProt] No
59 K>R RNA edited version [UniProt] No
70 T>A RNA edited version [UniProt] No
80 M>V RNA edited version [UniProt] No
84 E>G RNA edited version [UniProt] No
86 I>V RNA edited version [UniProt] No
91 E>G RNA edited version [UniProt] No
96 E>G RNA edited version [UniProt] No
101 N>G RNA edited version [UniProt] No
107 R>G RNA edited version [UniProt] No
113 S>G RNA edited version [UniProt] No
116 S>G RNA edited version [UniProt] No
130 N>S RNA edited version [UniProt] No
132 E>G RNA edited version [UniProt] No
135 S>G RNA edited version [UniProt] No
138 D>G RNA edited version [UniProt] No
139 S>G RNA edited version [UniProt] No
141 S>G RNA edited version [UniProt] No
163 K>R RNA edited version [UniProt] No
164 K>G RNA edited version [UniProt] No
183 K>G RNA edited version [UniProt] No
190 E>G RNA edited version [UniProt] No
193 N>G RNA edited version [UniProt] No
196 T>A RNA edited version [UniProt] No
200 H>R RNA edited version [UniProt] No
205 Y>C RNA edited version [UniProt] No
207 K>G RNA edited version [UniProt] No
213 T>A RNA edited version [UniProt] No
218 E>G RNA edited version [UniProt] No
220 K>G RNA edited version [UniProt] No
225 Q>R RNA edited version [UniProt] No
265 Y>C RNA edited version [UniProt] No
275 K>R RNA edited version [UniProt] No
298 K>G RNA edited version [UniProt] No
299 H>R RNA edited version [UniProt] No
302 T>A RNA edited version [UniProt] No
311 Q>R RNA edited version [UniProt] No
314 K>G RNA edited version [UniProt] No
319 K>R RNA edited version [UniProt] No
321 K>E RNA edited version [UniProt] No
322 Q>R RNA edited version [UniProt] No
328 T>A RNA edited version [UniProt] No
354 K>R RNA edited version [UniProt] No
355 N>S RNA edited version [UniProt] No
368 K>G RNA edited version [UniProt] No
381 E>G RNA edited version [UniProt] No
383 I>V RNA edited version [UniProt] No
389 T>A RNA edited version [UniProt] No
393 N>S RNA edited version [UniProt] No
396 E>G RNA edited version [UniProt] No
398 E>G RNA edited version [UniProt] No
400 T>A RNA edited version [UniProt] No
406 K>R RNA edited version [UniProt] No
409 K>E RNA edited version [UniProt] No
430 S>G RNA edited version [UniProt] No
431 H>R RNA edited version [UniProt] No
433 S>G RNA edited version [UniProt] No
437 N>S RNA edited version [UniProt] No
444 M>V RNA edited version [UniProt] No
453 E>G RNA edited version [UniProt] No
456 E>G RNA edited version [UniProt] No
482 Y>C RNA edited version [UniProt] No
490 S>G RNA edited version [UniProt] No
492 E>G RNA edited version [UniProt] No
493 Q>R RNA edited version [UniProt] No
497 S>G RNA edited version [UniProt] No
510 T>A RNA edited version [UniProt] No
513 Y>C RNA edited version [UniProt] No
516 Q>R RNA edited version [UniProt] No
520 R>G RNA edited version [UniProt] No
521 Y>C RNA edited version [UniProt] No
525 Q>R RNA edited version [UniProt] No
540 N>G RNA edited version [UniProt] No
551 Y>E RNA edited version [UniProt] No
552 P>R RNA edited version [UniProt] No
553 G>F RNA edited version [UniProt] No
554 S>E RNA edited version [UniProt] No
555 S>I RNA edited version [UniProt] No
556 I>del RNA edited version [UniProt] No

No associated diseases with Q9W4D2

5 regional properties for Q9W4D2

Type Name Position InterPro Accession
domain RNA recognition motif domain 724 - 801 IPR000504
repeat HAT (Half-A-TPR) repeat 353 - 385 IPR003107-1
repeat HAT (Half-A-TPR) repeat 453 - 485 IPR003107-2
repeat HAT (Half-A-TPR) repeat 536 - 570 IPR003107-3
domain LSM-interacting domain 922 - 940 IPR008669

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
ASAP complex A protein complex involved in regulation of mRNA processing and apoptosis. It binds to RNA in a sequence-independent manner and is recruited to the EJC prior to or during the splicing process. In humans the core proteins are RNPS1, SAP18 and ACIN1.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.

1 GO annotations of molecular function

Name Definition
mRNA binding Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.

2 GO annotations of biological process

Name Definition
central nervous system development The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord.
mRNA splicing, via spliceosome The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q15020 SART3 Squamous cell carcinoma antigen recognized by T-cells 3 Homo sapiens (Human) PR
Q9JLI8 Sart3 Squamous cell carcinoma antigen recognized by T-cells 3 Mus musculus (Mouse) PR
B3DJT0 sart3 Squamous cell carcinoma antigen recognized by T-cells 3 Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MDADKQLERQ LEKELDEMPA EDLDDDAYDE YDLIVIPDQG KGSPQQGHSE SPQQEEEHKS
70 80 90 100 110 120
EELRQRSRPT WPPSSAGGDM TTIELISSDD EPSVEETEGG NAAGRGRARN DSSSSSDDVG
130 140 150 160 170 180
VIEGSELESN SEVSSDSDSD SDNAGGGNQL ERSYQELNAL PSKKFAQMVS LIGIAFKLND
190 200 210 220 230 240
LEKIESSVLE LQNLATVPAH VWLKYLKARL VVTQTDEERK AFEEQCAKAL GYYYSIPLSE
250 260 270 280 290 300
YVVNYLVDQG NVQNHVLWAK LLADYDVERP DFGDKLRSLI STITDENEAA AFVEMLQKHC
310 320 330 340 350 360
VTWTCNVEQR QMIKSVVDKF KQHLDETTRG WDWSEQHKAH VYDVETLSLD DDLKNAVIRF
370 380 390 400 410 420
IFERSVAKFP IVDVLWLSYI EFIQFEGVTV PENEDENEVT AEMVAKRAKR LGKGFLRNTE
430 440 450 460 470 480
LDLANRGVRS HPSVQLNHRF LDLMERSDFE LAEVDEEIRL ILQRIVTDMD MTVELHLDYL
490 500 510 520 530 540
AYRIRNTNAS DEQQVASLRA AFNHAWEELT VLYGDQADTR YEVLQLWAQV EYTQLGSPDN
550 560 570 580 590 600
GREIWRQIMG YPGSSIRGLL WLNFAQMESE YNGGHGTRDV LRKALSQPVL ENGLMVQEFF
610 620 630 640 650 660
RRYERCYGTY ESIAACQALD LPVEYVKPRS RIKPNSQSAY PRQQKLKPRQ QQQQTNREPL
670 680 690 700 710 720
NREQRRRQAH EQQQQQQQQQ KHGIKKSRTE PSGGATSPPS KVKGPANAEA KESNFKYSPN
730 740 750 760 770 780
MEINKIFVRN LHPACSKEEL HELFSPFGTI KDVRLVHKLN KQFKGIAYVE FEKPGEAQRA
790 800 810 820 830 840
VAGRDGCLFK GMNISVAISN PPPRGTSAVK PSVAPKRRVP TSLIPTTLVR QEVAAKKLRL
850 860 870 880 890 900
LLPEPGDISS TSASVDVAIK REANGEEQKG DVQERDEQKG EEQKGEEQKG EEPKGEEQKG
910 920 930 940
DDQIGEEQSG VEQKGDEKKE EEMPAAVPKS NDDFRKLFLK D